# NINCDS-ADRDA Alzheimer's criteria (McKhann 1984) NINCDS-ADRDA Status: LIVE Price: $0.005 USDC `GET /api/calc/nincds_adrda` HTML: https://magentlab.com/docs/nincds-adrda Markdown: https://magentlab.com/docs/nincds-adrda.md Not a medical device. Not a diagnosis, dose, or listing recommendation. ## What it computes Echo the caller-assigned McKhann 1984 NINCDS-ADRDA diagnostic category (definite, probable, possible, or unlikely) with the published defining-features description. magent does not examine the patient. Not NIA-AA 2011/2018. Not DSM. ## When to use When an agent already has a McKhann 1984 NINCDS-ADRDA category as assigned by the caller and needs the published category description. magent does not examine the patient, apply NIA-AA 2011/2018, apply DSM, or diagnose Alzheimer's disease. ## When not to use - Not a medical device. magent does not examine the patient. - The caller assigns McKhann 1984 NINCDS-ADRDA category definite, probable, possible, or unlikely. magent does not apply the criteria to raw findings, read histopathology, or diagnose Alzheimer's disease. - McKhann 1984 NINCDS-ADRDA tokens only. Not NIA-AA 2011 or 2018. Not DSM. This tool does not convert NINCDS-ADRDA to NIA-AA or DSM. - Not an Alzheimer's diagnosis. Not a treatment order. ## Formula ``` category in {definite, probable, possible, unlikely} as assigned by the caller (McKhann 1984 NINCDS-ADRDA diagnostic categories). Not NIA-AA 2011/2018. Not DSM. magent does not examine the patient. ``` ## Citation [Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease](https://doi.org/10.1212/wnl.34.7.939) McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM Neurology. 1984;34(7):939-944 DOI: [10.1212/wnl.34.7.939](https://doi.org/10.1212/wnl.34.7.939) ## Worked example ### Probable Alzheimer's disease clinical criteria Given: `category=probable` 1. category probable as assigned by the caller 2. dementia; deficits in two or more areas of cognition; progressive worsening; no disturbance of consciousness; onset between 40 and 90; absence of other diseases that could account for the deficits ### Definite with histopathologic confirmation Given: `category=definite` 1. category definite as assigned by the caller 2. clinical criteria for probable Alzheimer's disease and histopathologic confirmation ## Also searched as - NINCDS-ADRDA - McKhann 1984 - NINCDS ADRDA criteria - probable Alzheimer's disease - definite Alzheimer's disease - NINCDS-ADRDA Work Group - McKhann Alzheimer criteria - possible Alzheimer - unlikely Alzheimer ## Parameters - `category` (string, required): McKhann 1984 NINCDS-ADRDA diagnostic category as assigned by the caller (definite: clinical criteria for probable Alzheimer's disease and histopathologic confirmation; probable: dementia, deficits in two or more areas of cognition, progressive worsening, no disturbance of consciousness, onset between 40 and 90, absence of other diseases that could account for the deficits; possible: dementia syndrome with atypical onset, presentation, or course, or a second systemic or brain disease capable of producing dementia but not thought to be the cause; unlikely: sudden onset, early focal neurologic findings, or seizures or gait disturbance at onset). Token definite, probable, possible, or unlikely only; case-insensitive. Reject NIA-AA, DSM, and probable AD. Not NIA-AA 2011/2018. Not DSM. magent does not examine the patient. ## Bulk (POST) POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement. Method: `POST /api/calc/nincds_adrda` Max items: 25 Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic) Status: PREVIEW - 1 to 25 items. Each item uses the same keys as the GET query parameters. - POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows. - The first invalid item fails the whole request (index in the 400 JSON). You are not charged. - HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row. - Catalog misses (empty matches, found=false) stay paid 200s inside that slot. - x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items. Example request: ```json { "items": [ { "category": "probable" }, { "category": "probable" } ] } ``` Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/nincds-adrda Example 200: ```json { "count": 2, "path": "/api/calc/nincds_adrda", "items": [ { "description": "Dementia; deficits in two or more areas of cognition; progressive worsening; no disturbance of consciousness; onset between 40 and 90; absence of other diseases that could account for the deficits", "components": [ { "factor": "definite", "met": false }, { "factor": "probable", "met": true }, { "factor": "possible", "met": false }, { "factor": "unlikely", "met": false } ], "category": "probable", "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM", "doi": "10.1212/wnl.34.7.939", "id": "mckhann-1984", "pmid": "6610841", "source": "Neurology. 1984;34(7):939-944", "title": "Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease" }, "formula": "nincds_adrda", "formula_expression": "category in {definite, probable, possible, unlikely} as assigned by the caller (McKhann 1984 NINCDS-ADRDA diagnostic categories). Not NIA-AA 2011/2018. Not DSM. magent does not examine the patient." }, { "description": "Dementia; deficits in two or more areas of cognition; progressive worsening; no disturbance of consciousness; onset between 40 and 90; absence of other diseases that could account for the deficits", "components": [ { "factor": "definite", "met": false }, { "factor": "probable", "met": true }, { "factor": "possible", "met": false }, { "factor": "unlikely", "met": false } ], "category": "probable", "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM", "doi": "10.1212/wnl.34.7.939", "id": "mckhann-1984", "pmid": "6610841", "source": "Neurology. 1984;34(7):939-944", "title": "Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease" }, "formula": "nincds_adrda", "formula_expression": "category in {definite, probable, possible, unlikely} as assigned by the caller (McKhann 1984 NINCDS-ADRDA diagnostic categories). Not NIA-AA 2011/2018. Not DSM. magent does not examine the patient." } ] } ``` ## Response fields - `formula` (string): nincds_adrda - `formula_expression` (string): Published McKhann 1984 NINCDS-ADRDA category rule - `category` (string): Caller-assigned McKhann 1984 token: definite, probable, possible, or unlikely - `description` (string): McKhann 1984 defining-features wording for that category - `components` (array): Per-category Tree rows definite, probable, possible, unlikely with factor and met; exactly one is met - `citation` (object): McKhann 1984 Neurology citation - `disclaimer` (string): Not-a-device notice ## Example JSON Frozen fixture. Not a live lookup. ```json { "description": "Dementia; deficits in two or more areas of cognition; progressive worsening; no disturbance of consciousness; onset between 40 and 90; absence of other diseases that could account for the deficits", "components": [ { "factor": "definite", "met": false }, { "factor": "probable", "met": true }, { "factor": "possible", "met": false }, { "factor": "unlikely", "met": false } ], "category": "probable", "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM", "doi": "10.1212/wnl.34.7.939", "id": "mckhann-1984", "pmid": "6610841", "source": "Neurology. 1984;34(7):939-944", "title": "Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease" }, "formula": "nincds_adrda", "formula_expression": "category in {definite, probable, possible, unlikely} as assigned by the caller (McKhann 1984 NINCDS-ADRDA diagnostic categories). Not NIA-AA 2011/2018. Not DSM. magent does not examine the patient." } ``` ## Errors - HTTP 400 `invalid_nincds_adrda`: NINCDS-ADRDA needs the McKhann 1984 category token definite, probable, possible, or unlikely. Returned before settlement; you are not charged. - HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged. - HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged. - HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged. Shared HTTP 402 and 503: https://magentlab.com/docs/payments ## Related tools - [GDS-15](https://magentlab.com/docs/gds-15) — Sum fifteen Sheikh 1986 GDS-15 yes/no items using that paper's reverse-scoring key and return the published 0-15 total. Does not apply later total-score severity bands. - [4AT](https://magentlab.com/docs/4at) — Sum the Bellelli 2014 4AT items and return unlikely (0), possible cognitive impairment (1–3), or possible delirium (≥4). ## Payment Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. - GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall). - HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote. - Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering. - Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional. - Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402. - offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront. - offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization. - not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search. Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers). Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments Stdio MCP (one process per host): https://magentlab.com/docs/mcp ## Guarantees - HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON. - exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE. - HTTP 402 is unpaid only. Do not sign a second authorization because of a 503. - Execution is timeout-bounded and concurrency-capped. - Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.