# Binet 1981 CLL staging

Binet

Status: LIVE
Price: $0.005 USDC
`GET /api/calc/binet`
HTML: https://magentlab.com/docs/binet
Markdown: https://magentlab.com/docs/binet.md

Not a medical device. Not a diagnosis, dose, or listing recommendation.

## What it computes

Apply Binet 1981 chronic lymphocytic leukemia staging and return stage A, B, or C from caller-assigned anemia (Hb <10 g/dL), thrombocytopenia (platelets <100×10^9/L), and involved lymphoid areas (0-5).

## When to use

When an agent already has CLL with lymphocytosis and caller-assigned anemia, thrombocytopenia, and Binet five-area count, and needs the published Binet 1981 stage. magent does not diagnose CLL and does not examine the patient.

## When not to use

- Not a medical device.
- Not a CLL diagnosis. The caller already has CLL with lymphocytosis; magent does not diagnose CLL.
- magent does not examine the patient or count lymph-node areas. The caller assigns the five-area count after Binet's uni/bilateral rule (cervical, axillary, inguinal — uni or bilateral counts as one area each — plus spleen, plus liver).
- This tool is Binet 1981 staging only. Not Rai staging (Rai anemia is Hb <11), not modified Rai, and not CLL-IPI. No A/B/C substages and no survival months.

## Formula

```
Binet C if anemia_hb_lt_10 or thrombocytopenia_plt_lt_100; else B if involved_areas >= 3; else A (involved_areas 0-2) (Binet 1981)
```

## Citation

[A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis](https://doi.org/10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V)
Binet JL, Auquier A, Dighiero G, et al.
Cancer. 1981;48(1):198-206
DOI: [10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V](https://doi.org/10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V)

## Worked example

### One involved area, no cytopenia

Given: `anemia_hb_lt_10=false, involved_areas=1, thrombocytopenia_plt_lt_100=false`

1. anemia_hb_lt_10 is false and thrombocytopenia_plt_lt_100 is false
2. involved_areas is 1, which is not >= 3
3. binet_stage is A


## Also searched as

- Binet staging
- Binet CLL
- Binet classification
- chronic lymphocytic leukemia staging
- Binet 1981
- CLL Binet stage
- Binet A B C
- lymphoid areas Binet

## Parameters

- `anemia_hb_lt_10` (boolean, required): Hb <10 g/dL as assigned by the caller (Binet 1981 stage C cutoff is 10 g/dL, not Rai 11). true or false. magent does not assay hemoglobin.
- `thrombocytopenia_plt_lt_100` (boolean, required): Platelets <100×10^9/L as assigned by the caller (Binet 1981 stage C). true or false. magent does not count platelets.
- `involved_areas` (integer, required): Count of involved Binet lymphoid areas (integer 0-5) as assigned by the caller after Binet 1981: cervical, axillary, and inguinal (unilateral or bilateral counts as one area each), plus spleen, plus liver. magent does not examine the patient or count lymph-node areas.

## Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

Method: `POST /api/calc/binet`
Max items: 25
Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic)
Status: PREVIEW

- 1 to 25 items. Each item uses the same keys as the GET query parameters.
- POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
- The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
- HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
- Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
- x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request:

```json
{
  "items": [
    {
      "anemia_hb_lt_10": "false",
      "involved_areas": "1",
      "thrombocytopenia_plt_lt_100": "false"
    },
    {
      "anemia_hb_lt_10": "false",
      "involved_areas": "1",
      "thrombocytopenia_plt_lt_100": "false"
    }
  ]
}
```

Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/binet

Example 200:

```json
{
  "count": 2,
  "path": "/api/calc/binet",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Binet JL, Auquier A, Dighiero G, et al.",
        "doi": "10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V",
        "id": "binet-1981",
        "pmid": "7237385",
        "source": "Cancer. 1981;48(1):198-206",
        "title": "A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis"
      },
      "formula": "binet",
      "formula_expression": "Binet C if anemia_hb_lt_10 or thrombocytopenia_plt_lt_100; else B if involved_areas >= 3; else A (involved_areas 0-2) (Binet 1981)",
      "criteria": [
        {
          "factor": "anemia_hb_lt_10",
          "met": false
        },
        {
          "factor": "thrombocytopenia_plt_lt_100",
          "met": false
        },
        {
          "factor": "involved_areas_ge_3",
          "met": false
        }
      ],
      "binet_stage": "A",
      "anemia_hb_lt_10": false,
      "involved_areas": 1,
      "thrombocytopenia_plt_lt_100": false
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Binet JL, Auquier A, Dighiero G, et al.",
        "doi": "10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V",
        "id": "binet-1981",
        "pmid": "7237385",
        "source": "Cancer. 1981;48(1):198-206",
        "title": "A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis"
      },
      "formula": "binet",
      "formula_expression": "Binet C if anemia_hb_lt_10 or thrombocytopenia_plt_lt_100; else B if involved_areas >= 3; else A (involved_areas 0-2) (Binet 1981)",
      "criteria": [
        {
          "factor": "anemia_hb_lt_10",
          "met": false
        },
        {
          "factor": "thrombocytopenia_plt_lt_100",
          "met": false
        },
        {
          "factor": "involved_areas_ge_3",
          "met": false
        }
      ],
      "binet_stage": "A",
      "anemia_hb_lt_10": false,
      "involved_areas": 1,
      "thrombocytopenia_plt_lt_100": false
    }
  ]
}
```

## Response fields

- `formula` (string): binet
- `formula_expression` (string): Binet 1981: C if anemia (Hb <10) or thrombocytopenia (plt <100); else B if involved_areas >= 3; else A
- `binet_stage` (string): A, B, or C (Binet 1981). Not Rai. No A/B/C substages.
- `involved_areas` (integer): Echo of the caller-assigned Binet five-area count (0-5)
- `anemia_hb_lt_10` (boolean): Echo of the caller-assigned Hb <10 g/dL flag
- `thrombocytopenia_plt_lt_100` (boolean): Echo of the caller-assigned platelets <100×10^9/L flag
- `criteria` (array): Per-factor rows with factor and met for anemia_hb_lt_10, thrombocytopenia_plt_lt_100, and involved_areas_ge_3
- `citation` (object): Binet 1981 Cancer citation
- `disclaimer` (string): Not-a-device notice

## Example JSON

Frozen fixture. Not a live lookup.

```json
{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Binet JL, Auquier A, Dighiero G, et al.",
    "doi": "10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V",
    "id": "binet-1981",
    "pmid": "7237385",
    "source": "Cancer. 1981;48(1):198-206",
    "title": "A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis"
  },
  "formula": "binet",
  "formula_expression": "Binet C if anemia_hb_lt_10 or thrombocytopenia_plt_lt_100; else B if involved_areas >= 3; else A (involved_areas 0-2) (Binet 1981)",
  "criteria": [
    {
      "factor": "anemia_hb_lt_10",
      "met": false
    },
    {
      "factor": "thrombocytopenia_plt_lt_100",
      "met": false
    },
    {
      "factor": "involved_areas_ge_3",
      "met": false
    }
  ],
  "binet_stage": "A",
  "anemia_hb_lt_10": false,
  "involved_areas": 1,
  "thrombocytopenia_plt_lt_100": false
}
```

## Errors

- HTTP 400 `invalid_binet`: anemia_hb_lt_10 and thrombocytopenia_plt_lt_100 must be true or false (Binet 1981). Returned before settlement; you are not charged.
- HTTP 400 `invalid_involved_areas`: involved_areas must be an integer from 0 to 5 (Binet 1981 five lymphoid areas). Returned before settlement; you are not charged.
- HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
- HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
- HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged.

Shared HTTP 402 and 503: https://magentlab.com/docs/payments

## Related tools

- [CLL-IPI](https://magentlab.com/docs/cll-ipi) — Sum the 2016 CLL-IPI (chronic lymphocytic leukaemia international prognostic index) and return low (0–1), intermediate (2–3), high (4–6), or very_high (7–10).
- [Rai](https://magentlab.com/docs/rai) — Apply Rai 1975 original clinical staging of chronic lymphocytic leukemia and return rai_stage 0-4 from four caller-assigned flags.

## Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s.

- GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall).
- HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote.
- Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering.
- Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional.
- Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402.

- offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront.
- offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization.

- not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search.

Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers).

Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments

Stdio MCP (one process per host): https://magentlab.com/docs/mcp

## Guarantees

- HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
- exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
- HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
- Execution is timeout-bounded and concurrency-capped.
- Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.