# DIPSS (primary myelofibrosis) DIPSS Status: LIVE Price: $0.005 USDC `GET /api/calc/dipss` HTML: https://magentlab.com/docs/dipss Markdown: https://magentlab.com/docs/dipss.md Not a medical device. Not a diagnosis, dose, or listing recommendation. ## What it computes Sum the Passamonti 2010 DIPSS (dynamic international prognostic scoring system) for primary myelofibrosis and return low (0), intermediate_1 (1–2), intermediate_2 (3–4), or high (5–6). ## When to use When an agent needs the published DIPSS point total and risk group and must not invent a myelofibrosis diagnosis or treatment choice, and must not substitute DIPSS Plus, aaDIPSS, or Cervantes 2009 IPSS. ## When not to use - Not a medical device and not a myelofibrosis diagnosis or treatment choice. magent does not examine the patient. - This is Passamonti 2010 DIPSS (all-ages Table 3) only, not DIPSS Plus, not aaDIPSS (Table 4), and not Cervantes 2009 IPSS-at-diagnosis. - magent does not read a smear or assay hemoglobin or WBC. hemoglobin_g_dl, wbc_10e9_l, and blasts_percent are caller-supplied labs. - Constitutional symptoms (weight loss >10% in 6 months, night sweats, or unexplained fever >37.5°C) are a single caller-assigned boolean. ## Formula ``` DIPSS = age_gt_65 1 + wbc_gt_25 1 + hemoglobin_lt_10 2 + blasts_ge_1 1 + constitutional_symptoms 1; Passamonti 2010 Table 3; max 6; low 0, intermediate_1 1-2, intermediate_2 3-4, high 5-6 ``` ## Citation [A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment)](https://doi.org/10.1182/blood-2009-09-245837) Passamonti F, Cervantes F, Vannucchi AM, et al. Blood. 2010;115(9):1703-1708 DOI: [10.1182/blood-2009-09-245837](https://doi.org/10.1182/blood-2009-09-245837) ## Worked example ### Age 50, no adverse factors Given: `age=50, blasts_percent=0, constitutional_symptoms=false, hemoglobin_g_dl=12, wbc_10e9_l=10` 1. age 50 is not >65 → 0; hemoglobin 12 ≥10 → 0; WBC 10 ≤25 → 0; blasts 0% <1 → 0; constitutional_symptoms false → 0 2. Score = 0 (max 6); risk_group = low ### All five adverse factors Given: `age=66, blasts_percent=1, constitutional_symptoms=true, hemoglobin_g_dl=9.9, wbc_10e9_l=25.1` 1. age >65 → 1; hemoglobin <10 → 2; WBC >25 → 1; blasts ≥1 → 1; constitutional_symptoms → 1 2. Score = 6 (max 6); risk_group = high (5–6) ## Also searched as - DIPSS - dynamic international prognostic scoring system - Passamonti DIPSS - primary myelofibrosis DIPSS - PMF DIPSS - IWG-MRT DIPSS - DIPSS myelofibrosis - Passamonti 2010 myelofibrosis ## Parameters - `age` (integer, required): Age in years (18-120). Age >65 scores 1 (Passamonti 2010 Table 3). Age 65 is the ≤65 arm and scores 0. - `hemoglobin_g_dl` (number, required): Hemoglobin in g/dL (3-20). <10 scores 2 (Passamonti 2010 Table 3; anemia HR 4.18). 10.0 is the ≥10 arm and scores 0. magent does not assay hemoglobin. - `wbc_10e9_l` (number, required): White-cell count in 10^9/L (0.1-500). >25 scores 1 (Passamonti 2010 Table 3). 25.0 is the ≤25 arm and scores 0. magent does not assay WBC. - `blasts_percent` (number, required): Peripheral-blood blasts as a percent (0-30). ≥1 scores 1 (Passamonti 2010 Table 3). 0.9 is the <1 arm and scores 0. magent does not read a smear. - `constitutional_symptoms` (boolean, required): Weight loss >10% in 6 months, night sweats, or unexplained fever >37.5°C as assigned by the caller (Passamonti 2010 methods). true scores 1. magent does not take a history. ## Bulk (POST) POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement. Method: `POST /api/calc/dipss` Max items: 25 Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic) Status: PREVIEW - 1 to 25 items. Each item uses the same keys as the GET query parameters. - POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows. - The first invalid item fails the whole request (index in the 400 JSON). You are not charged. - HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row. - Catalog misses (empty matches, found=false) stay paid 200s inside that slot. - x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items. Example request: ```json { "items": [ { "age": "50", "blasts_percent": "0", "constitutional_symptoms": "false", "hemoglobin_g_dl": "12", "wbc_10e9_l": "10" }, { "age": "50", "blasts_percent": "0", "constitutional_symptoms": "false", "hemoglobin_g_dl": "12", "wbc_10e9_l": "10" } ] } ``` Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/dipss Example 200: ```json { "count": 2, "path": "/api/calc/dipss", "items": [ { "components": [ { "value": 50, "factor": "age_gt_65", "points": 0, "present": false }, { "value": 10.0, "factor": "wbc_gt_25", "points": 0, "present": false }, { "value": 12.0, "factor": "hemoglobin_lt_10", "points": 0, "present": false }, { "value": 0.0, "factor": "blasts_ge_1", "points": 0, "present": false }, { "factor": "constitutional_symptoms", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "age_years": 50, "citation": { "authors": "Passamonti F, Cervantes F, Vannucchi AM, et al.", "doi": "10.1182/blood-2009-09-245837", "id": "passamonti-2010", "pmid": "20008785", "source": "Blood. 2010;115(9):1703-1708", "title": "A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment)" }, "formula": "dipss", "formula_expression": "DIPSS = age_gt_65 1 + wbc_gt_25 1 + hemoglobin_lt_10 2 + blasts_ge_1 1 + constitutional_symptoms 1; Passamonti 2010 Table 3; max 6; low 0, intermediate_1 1-2, intermediate_2 3-4, high 5-6", "max_score": 6, "score": 0, "wbc_10e9_l": 10.0, "risk_group": "low", "blasts_percent": 0.0, "constitutional_symptoms": false, "hemoglobin_g_dl": 12.0 }, { "components": [ { "value": 50, "factor": "age_gt_65", "points": 0, "present": false }, { "value": 10.0, "factor": "wbc_gt_25", "points": 0, "present": false }, { "value": 12.0, "factor": "hemoglobin_lt_10", "points": 0, "present": false }, { "value": 0.0, "factor": "blasts_ge_1", "points": 0, "present": false }, { "factor": "constitutional_symptoms", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "age_years": 50, "citation": { "authors": "Passamonti F, Cervantes F, Vannucchi AM, et al.", "doi": "10.1182/blood-2009-09-245837", "id": "passamonti-2010", "pmid": "20008785", "source": "Blood. 2010;115(9):1703-1708", "title": "A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment)" }, "formula": "dipss", "formula_expression": "DIPSS = age_gt_65 1 + wbc_gt_25 1 + hemoglobin_lt_10 2 + blasts_ge_1 1 + constitutional_symptoms 1; Passamonti 2010 Table 3; max 6; low 0, intermediate_1 1-2, intermediate_2 3-4, high 5-6", "max_score": 6, "score": 0, "wbc_10e9_l": 10.0, "risk_group": "low", "blasts_percent": 0.0, "constitutional_symptoms": false, "hemoglobin_g_dl": 12.0 } ] } ``` ## Response fields - `formula` (string): dipss - `formula_expression` (string): Exact expression used - `score` (integer): DIPSS points 0-6 - `max_score` (integer): Always 6 (1+1+2+1+1) - `risk_group` (string): low when score is 0, intermediate_1 when 1-2, intermediate_2 when 3-4, high when 5-6 (Passamonti 2010 Table 3). Not a myelofibrosis diagnosis. Not DIPSS Plus. Not aaDIPSS. - `age_years` (integer): Age used for the >65 criterion - `hemoglobin_g_dl` (number): Hemoglobin in g/dL used for the <10 criterion - `wbc_10e9_l` (number): WBC in 10^9/L used for the >25 criterion - `blasts_percent` (number): Peripheral-blood blast percent used for the ≥1 criterion - `constitutional_symptoms` (boolean): Caller-assigned constitutional-symptoms flag used - `components` (array): Per-factor points - `citation` (object): Passamonti et al. Blood 2010 DIPSS citation - `disclaimer` (string): Not-a-device notice ## Example JSON Frozen fixture. Not a live lookup. ```json { "components": [ { "value": 50, "factor": "age_gt_65", "points": 0, "present": false }, { "value": 10.0, "factor": "wbc_gt_25", "points": 0, "present": false }, { "value": 12.0, "factor": "hemoglobin_lt_10", "points": 0, "present": false }, { "value": 0.0, "factor": "blasts_ge_1", "points": 0, "present": false }, { "factor": "constitutional_symptoms", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "age_years": 50, "citation": { "authors": "Passamonti F, Cervantes F, Vannucchi AM, et al.", "doi": "10.1182/blood-2009-09-245837", "id": "passamonti-2010", "pmid": "20008785", "source": "Blood. 2010;115(9):1703-1708", "title": "A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment)" }, "formula": "dipss", "formula_expression": "DIPSS = age_gt_65 1 + wbc_gt_25 1 + hemoglobin_lt_10 2 + blasts_ge_1 1 + constitutional_symptoms 1; Passamonti 2010 Table 3; max 6; low 0, intermediate_1 1-2, intermediate_2 3-4, high 5-6", "max_score": 6, "score": 0, "wbc_10e9_l": 10.0, "risk_group": "low", "blasts_percent": 0.0, "constitutional_symptoms": false, "hemoglobin_g_dl": 12.0 } ``` ## Errors - HTTP 400 `invalid_age`: age must be an integer from 18 to 120 Returned before settlement; you are not charged. - HTTP 400 `invalid_dipss`: hemoglobin_g_dl 3-20, wbc_10e9_l 0.1-500, and blasts_percent 0-30 (Passamonti 2010 DIPSS labs; magent clamps, not paper ranges). Returned before settlement; you are not charged. - HTTP 400 `invalid_flag`: boolean clinical flags must be true or false Returned before settlement; you are not charged. - HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged. - HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged. - HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged. Shared HTTP 402 and 503: https://magentlab.com/docs/payments ## Related tools - [IPSS-R](https://magentlab.com/docs/ipss-r) — Sum the Greenberg 2012 IPSS-R (revised international prognostic scoring system) for myelodysplastic syndromes and return very_low (≤1.5), low (>1.5–3), intermediate (>3–4.5), high (>4.5–6), or very_high (>6). ## Payment Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. - GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall). - HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote. - Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering. - Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional. - Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402. - offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront. - offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization. - not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search. Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers). Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments Stdio MCP (one process per host): https://magentlab.com/docs/mcp ## Guarantees - HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON. - exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE. - HTTP 402 is unpaid only. Do not sign a second authorization because of a 503. - Execution is timeout-bounded and concurrency-capped. - Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.