# GALAD score GALAD Status: LIVE Price: $0.005 USDC `GET /api/calc/galad` HTML: https://magentlab.com/docs/galad Markdown: https://magentlab.com/docs/galad.md Not a medical device. Not a diagnosis, dose, or listing recommendation. ## What it computes Compute the Johnson 2014 GALAD linear predictor from age, sex, AFP, AFP-L3 percent, and DCP. ## When to use When an agent needs the published Johnson 2014 GALAD linear predictor from age, sex, and serological biomarkers and must not invent an HCC diagnosis, listing protocol, probability, or ALBI grade. ## When not to use - Not a medical device. Not an HCC diagnosis or transplant listing protocol. - Age 18–120 is an implementation clamp; Johnson 2014 is adult chronic liver disease. - AFP and DCP enter as ng/mL with log10. AFP-L3 enters as a raw percent, not logged. magent does not convert DCP from mAU/mL. - Johnson 2014 GALAD linear predictor only. Does not return a −0.63 cutoff, probability, or HCC-likely band. This is not Johnson 2015 ALBI. ## Formula ``` galad_score = -10.08 + 0.09*age + 1.67*sex + 2.34*log10(afp_ng_ml) + 0.04*afp_l3_percent + 1.33*log10(dcp_ng_ml) ``` ## Citation [The detection of hepatocellular carcinoma using a prospectively developed and validated model based on serological biomarkers](https://doi.org/10.1158/1055-9965.EPI-13-0870) Johnson PJ, Pirrie SJ, Cox TF, Berhane S, Teng M, Palmer D, Morse J, Hull D, Patman G, Kagebayashi C, et al. Cancer Epidemiol Biomarkers Prev. 2014;23(1):144-153 DOI: [10.1158/1055-9965.EPI-13-0870](https://doi.org/10.1158/1055-9965.EPI-13-0870) ## Worked example ### Age 60 male, AFP 10 ng/mL, AFP-L3 10%, DCP 10 ng/mL Given: `afp_l3_percent=10, afp_ng_ml=10, age=60, dcp_ng_ml=10, sex=male` 1. log10(10) = 1 for AFP and DCP 2. sex = 1 (male) 3. -10.08 + 0.09×60 + 1.67×1 + 2.34×1 + 0.04×10 + 1.33×1 = -10.08+5.4+1.67+2.34+0.4+1.33 = 1.06 ## Also searched as - GALAD score - GALAD model - Johnson GALAD - AFP AFP-L3 DCP - hepatocellular carcinoma biomarkers - des-gamma-carboxy prothrombin GALAD ## Parameters - `age` (integer, required): Age in years (18-120). Eighteen is an implementation clamp; Johnson 2014 is adult chronic liver disease. - `sex` (string, required): Sex used in the linear predictor (male = 1, female = 0). - `afp_ng_ml` (number, required): AFP in ng/mL (0.1-100000). Johnson 2014 uses log10 of ng/mL. Not a conversion from other units. - `afp_l3_percent` (number, required): AFP-L3 as a raw percent of total AFP (0-100). Enters unlogged. Johnson 2014 does not take log10 of AFP-L3. - `dcp_ng_ml` (number, required): DCP (des-gamma-carboxy prothrombin) in ng/mL (0.1-100000). Johnson 2014 uses log10 of ng/mL. Not mAU/mL; magent does not convert. ## Bulk (POST) POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement. Method: `POST /api/calc/galad` Max items: 25 Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic) Status: PREVIEW - 1 to 25 items. Each item uses the same keys as the GET query parameters. - POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows. - The first invalid item fails the whole request (index in the 400 JSON). You are not charged. - HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row. - Catalog misses (empty matches, found=false) stay paid 200s inside that slot. - x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items. Example request: ```json { "items": [ { "afp_l3_percent": "10", "afp_ng_ml": "10", "age": "60", "dcp_ng_ml": "10", "sex": "male" }, { "afp_l3_percent": "10", "afp_ng_ml": "10", "age": "60", "dcp_ng_ml": "10", "sex": "male" } ] } ``` Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/galad Example 200: ```json { "count": 2, "path": "/api/calc/galad", "items": [ { "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Johnson PJ, Pirrie SJ, Cox TF, Berhane S, Teng M, Palmer D, Morse J, Hull D, Patman G, Kagebayashi C, et al.", "doi": "10.1158/1055-9965.EPI-13-0870", "id": "johnson-2014", "pmid": "24220911", "source": "Cancer Epidemiol Biomarkers Prev. 2014;23(1):144-153", "title": "The detection of hepatocellular carcinoma using a prospectively developed and validated model based on serological biomarkers" }, "formula": "galad", "formula_expression": "galad_score = -10.08 + 0.09*age + 1.67*sex + 2.34*log10(afp_ng_ml) + 0.04*afp_l3_percent + 1.33*log10(dcp_ng_ml)", "age_years": 60, "sex": "male", "afp_l3_percent": 10.0, "afp_ng_ml": 10.0, "dcp_ng_ml": 10.0, "galad_score": 1.06 }, { "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Johnson PJ, Pirrie SJ, Cox TF, Berhane S, Teng M, Palmer D, Morse J, Hull D, Patman G, Kagebayashi C, et al.", "doi": "10.1158/1055-9965.EPI-13-0870", "id": "johnson-2014", "pmid": "24220911", "source": "Cancer Epidemiol Biomarkers Prev. 2014;23(1):144-153", "title": "The detection of hepatocellular carcinoma using a prospectively developed and validated model based on serological biomarkers" }, "formula": "galad", "formula_expression": "galad_score = -10.08 + 0.09*age + 1.67*sex + 2.34*log10(afp_ng_ml) + 0.04*afp_l3_percent + 1.33*log10(dcp_ng_ml)", "age_years": 60, "sex": "male", "afp_l3_percent": 10.0, "afp_ng_ml": 10.0, "dcp_ng_ml": 10.0, "galad_score": 1.06 } ] } ``` ## Response fields - `formula` (string): galad - `formula_expression` (string): Exact expression used - `age_years` (integer): Age used in the equation - `sex` (string): female or male - `afp_ng_ml` (number): AFP used in ng/mL - `afp_l3_percent` (number): AFP-L3 used as a raw percent (not logged) - `dcp_ng_ml` (number): DCP used in ng/mL - `galad_score` (number): Johnson 2014 linear predictor, 2 decimal places - `citation` (object): Johnson 2014 citation - `disclaimer` (string): Not-a-device notice ## Example JSON Frozen fixture. Not a live lookup. ```json { "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Johnson PJ, Pirrie SJ, Cox TF, Berhane S, Teng M, Palmer D, Morse J, Hull D, Patman G, Kagebayashi C, et al.", "doi": "10.1158/1055-9965.EPI-13-0870", "id": "johnson-2014", "pmid": "24220911", "source": "Cancer Epidemiol Biomarkers Prev. 2014;23(1):144-153", "title": "The detection of hepatocellular carcinoma using a prospectively developed and validated model based on serological biomarkers" }, "formula": "galad", "formula_expression": "galad_score = -10.08 + 0.09*age + 1.67*sex + 2.34*log10(afp_ng_ml) + 0.04*afp_l3_percent + 1.33*log10(dcp_ng_ml)", "age_years": 60, "sex": "male", "afp_l3_percent": 10.0, "afp_ng_ml": 10.0, "dcp_ng_ml": 10.0, "galad_score": 1.06 } ``` ## Errors - HTTP 400 `invalid_age`: age must be an integer from 18 to 120 Returned before settlement; you are not charged. - HTTP 400 `invalid_sex`: sex must be female or male Returned before settlement; you are not charged. - HTTP 400 `invalid_galad_afp`: afp_ng_ml must be a number from 0.1 to 100000 (Johnson 2014 GALAD log10 AFP). Returned before settlement; you are not charged. - HTTP 400 `invalid_galad_dcp`: dcp_ng_ml must be a number from 0.1 to 100000 (Johnson 2014 GALAD log10 DCP). Returned before settlement; you are not charged. - HTTP 400 `invalid_galad_afp_l3`: afp_l3_percent must be a number from 0 to 100 (Johnson 2014 GALAD). Returned before settlement; you are not charged. - HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged. - HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged. - HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged. Shared HTTP 402 and 503: https://magentlab.com/docs/payments ## Related tools - [ALBI](https://magentlab.com/docs/albi) — Compute the Johnson 2015 albumin-bilirubin (ALBI) linear predictor and grade from total bilirubin and albumin. - [FIB-4](https://magentlab.com/docs/fib4) — Compute the FIB-4 fibrosis index from age, AST, ALT, and platelets. ## Payment Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. - GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall). - HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote. - Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering. - Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional. - Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402. - offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront. - offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization. - not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search. Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers). Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments Stdio MCP (one process per host): https://magentlab.com/docs/mcp ## Guarantees - HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON. - exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE. - HTTP 402 is unpaid only. Do not sign a second authorization because of a 503. - Execution is timeout-bounded and concurrency-capped. - Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.