# EUTOS score

EUTOS score

Status: LIVE
Price: $0.005 USDC
`GET /api/calc/eutos`
HTML: https://magentlab.com/docs/eutos
Markdown: https://magentlab.com/docs/eutos.md

Not a medical device. Not a diagnosis, dose, or listing recommendation.

## What it computes

Compute the Hasford 2011 EUTOS score for baseline untreated chronic myeloid leukemia from spleen size below the costal margin and peripheral-blood basophil percent, with the paper’s two groups (low ≤87, high >87).

## When to use

When an agent needs the published Hasford 2011 EUTOS score and must not invent later CML scores, diagnose CML, or choose TKI therapy.

## When not to use

- Not a medical device. magent does not diagnose CML.
- Hasford 2011 applies to baseline untreated chronic myeloid leukemia (CML) only.
- Does not choose TKI therapy or any other treatment.

## Formula

```
eutos_score = 4 * spleen_cm + 7 * basophils_percent
```

## Citation

[Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: the EUTOS score](https://doi.org/10.1182/blood-2010-12-319038)
Hasford J, Baccarani M, Hoffmann V, Guilhot J, Saussele S, Rosti G, Guilhot F, Porkka K, Ossenkoppele G, Lindoerfer D, Simonsson B, Pfirrmann M, Hehlmann R
Blood. 2011;118(3):686-692
DOI: [10.1182/blood-2010-12-319038](https://doi.org/10.1182/blood-2010-12-319038)

## Worked example

### Spleen 5 cm, basophils 2%

Given: `basophils_percent=2, spleen_cm=5`

1. 4 × 5 = 20
2. 7 × 2 = 14
3. eutos_score = 20 + 14 = 34.0
4. 34.0 ≤ 87 → low


### Spleen 13 cm, basophils 5% (score 87)

Given: `basophils_percent=5, spleen_cm=13`

1. 4 × 13 = 52
2. 7 × 5 = 35
3. eutos_score = 52 + 35 = 87.0
4. 87.0 ≤ 87 → low


### Spleen 15 cm, basophils 5%

Given: `basophils_percent=5, spleen_cm=15`

1. 4 × 15 = 60
2. 7 × 5 = 35
3. eutos_score = 60 + 35 = 95.0
4. 95.0 > 87 → high


## Also searched as

- EUTOS score
- EUTOS CML
- Hasford 2011
- European Treatment and Outcome Study score
- CML EUTOS
- chronic myeloid leukemia EUTOS
- EUTOS prognostic score
- Hasford EUTOS

## Parameters

- `spleen_cm` (number, required): Spleen size in cm below the costal margin at baseline, untreated (0-40). Hasford 2011 EUTOS.
- `basophils_percent` (number, required): Peripheral-blood basophils as a percent of leukocytes (0-100). Hasford 2011 EUTOS.

## Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

Method: `POST /api/calc/eutos`
Max items: 25
Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic)
Status: PREVIEW

- 1 to 25 items. Each item uses the same keys as the GET query parameters.
- POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
- The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
- HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
- Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
- x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request:

```json
{
  "items": [
    {
      "basophils_percent": "2",
      "spleen_cm": "5"
    },
    {
      "basophils_percent": "2",
      "spleen_cm": "5"
    }
  ]
}
```

Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/eutos

Example 200:

```json
{
  "count": 2,
  "path": "/api/calc/eutos",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Hasford J, Baccarani M, Hoffmann V, Guilhot J, Saussele S, Rosti G, Guilhot F, Porkka K, Ossenkoppele G, Lindoerfer D, Simonsson B, Pfirrmann M, Hehlmann R",
        "doi": "10.1182/blood-2010-12-319038",
        "id": "hasford-2011",
        "pmid": "21536864",
        "source": "Blood. 2011;118(3):686-692",
        "title": "Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: the EUTOS score"
      },
      "formula": "eutos",
      "formula_expression": "eutos_score = 4 * spleen_cm + 7 * basophils_percent",
      "basophils_percent": 2.0,
      "eutos_band": "low",
      "eutos_score": 34.0,
      "spleen_cm": 5.0
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Hasford J, Baccarani M, Hoffmann V, Guilhot J, Saussele S, Rosti G, Guilhot F, Porkka K, Ossenkoppele G, Lindoerfer D, Simonsson B, Pfirrmann M, Hehlmann R",
        "doi": "10.1182/blood-2010-12-319038",
        "id": "hasford-2011",
        "pmid": "21536864",
        "source": "Blood. 2011;118(3):686-692",
        "title": "Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: the EUTOS score"
      },
      "formula": "eutos",
      "formula_expression": "eutos_score = 4 * spleen_cm + 7 * basophils_percent",
      "basophils_percent": 2.0,
      "eutos_band": "low",
      "eutos_score": 34.0,
      "spleen_cm": 5.0
    }
  ]
}
```

## Response fields

- `formula` (string): eutos
- `formula_expression` (string): Exact expression used
- `spleen_cm` (number): Spleen size used, cm below the costal margin
- `basophils_percent` (number): Peripheral-blood basophils used, percent of leukocytes
- `eutos_score` (number): Hasford 2011 EUTOS score, 1 decimal
- `eutos_band` (string): Hasford 2011 two groups: low (score ≤ 87), high (score > 87). Not a diagnosis and not a TKI choice.
- `citation` (object): Hasford 2011 Blood citation
- `disclaimer` (string): Not-a-device notice

## Example JSON

Frozen fixture. Not a live lookup.

```json
{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Hasford J, Baccarani M, Hoffmann V, Guilhot J, Saussele S, Rosti G, Guilhot F, Porkka K, Ossenkoppele G, Lindoerfer D, Simonsson B, Pfirrmann M, Hehlmann R",
    "doi": "10.1182/blood-2010-12-319038",
    "id": "hasford-2011",
    "pmid": "21536864",
    "source": "Blood. 2011;118(3):686-692",
    "title": "Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: the EUTOS score"
  },
  "formula": "eutos",
  "formula_expression": "eutos_score = 4 * spleen_cm + 7 * basophils_percent",
  "basophils_percent": 2.0,
  "eutos_band": "low",
  "eutos_score": 34.0,
  "spleen_cm": 5.0
}
```

## Errors

- HTTP 400 `invalid_spleen_cm`: spleen_cm must be a number from 0 to 40 (cm below the costal margin; Sokal 1984). Returned before settlement; you are not charged.
- HTTP 400 `invalid_basophil_percent`: basophils_percent must be a number from 0 to 100 (Hasford 2011 EUTOS). Returned before settlement; you are not charged.
- HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
- HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
- HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged.

Shared HTTP 402 and 503: https://magentlab.com/docs/payments

## Related tools

- [Sokal index](https://magentlab.com/docs/sokal) — Compute the Sokal 1984 relative-risk index for newly diagnosed untreated chronic granulocytic leukemia from age, spleen size below the costal margin, platelet count, and percent circulating blasts, with the paper’s three groups.
- [ANC](https://magentlab.com/docs/anc) — Compute absolute neutrophil count from WBC and neutrophil plus band percents, plus a Bodey 1966 granulocyte band.
- [NLR](https://magentlab.com/docs/nlr) — Compute the Zahorec 2001 neutrophil-to-lymphocyte ratio from relative neutrophil and lymphocyte percents.

## Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s.

- GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall).
- HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote.
- Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering.
- Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional.
- Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402.

- offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront.
- offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization.

- not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search.

Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers).

Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments

Stdio MCP (one process per host): https://magentlab.com/docs/mcp

## Guarantees

- HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged.
- exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
- HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
- Execution is timeout-bounded and concurrency-capped.
- Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.