# Simplified MIPI (mantle cell lymphoma) MIPI Status: LIVE Price: $0.005 USDC `GET /api/calc/mipi` HTML: https://magentlab.com/docs/mipi Markdown: https://magentlab.com/docs/mipi.md Not a medical device. Not a diagnosis, dose, or listing recommendation. ## What it computes Sum the Hoster 2008 simplified MIPI (mantle cell lymphoma international prognostic index) from age, ECOG, LDH/ULN, and WBC and return low (0–3), intermediate (4–5), or high (6–11). ## When to use When an agent needs the published simplified MIPI point total and risk group and must not invent a lymphoma diagnosis, and must not substitute continuous MIPI or MIPI-c. ## When not to use - Not a medical device and not a lymphoma diagnosis or treatment choice. magent does not examine the patient. - This is the simplified MIPI (Hoster 2008), not the continuous MIPI (log10 WBC formula) and not MIPI-c (Ki-67). - magent does not assign ECOG, assay LDH, or measure WBC. ldh_uln_ratio is the caller-assigned LDH/ULN ratio; WBC is caller-assigned. ## Formula ``` simplified MIPI = age (<50 0, 50–59 1, 60–69 2, ≥70 3) + ECOG (0–1 0, 2–4 2) + LDH/ULN (<0.67 0, 0.67–<1.0 1, 1.0–<1.5 2, ≥1.5 3) + WBC ×10^9/L (<6.7 0, 6.7–<10 1, 10–<15 2, ≥15 3); Hoster 2008; max 11; low 0-3, intermediate 4-5, high 6-11 ``` ## Citation [A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma](https://doi.org/10.1182/blood-2007-06-095331) Hoster E, Dreyling M, Klapper W, et al. Blood. 2008;111(2):558-565 DOI: [10.1182/blood-2007-06-095331](https://doi.org/10.1182/blood-2007-06-095331) ## Worked example ### Age 40, ECOG 0, LDH/ULN 0.5, WBC 5 ×10^9/L Given: `age=40, ecog=0, ldh_uln_ratio=0.5, wbc_k_ul=5` 1. Age 40 <50 → 0; ECOG 0 is 0–1 → 0; LDH/ULN 0.5 <0.67 → 0; WBC 5 <6.7 → 0 2. Score = 0 (max 11); risk_group = low ### Age 70, ECOG 4, LDH/ULN 1.5, WBC 15 ×10^9/L Given: `age=70, ecog=4, ldh_uln_ratio=1.5, wbc_k_ul=15` 1. Age ≥70 → 3; ECOG 2–4 → 2; LDH/ULN ≥1.5 → 3; WBC ≥15 → 3 2. Score = 11 (max 11); risk_group = high (6–11) ## Also searched as - MIPI - simplified MIPI - mantle cell lymphoma international prognostic index - Hoster MIPI - MCL MIPI - MIPI score - mantle cell prognostic index ## Parameters - `age` (integer, required): Age in years (18-120). <50 scores 0; 50–59 scores 1; 60–69 scores 2; ≥70 scores 3 (Hoster 2008 simplified MIPI). 50 and 59 score 1; 60 and 69 score 2; 70 scores 3. - `ecog` (integer, required): ECOG performance status 0-4 as assigned by the caller (Hoster 2008 simplified MIPI). 0–1 scores 0; 2–4 scores 2. magent does not assign ECOG. - `ldh_uln_ratio` (number, required): Serum LDH divided by the laboratory ULN (0.1-20). <0.67 scores 0; 0.67–<1.0 scores 1; 1.0–<1.5 scores 2; ≥1.5 scores 3 (0.67 scores 1; 0.99 scores 1; 1.0 scores 2; 1.49 scores 2; 1.5 scores 3). magent does not assay LDH. - `wbc_k_ul` (number, optional): WBC in 10^3/µL (same as 10^9/L). Provide wbc_k_ul or wbc_ul, not both. Range 0.01-500. Converted to ×10^9/L: <6.7 scores 0; 6.7–<10 scores 1; 10–<15 scores 2; ≥15 scores 3 (6.7 scores 1; 9.999 scores 1; 10 scores 2; 14.999 scores 2; 15 scores 3). - `wbc_ul` (number, optional): WBC in cells/µL (same as cells/mm^3). Provide wbc_k_ul or wbc_ul, not both. Range 10-500000. Converted to ×10^9/L (= wbc_ul/1000): <6.7 scores 0; 6.7–<10 scores 1; 10–<15 scores 2; ≥15 scores 3 (6.7 scores 1; 9.999 scores 1; 10 scores 2; 14.999 scores 2; 15 scores 3). ## Bulk (POST) POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement. Method: `POST /api/calc/mipi` Max items: 25 Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic) Status: PREVIEW - 1 to 25 items. Each item uses the same keys as the GET query parameters. - POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows. - The first invalid item fails the whole request (index in the 400 JSON). You are not charged. - HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row. - Catalog misses (empty matches, found=false) stay paid 200s inside that slot. - x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items. Example request: ```json { "items": [ { "age": "40", "ecog": "0", "ldh_uln_ratio": "0.5", "wbc_k_ul": "5" }, { "age": "40", "ecog": "0", "ldh_uln_ratio": "0.5", "wbc_k_ul": "5" } ] } ``` Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/mipi Example 200: ```json { "count": 2, "path": "/api/calc/mipi", "items": [ { "components": [ { "value": 40, "factor": "age", "points": 0, "present": false }, { "value": 0, "factor": "ecog", "points": 0, "present": false }, { "value": 0.5, "factor": "ldh_uln_ratio", "points": 0, "present": false }, { "value": 5.0e3, "factor": "wbc", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Hoster E, Dreyling M, Klapper W, et al.", "doi": "10.1182/blood-2007-06-095331", "id": "hoster-2008", "pmid": "17934064", "source": "Blood. 2008;111(2):558-565", "title": "A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma" }, "formula": "mipi", "formula_expression": "simplified MIPI = age (<50 0, 50–59 1, 60–69 2, ≥70 3) + ECOG (0–1 0, 2–4 2) + LDH/ULN (<0.67 0, 0.67–<1.0 1, 1.0–<1.5 2, ≥1.5 3) + WBC ×10^9/L (<6.7 0, 6.7–<10 1, 10–<15 2, ≥15 3); Hoster 2008; max 11; low 0-3, intermediate 4-5, high 6-11", "age_years": 40, "max_score": 11, "score": 0, "wbc_10e9_l": 5.0, "wbc_ul": 5.0e3, "risk_group": "low", "ecog": 0, "ldh_uln_ratio": 0.5 }, { "components": [ { "value": 40, "factor": "age", "points": 0, "present": false }, { "value": 0, "factor": "ecog", "points": 0, "present": false }, { "value": 0.5, "factor": "ldh_uln_ratio", "points": 0, "present": false }, { "value": 5.0e3, "factor": "wbc", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Hoster E, Dreyling M, Klapper W, et al.", "doi": "10.1182/blood-2007-06-095331", "id": "hoster-2008", "pmid": "17934064", "source": "Blood. 2008;111(2):558-565", "title": "A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma" }, "formula": "mipi", "formula_expression": "simplified MIPI = age (<50 0, 50–59 1, 60–69 2, ≥70 3) + ECOG (0–1 0, 2–4 2) + LDH/ULN (<0.67 0, 0.67–<1.0 1, 1.0–<1.5 2, ≥1.5 3) + WBC ×10^9/L (<6.7 0, 6.7–<10 1, 10–<15 2, ≥15 3); Hoster 2008; max 11; low 0-3, intermediate 4-5, high 6-11", "age_years": 40, "max_score": 11, "score": 0, "wbc_10e9_l": 5.0, "wbc_ul": 5.0e3, "risk_group": "low", "ecog": 0, "ldh_uln_ratio": 0.5 } ] } ``` ## Response fields - `formula` (string): mipi - `formula_expression` (string): Exact expression used - `score` (integer): Simplified MIPI points 0-11 - `max_score` (integer): Always 11 - `risk_group` (string): low when score is 0-3, intermediate when 4-5, high when 6-11 (Hoster 2008 simplified MIPI). Not a lymphoma diagnosis. Not continuous MIPI. Not MIPI-c. - `age_years` (integer): Age used for the simplified MIPI age bands - `ecog` (integer): Caller-assigned ECOG 0-4 used for 0–1 vs 2–4 - `ldh_uln_ratio` (number): Caller-assigned LDH/ULN ratio used for scoring - `wbc_ul` (number): Normalized WBC in cells/µL used for scoring - `wbc_10e9_l` (number): WBC converted to ×10^9/L (wbc_ul / 1000) for Hoster 2008 simplified MIPI bands - `components` (array): Per-factor points - `citation` (object): Hoster 2008 Blood citation - `disclaimer` (string): Not-a-device notice ## Example JSON Frozen fixture. Not a live lookup. ```json { "components": [ { "value": 40, "factor": "age", "points": 0, "present": false }, { "value": 0, "factor": "ecog", "points": 0, "present": false }, { "value": 0.5, "factor": "ldh_uln_ratio", "points": 0, "present": false }, { "value": 5.0e3, "factor": "wbc", "points": 0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Hoster E, Dreyling M, Klapper W, et al.", "doi": "10.1182/blood-2007-06-095331", "id": "hoster-2008", "pmid": "17934064", "source": "Blood. 2008;111(2):558-565", "title": "A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma" }, "formula": "mipi", "formula_expression": "simplified MIPI = age (<50 0, 50–59 1, 60–69 2, ≥70 3) + ECOG (0–1 0, 2–4 2) + LDH/ULN (<0.67 0, 0.67–<1.0 1, 1.0–<1.5 2, ≥1.5 3) + WBC ×10^9/L (<6.7 0, 6.7–<10 1, 10–<15 2, ≥15 3); Hoster 2008; max 11; low 0-3, intermediate 4-5, high 6-11", "age_years": 40, "max_score": 11, "score": 0, "wbc_10e9_l": 5.0, "wbc_ul": 5.0e3, "risk_group": "low", "ecog": 0, "ldh_uln_ratio": 0.5 } ``` ## Errors - HTTP 400 `invalid_age`: age must be an integer from 18 to 120 Returned before settlement; you are not charged. - HTTP 400 `invalid_ecog`: ecog must be an integer from 0 to 4 (Shipp 1993 IPI). Returned before settlement; you are not charged. - HTTP 400 `invalid_ldh_ratio`: ldh_uln_ratio must be a number from 0.1 to 20 (Hoster 2008 simplified MIPI). Returned before settlement; you are not charged. - HTTP 400 `invalid_wbc`: wbc_k_ul (0.01-500) or wbc_ul (10-500000) is required Returned before settlement; you are not charged. - HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged. - HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged. - HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged. Shared HTTP 402 and 503: https://magentlab.com/docs/payments ## Related tools - [IPI](https://magentlab.com/docs/ipi) — Sum the Shipp 1993 five-factor International Prognostic Index (all ages) and return low (0–1), low_intermediate (2), high_intermediate (3), or high (4–5). - [FLIPI](https://magentlab.com/docs/flipi) — Sum the Solal-Céligny 2004 FLIPI adverse factors for follicular lymphoma and return low (0–1), intermediate (2), or high (≥3). ## Payment Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. - GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall). - HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote. - Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering. - Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional. - Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402. - offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront. - offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization. - not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search. Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers). Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments Stdio MCP (one process per host): https://magentlab.com/docs/mcp ## Guarantees - HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON. - exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE. - HTTP 402 is unpaid only. Do not sign a second authorization because of a 503. - Execution is timeout-bounded and concurrency-capped. - Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.