# NCI CTC v2.0 radiation mucositis NCI CTC mucositis Status: LIVE Price: $0.005 USDC `GET /api/calc/nci_ctc_mucositis` HTML: https://magentlab.com/docs/nci-ctc-mucositis Markdown: https://magentlab.com/docs/nci-ctc-mucositis.md Not a medical device. Not a diagnosis, dose, or listing recommendation. ## What it computes Apply NCI CTC v2.0 Mucositis due to radiation (Trotti 2000; CTC 30 April 1999) and return grade 0–4 from a caller-assigned mucosal appearance token. magent does not examine the mucosa. ## When to use When an agent already has a caller-assigned NCI CTC v2.0 radiation mucositis appearance (none, erythema, patchy_pseudomembrane, confluent_pseudomembrane, or necrosis_or_deep_ulcer) and needs the published grade. Not CTC stomatitis/pharyngitis (chemotherapy oral mucositis), not CTCAE v3/v4/v5, and not WHO mucositis. ## When not to use - Not a medical device. - Not a diagnosis. magent does not examine the mucosa. The caller assigns appearance. - NCI CTC v2.0 Mucositis due to radiation (30 April 1999) only. Not CTC stomatitis or pharyngitis (chemotherapy oral mucositis) grades. - Not CTCAE v3, v4, or v5 mucositis. - Not WHO mucositis. - Grade 5 (death related to toxicity) is not a token. This tool maps appearance to grades 0–4 only. ## Formula ``` nci_ctc_mucositis appearance none → grade 0; erythema → 1 (erythema of the mucosa); patchy_pseudomembrane → 2 (patchy pseudomembranous reaction, patches generally ≤1.5 cm and noncontiguous); confluent_pseudomembrane → 3 (confluent pseudomembranous reaction, contiguous patches generally >1.5 cm); necrosis_or_deep_ulcer → 4 (necrosis or deep ulceration; may include bleeding not induced by minor trauma or abrasion) (NCI CTC v2.0 Mucositis due to radiation; Trotti 2000). Not CTC stomatitis/pharyngitis. Not CTCAE. Not WHO mucositis. magent does not examine the mucosa. Not a diagnosis ``` ## Citation [Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy](https://doi.org/10.1016/s0360-3016(99)00559-3) Trotti A, Byhardt R, Stetz J, Gwede C, Corn B, Fu K, Gunderson L, McCormick B, Morrisintegral M, Rich T, Shipley W, Curran W Int J Radiat Oncol Biol Phys. 2000;47(1):13-47 DOI: [10.1016/s0360-3016(99)00559-3](https://doi.org/10.1016/s0360-3016(99)00559-3) ## Worked example ### Erythema of the mucosa, grade 1 Given: `appearance=erythema` 1. appearance erythema (erythema of the mucosa, as assigned by the caller) 2. NCI CTC v2.0 Mucositis due to radiation grade is 1 ## Also searched as - NCI CTC mucositis - CTC v2.0 mucositis due to radiation - radiation mucositis grade - NCI Common Toxicity Criteria mucositis - Trotti 2000 CTC - CTC radiation mucositis - pseudomembranous mucositis - NCI CTC v2 mucositis ## Parameters - `appearance` (string, required): NCI CTC v2.0 Mucositis due to radiation appearance as assigned by the caller: none (grade 0), erythema (grade 1, erythema of the mucosa), patchy_pseudomembrane (grade 2, patchy pseudomembranous reaction, patches generally ≤1.5 cm and noncontiguous), confluent_pseudomembrane (grade 3, confluent pseudomembranous reaction, contiguous patches generally >1.5 cm), or necrosis_or_deep_ulcer (grade 4, necrosis or deep ulceration; may include bleeding not induced by minor trauma or abrasion). Case-insensitive. Not CTC stomatitis/pharyngitis. magent does not examine the mucosa. ## Bulk (POST) POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement. Method: `POST /api/calc/nci_ctc_mucositis` Max items: 25 Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic) Status: PREVIEW - 1 to 25 items. Each item uses the same keys as the GET query parameters. - POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows. - The first invalid item fails the whole request (index in the 400 JSON). You are not charged. - HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row. - Catalog misses (empty matches, found=false) stay paid 200s inside that slot. - x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items. Example request: ```json { "items": [ { "appearance": "erythema" }, { "appearance": "erythema" } ] } ``` Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/nci-ctc-mucositis Example 200: ```json { "count": 2, "path": "/api/calc/nci_ctc_mucositis", "items": [ { "description": "Erythema of the mucosa", "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Trotti A, Byhardt R, Stetz J, Gwede C, Corn B, Fu K, Gunderson L, McCormick B, Morrisintegral M, Rich T, Shipley W, Curran W", "doi": "10.1016/s0360-3016(99)00559-3", "id": "trotti-2000", "pmid": "10758303", "source": "Int J Radiat Oncol Biol Phys. 2000;47(1):13-47", "title": "Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy" }, "formula": "nci_ctc_mucositis", "formula_expression": "nci_ctc_mucositis appearance none → grade 0; erythema → 1 (erythema of the mucosa); patchy_pseudomembrane → 2 (patchy pseudomembranous reaction, patches generally ≤1.5 cm and noncontiguous); confluent_pseudomembrane → 3 (confluent pseudomembranous reaction, contiguous patches generally >1.5 cm); necrosis_or_deep_ulcer → 4 (necrosis or deep ulceration; may include bleeding not induced by minor trauma or abrasion) (NCI CTC v2.0 Mucositis due to radiation; Trotti 2000). Not CTC stomatitis/pharyngitis. Not CTCAE. Not WHO mucositis. magent does not examine the mucosa. Not a diagnosis", "criteria": [ { "factor": "none", "met": false }, { "factor": "erythema", "met": true }, { "factor": "patchy_pseudomembrane", "met": false }, { "factor": "confluent_pseudomembrane", "met": false }, { "factor": "necrosis_or_deep_ulcer", "met": false } ], "grade": 1, "appearance": "erythema" }, { "description": "Erythema of the mucosa", "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Trotti A, Byhardt R, Stetz J, Gwede C, Corn B, Fu K, Gunderson L, McCormick B, Morrisintegral M, Rich T, Shipley W, Curran W", "doi": "10.1016/s0360-3016(99)00559-3", "id": "trotti-2000", "pmid": "10758303", "source": "Int J Radiat Oncol Biol Phys. 2000;47(1):13-47", "title": "Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy" }, "formula": "nci_ctc_mucositis", "formula_expression": "nci_ctc_mucositis appearance none → grade 0; erythema → 1 (erythema of the mucosa); patchy_pseudomembrane → 2 (patchy pseudomembranous reaction, patches generally ≤1.5 cm and noncontiguous); confluent_pseudomembrane → 3 (confluent pseudomembranous reaction, contiguous patches generally >1.5 cm); necrosis_or_deep_ulcer → 4 (necrosis or deep ulceration; may include bleeding not induced by minor trauma or abrasion) (NCI CTC v2.0 Mucositis due to radiation; Trotti 2000). Not CTC stomatitis/pharyngitis. Not CTCAE. Not WHO mucositis. magent does not examine the mucosa. Not a diagnosis", "criteria": [ { "factor": "none", "met": false }, { "factor": "erythema", "met": true }, { "factor": "patchy_pseudomembrane", "met": false }, { "factor": "confluent_pseudomembrane", "met": false }, { "factor": "necrosis_or_deep_ulcer", "met": false } ], "grade": 1, "appearance": "erythema" } ] } ``` ## Response fields - `formula` (string): nci_ctc_mucositis - `formula_expression` (string): Published NCI CTC v2.0 Mucositis due to radiation appearance-to-grade rule - `appearance` (string): Canonical lowercase appearance token: none, erythema, patchy_pseudomembrane, confluent_pseudomembrane, or necrosis_or_deep_ulcer - `grade` (integer): NCI CTC v2.0 radiation mucositis grade 0–4 for that appearance. Not a diagnosis. - `description` (string): CTC v2.0 radiation-row wording for that appearance - `criteria` (array): Per-appearance Tree rows with factor and met for none, erythema, patchy_pseudomembrane, confluent_pseudomembrane, and necrosis_or_deep_ulcer; exactly one is met - `citation` (object): Trotti 2000 Int J Radiat Oncol Biol Phys CTC v2.0 citation - `disclaimer` (string): Not-a-device notice ## Example JSON Frozen fixture. Not a live lookup. ```json { "description": "Erythema of the mucosa", "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Trotti A, Byhardt R, Stetz J, Gwede C, Corn B, Fu K, Gunderson L, McCormick B, Morrisintegral M, Rich T, Shipley W, Curran W", "doi": "10.1016/s0360-3016(99)00559-3", "id": "trotti-2000", "pmid": "10758303", "source": "Int J Radiat Oncol Biol Phys. 2000;47(1):13-47", "title": "Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy" }, "formula": "nci_ctc_mucositis", "formula_expression": "nci_ctc_mucositis appearance none → grade 0; erythema → 1 (erythema of the mucosa); patchy_pseudomembrane → 2 (patchy pseudomembranous reaction, patches generally ≤1.5 cm and noncontiguous); confluent_pseudomembrane → 3 (confluent pseudomembranous reaction, contiguous patches generally >1.5 cm); necrosis_or_deep_ulcer → 4 (necrosis or deep ulceration; may include bleeding not induced by minor trauma or abrasion) (NCI CTC v2.0 Mucositis due to radiation; Trotti 2000). Not CTC stomatitis/pharyngitis. Not CTCAE. Not WHO mucositis. magent does not examine the mucosa. Not a diagnosis", "criteria": [ { "factor": "none", "met": false }, { "factor": "erythema", "met": true }, { "factor": "patchy_pseudomembrane", "met": false }, { "factor": "confluent_pseudomembrane", "met": false }, { "factor": "necrosis_or_deep_ulcer", "met": false } ], "grade": 1, "appearance": "erythema" } ``` ## Errors - HTTP 400 `invalid_mucositis_appearance`: appearance must be none, erythema, patchy_pseudomembrane, confluent_pseudomembrane, or necrosis_or_deep_ulcer (NCI CTC v2.0 Mucositis due to radiation). Returned before settlement; you are not charged. - HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged. - HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged. - HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged. Shared HTTP 402 and 503: https://magentlab.com/docs/payments ## Related tools - [ASTCT CRS](https://magentlab.com/docs/astct-crs) — Apply Lee 2019 ASTCT Table 1 cytokine release syndrome grading and return grade 0–4 from caller-assigned fever, fever waiver, hypotension, and hypoxia. Grade is the more severe of hypotension versus hypoxia. Organ toxicities do not influence grade. Not ICANS. - [TDN Grade](https://magentlab.com/docs/tdn-grade) — Apply the Terrapon 2021 Therapy-Disability-Neurology grade and return tdn_grade 1-5 as the maximum of caller-assigned therapy, mapped mRS disability, and new-deficit neurology grades. ## Payment Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. - GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall). - HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote. - Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering. - Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional. - Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402. - offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront. - offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization. - not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search. Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers). Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments Stdio MCP (one process per host): https://magentlab.com/docs/mcp ## Guarantees - HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON. - exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE. - HTTP 402 is unpaid only. Do not sign a second authorization because of a 503. - Execution is timeout-bounded and concurrency-capped. - Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.