# Fuhrman nuclear grade (1982) Fuhrman Status: LIVE Price: $0.005 USDC `GET /api/calc/fuhrman` HTML: https://magentlab.com/docs/fuhrman Markdown: https://magentlab.com/docs/fuhrman.md Not a medical device. Not a diagnosis, dose, or listing recommendation. ## What it computes Echo the caller-assigned Fuhrman 1982 nuclear grade (1-4) with the published nuclear-feature description. magent does not read slides. Not WHO/ISUP 2016. ## When to use When an agent already has a Fuhrman 1982 nuclear grade as assigned by the caller and needs the published grade description. magent does not read slides, assign grade from histology, or map to WHO/ISUP 2016. ## When not to use - Not a medical device. magent does not read slides. - The caller assigns Fuhrman 1982 nuclear grade 1-4. magent does not grade nuclei, measure nuclear diameter, or inspect nucleoli. - Fuhrman 1982 four nuclear grades only. Not WHO/ISUP 2016. This tool does not convert Fuhrman grade to WHO/ISUP grade. - Not an RCC diagnosis. Not a treatment or nephrectomy order. No survival bands. ## Formula ``` fuhrman_grade in {1, 2, 3, 4} as assigned by the caller (Fuhrman 1982 four nuclear grades in order of increasing nuclear size, irregularity, and nucleolar prominence). Not WHO/ISUP 2016. magent does not read slides. ``` ## Citation [Prognostic significance of morphologic parameters in renal cell carcinoma](https://doi.org/10.1097/00000478-198210000-00007) Fuhrman SA, Lasky LC, Limas C Am J Surg Pathol. 1982;6(7):655-663 DOI: [10.1097/00000478-198210000-00007](https://doi.org/10.1097/00000478-198210000-00007) ## Worked example ### Grade 1 small uniform nuclei Given: `fuhrman_grade=1` 1. fuhrman_grade 1 as assigned by the caller 2. small (~10 μm) round, uniform nuclei; nucleoli absent or inconspicuous ### Grade 4 bizarre multilobed nuclei Given: `fuhrman_grade=4` 1. fuhrman_grade 4 as assigned by the caller 2. as for grade 3 with bizarre often multilobed nuclei ± spindle cells ## Also searched as - Fuhrman grade - Fuhrman nuclear grade - Fuhrman 1982 - RCC nuclear grade - renal cell carcinoma grade - Fuhrman 1-4 - nuclear grading RCC - Fuhrman nucleolar grade ## Parameters - `fuhrman_grade` (integer, required): Fuhrman 1982 nuclear grade 1-4 as assigned by the caller (1 small ~10 μm round uniform nuclei, nucleoli absent or inconspicuous; 2 larger ~15 μm nuclei with outline irregularities, nucleoli visible at ×400; 3 even larger ~20 μm with obvious irregular outline, nucleoli prominent at ×100; 4 as for grade 3 with bizarre often multilobed nuclei ± spindle cells). Integer 1-4 only; reject 0, 5, 1.5, and roman I. Not WHO/ISUP 2016. magent does not read slides. ## Bulk (POST) POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement. Method: `POST /api/calc/fuhrman` Max items: 25 Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic) Status: PREVIEW - 1 to 25 items. Each item uses the same keys as the GET query parameters. - POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows. - The first invalid item fails the whole request (index in the 400 JSON). You are not charged. - HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row. - Catalog misses (empty matches, found=false) stay paid 200s inside that slot. - x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items. Example request: ```json { "items": [ { "fuhrman_grade": "1" }, { "fuhrman_grade": "1" } ] } ``` Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/fuhrman Example 200: ```json { "count": 2, "path": "/api/calc/fuhrman", "items": [ { "description": "Small (~10 μm) round, uniform nuclei; nucleoli absent or inconspicuous", "components": [ { "factor": "grade_1", "met": true }, { "factor": "grade_2", "met": false }, { "factor": "grade_3", "met": false }, { "factor": "grade_4", "met": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Fuhrman SA, Lasky LC, Limas C", "doi": "10.1097/00000478-198210000-00007", "id": "fuhrman-1982", "pmid": "7180965", "source": "Am J Surg Pathol. 1982;6(7):655-663", "title": "Prognostic significance of morphologic parameters in renal cell carcinoma" }, "formula": "fuhrman", "formula_expression": "fuhrman_grade in {1, 2, 3, 4} as assigned by the caller (Fuhrman 1982 four nuclear grades in order of increasing nuclear size, irregularity, and nucleolar prominence). Not WHO/ISUP 2016. magent does not read slides.", "fuhrman_grade": 1 }, { "description": "Small (~10 μm) round, uniform nuclei; nucleoli absent or inconspicuous", "components": [ { "factor": "grade_1", "met": true }, { "factor": "grade_2", "met": false }, { "factor": "grade_3", "met": false }, { "factor": "grade_4", "met": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Fuhrman SA, Lasky LC, Limas C", "doi": "10.1097/00000478-198210000-00007", "id": "fuhrman-1982", "pmid": "7180965", "source": "Am J Surg Pathol. 1982;6(7):655-663", "title": "Prognostic significance of morphologic parameters in renal cell carcinoma" }, "formula": "fuhrman", "formula_expression": "fuhrman_grade in {1, 2, 3, 4} as assigned by the caller (Fuhrman 1982 four nuclear grades in order of increasing nuclear size, irregularity, and nucleolar prominence). Not WHO/ISUP 2016. magent does not read slides.", "fuhrman_grade": 1 } ] } ``` ## Response fields - `formula` (string): fuhrman - `formula_expression` (string): Published Fuhrman 1982 nuclear-grade rule - `fuhrman_grade` (integer): Caller-assigned Fuhrman 1982 nuclear grade 1-4 - `description` (string): Fuhrman 1982 nuclear-feature wording for that grade - `components` (array): Per-grade Tree rows grade_1, grade_2, grade_3, grade_4 with factor and met; exactly one is met - `citation` (object): Fuhrman 1982 Am J Surg Pathol citation - `disclaimer` (string): Not-a-device notice ## Example JSON Frozen fixture. Not a live lookup. ```json { "description": "Small (~10 μm) round, uniform nuclei; nucleoli absent or inconspicuous", "components": [ { "factor": "grade_1", "met": true }, { "factor": "grade_2", "met": false }, { "factor": "grade_3", "met": false }, { "factor": "grade_4", "met": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Fuhrman SA, Lasky LC, Limas C", "doi": "10.1097/00000478-198210000-00007", "id": "fuhrman-1982", "pmid": "7180965", "source": "Am J Surg Pathol. 1982;6(7):655-663", "title": "Prognostic significance of morphologic parameters in renal cell carcinoma" }, "formula": "fuhrman", "formula_expression": "fuhrman_grade in {1, 2, 3, 4} as assigned by the caller (Fuhrman 1982 four nuclear grades in order of increasing nuclear size, irregularity, and nucleolar prominence). Not WHO/ISUP 2016. magent does not read slides.", "fuhrman_grade": 1 } ``` ## Errors - HTTP 400 `invalid_fuhrman`: fuhrman_grade must be 1, 2, 3, or 4 (Fuhrman 1982 nuclear grade). Returned before settlement; you are not charged. - HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged. - HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged. - HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged. Shared HTTP 402 and 503: https://magentlab.com/docs/payments ## Related tools - [R.E.N.A.L. nephrometry](https://magentlab.com/docs/renal-nephrometry) — Sum the Kutikov 2009 R.E.N.A.L. nephrometry score for a renal mass from four caller-assigned published item points (radius, exophytic/endophytic, nearness, location) and return the integer total (4–12) plus anterior and hilar descriptors. Does not return complexity bands. - [Motzer](https://magentlab.com/docs/motzer) — Sum the Motzer 1999 MSKCC adverse factors for advanced RCC and return favorable (0), intermediate (1–2), or poor (≥3). Motzer 1999 reported median survival of 20, 10, and 4 months in those interferon-era groups as published cohort results, not a predicted survival. ## Payment Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. - GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall). - HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote. - Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering. - Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional. - Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402. - offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront. - offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization. - not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search. Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers). Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments Stdio MCP (one process per host): https://magentlab.com/docs/mcp ## Guarantees - HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON. - exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE. - HTTP 402 is unpaid only. Do not sign a second authorization because of a 503. - Execution is timeout-bounded and concurrency-capped. - Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.