# Cryoprecipitate bag estimate Cryoprecipitate bag estimate Status: LIVE Price: $0.005 USDC `GET /api/calc/cryoprecipitate` HTML: https://magentlab.com/docs/cryoprecipitate Markdown: https://magentlab.com/docs/cryoprecipitate.md Not a medical device. Not a diagnosis, dose, or listing recommendation. ## What it computes Compute a cryoprecipitate bag estimate from the AABB Technical Manual calculation as reprinted in Nascimento 2011: blood volume 70 mL/kg and 250 mg fibrinogen per bag. ## When to use When an agent needs the published AABB cryoprecipitate bag arithmetic reprinted in Nascimento 2011 and must not invent a fibrinogen-concentrate brand dose, a major-haemorrhage pool, a product or ABO-group choice, or a transfusion order. ## When not to use - Not a medical device. Not a transfusion order. - Nascimento 2011 notes that 100% recovery is likely false and fibrinogen per bag varies. - magent does not choose a product or ABO group. - Not a major-haemorrhage protocol. ## Formula ``` blood_volume_ml = 70 * weight_kg; plasma_volume_ml = blood_volume_ml * (1 - hematocrit_percent/100); mg_fibrinogen = (desired_fibrinogen_mg_dl - current_fibrinogen_mg_dl) * plasma_volume_ml / 100; bags = ceil(mg_fibrinogen / 250) ``` ## Citation [Cryoprecipitate transfusion: assessing appropriateness and dosing in trauma](https://doi.org/10.1111/j.1365-3148.2011.01098.x) Nascimento B, Rizoli S, Rubenfeld G, Lin Y, Callum J, Tien HC Transfus Med. 2011;21(6):394-401 DOI: [10.1111/j.1365-3148.2011.01098.x](https://doi.org/10.1111/j.1365-3148.2011.01098.x) ## Worked example ### 70 kg, hematocrit 40, fibrinogen 100 to 200 mg/dL Given: `current_fibrinogen_mg_dl=100, desired_fibrinogen_mg_dl=200, hematocrit_percent=40, weight_kg=70` 1. blood_volume_ml = 70 * 70 = 4900.0 2. plasma_volume_ml = 4900.0 * (1 - 40/100) = 2940.0 3. mg_fibrinogen = (200 - 100) * 2940.0 / 100 = 2940.0 4. bags = ceil(2940.0 / 250) = ceil(11.76) = 12 ### 70 kg, hematocrit 40, fibrinogen 150 to 200 mg/dL Given: `current_fibrinogen_mg_dl=150, desired_fibrinogen_mg_dl=200, hematocrit_percent=40, weight_kg=70` 1. blood_volume_ml = 70 * 70 = 4900.0 2. plasma_volume_ml = 4900.0 * (1 - 40/100) = 2940.0 3. mg_fibrinogen = (200 - 150) * 2940.0 / 100 = 1470.0 4. bags = ceil(1470.0 / 250) = ceil(5.88) = 6 ## Also searched as - cryoprecipitate bags - AABB cryoprecipitate - fibrinogen replacement bags - Nascimento 2011 cryoprecipitate - cryoprecipitate dose - cryo bag estimate - AABB Technical Manual cryoprecipitate ## Parameters - `weight_kg` (number, required): Weight in kilograms (1-200). Required. - `hematocrit_percent` (number, required): Hematocrit as a percent (10-70). Required. Not a 0-1 fraction; magent does not accept hematocrit_fraction. - `current_fibrinogen_mg_dl` (number, required): Current fibrinogen in mg/dL (0-400). Required. - `desired_fibrinogen_mg_dl` (number, required): Desired fibrinogen in mg/dL (50-400). Must be strictly greater than current_fibrinogen_mg_dl. ## Bulk (POST) POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement. Method: `POST /api/calc/cryoprecipitate` Max items: 25 Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic) Status: PREVIEW - 1 to 25 items. Each item uses the same keys as the GET query parameters. - POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows. - The first invalid item fails the whole request (index in the 400 JSON). You are not charged. - HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row. - Catalog misses (empty matches, found=false) stay paid 200s inside that slot. - x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items. Example request: ```json { "items": [ { "current_fibrinogen_mg_dl": "100", "desired_fibrinogen_mg_dl": "200", "hematocrit_percent": "40", "weight_kg": "70" }, { "current_fibrinogen_mg_dl": "100", "desired_fibrinogen_mg_dl": "200", "hematocrit_percent": "40", "weight_kg": "70" } ] } ``` Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/cryoprecipitate Example 200: ```json { "count": 2, "path": "/api/calc/cryoprecipitate", "items": [ { "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Nascimento B, Rizoli S, Rubenfeld G, Lin Y, Callum J, Tien HC", "doi": "10.1111/j.1365-3148.2011.01098.x", "id": "nascimento-2011", "pmid": "21851429", "source": "Transfus Med. 2011;21(6):394-401", "title": "Cryoprecipitate transfusion: assessing appropriateness and dosing in trauma" }, "formula": "nascimento_2011", "formula_expression": "blood_volume_ml = 70 * weight_kg; plasma_volume_ml = blood_volume_ml * (1 - hematocrit_percent/100); mg_fibrinogen = (desired_fibrinogen_mg_dl - current_fibrinogen_mg_dl) * plasma_volume_ml / 100; bags = ceil(mg_fibrinogen / 250)", "hematocrit_percent": 40.0, "weight_kg": 70.0, "bags": 12, "blood_volume_ml": 4.9e3, "current_fibrinogen_mg_dl": 100.0, "desired_fibrinogen_mg_dl": 200.0, "mg_fibrinogen": 2940.0, "plasma_volume_ml": 2940.0 }, { "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Nascimento B, Rizoli S, Rubenfeld G, Lin Y, Callum J, Tien HC", "doi": "10.1111/j.1365-3148.2011.01098.x", "id": "nascimento-2011", "pmid": "21851429", "source": "Transfus Med. 2011;21(6):394-401", "title": "Cryoprecipitate transfusion: assessing appropriateness and dosing in trauma" }, "formula": "nascimento_2011", "formula_expression": "blood_volume_ml = 70 * weight_kg; plasma_volume_ml = blood_volume_ml * (1 - hematocrit_percent/100); mg_fibrinogen = (desired_fibrinogen_mg_dl - current_fibrinogen_mg_dl) * plasma_volume_ml / 100; bags = ceil(mg_fibrinogen / 250)", "hematocrit_percent": 40.0, "weight_kg": 70.0, "bags": 12, "blood_volume_ml": 4.9e3, "current_fibrinogen_mg_dl": 100.0, "desired_fibrinogen_mg_dl": 200.0, "mg_fibrinogen": 2940.0, "plasma_volume_ml": 2940.0 } ] } ``` ## Response fields - `formula` (string): nascimento_2011 - `formula_expression` (string): Exact expression used - `weight_kg` (number): Input weight in kg - `hematocrit_percent` (number): Hematocrit percent used - `current_fibrinogen_mg_dl` (number): Current fibrinogen in mg/dL - `desired_fibrinogen_mg_dl` (number): Desired fibrinogen in mg/dL - `blood_volume_ml` (number): Estimated blood volume in mL (70 mL/kg), 1 decimal - `plasma_volume_ml` (number): Estimated plasma volume in mL, 1 decimal - `mg_fibrinogen` (number): Fibrinogen increment in mg, 1 decimal - `bags` (integer): Cryoprecipitate bags, ceil(mg_fibrinogen / 250) - `citation` (object): Nascimento et al. 2011 citation - `disclaimer` (string): Not-a-device notice ## Example JSON Frozen fixture. Not a live lookup. ```json { "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Nascimento B, Rizoli S, Rubenfeld G, Lin Y, Callum J, Tien HC", "doi": "10.1111/j.1365-3148.2011.01098.x", "id": "nascimento-2011", "pmid": "21851429", "source": "Transfus Med. 2011;21(6):394-401", "title": "Cryoprecipitate transfusion: assessing appropriateness and dosing in trauma" }, "formula": "nascimento_2011", "formula_expression": "blood_volume_ml = 70 * weight_kg; plasma_volume_ml = blood_volume_ml * (1 - hematocrit_percent/100); mg_fibrinogen = (desired_fibrinogen_mg_dl - current_fibrinogen_mg_dl) * plasma_volume_ml / 100; bags = ceil(mg_fibrinogen / 250)", "hematocrit_percent": 40.0, "weight_kg": 70.0, "bags": 12, "blood_volume_ml": 4.9e3, "current_fibrinogen_mg_dl": 100.0, "desired_fibrinogen_mg_dl": 200.0, "mg_fibrinogen": 2940.0, "plasma_volume_ml": 2940.0 } ``` ## Errors - HTTP 400 `invalid_cryo`: Cryoprecipitate bag arithmetic must match the AABB Technical Manual calculation reprinted in Nascimento 2011 weight, hematocrit, and fibrinogen increment from that paper. Returned before settlement; you are not charged. - HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged. - HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged. - HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged. Shared HTTP 402 and 503: https://magentlab.com/docs/payments ## Related tools - [Plasma starting dose](https://magentlab.com/docs/plasma-dosage) — Compute the BSH Green 2018 starting plasma volume from body weight: 15 mL/kg in the absence of major bleeding. Adult starting dose only. - [Kaplan plasma volume](https://magentlab.com/docs/tpe) — Compute Kaplan 1990 estimated plasma volume for therapeutic plasma exchange from weight and hematocrit as a percent, returning one plasma volume in liters and milliliters. - [Ganzoni iron deficit](https://magentlab.com/docs/ganzoni) — Compute the Ganzoni 1970 iron deficit from weight, measured hemoglobin, a caller-supplied target hemoglobin, and depot iron stores. ## Payment Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. - GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall). - HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote. - Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering. - Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional. - Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402. - offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront. - offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization. - not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search. Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers). Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments Stdio MCP (one process per host): https://magentlab.com/docs/mcp ## Guarantees - HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON. - exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE. - HTTP 402 is unpaid only. Do not sign a second authorization because of a 503. - Execution is timeout-bounded and concurrency-capped. - Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.