# du Bois IPF score du Bois IPF Status: LIVE Price: $0.005 USDC `GET /api/calc/du_bois` HTML: https://magentlab.com/docs/du-bois Markdown: https://magentlab.com/docs/du-bois.md Not a medical device. Not a diagnosis, dose, or listing recommendation. ## What it computes Sum du Bois 2011 Table 4 points from age, 24-week respiratory hospitalization, FVC percent predicted, and 24-week change in FVC percent predicted (abbreviated four-predictor model). ## When to use When an agent needs the published du Bois 2011 four-predictor IPF point total and must not invent a 1-year mortality percent, a GAP stage, or a transplant listing. ## When not to use - Not a medical device and not a transplant listing protocol. Returns the published du Bois 2011 Table 4 point total only; Table 4 expected 1-year risk percents have gaps and are not interpolated. - Not the Ley 2012 GAP index. Age and FVC bands follow du Bois 2011 Table 4, not GAP cutoffs. - FVC percent predicted and 24-week FVC change are caller-supplied. magent does not perform spirometry or compute percent predicted from raw volumes. - Abbreviated four-predictor clinical model omits DLCO and SGRQ by design (du Bois 2011). Respiratory hospitalization is a caller-assigned 24-week history flag. ## Formula ``` du_bois = age_points + hospitalization_points + fvc_points + fvc_change_points; age <60 -> 0, 60-69 -> 4, >=70 -> 8; respiratory_hospitalization false -> 0, true -> 14; FVC% <50 -> 18, 51-65 -> 13, 66-79 -> 8, >80 -> 0 (50 and 80 unpublished); 24-wk FVC% change <= -10 -> 21, > -10 and < -4.9 -> 10, >= -4.9 -> 0; max 61; score only ``` ## Citation [Ascertainment of individual risk of mortality for patients with idiopathic pulmonary fibrosis](https://doi.org/10.1164/rccm.201011-1790OC) du Bois RM, Weycker D, Albera C, Bradford WZ, Costabel U, Kartashov A, Lancaster L, Noble PW, Raghu G, Sahn SA, Szwarcberg J, Thomeer M, Valeyre D, King TE Jr Am J Respir Crit Care Med. 2011;184(4):459-466 DOI: [10.1164/rccm.201011-1790OC](https://doi.org/10.1164/rccm.201011-1790OC) ## Worked example ### Table 4 footnote (score 31) Given: `age=70, fvc_change_24wk=-7, fvc_percent_predicted=55, respiratory_hospitalization=false` 1. Age 70 ≥70 → 8; no respiratory hospitalization → 0; FVC 55% in 51–65 → 13; 24-week change −7 (between −10 and −4.9) → 10 2. Score = 31 ### All 0-point bands Given: `age=55, fvc_change_24wk=0, fvc_percent_predicted=81, respiratory_hospitalization=false` 1. Age 55 <60 → 0; no hospitalization → 0; FVC 81% >80 → 0; 24-week change 0 ≥ −4.9 → 0 2. Score = 0 ## Also searched as - du Bois score - du Bois IPF - IPF mortality score - idiopathic pulmonary fibrosis risk - four-predictor IPF - du Bois 2011 ## Parameters - `age` (integer, required): Age in years (integer 18-120). du Bois 2011 Table 4: <60 scores 0; 60-69 scores 4; >=70 scores 8. - `respiratory_hospitalization` (boolean, required): 24-week history of respiratory hospitalization (true or false). du Bois 2011 Table 4: false scores 0; true scores 14. - `fvc_percent_predicted` (number, required): FVC percent predicted (10-150). du Bois 2011 Table 4: <50 scores 18; 51-65 scores 13; 66-79 scores 8; >80 scores 0. Exactly 50 or 80 is unpublished. - `fvc_change_24wk` (number, required): 24-week change in FVC percent predicted, in percentage points (-50 to 50). du Bois 2011 Table 4: <= -10 scores 21; > -10 and < -4.9 scores 10; >= -4.9 scores 0. ## Bulk (POST) POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement. Method: `POST /api/calc/du_bois` Max items: 25 Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic) Status: PREVIEW - 1 to 25 items. Each item uses the same keys as the GET query parameters. - POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows. - The first invalid item fails the whole request (index in the 400 JSON). You are not charged. - HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row. - Catalog misses (empty matches, found=false) stay paid 200s inside that slot. - x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items. Example request: ```json { "items": [ { "age": "70", "fvc_change_24wk": "-7", "fvc_percent_predicted": "55", "respiratory_hospitalization": "false" }, { "age": "70", "fvc_change_24wk": "-7", "fvc_percent_predicted": "55", "respiratory_hospitalization": "false" } ] } ``` Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/du-bois Example 200: ```json { "count": 2, "path": "/api/calc/du_bois", "items": [ { "components": [ { "value": 70, "factor": "age", "points": 8, "present": true }, { "value": false, "factor": "respiratory_hospitalization", "points": 0, "present": false }, { "value": 55.0, "factor": "fvc", "points": 13, "present": true }, { "value": -7.0, "factor": "fvc_change", "points": 10, "present": true } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "age_years": 70, "citation": { "authors": "du Bois RM, Weycker D, Albera C, Bradford WZ, Costabel U, Kartashov A, Lancaster L, Noble PW, Raghu G, Sahn SA, Szwarcberg J, Thomeer M, Valeyre D, King TE Jr", "doi": "10.1164/rccm.201011-1790OC", "id": "du-bois-2011", "pmid": "21616999", "source": "Am J Respir Crit Care Med. 2011;184(4):459-466", "title": "Ascertainment of individual risk of mortality for patients with idiopathic pulmonary fibrosis" }, "formula": "du_bois", "formula_expression": "du_bois = age_points + hospitalization_points + fvc_points + fvc_change_points; age <60 -> 0, 60-69 -> 4, >=70 -> 8; respiratory_hospitalization false -> 0, true -> 14; FVC% <50 -> 18, 51-65 -> 13, 66-79 -> 8, >80 -> 0 (50 and 80 unpublished); 24-wk FVC% change <= -10 -> 21, > -10 and < -4.9 -> 10, >= -4.9 -> 0; max 61; score only", "max_score": 61, "score": 31, "fvc_change_24wk": -7.0, "fvc_percent_predicted": 55.0, "respiratory_hospitalization": false }, { "components": [ { "value": 70, "factor": "age", "points": 8, "present": true }, { "value": false, "factor": "respiratory_hospitalization", "points": 0, "present": false }, { "value": 55.0, "factor": "fvc", "points": 13, "present": true }, { "value": -7.0, "factor": "fvc_change", "points": 10, "present": true } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "age_years": 70, "citation": { "authors": "du Bois RM, Weycker D, Albera C, Bradford WZ, Costabel U, Kartashov A, Lancaster L, Noble PW, Raghu G, Sahn SA, Szwarcberg J, Thomeer M, Valeyre D, King TE Jr", "doi": "10.1164/rccm.201011-1790OC", "id": "du-bois-2011", "pmid": "21616999", "source": "Am J Respir Crit Care Med. 2011;184(4):459-466", "title": "Ascertainment of individual risk of mortality for patients with idiopathic pulmonary fibrosis" }, "formula": "du_bois", "formula_expression": "du_bois = age_points + hospitalization_points + fvc_points + fvc_change_points; age <60 -> 0, 60-69 -> 4, >=70 -> 8; respiratory_hospitalization false -> 0, true -> 14; FVC% <50 -> 18, 51-65 -> 13, 66-79 -> 8, >80 -> 0 (50 and 80 unpublished); 24-wk FVC% change <= -10 -> 21, > -10 and < -4.9 -> 10, >= -4.9 -> 0; max 61; score only", "max_score": 61, "score": 31, "fvc_change_24wk": -7.0, "fvc_percent_predicted": 55.0, "respiratory_hospitalization": false } ] } ``` ## Response fields - `formula` (string): du_bois - `formula_expression` (string): Exact du Bois 2011 four-predictor Table 4 expression - `score` (integer): du Bois 2011 Table 4 points 0-61 - `max_score` (integer): Always 61 - `age_years` (integer): Age in years used - `respiratory_hospitalization` (boolean): Caller-assigned 24-week respiratory hospitalization flag - `fvc_percent_predicted` (number): FVC percent predicted used - `fvc_change_24wk` (number): 24-week change in FVC percent predicted, in percentage points - `components` (array): Per-factor points for age, hospitalization, fvc, and fvc_change - `citation` (object): du Bois et al. Am J Respir Crit Care Med 2011 citation - `disclaimer` (string): Not-a-device notice ## Example JSON Frozen fixture. Not a live lookup. ```json { "components": [ { "value": 70, "factor": "age", "points": 8, "present": true }, { "value": false, "factor": "respiratory_hospitalization", "points": 0, "present": false }, { "value": 55.0, "factor": "fvc", "points": 13, "present": true }, { "value": -7.0, "factor": "fvc_change", "points": 10, "present": true } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "age_years": 70, "citation": { "authors": "du Bois RM, Weycker D, Albera C, Bradford WZ, Costabel U, Kartashov A, Lancaster L, Noble PW, Raghu G, Sahn SA, Szwarcberg J, Thomeer M, Valeyre D, King TE Jr", "doi": "10.1164/rccm.201011-1790OC", "id": "du-bois-2011", "pmid": "21616999", "source": "Am J Respir Crit Care Med. 2011;184(4):459-466", "title": "Ascertainment of individual risk of mortality for patients with idiopathic pulmonary fibrosis" }, "formula": "du_bois", "formula_expression": "du_bois = age_points + hospitalization_points + fvc_points + fvc_change_points; age <60 -> 0, 60-69 -> 4, >=70 -> 8; respiratory_hospitalization false -> 0, true -> 14; FVC% <50 -> 18, 51-65 -> 13, 66-79 -> 8, >80 -> 0 (50 and 80 unpublished); 24-wk FVC% change <= -10 -> 21, > -10 and < -4.9 -> 10, >= -4.9 -> 0; max 61; score only", "max_score": 61, "score": 31, "fvc_change_24wk": -7.0, "fvc_percent_predicted": 55.0, "respiratory_hospitalization": false } ``` ## Errors - HTTP 400 `invalid_age`: age must be an integer from 18 to 120 Returned before settlement; you are not charged. - HTTP 400 `invalid_flag`: boolean clinical flags must be true or false Returned before settlement; you are not charged. - HTTP 400 `invalid_fvc_percent`: fvc_percent_predicted must be a number from 10 to 150. Returned before settlement; you are not charged. - HTTP 400 `invalid_du_bois_fvc`: fvc_percent_predicted must be <50, 51-65, 66-79, or >80 (du Bois 2011 Table 4; 50 and 80 are not published cells). Returned before settlement; you are not charged. - HTTP 400 `invalid_fvc_change`: fvc_change_24wk must be a number from -50 to 50 (du Bois 2011 24-week change in % predicted FVC). Returned before settlement; you are not charged. - HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged. - HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged. - HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged. Shared HTTP 402 and 503: https://magentlab.com/docs/payments ## Related tools - [GAP index](https://magentlab.com/docs/gap-index) — Sum Ley 2012 GAP index points from sex, age, FVC percent predicted, and DLCO percent predicted or cannot-perform. ## Payment Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. - GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall). - HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote. - Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering. - Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional. - Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402. - offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront. - offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization. - not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search. Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers). Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments Stdio MCP (one process per host): https://magentlab.com/docs/mcp ## Guarantees - HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON. - exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE. - HTTP 402 is unpaid only. Do not sign a second authorization because of a 503. - Execution is timeout-bounded and concurrency-capped. - Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.