# Kasymjanova NSCLC prognostic index

Kasymjanova PI

Status: LIVE
Price: $0.005 USDC
`GET /api/calc/kasymjanova`
HTML: https://magentlab.com/docs/kasymjanova
Markdown: https://magentlab.com/docs/kasymjanova.md

Not a medical device. Not a diagnosis, dose, or listing recommendation.

## What it computes

Apply the Kasymjanova 2010 prognostic index (PI 0–2) from caller-supplied CRP in mg/L and WBC in ×10^9/L.

## When to use

When an agent has pre-treatment CRP and WBC for advanced NSCLC and needs the published Kasymjanova 2010 PI, not GPS/mGPS, and not a chemotherapy order.

## When not to use

- Not a medical device. magent does not examine the patient and does not assay CRP or WBC.
- This is the Kasymjanova 2010 advanced NSCLC prognostic index from CRP and WBC only. It is not Glasgow Prognostic Score (GPS), not McMillan mGPS, and not a chemotherapy order.
- Not a cancer diagnosis or staging decision. Does not return survival months or percents.

## Formula

```
PI = crp_elevated + wbc_elevated; CRP elevated if crp_mg_l > 10 (≤10 not elevated); WBC elevated if wbc_10e9_l > 11 (≤11 not elevated); each 1; Kasymjanova 2010; max 2
```

## Citation

[The predictive value of pre-treatment inflammatory markers in advanced non-small-cell lung cancer](https://doi.org/10.3747/co.v17i4.567)
Kasymjanova G, MacDonald N, Agulnik JS, Cohen V, Pepe C, Kreisman H, Sharma R, Small D
Curr Oncol. 2010;17(4):52-58
DOI: [10.3747/co.v17i4.567](https://doi.org/10.3747/co.v17i4.567)

## Worked example

### CRP 10 mg/L, WBC 11 ×10^9/L

Given: `crp_mg_l=10, wbc_10e9_l=11`

1. CRP 10 mg/L is ≤ 10, so CRP is not elevated
2. WBC 11 ×10^9/L is ≤ 11, so WBC is not elevated
3. PI 0


### CRP 20 mg/L, WBC 15 ×10^9/L

Given: `crp_mg_l=20, wbc_10e9_l=15`

1. CRP 20 mg/L is > 10, so CRP is elevated (1)
2. WBC 15 ×10^9/L is > 11, so WBC is elevated (1)
3. PI 2


## Also searched as

- Kasymjanova PI
- Kasymjanova prognostic index
- NSCLC CRP WBC index
- Kasymjanova 2010
- advanced NSCLC inflammatory index
- CRP WBC prognostic index NSCLC

## Parameters

- `crp_mg_l` (number, required): C-reactive protein in mg/L (0-500), not mg/dL. Kasymjanova 2010 elevated CRP is >10 mg/L. CRP = 10 is not elevated. magent does not assay CRP.
- `wbc_10e9_l` (number, required): White-cell count in ×10^9/L (0.01-500). Kasymjanova 2010 elevated WBC is >11 ×10^9/L. WBC = 11 is not elevated. magent does not assay WBC.

## Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

Method: `POST /api/calc/kasymjanova`
Max items: 25
Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic)
Status: PREVIEW

- 1 to 25 items. Each item uses the same keys as the GET query parameters.
- POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
- The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
- HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
- Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
- x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request:

```json
{
  "items": [
    {
      "crp_mg_l": "10",
      "wbc_10e9_l": "11"
    },
    {
      "crp_mg_l": "10",
      "wbc_10e9_l": "11"
    }
  ]
}
```

Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/kasymjanova

Example 200:

```json
{
  "count": 2,
  "path": "/api/calc/kasymjanova",
  "items": [
    {
      "components": [
        {
          "value": 10.0,
          "factor": "crp_elevated",
          "points": 0,
          "present": false
        },
        {
          "value": 11.0,
          "factor": "wbc_elevated",
          "points": 0,
          "present": false
        }
      ],
      "pi": 0,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Kasymjanova G, MacDonald N, Agulnik JS, Cohen V, Pepe C, Kreisman H, Sharma R, Small D",
        "doi": "10.3747/co.v17i4.567",
        "id": "kasymjanova-2010",
        "pmid": "20697518",
        "source": "Curr Oncol. 2010;17(4):52-58",
        "title": "The predictive value of pre-treatment inflammatory markers in advanced non-small-cell lung cancer"
      },
      "formula": "kasymjanova",
      "formula_expression": "PI = crp_elevated + wbc_elevated; CRP elevated if crp_mg_l > 10 (≤10 not elevated); WBC elevated if wbc_10e9_l > 11 (≤11 not elevated); each 1; Kasymjanova 2010; max 2",
      "max_score": 2,
      "score": 0,
      "crp_mg_l": 10.0,
      "wbc_10e9_l": 11.0
    },
    {
      "components": [
        {
          "value": 10.0,
          "factor": "crp_elevated",
          "points": 0,
          "present": false
        },
        {
          "value": 11.0,
          "factor": "wbc_elevated",
          "points": 0,
          "present": false
        }
      ],
      "pi": 0,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Kasymjanova G, MacDonald N, Agulnik JS, Cohen V, Pepe C, Kreisman H, Sharma R, Small D",
        "doi": "10.3747/co.v17i4.567",
        "id": "kasymjanova-2010",
        "pmid": "20697518",
        "source": "Curr Oncol. 2010;17(4):52-58",
        "title": "The predictive value of pre-treatment inflammatory markers in advanced non-small-cell lung cancer"
      },
      "formula": "kasymjanova",
      "formula_expression": "PI = crp_elevated + wbc_elevated; CRP elevated if crp_mg_l > 10 (≤10 not elevated); WBC elevated if wbc_10e9_l > 11 (≤11 not elevated); each 1; Kasymjanova 2010; max 2",
      "max_score": 2,
      "score": 0,
      "crp_mg_l": 10.0,
      "wbc_10e9_l": 11.0
    }
  ]
}
```

## Response fields

- `formula` (string): kasymjanova
- `formula_expression` (string): Kasymjanova 2010 PI 0 / 1 / 2 rules in paper units (mg/L and ×10^9/L)
- `crp_mg_l` (number): C-reactive protein used in mg/L
- `wbc_10e9_l` (number): White-cell count used in ×10^9/L
- `pi` (integer): 0, 1, or 2 (Kasymjanova 2010). Neither elevated is 0; exactly one is 1; both are 2. Not GPS/mGPS.
- `score` (integer): PI points 0-2 (same as pi)
- `max_score` (integer): 2
- `components` (array): Per-marker points
- `citation` (object): Kasymjanova et al. Curr Oncol 2010 citation
- `disclaimer` (string): Not-a-device notice

## Example JSON

Frozen fixture. Not a live lookup.

```json
{
  "components": [
    {
      "value": 10.0,
      "factor": "crp_elevated",
      "points": 0,
      "present": false
    },
    {
      "value": 11.0,
      "factor": "wbc_elevated",
      "points": 0,
      "present": false
    }
  ],
  "pi": 0,
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Kasymjanova G, MacDonald N, Agulnik JS, Cohen V, Pepe C, Kreisman H, Sharma R, Small D",
    "doi": "10.3747/co.v17i4.567",
    "id": "kasymjanova-2010",
    "pmid": "20697518",
    "source": "Curr Oncol. 2010;17(4):52-58",
    "title": "The predictive value of pre-treatment inflammatory markers in advanced non-small-cell lung cancer"
  },
  "formula": "kasymjanova",
  "formula_expression": "PI = crp_elevated + wbc_elevated; CRP elevated if crp_mg_l > 10 (≤10 not elevated); WBC elevated if wbc_10e9_l > 11 (≤11 not elevated); each 1; Kasymjanova 2010; max 2",
  "max_score": 2,
  "score": 0,
  "crp_mg_l": 10.0,
  "wbc_10e9_l": 11.0
}
```

## Errors

- HTTP 400 `invalid_crp`: crp_mg_l must be a number from 0 to 500. Returned before settlement; you are not charged.
- HTTP 400 `invalid_wbc`: wbc_k_ul (0.01-500) or wbc_ul (10-500000) is required Returned before settlement; you are not charged.
- HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
- HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
- HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged.

Shared HTTP 402 and 503: https://magentlab.com/docs/payments

## Related tools

- [mGPS](https://magentlab.com/docs/mgps) — Apply the McMillan 2007 modified Glasgow Prognostic Score (mGPS) from caller-supplied CRP in mg/L and albumin.
- [ANC](https://magentlab.com/docs/anc) — Compute absolute neutrophil count from WBC and neutrophil plus band percents, plus a Bodey 1966 granulocyte band.
- [NCCN-IPI](https://magentlab.com/docs/nccn-ipi) — Sum the Zhou 2014 NCCN International Prognostic Index (enhanced IPI for DLBCL treated in the rituximab era) and return low (0–1), low_intermediate (2–3), high_intermediate (4–5), or high (6–8).

## Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s.

- GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall).
- HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote.
- Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering.
- Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional.
- Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402.

- offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront.
- offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization.

- not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search.

Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers).

Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments

Stdio MCP (one process per host): https://magentlab.com/docs/mcp

## Guarantees

- HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
- exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
- HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
- Execution is timeout-bounded and concurrency-capped.
- Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.