# CLIF-C ACLF

CLIF-C ACLF

Status: LIVE
Price: $0.005 USDC
`GET /api/calc/clif_c_aclf`
HTML: https://magentlab.com/docs/clif-c-aclf
Markdown: https://magentlab.com/docs/clif-c-aclf.md

Not a medical device. Not a diagnosis, dose, or listing recommendation.

## What it computes

Compute the Jalan 2014 CLIF-C ACLF score from a caller-assigned CLIF-C OF (integer 6-18), age, and white-cell count in 10^9/L. magent does not score the six organs.

## When to use

When an agent needs published Jalan 2014 CLIF-C ACLF (CANONIC) arithmetic from a caller-assigned CLIF-C OF, age, and WBC and must not invent MELD, Child-Pugh, or organ-failure subscores.

## When not to use

- Not a medical device. Not a diagnosis and not a transplant listing protocol.
- Caller supplies clif_c_of (integer 6-18). magent does not compute CLIF-C OF from organs and does not score CLIF-SOFA.
- Not MELD, not MELD-Na, and not Child-Pugh. This is the Jalan 2014 CLIF-C ACLF equation only.

## Formula

```
clif_c_aclf = 10 * (0.33 * clif_c_of + 0.04 * age + 0.63 * ln(wbc_10e9_l) - 2); caller-assigned CLIF-C OF 6-18; round 1 decimal then clamp 0-100 (Jalan 2014 CANONIC)
```

## Citation

[Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure.](https://doi.org/10.1016/j.jhep.2014.06.012)
Jalan R, Saliba F, Pavesi M, et al.
J Hepatol. 2014;61(5):1038-1047
DOI: [10.1016/j.jhep.2014.06.012](https://doi.org/10.1016/j.jhep.2014.06.012)

## Worked example

### CLIF-C OF 6, age 50, WBC 5

Given: `age=50, clif_c_of=6, wbc_10e9_l=5`

1. Caller-assigned CLIF-C OF = 6 (magent does not score organs)
2. CLIF-C ACLF = 10 × (0.33×6 + 0.04×50 + 0.63×ln(5) − 2)
3. Round 1 decimal then clamp 0-100 → 29.9


## Also searched as

- CLIF-C ACLF
- CLIF Consortium ACLF
- acute-on-chronic liver failure score
- Jalan 2014 ACLF
- CANONIC ACLF
- CLIF-C OF ACLF score

## Parameters

- `clif_c_of` (integer, required): Caller-assigned CLIF-C organ-failure score, integer 6-18 (Jalan 2014). magent does not score the six organs or compute CLIF-C OF.
- `age` (integer, required): Age in years (18-120).
- `wbc_10e9_l` (number, required): White-cell count in 10^9/L (0.1-200). Natural log in the equation.

## Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

Method: `POST /api/calc/clif_c_aclf`
Max items: 25
Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic)
Status: PREVIEW

- 1 to 25 items. Each item uses the same keys as the GET query parameters.
- POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
- The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
- HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
- Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
- x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request:

```json
{
  "items": [
    {
      "age": "50",
      "clif_c_of": "6",
      "wbc_10e9_l": "5"
    },
    {
      "age": "50",
      "clif_c_of": "6",
      "wbc_10e9_l": "5"
    }
  ]
}
```

Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/clif-c-aclf

Example 200:

```json
{
  "count": 2,
  "path": "/api/calc/clif_c_aclf",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Jalan R, Saliba F, Pavesi M, et al.",
        "doi": "10.1016/j.jhep.2014.06.012",
        "id": "jalan-2014",
        "pmid": "24950482",
        "source": "J Hepatol. 2014;61(5):1038-1047",
        "title": "Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure."
      },
      "formula": "clif_c_aclf",
      "formula_expression": "clif_c_aclf = 10 * (0.33 * clif_c_of + 0.04 * age + 0.63 * ln(wbc_10e9_l) - 2); caller-assigned CLIF-C OF 6-18; round 1 decimal then clamp 0-100 (Jalan 2014 CANONIC)",
      "age_years": 50,
      "wbc_10e9_l": 5.0,
      "clif_c_aclf": 29.9,
      "clif_c_of": 6
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Jalan R, Saliba F, Pavesi M, et al.",
        "doi": "10.1016/j.jhep.2014.06.012",
        "id": "jalan-2014",
        "pmid": "24950482",
        "source": "J Hepatol. 2014;61(5):1038-1047",
        "title": "Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure."
      },
      "formula": "clif_c_aclf",
      "formula_expression": "clif_c_aclf = 10 * (0.33 * clif_c_of + 0.04 * age + 0.63 * ln(wbc_10e9_l) - 2); caller-assigned CLIF-C OF 6-18; round 1 decimal then clamp 0-100 (Jalan 2014 CANONIC)",
      "age_years": 50,
      "wbc_10e9_l": 5.0,
      "clif_c_aclf": 29.9,
      "clif_c_of": 6
    }
  ]
}
```

## Response fields

- `formula` (string): clif_c_aclf
- `formula_expression` (string): Exact Jalan 2014 CLIF-C ACLF expression, including 1-decimal round and 0-100 clamp
- `clif_c_of` (integer): Caller-assigned CLIF-C OF used (6-18). Not scored from organs.
- `age_years` (integer): Age in years used
- `wbc_10e9_l` (number): White-cell count in 10^9/L
- `clif_c_aclf` (number): CLIF-C ACLF score, 1 decimal, clamped 0-100. Not MELD or Child-Pugh.
- `citation` (object): Jalan J Hepatol 2014 citation
- `disclaimer` (string): Not-a-device notice

## Example JSON

Frozen fixture. Not a live lookup.

```json
{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Jalan R, Saliba F, Pavesi M, et al.",
    "doi": "10.1016/j.jhep.2014.06.012",
    "id": "jalan-2014",
    "pmid": "24950482",
    "source": "J Hepatol. 2014;61(5):1038-1047",
    "title": "Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure."
  },
  "formula": "clif_c_aclf",
  "formula_expression": "clif_c_aclf = 10 * (0.33 * clif_c_of + 0.04 * age + 0.63 * ln(wbc_10e9_l) - 2); caller-assigned CLIF-C OF 6-18; round 1 decimal then clamp 0-100 (Jalan 2014 CANONIC)",
  "age_years": 50,
  "wbc_10e9_l": 5.0,
  "clif_c_aclf": 29.9,
  "clif_c_of": 6
}
```

## Errors

- HTTP 400 `invalid_clif_aclf`: clif_c_of must be an integer 6-18 and wbc_10e9_l a number from 0.1 to 200 (Jalan 2014 CLIF-C ACLF; caller-assigned CLIF-C OF). Returned before settlement; you are not charged.
- HTTP 400 `invalid_age`: age must be an integer from 18 to 120 Returned before settlement; you are not charged.
- HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
- HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
- HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged.

Shared HTTP 402 and 503: https://magentlab.com/docs/payments

## Related tools

- [MELD](https://magentlab.com/docs/meld) — Compute the Kamath 2001 model for end-stage liver disease (MELD) integer from creatinine, bilirubin, INR, and cholestatic or alcoholic etiology.
- [Child–Pugh](https://magentlab.com/docs/child-pugh) — Compute the Child–Turcotte–Pugh cirrhosis severity score from bilirubin, albumin, INR, encephalopathy, and ascites.

## Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s.

- GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall).
- HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote.
- Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering.
- Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional.
- Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402.

- offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront.
- offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization.

- not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search.

Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers).

Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments

Stdio MCP (one process per host): https://magentlab.com/docs/mcp

## Guarantees

- HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
- exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
- HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
- Execution is timeout-bounded and concurrency-capped.
- Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.