# International Prognostic Index (Shipp) IPI Status: LIVE Price: $0.005 USDC `GET /api/calc/ipi` HTML: https://magentlab.com/docs/ipi Markdown: https://magentlab.com/docs/ipi.md Not a medical device. Not a diagnosis, dose, or listing recommendation. ## What it computes Sum the Shipp 1993 five-factor International Prognostic Index (all ages) and return low (0–1), low_intermediate (2), high_intermediate (3), or high (4–5). ## When to use When an agent needs the published IPI 1993 point total and risk group and must not invent a lymphoma diagnosis or treatment choice, and must not substitute age-adjusted IPI, R-IPI, or NCCN-IPI. ## When not to use - Not a medical device and not a lymphoma diagnosis or treatment choice. magent does not examine the patient. - This is the five-factor International Prognostic Index for all ages (Shipp / NEJM 1993), not the age-adjusted three-factor IPI for patients ≤60, not R-IPI (Sehn 2007), and not NCCN-IPI. - magent does not stage lymphoma, count extranodal sites, assign ECOG, or assay LDH. stage_iii_or_iv, extranodal_gt_1, and ldh_gt_uln are caller-assigned flags; ECOG is a caller-assigned integer 0–4. ## Formula ``` IPI = age_gt_60 1 + stage_iii_or_iv 1 + extranodal_gt_1 1 + ecog_ge_2 1 + ldh_gt_uln 1; Shipp 1993; max 5; low 0-1, low_intermediate 2, high_intermediate 3, high 4-5 ``` ## Citation [A predictive model for aggressive non-Hodgkin's lymphoma](https://doi.org/10.1056/NEJM199309303291402) The International Non-Hodgkin's Lymphoma Prognostic Factors Project N Engl J Med. 1993;329(14):987-994 DOI: [10.1056/NEJM199309303291402](https://doi.org/10.1056/NEJM199309303291402) ## Worked example ### Age 50, no adverse factors Given: `age=50, ecog=0, extranodal_gt_1=false, ldh_gt_uln=false, stage_iii_or_iv=false` 1. Age 50 is not >60 → 0; all flags false; ECOG 0 is not ≥2 → 0 2. Score = 0 (max 5); ipi_risk = low ### Ann Arbor III–IV, extranodal >1, ECOG 2, LDH > ULN Given: `age=50, ecog=2, extranodal_gt_1=true, ldh_gt_uln=true, stage_iii_or_iv=true` 1. age_gt_60 → 0; stage_iii_or_iv → 1; extranodal_gt_1 → 1; ecog_ge_2 → 1; ldh_gt_uln → 1 2. Score = 4 (max 5); ipi_risk = high (4–5) ## Also searched as - IPI - International Prognostic Index - Shipp IPI - NHL IPI - aggressive lymphoma IPI - Ann Arbor IPI - IPI score - non-Hodgkin lymphoma prognostic index ## Parameters - `age` (integer, required): Age in years (18-120). Age >60 scores 1 (Shipp 1993). Age 60 is the ≤60 arm and scores 0. - `stage_iii_or_iv` (boolean, required): Ann Arbor stage III or IV as assigned by the caller (Shipp 1993). true scores 1. magent does not stage lymphoma. - `extranodal_gt_1` (boolean, required): More than one extranodal site as assigned by the caller (Shipp 1993). true scores 1. magent does not count extranodal sites. - `ecog` (integer, required): ECOG performance status 0-4 as assigned by the caller (Shipp 1993). ≥2 scores 1. magent does not assign ECOG. - `ldh_gt_uln` (boolean, required): Serum LDH above the upper limit of normal as assigned by the caller (Shipp 1993). true scores 1. magent does not assay LDH. ## Bulk (POST) POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement. Method: `POST /api/calc/ipi` Max items: 25 Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic) Status: PREVIEW - 1 to 25 items. Each item uses the same keys as the GET query parameters. - POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows. - The first invalid item fails the whole request (index in the 400 JSON). You are not charged. - HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row. - Catalog misses (empty matches, found=false) stay paid 200s inside that slot. - x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items. Example request: ```json { "items": [ { "age": "50", "ecog": "0", "extranodal_gt_1": "false", "ldh_gt_uln": "false", "stage_iii_or_iv": "false" }, { "age": "50", "ecog": "0", "extranodal_gt_1": "false", "ldh_gt_uln": "false", "stage_iii_or_iv": "false" } ] } ``` Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/ipi Example 200: ```json { "count": 2, "path": "/api/calc/ipi", "items": [ { "components": [ { "value": 50, "factor": "age_gt_60", "points": 0, "present": false }, { "factor": "stage_iii_or_iv", "points": 0, "present": false }, { "factor": "extranodal_gt_1", "points": 0, "present": false }, { "value": 0, "factor": "ecog_ge_2", "points": 0, "present": false }, { "factor": "ldh_gt_uln", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "The International Non-Hodgkin's Lymphoma Prognostic Factors Project", "doi": "10.1056/NEJM199309303291402", "id": "shipp-1993", "pmid": "8141877", "source": "N Engl J Med. 1993;329(14):987-994", "title": "A predictive model for aggressive non-Hodgkin's lymphoma" }, "formula": "ipi", "formula_expression": "IPI = age_gt_60 1 + stage_iii_or_iv 1 + extranodal_gt_1 1 + ecog_ge_2 1 + ldh_gt_uln 1; Shipp 1993; max 5; low 0-1, low_intermediate 2, high_intermediate 3, high 4-5", "age_years": 50, "max_score": 5, "score": 0, "ecog": 0, "ipi_risk": "low" }, { "components": [ { "value": 50, "factor": "age_gt_60", "points": 0, "present": false }, { "factor": "stage_iii_or_iv", "points": 0, "present": false }, { "factor": "extranodal_gt_1", "points": 0, "present": false }, { "value": 0, "factor": "ecog_ge_2", "points": 0, "present": false }, { "factor": "ldh_gt_uln", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "The International Non-Hodgkin's Lymphoma Prognostic Factors Project", "doi": "10.1056/NEJM199309303291402", "id": "shipp-1993", "pmid": "8141877", "source": "N Engl J Med. 1993;329(14):987-994", "title": "A predictive model for aggressive non-Hodgkin's lymphoma" }, "formula": "ipi", "formula_expression": "IPI = age_gt_60 1 + stage_iii_or_iv 1 + extranodal_gt_1 1 + ecog_ge_2 1 + ldh_gt_uln 1; Shipp 1993; max 5; low 0-1, low_intermediate 2, high_intermediate 3, high 4-5", "age_years": 50, "max_score": 5, "score": 0, "ecog": 0, "ipi_risk": "low" } ] } ``` ## Response fields - `formula` (string): ipi - `formula_expression` (string): Exact expression used - `score` (integer): IPI points 0-5 - `max_score` (integer): Always 5 - `ipi_risk` (string): low when score is 0-1, low_intermediate when 2, high_intermediate when 3, high when 4-5 (Shipp 1993). Not a lymphoma diagnosis or treatment choice. Five-factor IPI (all ages), not age-adjusted IPI, not R-IPI, not NCCN-IPI. - `age_years` (integer): Age used for the >60 criterion - `ecog` (integer): Caller-assigned ECOG 0-4 used for ≥2 - `components` (array): Per-factor points - `citation` (object): Shipp 1993 N Engl J Med citation - `disclaimer` (string): Not-a-device notice ## Example JSON Frozen fixture. Not a live lookup. ```json { "components": [ { "value": 50, "factor": "age_gt_60", "points": 0, "present": false }, { "factor": "stage_iii_or_iv", "points": 0, "present": false }, { "factor": "extranodal_gt_1", "points": 0, "present": false }, { "value": 0, "factor": "ecog_ge_2", "points": 0, "present": false }, { "factor": "ldh_gt_uln", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "The International Non-Hodgkin's Lymphoma Prognostic Factors Project", "doi": "10.1056/NEJM199309303291402", "id": "shipp-1993", "pmid": "8141877", "source": "N Engl J Med. 1993;329(14):987-994", "title": "A predictive model for aggressive non-Hodgkin's lymphoma" }, "formula": "ipi", "formula_expression": "IPI = age_gt_60 1 + stage_iii_or_iv 1 + extranodal_gt_1 1 + ecog_ge_2 1 + ldh_gt_uln 1; Shipp 1993; max 5; low 0-1, low_intermediate 2, high_intermediate 3, high 4-5", "age_years": 50, "max_score": 5, "score": 0, "ecog": 0, "ipi_risk": "low" } ``` ## Errors - HTTP 400 `invalid_age`: age must be an integer from 18 to 120 Returned before settlement; you are not charged. - HTTP 400 `invalid_ecog`: ecog must be an integer from 0 to 4 (Shipp 1993 IPI). Returned before settlement; you are not charged. - HTTP 400 `invalid_flag`: boolean clinical flags must be true or false Returned before settlement; you are not charged. - HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged. - HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged. - HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged. Shared HTTP 402 and 503: https://magentlab.com/docs/payments ## Related tools - [FLIPI](https://magentlab.com/docs/flipi) — Sum the Solal-Céligny 2004 FLIPI adverse factors for follicular lymphoma and return low (0–1), intermediate (2), or high (≥3). - [Myeloma ISS](https://magentlab.com/docs/myeloma-iss) — Apply the Greipp 2005 International Staging System for multiple myeloma from serum beta-2 microglobulin and albumin. ## Payment Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. - GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall). - HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote. - Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering. - Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional. - Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402. - offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront. - offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization. - not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search. Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers). Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments Stdio MCP (one process per host): https://magentlab.com/docs/mcp ## Guarantees - HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. - exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE. - HTTP 402 is unpaid only. Do not sign a second authorization because of a 503. - Execution is timeout-bounded and concurrency-capped. - Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.