# FLIPI (Solal-Céligny) FLIPI Status: LIVE Price: $0.005 USDC `GET /api/calc/flipi` HTML: https://magentlab.com/docs/flipi Markdown: https://magentlab.com/docs/flipi.md Not a medical device. Not a diagnosis, dose, or listing recommendation. ## What it computes Sum the Solal-Céligny 2004 FLIPI adverse factors for follicular lymphoma and return low (0–1), intermediate (2), or high (≥3). ## When to use When an agent needs the published FLIPI 2004 point total and class and must not invent a follicular-lymphoma diagnosis or treatment choice, and must not substitute FLIPI-2. ## When not to use - Not a medical device and not a follicular-lymphoma diagnosis or treatment choice. magent does not examine the patient. - This is FLIPI 2004 (Solal-Céligny), not FLIPI-2. - magent does not stage lymphoma, assay hemoglobin, count nodal sites, or measure LDH. All five inputs are caller-assigned flags. ## Formula ``` FLIPI = age_gt_60 1 + stage_iii_iv 1 + hemoglobin_lt_120_g_l 1 + nodal_sites_gt_4 1 + ldh_above_uln 1; Solal-Céligny 2004; max 5; low 0-1, intermediate 2, high ≥3 ``` ## Citation [Follicular lymphoma international prognostic index](https://doi.org/10.1182/blood-2003-12-4434) Solal-Céligny P, Roy P, Colombat P, White J, Armitage JO, Arranz-Saez R, Au WY, Bellei M, Brice P, Caballero D, Coiffier B, Conde-Garcia E, Doyen C, Federico M, Fisher RI, Garcia-Conde JF, Gisselbrecht C, Haioun C, LeBlanc M, Lister AT, Lopez-Guillermo A, McLaughlin P, Milpied N, Morel P, Mounier N, Proctor SJ, Rohatiner A, Smith P, Soubeyran P, Tilly H, Vitolo U, Zinzani PL, Zucca E, Montserrat E Blood. 2004;104(5):1258-1265 DOI: [10.1182/blood-2003-12-4434](https://doi.org/10.1182/blood-2003-12-4434) ## Worked example ### All flags false Given: `age_gt_60=false, hemoglobin_lt_120_g_l=false, ldh_above_uln=false, nodal_sites_gt_4=false, stage_iii_iv=false` 1. All five caller-assigned flags false → 0 2. Score = 0 (max 5); flipi_band = low ### Age >60, Ann Arbor III–IV, and hemoglobin <120 g/L Given: `age_gt_60=true, hemoglobin_lt_120_g_l=true, ldh_above_uln=false, nodal_sites_gt_4=false, stage_iii_iv=true` 1. age_gt_60 → 1; stage_iii_iv → 1; hemoglobin_lt_120_g_l → 1; remaining flags 0 2. Score = 3 (max 5); flipi_band = high (≥3) ## Also searched as - FLIPI - Follicular lymphoma international prognostic index - Solal-Céligny FLIPI - FLIPI 2004 - follicular lymphoma prognostic index - Ann Arbor FLIPI - FLIPI score ## Parameters - `age_gt_60` (boolean, required): Age >60 years as assigned by the caller (Solal-Céligny 2004). true scores 1. magent does not assign age. - `stage_iii_iv` (boolean, required): Ann Arbor stage III–IV as assigned by the caller (Solal-Céligny 2004). true scores 1. magent does not stage lymphoma. - `hemoglobin_lt_120_g_l` (boolean, required): Hemoglobin <120 g/L as assigned by the caller (Solal-Céligny 2004). true scores 1. magent does not assay hemoglobin. - `nodal_sites_gt_4` (boolean, required): Nodal areas >4 as assigned by the caller (Solal-Céligny 2004). true scores 1. magent does not count nodal sites. - `ldh_above_uln` (boolean, required): Serum LDH above the upper limit of normal as assigned by the caller (Solal-Céligny 2004). true scores 1. magent does not measure LDH. ## Bulk (POST) POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement. Method: `POST /api/calc/flipi` Max items: 25 Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic) Status: PREVIEW - 1 to 25 items. Each item uses the same keys as the GET query parameters. - POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows. - The first invalid item fails the whole request (index in the 400 JSON). You are not charged. - HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row. - Catalog misses (empty matches, found=false) stay paid 200s inside that slot. - x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items. Example request: ```json { "items": [ { "age_gt_60": "false", "hemoglobin_lt_120_g_l": "false", "ldh_above_uln": "false", "nodal_sites_gt_4": "false", "stage_iii_iv": "false" }, { "age_gt_60": "false", "hemoglobin_lt_120_g_l": "false", "ldh_above_uln": "false", "nodal_sites_gt_4": "false", "stage_iii_iv": "false" } ] } ``` Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/flipi Example 200: ```json { "count": 2, "path": "/api/calc/flipi", "items": [ { "components": [ { "factor": "age_gt_60", "points": 0, "present": false }, { "factor": "stage_iii_iv", "points": 0, "present": false }, { "factor": "hemoglobin_lt_120_g_l", "points": 0, "present": false }, { "factor": "nodal_sites_gt_4", "points": 0, "present": false }, { "factor": "ldh_above_uln", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Solal-Céligny P, Roy P, Colombat P, White J, Armitage JO, Arranz-Saez R, Au WY, Bellei M, Brice P, Caballero D, Coiffier B, Conde-Garcia E, Doyen C, Federico M, Fisher RI, Garcia-Conde JF, Gisselbrecht C, Haioun C, LeBlanc M, Lister AT, Lopez-Guillermo A, McLaughlin P, Milpied N, Morel P, Mounier N, Proctor SJ, Rohatiner A, Smith P, Soubeyran P, Tilly H, Vitolo U, Zinzani PL, Zucca E, Montserrat E", "doi": "10.1182/blood-2003-12-4434", "id": "solal-celigny-2004", "pmid": "15126323", "source": "Blood. 2004;104(5):1258-1265", "title": "Follicular lymphoma international prognostic index" }, "formula": "flipi", "formula_expression": "FLIPI = age_gt_60 1 + stage_iii_iv 1 + hemoglobin_lt_120_g_l 1 + nodal_sites_gt_4 1 + ldh_above_uln 1; Solal-Céligny 2004; max 5; low 0-1, intermediate 2, high ≥3", "max_score": 5, "score": 0, "flipi_band": "low" }, { "components": [ { "factor": "age_gt_60", "points": 0, "present": false }, { "factor": "stage_iii_iv", "points": 0, "present": false }, { "factor": "hemoglobin_lt_120_g_l", "points": 0, "present": false }, { "factor": "nodal_sites_gt_4", "points": 0, "present": false }, { "factor": "ldh_above_uln", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Solal-Céligny P, Roy P, Colombat P, White J, Armitage JO, Arranz-Saez R, Au WY, Bellei M, Brice P, Caballero D, Coiffier B, Conde-Garcia E, Doyen C, Federico M, Fisher RI, Garcia-Conde JF, Gisselbrecht C, Haioun C, LeBlanc M, Lister AT, Lopez-Guillermo A, McLaughlin P, Milpied N, Morel P, Mounier N, Proctor SJ, Rohatiner A, Smith P, Soubeyran P, Tilly H, Vitolo U, Zinzani PL, Zucca E, Montserrat E", "doi": "10.1182/blood-2003-12-4434", "id": "solal-celigny-2004", "pmid": "15126323", "source": "Blood. 2004;104(5):1258-1265", "title": "Follicular lymphoma international prognostic index" }, "formula": "flipi", "formula_expression": "FLIPI = age_gt_60 1 + stage_iii_iv 1 + hemoglobin_lt_120_g_l 1 + nodal_sites_gt_4 1 + ldh_above_uln 1; Solal-Céligny 2004; max 5; low 0-1, intermediate 2, high ≥3", "max_score": 5, "score": 0, "flipi_band": "low" } ] } ``` ## Response fields - `formula` (string): flipi - `formula_expression` (string): Exact expression used - `score` (integer): FLIPI points 0-5 - `max_score` (integer): Always 5 - `flipi_band` (string): low when score is 0-1, intermediate when 2, high when ≥3 (Solal-Céligny 2004). Not a follicular-lymphoma diagnosis or treatment choice. FLIPI 2004, not FLIPI-2. - `components` (array): Per-factor points - `citation` (object): Solal-Céligny 2004 Blood citation - `disclaimer` (string): Not-a-device notice ## Example JSON Frozen fixture. Not a live lookup. ```json { "components": [ { "factor": "age_gt_60", "points": 0, "present": false }, { "factor": "stage_iii_iv", "points": 0, "present": false }, { "factor": "hemoglobin_lt_120_g_l", "points": 0, "present": false }, { "factor": "nodal_sites_gt_4", "points": 0, "present": false }, { "factor": "ldh_above_uln", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Solal-Céligny P, Roy P, Colombat P, White J, Armitage JO, Arranz-Saez R, Au WY, Bellei M, Brice P, Caballero D, Coiffier B, Conde-Garcia E, Doyen C, Federico M, Fisher RI, Garcia-Conde JF, Gisselbrecht C, Haioun C, LeBlanc M, Lister AT, Lopez-Guillermo A, McLaughlin P, Milpied N, Morel P, Mounier N, Proctor SJ, Rohatiner A, Smith P, Soubeyran P, Tilly H, Vitolo U, Zinzani PL, Zucca E, Montserrat E", "doi": "10.1182/blood-2003-12-4434", "id": "solal-celigny-2004", "pmid": "15126323", "source": "Blood. 2004;104(5):1258-1265", "title": "Follicular lymphoma international prognostic index" }, "formula": "flipi", "formula_expression": "FLIPI = age_gt_60 1 + stage_iii_iv 1 + hemoglobin_lt_120_g_l 1 + nodal_sites_gt_4 1 + ldh_above_uln 1; Solal-Céligny 2004; max 5; low 0-1, intermediate 2, high ≥3", "max_score": 5, "score": 0, "flipi_band": "low" } ``` ## Errors - HTTP 400 `invalid_flag`: boolean clinical flags must be true or false Returned before settlement; you are not charged. - HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged. - HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged. - HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged. Shared HTTP 402 and 503: https://magentlab.com/docs/payments ## Related tools - [ANC](https://magentlab.com/docs/anc) — Compute absolute neutrophil count from WBC and neutrophil plus band percents, plus a Bodey 1966 granulocyte band. - [NLR](https://magentlab.com/docs/nlr) — Compute the Zahorec 2001 neutrophil-to-lymphocyte ratio from relative neutrophil and lymphocyte percents. - [ISTH overt DIC](https://magentlab.com/docs/isth-dic) — Sum the four Taylor 2001 ISTH SSC overt DIC laboratory items (platelets, fibrin-related marker, PT prolongation, fibrinogen) and return the published <5 / >=5 band. ## Payment Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. - GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall). - HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote. - Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering. - Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional. - Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402. - offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront. - offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization. - not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search. Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers). Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments Stdio MCP (one process per host): https://magentlab.com/docs/mcp ## Guarantees - HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. - exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE. - HTTP 402 is unpaid only. Do not sign a second authorization because of a 503. - Execution is timeout-bounded and concurrency-capped. - Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.