# Duval 2010 AML score (Table 5) Duval AML Status: LIVE Price: $0.005 USDC `GET /api/calc/duval_aml` HTML: https://magentlab.com/docs/duval-aml Markdown: https://magentlab.com/docs/duval-aml.md Not a medical device. Not a diagnosis, dose, or listing recommendation. ## What it computes Sum the Duval 2010 AML Table 5 points and return risk_group 0, 1, 2, or ge_3 (scores ≥3 share one group). ## When to use When an agent needs the published Duval 2010 AML (not ALL) Table 5 point total from caller-assigned categories and must not invent a transplant listing, karyotype parse, or ALL score. ## When not to use - Not a medical device and not a diagnosis. Not a transplant listing. magent does not examine the patient. - This is Duval 2010 Table 5 for AML only. It does not implement the ALL table in the same paper. - magent does not read a karyotype string or HLA type. The caller assigns disease_group, ECOG/SWOG cytogenetics (poor vs good/intermediate), and the Table 5 three-level hla_match. - magent does not collect numeric Karnofsky or Lansky. kps_lt_90 is a caller-assigned flag. - Table 5 groups scores ≥3 together. Published 3-year overall survival in the derivation cohort was 42% at score 0 and 6% at score ≥3. Those figures are not returned on the JSON 200. ## Formula ``` Duval AML Table 5 = disease_group (pif_or_cr1_gt_6mo 0, cr1_lt_6mo 1) + cytogenetics (good_or_intermediate 0, poor 1) + hla_match (sibling_or_matched_unrelated 0, mismatched_unrelated 1, related_other 2) + circulating_blasts 1 + kps_lt_90 1; Duval 2010 AML only (not ALL); max 6; risk_group 0 / 1 / 2 / ge_3 ``` ## Citation [Hematopoietic Stem-Cell Transplantation for Acute Leukemia in Relapse or Primary Induction Failure](https://doi.org/10.1200/JCO.2010.28.8852) Duval M, Klein JP, He W, et al J Clin Oncol. 2010;28(23):3730-3738 DOI: [10.1200/JCO.2010.28.8852](https://doi.org/10.1200/JCO.2010.28.8852) ## Worked example ### All favorable AML Table 5 categories Given: `circulating_blasts=false, cytogenetics=good_or_intermediate, disease_group=pif_or_cr1_gt_6mo, hla_match=sibling_or_matched_unrelated, kps_lt_90=false` 1. disease_group pif_or_cr1_gt_6mo → 0; cytogenetics good_or_intermediate → 0; hla_match sibling_or_matched_unrelated → 0; circulating_blasts false → 0; kps_lt_90 false → 0 2. Score = 0 (max 6); risk_group = 0 ### Maximum published AML Table 5 score Given: `circulating_blasts=true, cytogenetics=poor, disease_group=cr1_lt_6mo, hla_match=related_other, kps_lt_90=true` 1. cr1_lt_6mo → 1; poor cytogenetics → 1; related_other → 2; circulating_blasts → 1; kps_lt_90 → 1 2. Score = 6 (max 6); risk_group = ge_3 ## Also searched as - Duval AML score - Duval 2010 AML - CIBMTR AML score - AML transplant score Duval - Duval Table 5 AML - AML PIF relapse HCT score - Duval CIBMTR AML - hematopoietic stem-cell AML score ## Parameters - `disease_group` (string, required): Duval 2010 AML Table 5 disease status as assigned by the caller. pif_or_cr1_gt_6mo is primary induction failure or duration of first CR >6 months and scores 0. cr1_lt_6mo is duration of first CR <6 months and scores 1. magent does not date remissions. - `cytogenetics` (string, required): ECOG/SWOG cytogenetic risk as assigned by the caller (Duval 2010). poor is −5/del(5q), −7/del(7q), inv(3q), abn11q, 20q or 21q, del(9q), t(6;9), t(9;22), abn17p, or complex (≥3 abnormalities) and scores 1. good_or_intermediate is everything else in that classification and scores 0. magent does not read a karyotype string. - `hla_match` (string, required): Duval 2010 AML Table 5 donor HLA match as assigned by the caller (not a flattened 0/1 donor flag). sibling_or_matched_unrelated is HLA-identical sibling or well matched or partially matched unrelated and scores 0. mismatched_unrelated scores 1. related_other is related other than HLA-identical sibling and scores 2. magent does not HLA-type. - `circulating_blasts` (boolean, required): Circulating blasts present as assigned by the caller (Duval 2010 AML Table 5). true scores 1. magent does not count blasts. - `kps_lt_90` (boolean, required): Karnofsky or Lansky <90 as assigned by the caller (Duval 2010 AML Table 5). true scores 1. magent does not collect numeric KPS or Lansky. ## Bulk (POST) POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement. Method: `POST /api/calc/duval_aml` Max items: 25 Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic) Status: PREVIEW - 1 to 25 items. Each item uses the same keys as the GET query parameters. - POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows. - The first invalid item fails the whole request (index in the 400 JSON). You are not charged. - HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row. - Catalog misses (empty matches, found=false) stay paid 200s inside that slot. - x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items. Example request: ```json { "items": [ { "circulating_blasts": "false", "cytogenetics": "good_or_intermediate", "disease_group": "pif_or_cr1_gt_6mo", "hla_match": "sibling_or_matched_unrelated", "kps_lt_90": "false" }, { "circulating_blasts": "false", "cytogenetics": "good_or_intermediate", "disease_group": "pif_or_cr1_gt_6mo", "hla_match": "sibling_or_matched_unrelated", "kps_lt_90": "false" } ] } ``` Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/duval-aml Example 200: ```json { "count": 2, "path": "/api/calc/duval_aml", "items": [ { "components": [ { "value": "pif_or_cr1_gt_6mo", "factor": "disease_group", "points": 0, "present": false }, { "value": "good_or_intermediate", "factor": "cytogenetics", "points": 0, "present": false }, { "value": "sibling_or_matched_unrelated", "factor": "hla_match", "points": 0, "present": false }, { "factor": "circulating_blasts", "points": 0, "present": false }, { "factor": "kps_lt_90", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Duval M, Klein JP, He W, et al", "doi": "10.1200/JCO.2010.28.8852", "id": "duval-2010", "pmid": "20625126", "source": "J Clin Oncol. 2010;28(23):3730-3738", "title": "Hematopoietic Stem-Cell Transplantation for Acute Leukemia in Relapse or Primary Induction Failure" }, "formula": "duval_aml", "formula_expression": "Duval AML Table 5 = disease_group (pif_or_cr1_gt_6mo 0, cr1_lt_6mo 1) + cytogenetics (good_or_intermediate 0, poor 1) + hla_match (sibling_or_matched_unrelated 0, mismatched_unrelated 1, related_other 2) + circulating_blasts 1 + kps_lt_90 1; Duval 2010 AML only (not ALL); max 6; risk_group 0 / 1 / 2 / ge_3", "max_score": 6, "score": 0, "risk_group": "0", "circulating_blasts": false, "cytogenetics": "good_or_intermediate", "disease_group": "pif_or_cr1_gt_6mo", "hla_match": "sibling_or_matched_unrelated", "kps_lt_90": false }, { "components": [ { "value": "pif_or_cr1_gt_6mo", "factor": "disease_group", "points": 0, "present": false }, { "value": "good_or_intermediate", "factor": "cytogenetics", "points": 0, "present": false }, { "value": "sibling_or_matched_unrelated", "factor": "hla_match", "points": 0, "present": false }, { "factor": "circulating_blasts", "points": 0, "present": false }, { "factor": "kps_lt_90", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Duval M, Klein JP, He W, et al", "doi": "10.1200/JCO.2010.28.8852", "id": "duval-2010", "pmid": "20625126", "source": "J Clin Oncol. 2010;28(23):3730-3738", "title": "Hematopoietic Stem-Cell Transplantation for Acute Leukemia in Relapse or Primary Induction Failure" }, "formula": "duval_aml", "formula_expression": "Duval AML Table 5 = disease_group (pif_or_cr1_gt_6mo 0, cr1_lt_6mo 1) + cytogenetics (good_or_intermediate 0, poor 1) + hla_match (sibling_or_matched_unrelated 0, mismatched_unrelated 1, related_other 2) + circulating_blasts 1 + kps_lt_90 1; Duval 2010 AML only (not ALL); max 6; risk_group 0 / 1 / 2 / ge_3", "max_score": 6, "score": 0, "risk_group": "0", "circulating_blasts": false, "cytogenetics": "good_or_intermediate", "disease_group": "pif_or_cr1_gt_6mo", "hla_match": "sibling_or_matched_unrelated", "kps_lt_90": false } ] } ``` ## Response fields - `formula` (string): duval_aml - `formula_expression` (string): Exact expression used - `score` (integer): Duval 2010 AML Table 5 points 0-6 - `max_score` (integer): 6 (1+1+2+1+1) - `risk_group` (string): 0, 1, 2, or ge_3 when score is ≥3 (Duval 2010 Table 5 note). Not a transplant listing. Not a diagnosis. Not the ALL table. - `disease_group` (string): Caller-assigned pif_or_cr1_gt_6mo or cr1_lt_6mo - `cytogenetics` (string): Caller-assigned good_or_intermediate or poor - `hla_match` (string): Caller-assigned sibling_or_matched_unrelated, mismatched_unrelated, or related_other - `circulating_blasts` (boolean): Caller-assigned circulating-blasts flag used - `kps_lt_90` (boolean): Caller-assigned Karnofsky or Lansky <90 flag used - `components` (array): Per-factor points - `citation` (object): Duval et al. J Clin Oncol 2010 citation - `disclaimer` (string): Not-a-device notice ## Example JSON Frozen fixture. Not a live lookup. ```json { "components": [ { "value": "pif_or_cr1_gt_6mo", "factor": "disease_group", "points": 0, "present": false }, { "value": "good_or_intermediate", "factor": "cytogenetics", "points": 0, "present": false }, { "value": "sibling_or_matched_unrelated", "factor": "hla_match", "points": 0, "present": false }, { "factor": "circulating_blasts", "points": 0, "present": false }, { "factor": "kps_lt_90", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Duval M, Klein JP, He W, et al", "doi": "10.1200/JCO.2010.28.8852", "id": "duval-2010", "pmid": "20625126", "source": "J Clin Oncol. 2010;28(23):3730-3738", "title": "Hematopoietic Stem-Cell Transplantation for Acute Leukemia in Relapse or Primary Induction Failure" }, "formula": "duval_aml", "formula_expression": "Duval AML Table 5 = disease_group (pif_or_cr1_gt_6mo 0, cr1_lt_6mo 1) + cytogenetics (good_or_intermediate 0, poor 1) + hla_match (sibling_or_matched_unrelated 0, mismatched_unrelated 1, related_other 2) + circulating_blasts 1 + kps_lt_90 1; Duval 2010 AML only (not ALL); max 6; risk_group 0 / 1 / 2 / ge_3", "max_score": 6, "score": 0, "risk_group": "0", "circulating_blasts": false, "cytogenetics": "good_or_intermediate", "disease_group": "pif_or_cr1_gt_6mo", "hla_match": "sibling_or_matched_unrelated", "kps_lt_90": false } ``` ## Errors - HTTP 400 `invalid_flag`: boolean clinical flags must be true or false Returned before settlement; you are not charged. - HTTP 400 `invalid_duval`: each Duval 2010 AML item must be a published Table 5 category. Returned before settlement; you are not charged. - HTTP 400 `invalid_hla_match`: hla_match must be sibling_or_matched_unrelated, mismatched_unrelated, or related_other (Duval 2010). Returned before settlement; you are not charged. - HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged. - HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged. - HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged. Shared HTTP 402 and 503: https://magentlab.com/docs/payments ## Related tools - [Karnofsky](https://magentlab.com/docs/karnofsky) — Return the Karnofsky 1949 Performance Status 10-100 from a caller-assigned integer, with a stable label. ## Payment Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. - GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall). - HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote. - Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering. - Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional. - Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402. - offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront. - offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization. - not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search. Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers). Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments Stdio MCP (one process per host): https://magentlab.com/docs/mcp ## Guarantees - HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON. - exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE. - HTTP 402 is unpaid only. Do not sign a second authorization because of a 503. - Execution is timeout-bounded and concurrency-capped. - Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.