# ASCOD ischemic stroke phenotyping (Amarenco 2013) ASCOD Status: LIVE Price: $0.005 USDC `GET /api/calc/ascod` HTML: https://magentlab.com/docs/ascod Markdown: https://magentlab.com/docs/ascod.md Not a medical device. Not a diagnosis, dose, or listing recommendation. ## What it computes Echo caller-assigned Amarenco 2013 ASCOD grades for atherosclerosis (A), small-vessel disease (S), cardiac pathology (C), other causes (O), and dissection (D) and return the canonical phenotype string (for example A1-S0-C2-O0-D0). magent does not read imaging and does not convert the five grades into a single ASCOD score. ## When to use When an agent already has Amarenco 2013 ASCOD grades as assigned by the caller and needs the canonical phenotype string. magent does not apply TOAST or CCS, does not read imaging, and does not assign treatment. ## When not to use - Not a medical device. magent does not read imaging. - The caller assigns each ASCOD grade (1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, 9 insufficient workup). magent does not grade from stenosis percent, infarct pattern, or cardiac tests. - Not TOAST and not CCS. ASCOD describes overlapping phenotypes, not a single causative subtype. - The five grades are independent and are not summed into an ASCOD score. magent does not invent treatment. ## Formula ``` ASCOD phenotype A{atherosclerosis}-S{small_vessel}-C{cardiac}-O{other}-D{dissection}; each caller-assigned Amarenco 2013 grade is 1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, or 9 insufficient workup to rule out the disease; grades are independent and are not summed; not TOAST; not CCS; magent does not read imaging ``` ## Citation [The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping)](https://doi.org/10.1159/000352050) Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG Cerebrovasc Dis. 2013;36(1):1-5 DOI: [10.1159/000352050](https://doi.org/10.1159/000352050) ## Worked example ### All phenotypes grade 0 (absent) Given: `atherosclerosis=0, cardiac=0, dissection=0, other=0, small_vessel=0` 1. atherosclerosis 0, small_vessel 0, cardiac 0, other 0, dissection 0 as assigned by the caller 2. canonical phenotype is A0-S0-C0-O0-D0; grades are not summed ### Potentially causal atherosclerosis Given: `atherosclerosis=1, cardiac=0, dissection=0, other=0, small_vessel=0` 1. atherosclerosis 1 (potentially causal); other phenotypes 0 (absent) 2. canonical phenotype is A1-S0-C0-O0-D0; grades are not summed ## Also searched as - ASCOD phenotyping - ASCO phenotyping - Amarenco ASCOD - ischemic stroke phenotype - A-S-C-O-D - Updated ASCO phenotyping - atherosclerosis small-vessel cardiac dissection - ASCOD ischemic stroke ## Parameters - `atherosclerosis` (integer, required): Caller-assigned Amarenco 2013 atherosclerosis (A) grade: 1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, or 9 insufficient workup. magent does not read imaging. - `small_vessel` (integer, required): Caller-assigned Amarenco 2013 small-vessel disease (S) grade: 1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, or 9 insufficient workup. magent does not read imaging. - `cardiac` (integer, required): Caller-assigned Amarenco 2013 cardiac pathology (C) grade: 1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, or 9 insufficient workup. magent does not read imaging. - `other` (integer, required): Caller-assigned Amarenco 2013 other causes (O) grade: 1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, or 9 insufficient workup. magent does not read imaging. - `dissection` (integer, required): Caller-assigned Amarenco 2013 dissection (D) grade: 1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, or 9 insufficient workup. magent does not read imaging. ## Bulk (POST) POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement. Method: `POST /api/calc/ascod` Max items: 25 Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic) Status: PREVIEW - 1 to 25 items. Each item uses the same keys as the GET query parameters. - POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows. - The first invalid item fails the whole request (index in the 400 JSON). You are not charged. - HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row. - Catalog misses (empty matches, found=false) stay paid 200s inside that slot. - x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items. Example request: ```json { "items": [ { "atherosclerosis": "0", "cardiac": "0", "dissection": "0", "other": "0", "small_vessel": "0" }, { "atherosclerosis": "0", "cardiac": "0", "dissection": "0", "other": "0", "small_vessel": "0" } ] } ``` Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/ascod Example 200: ```json { "count": 2, "path": "/api/calc/ascod", "items": [ { "other": 0, "components": [ { "value": 0, "factor": "atherosclerosis", "met": true }, { "value": 0, "factor": "small_vessel", "met": true }, { "value": 0, "factor": "cardiac", "met": true }, { "value": 0, "factor": "other", "met": true }, { "value": 0, "factor": "dissection", "met": true } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG", "doi": "10.1159/000352050", "id": "amarenco-2013", "pmid": "23899749", "source": "Cerebrovasc Dis. 2013;36(1):1-5", "title": "The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping)" }, "formula": "ascod", "formula_expression": "ASCOD phenotype A{atherosclerosis}-S{small_vessel}-C{cardiac}-O{other}-D{dissection}; each caller-assigned Amarenco 2013 grade is 1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, or 9 insufficient workup to rule out the disease; grades are independent and are not summed; not TOAST; not CCS; magent does not read imaging", "atherosclerosis": 0, "cardiac": 0, "dissection": 0, "phenotype": "A0-S0-C0-O0-D0", "small_vessel": 0 }, { "other": 0, "components": [ { "value": 0, "factor": "atherosclerosis", "met": true }, { "value": 0, "factor": "small_vessel", "met": true }, { "value": 0, "factor": "cardiac", "met": true }, { "value": 0, "factor": "other", "met": true }, { "value": 0, "factor": "dissection", "met": true } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG", "doi": "10.1159/000352050", "id": "amarenco-2013", "pmid": "23899749", "source": "Cerebrovasc Dis. 2013;36(1):1-5", "title": "The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping)" }, "formula": "ascod", "formula_expression": "ASCOD phenotype A{atherosclerosis}-S{small_vessel}-C{cardiac}-O{other}-D{dissection}; each caller-assigned Amarenco 2013 grade is 1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, or 9 insufficient workup to rule out the disease; grades are independent and are not summed; not TOAST; not CCS; magent does not read imaging", "atherosclerosis": 0, "cardiac": 0, "dissection": 0, "phenotype": "A0-S0-C0-O0-D0", "small_vessel": 0 } ] } ``` ## Response fields - `formula` (string): ascod - `formula_expression` (string): Published Amarenco 2013 ASCOD phenotype rule - `phenotype` (string): Canonical A{grade}-S{grade}-C{grade}-O{grade}-D{grade} string - `atherosclerosis` (integer): Caller-assigned atherosclerosis (A) grade 0, 1, 2, 3, or 9 - `small_vessel` (integer): Caller-assigned small-vessel disease (S) grade 0, 1, 2, 3, or 9 - `cardiac` (integer): Caller-assigned cardiac pathology (C) grade 0, 1, 2, 3, or 9 - `other` (integer): Caller-assigned other causes (O) grade 0, 1, 2, 3, or 9 - `dissection` (integer): Caller-assigned dissection (D) grade 0, 1, 2, 3, or 9 - `components` (array): Per-phenotype Tree rows atherosclerosis, small_vessel, cardiac, other, dissection with factor, met, and value - `citation` (object): Amarenco 2013 Cerebrovasc Dis citation - `disclaimer` (string): Not-a-device notice ## Example JSON Frozen fixture. Not a live lookup. ```json { "other": 0, "components": [ { "value": 0, "factor": "atherosclerosis", "met": true }, { "value": 0, "factor": "small_vessel", "met": true }, { "value": 0, "factor": "cardiac", "met": true }, { "value": 0, "factor": "other", "met": true }, { "value": 0, "factor": "dissection", "met": true } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG", "doi": "10.1159/000352050", "id": "amarenco-2013", "pmid": "23899749", "source": "Cerebrovasc Dis. 2013;36(1):1-5", "title": "The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping)" }, "formula": "ascod", "formula_expression": "ASCOD phenotype A{atherosclerosis}-S{small_vessel}-C{cardiac}-O{other}-D{dissection}; each caller-assigned Amarenco 2013 grade is 1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, or 9 insufficient workup to rule out the disease; grades are independent and are not summed; not TOAST; not CCS; magent does not read imaging", "atherosclerosis": 0, "cardiac": 0, "dissection": 0, "phenotype": "A0-S0-C0-O0-D0", "small_vessel": 0 } ``` ## Errors - HTTP 400 `invalid_ascod`: ASCOD needs Amarenco 2013 grades 0-3 (or 9 insufficient) for A, S, C, O, and D. Returned before settlement; you are not charged. - HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged. - HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged. - HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged. Shared HTTP 402 and 503: https://magentlab.com/docs/payments ## Related tools - [NIHSS](https://magentlab.com/docs/nihss) — Sum Brott 1989 NIH stroke scale points from 15 caller-assigned examination integers, including pupillary response and plantar reflex. Weaker-limb motor arm and leg. Does not apply later total-score severity bands. - [ABCD2 score](https://magentlab.com/docs/abcd2) — Compute the ABCD2 score as age, blood pressure, caller-assigned clinical features, symptom duration, and diabetes. ## Payment Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. - GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall). - HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote. - Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering. - Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional. - Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402. - offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront. - offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization. - not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search. Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers). Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments Stdio MCP (one process per host): https://magentlab.com/docs/mcp ## Guarantees - HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON. - exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE. - HTTP 402 is unpaid only. Do not sign a second authorization because of a 503. - Execution is timeout-bounded and concurrency-capped. - Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.