# HCT-CI (hematopoietic cell transplantation comorbidity index) HCT-CI Status: LIVE Price: $0.005 USDC `GET /api/calc/hct_ci` HTML: https://magentlab.com/docs/hct-ci Markdown: https://magentlab.com/docs/hct-ci.md Not a medical device. Not a diagnosis, dose, or listing recommendation. ## What it computes Sum the Sorror 2005 HCT-specific comorbidity index weights and return low (0), intermediate (1–2), or high (≥3). ## When to use When an agent needs the published HCT-CI point total and risk group from caller-assigned comorbidities and must not substitute Charlson weights or invent a transplant listing. ## When not to use - Not a medical device and not a diagnosis. Not a transplant listing. magent does not examine the patient. - This is the Sorror 2005 HCT-CI, not the Charlson comorbidity index. Weights are the HCT-CI published integers, not Charlson weights. - magent does not interpret PFTs, echo, BMI, or laboratory values. The caller assigns each comorbidity as present or absent, including the published pulmonary and hepatic grades. - Moderate and severe pulmonary grades are mutually exclusive. Mild and moderate/severe hepatic grades are mutually exclusive. Both-true returns HTTP 400. Mild pulmonary and mild renal are not scored in Sorror 2005. - Risk groups follow Sorror 2005 (0 low, 1–2 intermediate, ≥3 high). JSON does not include unofficial survival percentages. ## Formula ``` HCT-CI = arrhythmia 1 + cardiac 1 + inflammatory_bowel_disease 1 + diabetes 1 + cerebrovascular_disease 1 + psychiatric_disturbance 1 + mild_hepatic 1 + obesity 1 + infection 1 + rheumatologic 2 + peptic_ulcer 2 + moderate_severe_renal 2 + moderate_pulmonary 2 + prior_solid_tumor 3 + heart_valve_disease 3 + severe_pulmonary 3 + moderate_severe_hepatic 3; Sorror 2005 HCT-CI weights; max 26; pulmonary moderate vs severe exclusive; hepatic mild vs moderate/severe exclusive; risk groups 0 low / 1-2 intermediate / >=3 high ``` ## Citation [Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT](https://doi.org/10.1182/blood-2005-05-2004) Sorror ML, Maris MB, Storb R, et al. Blood. 2005;106(9):2912-2919 DOI: [10.1182/blood-2005-05-2004](https://doi.org/10.1182/blood-2005-05-2004) ## Worked example ### No comorbidities Given: `arrhythmia=false, cardiac=false, cerebrovascular_disease=false, diabetes=false, heart_valve_disease=false, infection=false, inflammatory_bowel_disease=false, mild_hepatic=false, moderate_pulmonary=false, moderate_severe_hepatic=false, moderate_severe_renal=false, obesity=false, peptic_ulcer=false, prior_solid_tumor=false, psychiatric_disturbance=false, rheumatologic=false, severe_pulmonary=false` 1. All 17 flags false 2. score = 0 3. risk_group = low ### Mutually compatible maxima Given: `arrhythmia=true, cardiac=true, cerebrovascular_disease=true, diabetes=true, heart_valve_disease=true, infection=true, inflammatory_bowel_disease=true, mild_hepatic=false, moderate_pulmonary=false, moderate_severe_hepatic=true, moderate_severe_renal=true, obesity=true, peptic_ulcer=true, prior_solid_tumor=true, psychiatric_disturbance=true, rheumatologic=true, severe_pulmonary=true` 1. Severe pulmonary 3 and moderate/severe hepatic 3; remaining independent weights 2. score = 26 (max 26); risk_group = high ## Also searched as - HCT-CI - hematopoietic cell transplantation comorbidity index - HCT specific comorbidity index - Sorror comorbidity index - Sorror 2005 HCT-CI - HCT comorbidity index - hematopoietic cell transplant CI ## Parameters - `arrhythmia` (boolean, required): Arrhythmia as assigned by the caller (Sorror 2005: atrial fibrillation or flutter, sick sinus syndrome, or ventricular arrhythmias). true scores 1. magent does not diagnose arrhythmia. - `cardiac` (boolean, required): Cardiac comorbidity as assigned by the caller (Sorror 2005: coronary artery disease, congestive heart failure, myocardial infarction, or ejection fraction ≤50%). true scores 1. magent does not interpret echo or diagnose cardiac disease. - `inflammatory_bowel_disease` (boolean, required): Inflammatory bowel disease as assigned by the caller (Sorror 2005: Crohn disease or ulcerative colitis). true scores 1. magent does not diagnose IBD. - `diabetes` (boolean, required): Diabetes requiring insulin or oral hypoglycemics, not diet alone, as assigned by the caller (Sorror 2005). true scores 1. magent does not diagnose diabetes. - `cerebrovascular_disease` (boolean, required): Cerebrovascular disease as assigned by the caller (Sorror 2005: TIA or cerebrovascular accident). true scores 1. magent does not diagnose stroke or TIA. - `psychiatric_disturbance` (boolean, required): Psychiatric disturbance as assigned by the caller (Sorror 2005: depression or anxiety requiring psychiatric consult or treatment). true scores 1. magent does not diagnose psychiatric disease. - `mild_hepatic` (boolean, required): Mild hepatic comorbidity as assigned by the caller (Sorror 2005: chronic hepatitis, bilirubin >ULN to 1.5×ULN, or AST/ALT >ULN to 2.5×ULN). true scores 1. Mutually exclusive with moderate_severe_hepatic. magent does not grade liver tests. - `obesity` (boolean, required): Obesity as assigned by the caller (Sorror 2005: body mass index >35 kg/m²). true scores 1. magent does not compute BMI. - `infection` (boolean, required): Infection requiring continuation of antimicrobial treatment after day 0 as assigned by the caller (Sorror 2005). true scores 1. magent does not diagnose infection. - `rheumatologic` (boolean, required): Rheumatologic comorbidity as assigned by the caller (Sorror 2005: SLE, RA, polymyositis, mixed CTD, or polymyalgia rheumatica). true scores 2. magent does not diagnose rheumatologic disease. - `peptic_ulcer` (boolean, required): Peptic ulcer requiring treatment as assigned by the caller (Sorror 2005). true scores 2. magent does not diagnose ulcer disease. - `moderate_severe_renal` (boolean, required): Moderate/severe renal comorbidity as assigned by the caller (Sorror 2005: serum creatinine >2 mg/dL, dialysis, or prior renal transplantation). true scores 2. magent does not grade kidney disease from creatinine. - `moderate_pulmonary` (boolean, required): Moderate pulmonary comorbidity as assigned by the caller (Sorror 2005: DLco and/or FEV1 66%–80% or dyspnea on slight activity). true scores 2. Mutually exclusive with severe_pulmonary. magent does not interpret PFTs. - `prior_solid_tumor` (boolean, required): Prior solid tumor treated at any time, excluding nonmelanoma skin cancer, as assigned by the caller (Sorror 2005). true scores 3. magent does not diagnose cancer. - `heart_valve_disease` (boolean, required): Heart valve disease except mitral valve prolapse as assigned by the caller (Sorror 2005). true scores 3. magent does not interpret echo. - `severe_pulmonary` (boolean, required): Severe pulmonary comorbidity as assigned by the caller (Sorror 2005: DLco and/or FEV1 ≤65% or dyspnea at rest or requiring oxygen). true scores 3. Mutually exclusive with moderate_pulmonary. magent does not interpret PFTs. - `moderate_severe_hepatic` (boolean, required): Moderate/severe hepatic comorbidity as assigned by the caller (Sorror 2005: cirrhosis, bilirubin >1.5×ULN, or AST/ALT >2.5×ULN). true scores 3. Mutually exclusive with mild_hepatic. magent does not grade liver tests. ## Bulk (POST) POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement. Method: `POST /api/calc/hct_ci` Max items: 25 Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic) Status: PREVIEW - 1 to 25 items. Each item uses the same keys as the GET query parameters. - POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows. - The first invalid item fails the whole request (index in the 400 JSON). You are not charged. - HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row. - Catalog misses (empty matches, found=false) stay paid 200s inside that slot. - x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items. Example request: ```json { "items": [ { "arrhythmia": "false", "cardiac": "false", "cerebrovascular_disease": "false", "diabetes": "false", "heart_valve_disease": "false", "infection": "false", "inflammatory_bowel_disease": "false", "mild_hepatic": "false", "moderate_pulmonary": "false", "moderate_severe_hepatic": "false", "moderate_severe_renal": "false", "obesity": "false", "peptic_ulcer": "false", "prior_solid_tumor": "false", "psychiatric_disturbance": "false", "rheumatologic": "false", "severe_pulmonary": "false" }, { "arrhythmia": "false", "cardiac": "false", "cerebrovascular_disease": "false", "diabetes": "false", "heart_valve_disease": "false", "infection": "false", "inflammatory_bowel_disease": "false", "mild_hepatic": "false", "moderate_pulmonary": "false", "moderate_severe_hepatic": "false", "moderate_severe_renal": "false", "obesity": "false", "peptic_ulcer": "false", "prior_solid_tumor": "false", "psychiatric_disturbance": "false", "rheumatologic": "false", "severe_pulmonary": "false" } ] } ``` Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/hct-ci Example 200: ```json { "count": 2, "path": "/api/calc/hct_ci", "items": [ { "components": [ { "factor": "arrhythmia", "points": 0, "present": false }, { "factor": "cardiac", "points": 0, "present": false }, { "factor": "inflammatory_bowel_disease", "points": 0, "present": false }, { "factor": "diabetes", "points": 0, "present": false }, { "factor": "cerebrovascular_disease", "points": 0, "present": false }, { "factor": "psychiatric_disturbance", "points": 0, "present": false }, { "factor": "mild_hepatic", "points": 0, "present": false }, { "factor": "obesity", "points": 0, "present": false }, { "factor": "infection", "points": 0, "present": false }, { "factor": "rheumatologic", "points": 0, "present": false }, { "factor": "peptic_ulcer", "points": 0, "present": false }, { "factor": "moderate_severe_renal", "points": 0, "present": false }, { "factor": "moderate_pulmonary", "points": 0, "present": false }, { "factor": "prior_solid_tumor", "points": 0, "present": false }, { "factor": "heart_valve_disease", "points": 0, "present": false }, { "factor": "severe_pulmonary", "points": 0, "present": false }, { "factor": "moderate_severe_hepatic", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Sorror ML, Maris MB, Storb R, et al.", "doi": "10.1182/blood-2005-05-2004", "id": "sorror-2005", "pmid": "15994282", "source": "Blood. 2005;106(9):2912-2919", "title": "Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT" }, "formula": "hct_ci", "formula_expression": "HCT-CI = arrhythmia 1 + cardiac 1 + inflammatory_bowel_disease 1 + diabetes 1 + cerebrovascular_disease 1 + psychiatric_disturbance 1 + mild_hepatic 1 + obesity 1 + infection 1 + rheumatologic 2 + peptic_ulcer 2 + moderate_severe_renal 2 + moderate_pulmonary 2 + prior_solid_tumor 3 + heart_valve_disease 3 + severe_pulmonary 3 + moderate_severe_hepatic 3; Sorror 2005 HCT-CI weights; max 26; pulmonary moderate vs severe exclusive; hepatic mild vs moderate/severe exclusive; risk groups 0 low / 1-2 intermediate / >=3 high", "max_score": 26, "score": 0, "risk_group": "low" }, { "components": [ { "factor": "arrhythmia", "points": 0, "present": false }, { "factor": "cardiac", "points": 0, "present": false }, { "factor": "inflammatory_bowel_disease", "points": 0, "present": false }, { "factor": "diabetes", "points": 0, "present": false }, { "factor": "cerebrovascular_disease", "points": 0, "present": false }, { "factor": "psychiatric_disturbance", "points": 0, "present": false }, { "factor": "mild_hepatic", "points": 0, "present": false }, { "factor": "obesity", "points": 0, "present": false }, { "factor": "infection", "points": 0, "present": false }, { "factor": "rheumatologic", "points": 0, "present": false }, { "factor": "peptic_ulcer", "points": 0, "present": false }, { "factor": "moderate_severe_renal", "points": 0, "present": false }, { "factor": "moderate_pulmonary", "points": 0, "present": false }, { "factor": "prior_solid_tumor", "points": 0, "present": false }, { "factor": "heart_valve_disease", "points": 0, "present": false }, { "factor": "severe_pulmonary", "points": 0, "present": false }, { "factor": "moderate_severe_hepatic", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Sorror ML, Maris MB, Storb R, et al.", "doi": "10.1182/blood-2005-05-2004", "id": "sorror-2005", "pmid": "15994282", "source": "Blood. 2005;106(9):2912-2919", "title": "Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT" }, "formula": "hct_ci", "formula_expression": "HCT-CI = arrhythmia 1 + cardiac 1 + inflammatory_bowel_disease 1 + diabetes 1 + cerebrovascular_disease 1 + psychiatric_disturbance 1 + mild_hepatic 1 + obesity 1 + infection 1 + rheumatologic 2 + peptic_ulcer 2 + moderate_severe_renal 2 + moderate_pulmonary 2 + prior_solid_tumor 3 + heart_valve_disease 3 + severe_pulmonary 3 + moderate_severe_hepatic 3; Sorror 2005 HCT-CI weights; max 26; pulmonary moderate vs severe exclusive; hepatic mild vs moderate/severe exclusive; risk groups 0 low / 1-2 intermediate / >=3 high", "max_score": 26, "score": 0, "risk_group": "low" } ] } ``` ## Response fields - `formula` (string): hct_ci - `formula_expression` (string): Exact expression used - `score` (integer): HCT-CI points 0-26 - `max_score` (integer): 26 - `risk_group` (string): low when score is 0, intermediate when 1-2, high when ≥3 (Sorror 2005). A group, not a diagnosis and not a transplant listing. - `components` (array): Per-comorbidity points - `citation` (object): Sorror et al. Blood 2005 citation - `disclaimer` (string): Not-a-device notice ## Example JSON Frozen fixture. Not a live lookup. ```json { "components": [ { "factor": "arrhythmia", "points": 0, "present": false }, { "factor": "cardiac", "points": 0, "present": false }, { "factor": "inflammatory_bowel_disease", "points": 0, "present": false }, { "factor": "diabetes", "points": 0, "present": false }, { "factor": "cerebrovascular_disease", "points": 0, "present": false }, { "factor": "psychiatric_disturbance", "points": 0, "present": false }, { "factor": "mild_hepatic", "points": 0, "present": false }, { "factor": "obesity", "points": 0, "present": false }, { "factor": "infection", "points": 0, "present": false }, { "factor": "rheumatologic", "points": 0, "present": false }, { "factor": "peptic_ulcer", "points": 0, "present": false }, { "factor": "moderate_severe_renal", "points": 0, "present": false }, { "factor": "moderate_pulmonary", "points": 0, "present": false }, { "factor": "prior_solid_tumor", "points": 0, "present": false }, { "factor": "heart_valve_disease", "points": 0, "present": false }, { "factor": "severe_pulmonary", "points": 0, "present": false }, { "factor": "moderate_severe_hepatic", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Sorror ML, Maris MB, Storb R, et al.", "doi": "10.1182/blood-2005-05-2004", "id": "sorror-2005", "pmid": "15994282", "source": "Blood. 2005;106(9):2912-2919", "title": "Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT" }, "formula": "hct_ci", "formula_expression": "HCT-CI = arrhythmia 1 + cardiac 1 + inflammatory_bowel_disease 1 + diabetes 1 + cerebrovascular_disease 1 + psychiatric_disturbance 1 + mild_hepatic 1 + obesity 1 + infection 1 + rheumatologic 2 + peptic_ulcer 2 + moderate_severe_renal 2 + moderate_pulmonary 2 + prior_solid_tumor 3 + heart_valve_disease 3 + severe_pulmonary 3 + moderate_severe_hepatic 3; Sorror 2005 HCT-CI weights; max 26; pulmonary moderate vs severe exclusive; hepatic mild vs moderate/severe exclusive; risk groups 0 low / 1-2 intermediate / >=3 high", "max_score": 26, "score": 0, "risk_group": "low" } ``` ## Errors - HTTP 400 `invalid_flag`: boolean clinical flags must be true or false Returned before settlement; you are not charged. - HTTP 400 `invalid_hct_ci`: each HCT-CI 2005 comorbidity must be scored as in Sorror 2005. Returned before settlement; you are not charged. - HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged. - HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged. - HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged. Shared HTTP 402 and 503: https://magentlab.com/docs/payments ## Related tools - [Charlson CCI](https://magentlab.com/docs/charlson) — Sum the nineteen Charlson 1987 original comorbidity weights and return the published 1-year mortality group. ## Payment Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. - GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall). - HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote. - Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering. - Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional. - Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402. - offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront. - offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization. - not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search. Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers). Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments Stdio MCP (one process per host): https://magentlab.com/docs/mcp ## Guarantees - HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON. - exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE. - HTTP 402 is unpaid only. Do not sign a second authorization because of a 503. - Execution is timeout-bounded and concurrency-capped. - Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.