# CLL-IPI (chronic lymphocytic leukaemia) CLL-IPI Status: LIVE Price: $0.005 USDC `GET /api/calc/cll_ipi` HTML: https://magentlab.com/docs/cll-ipi Markdown: https://magentlab.com/docs/cll-ipi.md Not a medical device. Not a diagnosis, dose, or listing recommendation. ## What it computes Sum the 2016 CLL-IPI (chronic lymphocytic leukaemia international prognostic index) and return low (0–1), intermediate (2–3), high (4–6), or very_high (7–10). ## When to use When an agent needs the published CLL-IPI point total and risk group and must not invent a CLL diagnosis or treatment choice, and must not substitute Shipp IPI or MIPI. ## When not to use - Not a medical device and not a CLL diagnosis or treatment choice. magent does not examine the patient. - This is the 2016 CLL-IPI (Lancet Oncol), not the Shipp 1993 five-factor IPI for aggressive non-Hodgkin lymphoma, not MIPI, and not Rai or Binet stage alone. - magent does not assay TP53, IGHV, or beta-2 microglobulin, and does not assign Binet or Rai stage. tp53_abnormal, ighv_unmutated, and advanced_stage are caller-assigned flags. ## Formula ``` CLL-IPI = tp53_abnormal 4 + ighv_unmutated 2 + beta2_microglobulin_gt_3_5 2 + advanced_stage 1 + age_gt_65 1; International CLL-IPI working group 2016; max 10; low 0-1, intermediate 2-3, high 4-6, very_high 7-10 ``` ## Citation [An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI)](https://doi.org/10.1016/S1470-2045(16)30029-8) The International CLL-IPI working group Lancet Oncol. 2016;17(6):779-790 DOI: [10.1016/S1470-2045(16)30029-8](https://doi.org/10.1016/S1470-2045(16)30029-8) ## Worked example ### Age 50, no adverse factors Given: `advanced_stage=false, age=50, beta2_microglobulin_mg_l=2.0, ighv_unmutated=false, tp53_abnormal=false` 1. tp53_abnormal false → 0; ighv_unmutated false → 0; beta2_microglobulin 2.0 is not >3.5 → 0; advanced_stage false → 0; age 50 is not >65 → 0 2. Score = 0 (max 10); risk_group = low ### All five adverse factors Given: `advanced_stage=true, age=66, beta2_microglobulin_mg_l=4.0, ighv_unmutated=true, tp53_abnormal=true` 1. tp53_abnormal → 4; ighv_unmutated → 2; beta2_microglobulin >3.5 → 2; advanced_stage → 1; age >65 → 1 2. Score = 10 (max 10); risk_group = very_high (7–10) ## Also searched as - CLL-IPI - CLL international prognostic index - chronic lymphocytic leukaemia IPI - chronic lymphocytic leukemia prognostic index - CLL IPI 2016 - International CLL-IPI - TP53 IGHV CLL score ## Parameters - `tp53_abnormal` (boolean, required): del(17p) and/or TP53 mutation as assigned by the caller (CLL-IPI 2016). true scores 4. magent does not assay TP53. - `ighv_unmutated` (boolean, required): Unmutated IGHV as assigned by the caller (CLL-IPI 2016). true scores 2. magent does not sequence IGHV. - `beta2_microglobulin_mg_l` (number, required): Serum beta-2 microglobulin in mg/L (0.2-40). >3.5 scores 2 (CLL-IPI 2016). 3.5 is the ≤3.5 arm and scores 0. magent does not assay beta-2 microglobulin. - `advanced_stage` (boolean, required): Binet B/C or Rai I–IV as assigned by the caller (CLL-IPI 2016). true scores 1. false is Binet A / Rai 0. magent does not stage CLL. - `age` (integer, required): Age in years (18-120). Age >65 scores 1 (CLL-IPI 2016). Age 65 is the ≤65 arm and scores 0. ## Bulk (POST) POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement. Method: `POST /api/calc/cll_ipi` Max items: 25 Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic) Status: PREVIEW - 1 to 25 items. Each item uses the same keys as the GET query parameters. - POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows. - The first invalid item fails the whole request (index in the 400 JSON). You are not charged. - HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row. - Catalog misses (empty matches, found=false) stay paid 200s inside that slot. - x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items. Example request: ```json { "items": [ { "advanced_stage": "false", "age": "50", "beta2_microglobulin_mg_l": "2.0", "ighv_unmutated": "false", "tp53_abnormal": "false" }, { "advanced_stage": "false", "age": "50", "beta2_microglobulin_mg_l": "2.0", "ighv_unmutated": "false", "tp53_abnormal": "false" } ] } ``` Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/cll-ipi Example 200: ```json { "count": 2, "path": "/api/calc/cll_ipi", "items": [ { "components": [ { "factor": "tp53_abnormal", "points": 0, "present": false }, { "factor": "ighv_unmutated", "points": 0, "present": false }, { "value": 2.0, "factor": "beta2_microglobulin_gt_3_5", "points": 0, "present": false }, { "factor": "advanced_stage", "points": 0, "present": false }, { "value": 50, "factor": "age_gt_65", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "The International CLL-IPI working group", "doi": "10.1016/S1470-2045(16)30029-8", "id": "cll-ipi-2016", "pmid": "27153538", "source": "Lancet Oncol. 2016;17(6):779-790", "title": "An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI)" }, "formula": "cll_ipi", "formula_expression": "CLL-IPI = tp53_abnormal 4 + ighv_unmutated 2 + beta2_microglobulin_gt_3_5 2 + advanced_stage 1 + age_gt_65 1; International CLL-IPI working group 2016; max 10; low 0-1, intermediate 2-3, high 4-6, very_high 7-10", "max_score": 10, "score": 0, "age_years": 50, "beta2_microglobulin_mg_l": 2.0, "risk_group": "low" }, { "components": [ { "factor": "tp53_abnormal", "points": 0, "present": false }, { "factor": "ighv_unmutated", "points": 0, "present": false }, { "value": 2.0, "factor": "beta2_microglobulin_gt_3_5", "points": 0, "present": false }, { "factor": "advanced_stage", "points": 0, "present": false }, { "value": 50, "factor": "age_gt_65", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "The International CLL-IPI working group", "doi": "10.1016/S1470-2045(16)30029-8", "id": "cll-ipi-2016", "pmid": "27153538", "source": "Lancet Oncol. 2016;17(6):779-790", "title": "An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI)" }, "formula": "cll_ipi", "formula_expression": "CLL-IPI = tp53_abnormal 4 + ighv_unmutated 2 + beta2_microglobulin_gt_3_5 2 + advanced_stage 1 + age_gt_65 1; International CLL-IPI working group 2016; max 10; low 0-1, intermediate 2-3, high 4-6, very_high 7-10", "max_score": 10, "score": 0, "age_years": 50, "beta2_microglobulin_mg_l": 2.0, "risk_group": "low" } ] } ``` ## Response fields - `formula` (string): cll_ipi - `formula_expression` (string): Exact expression used - `score` (integer): CLL-IPI points 0-10 - `max_score` (integer): Always 10 - `risk_group` (string): low when score is 0-1, intermediate when 2-3, high when 4-6, very_high when 7-10 (CLL-IPI 2016). Not a CLL diagnosis. Not Shipp IPI. Not MIPI. - `age_years` (integer): Age used for the >65 criterion - `beta2_microglobulin_mg_l` (number): Serum beta-2 microglobulin in mg/L used for the >3.5 criterion - `components` (array): Per-factor points - `citation` (object): International CLL-IPI working group Lancet Oncol 2016 citation - `disclaimer` (string): Not-a-device notice ## Example JSON Frozen fixture. Not a live lookup. ```json { "components": [ { "factor": "tp53_abnormal", "points": 0, "present": false }, { "factor": "ighv_unmutated", "points": 0, "present": false }, { "value": 2.0, "factor": "beta2_microglobulin_gt_3_5", "points": 0, "present": false }, { "factor": "advanced_stage", "points": 0, "present": false }, { "value": 50, "factor": "age_gt_65", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "The International CLL-IPI working group", "doi": "10.1016/S1470-2045(16)30029-8", "id": "cll-ipi-2016", "pmid": "27153538", "source": "Lancet Oncol. 2016;17(6):779-790", "title": "An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI)" }, "formula": "cll_ipi", "formula_expression": "CLL-IPI = tp53_abnormal 4 + ighv_unmutated 2 + beta2_microglobulin_gt_3_5 2 + advanced_stage 1 + age_gt_65 1; International CLL-IPI working group 2016; max 10; low 0-1, intermediate 2-3, high 4-6, very_high 7-10", "max_score": 10, "score": 0, "age_years": 50, "beta2_microglobulin_mg_l": 2.0, "risk_group": "low" } ``` ## Errors - HTTP 400 `invalid_flag`: boolean clinical flags must be true or false Returned before settlement; you are not charged. - HTTP 400 `invalid_beta2_microglobulin`: beta2_microglobulin_mg_l must be a number from 0.2 to 40 (Greipp 2005 ISS). Returned before settlement; you are not charged. - HTTP 400 `invalid_age`: age must be an integer from 18 to 120 Returned before settlement; you are not charged. - HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged. - HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged. - HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged. Shared HTTP 402 and 503: https://magentlab.com/docs/payments ## Related tools - [IPI](https://magentlab.com/docs/ipi) — Sum the Shipp 1993 five-factor International Prognostic Index (all ages) and return low (0–1), low_intermediate (2), high_intermediate (3), or high (4–5). - [MIPI](https://magentlab.com/docs/mipi) — Sum the Hoster 2008 simplified MIPI (mantle cell lymphoma international prognostic index) from age, ECOG, LDH/ULN, and WBC and return low (0–3), intermediate (4–5), or high (6–11). ## Payment Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. - GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall). - HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote. - Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering. - Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional. - Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402. - offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront. - offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization. - not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search. Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers). Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments Stdio MCP (one process per host): https://magentlab.com/docs/mcp ## Guarantees - HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON. - exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE. - HTTP 402 is unpaid only. Do not sign a second authorization because of a 503. - Execution is timeout-bounded and concurrency-capped. - Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.