# GELF criteria

GELF criteria

Status: LIVE
Price: $0.005 USDC
`GET /api/calc/gelf`
HTML: https://magentlab.com/docs/gelf
Markdown: https://magentlab.com/docs/gelf.md

Not a medical device. Not a diagnosis, dose, or listing recommendation.

## What it computes

Apply the Brice 1997 GELF high-tumor-burden checklist and return low_burden or high_burden from eight caller-assigned items.

## When to use

When an agent already has follicular lymphoma findings as assigned by the caller and needs the published Brice 1997 GELF high-versus-low tumor-burden checklist.

## When not to use

- Not a medical device and not a follicular-lymphoma diagnosis or a treatment-initiation or watchful-waiting order. magent does not examine the patient.
- This tool is the Brice 1997 original GELF high-tumor-burden checklist only. It is not FLIPI and not IPI. It is not modified GELF (LDH or β2-microglobulin).
- The caller assigns all eight items. magent does not measure nodes, spleen, counts, or effusions.
- High tumor burden is the published any-criterion rule only: any yes is high_burden; all absent is low_burden.

## Formula

```
high tumor burden iff any of the 8 Brice 1997 GELF criteria
```

## Citation

[Comparison in low-tumor-burden follicular lymphomas between an initial no-treatment policy, prednimustine, or interferon alfa: a randomized study from the Groupe d'Etude des Lymphomes Folliculaires](https://doi.org/10.1200/JCO.1997.15.3.1110)
Brice P, Bastion Y, Lepage E, Brousse N, Haïoun C, Moreau P, Straetmans N, Tilly H, Tabah I, Solal-Céligny P
J Clin Oncol. 1997;15(3):1110-1117
DOI: [10.1200/JCO.1997.15.3.1110](https://doi.org/10.1200/JCO.1997.15.3.1110)

## Worked example

### All eight criteria absent

Given: `b_symptoms=false, compression=false, cytopenia=false, effusion=false, leukemic_phase=false, mass_gt_7cm=false, spleen_below_umbilicus=false, three_nodes_gt_3cm=false`

1. All eight caller-assigned GELF flags are false
2. tumor_burden = low_burden


### Mass >7 cm is high tumor burden

Given: `b_symptoms=false, compression=false, cytopenia=false, effusion=false, leukemic_phase=false, mass_gt_7cm=true, spleen_below_umbilicus=false, three_nodes_gt_3cm=false`

1. mass_gt_7cm is true (caller-assigned nodal or extranodal mass >7 cm)
2. Any yes is high_burden


## Also searched as

- GELF criteria
- Groupe d'Etude des Lymphomes Folliculaires
- Brice GELF
- GELF tumor burden
- follicular lymphoma GELF
- high tumor burden follicular lymphoma
- original GELF criteria

## Parameters

- `mass_gt_7cm` (boolean, required): Any nodal or extranodal tumor mass >7 cm as assigned by the caller. true or false. magent does not measure nodes or extranodal masses.
- `three_nodes_gt_3cm` (boolean, required): At least 3 nodal sites, each with diameter >3 cm, as assigned by the caller. true or false. magent does not count or measure nodes.
- `b_symptoms` (boolean, required): Systemic / B symptoms as assigned by the caller. true or false. magent does not take a history.
- `spleen_below_umbilicus` (boolean, required): Substantial splenic enlargement (inferior margin below the umbilicus) as assigned by the caller. true or false. magent does not measure the spleen.
- `compression` (boolean, required): Compression syndrome (ureter, GI tract, great vessels, or other vital organ as assigned by the caller). true or false. magent does not diagnose compression.
- `effusion` (boolean, required): Pleural or peritoneal serous effusion as assigned by the caller. true or false. magent does not image or tap an effusion.
- `leukemic_phase` (boolean, required): Leukemic phase as assigned by the caller (paper: circulating malignant cells >5.0×10^9/L). true or false. magent does not count cells.
- `cytopenia` (boolean, required): Cytopenia as assigned by the caller (paper: granulocytes <1.0×10^9/L and/or platelets <100×10^9/L). true or false. magent does not count cells.

## Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

Method: `POST /api/calc/gelf`
Max items: 25
Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic)
Status: PREVIEW

- 1 to 25 items. Each item uses the same keys as the GET query parameters.
- POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
- The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
- HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
- Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
- x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request:

```json
{
  "items": [
    {
      "b_symptoms": "false",
      "compression": "false",
      "cytopenia": "false",
      "effusion": "false",
      "leukemic_phase": "false",
      "mass_gt_7cm": "false",
      "spleen_below_umbilicus": "false",
      "three_nodes_gt_3cm": "false"
    },
    {
      "b_symptoms": "false",
      "compression": "false",
      "cytopenia": "false",
      "effusion": "false",
      "leukemic_phase": "false",
      "mass_gt_7cm": "false",
      "spleen_below_umbilicus": "false",
      "three_nodes_gt_3cm": "false"
    }
  ]
}
```

Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/gelf

Example 200:

```json
{
  "count": 2,
  "path": "/api/calc/gelf",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Brice P, Bastion Y, Lepage E, Brousse N, Haïoun C, Moreau P, Straetmans N, Tilly H, Tabah I, Solal-Céligny P",
        "doi": "10.1200/JCO.1997.15.3.1110",
        "id": "brice-1997",
        "pmid": "9060552",
        "source": "J Clin Oncol. 1997;15(3):1110-1117",
        "title": "Comparison in low-tumor-burden follicular lymphomas between an initial no-treatment policy, prednimustine, or interferon alfa: a randomized study from the Groupe d'Etude des Lymphomes Folliculaires"
      },
      "formula": "gelf",
      "formula_expression": "high tumor burden iff any of the 8 Brice 1997 GELF criteria",
      "criteria": [
        {
          "factor": "mass_gt_7cm",
          "met": false
        },
        {
          "factor": "three_nodes_gt_3cm",
          "met": false
        },
        {
          "factor": "b_symptoms",
          "met": false
        },
        {
          "factor": "spleen_below_umbilicus",
          "met": false
        },
        {
          "factor": "compression",
          "met": false
        },
        {
          "factor": "effusion",
          "met": false
        },
        {
          "factor": "leukemic_phase",
          "met": false
        },
        {
          "factor": "cytopenia",
          "met": false
        }
      ],
      "tumor_burden": "low_burden"
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Brice P, Bastion Y, Lepage E, Brousse N, Haïoun C, Moreau P, Straetmans N, Tilly H, Tabah I, Solal-Céligny P",
        "doi": "10.1200/JCO.1997.15.3.1110",
        "id": "brice-1997",
        "pmid": "9060552",
        "source": "J Clin Oncol. 1997;15(3):1110-1117",
        "title": "Comparison in low-tumor-burden follicular lymphomas between an initial no-treatment policy, prednimustine, or interferon alfa: a randomized study from the Groupe d'Etude des Lymphomes Folliculaires"
      },
      "formula": "gelf",
      "formula_expression": "high tumor burden iff any of the 8 Brice 1997 GELF criteria",
      "criteria": [
        {
          "factor": "mass_gt_7cm",
          "met": false
        },
        {
          "factor": "three_nodes_gt_3cm",
          "met": false
        },
        {
          "factor": "b_symptoms",
          "met": false
        },
        {
          "factor": "spleen_below_umbilicus",
          "met": false
        },
        {
          "factor": "compression",
          "met": false
        },
        {
          "factor": "effusion",
          "met": false
        },
        {
          "factor": "leukemic_phase",
          "met": false
        },
        {
          "factor": "cytopenia",
          "met": false
        }
      ],
      "tumor_burden": "low_burden"
    }
  ]
}
```

## Response fields

- `formula` (string): gelf
- `formula_expression` (string): High tumor burden iff any of the 8 Brice 1997 GELF criteria
- `tumor_burden` (string): low_burden when all eight criteria are absent; high_burden when any criterion is present. Not a treatment order.
- `criteria` (array): Per-factor rows with factor and met; met is true when that GELF criterion is present
- `citation` (object): Brice 1997 J Clin Oncol citation
- `disclaimer` (string): Not-a-device notice

## Example JSON

Frozen fixture. Not a live lookup.

```json
{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Brice P, Bastion Y, Lepage E, Brousse N, Haïoun C, Moreau P, Straetmans N, Tilly H, Tabah I, Solal-Céligny P",
    "doi": "10.1200/JCO.1997.15.3.1110",
    "id": "brice-1997",
    "pmid": "9060552",
    "source": "J Clin Oncol. 1997;15(3):1110-1117",
    "title": "Comparison in low-tumor-burden follicular lymphomas between an initial no-treatment policy, prednimustine, or interferon alfa: a randomized study from the Groupe d'Etude des Lymphomes Folliculaires"
  },
  "formula": "gelf",
  "formula_expression": "high tumor burden iff any of the 8 Brice 1997 GELF criteria",
  "criteria": [
    {
      "factor": "mass_gt_7cm",
      "met": false
    },
    {
      "factor": "three_nodes_gt_3cm",
      "met": false
    },
    {
      "factor": "b_symptoms",
      "met": false
    },
    {
      "factor": "spleen_below_umbilicus",
      "met": false
    },
    {
      "factor": "compression",
      "met": false
    },
    {
      "factor": "effusion",
      "met": false
    },
    {
      "factor": "leukemic_phase",
      "met": false
    },
    {
      "factor": "cytopenia",
      "met": false
    }
  ],
  "tumor_burden": "low_burden"
}
```

## Errors

- HTTP 400 `invalid_flag`: boolean clinical flags must be true or false Returned before settlement; you are not charged.
- HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
- HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
- HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged.

Shared HTTP 402 and 503: https://magentlab.com/docs/payments

## Related tools

- [FLIPI](https://magentlab.com/docs/flipi) — Sum the Solal-Céligny 2004 FLIPI adverse factors for follicular lymphoma and return low (0–1), intermediate (2), or high (≥3).
- [IPI](https://magentlab.com/docs/ipi) — Sum the Shipp 1993 five-factor International Prognostic Index (all ages) and return low (0–1), low_intermediate (2), high_intermediate (3), or high (4–5).

## Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s.

- GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall).
- HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote.
- Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering.
- Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional.
- Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402.

- offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront.
- offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization.

- not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search.

Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers).

Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments

Stdio MCP (one process per host): https://magentlab.com/docs/mcp

## Guarantees

- HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged.
- exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
- HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
- Execution is timeout-bounded and concurrency-capped.
- Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.