# SIC score

SIC score

Status: LIVE
Price: $0.005 USDC
`GET /api/calc/sic`
HTML: https://magentlab.com/docs/sic
Markdown: https://magentlab.com/docs/sic.md

Not a medical device. Not a diagnosis, dose, or listing recommendation.

## What it computes

Sum Iba 2017 Table 3 SIC items (platelets, INR, and four-item SOFA capped at 2) and return the point total and whether published SIC criteria are met.

## When to use

When an agent has platelet count, INR, and the caller-assigned respiratory plus cardiovascular plus hepatic plus renal SOFA sum and needs the published SIC total, and must not invent a sepsis or DIC diagnosis or an anticoagulant order.

## When not to use

- Not a medical device.
- Not a diagnosis of sepsis, DIC, or SIC. Suspected sepsis is caller-side; magent scores the three published items only.
- magent does not start anticoagulants.
- sofa_four_items is the caller-assigned sum of respiratory, cardiovascular, hepatic, and renal SOFA only (not coagulation, not CNS). magent does not compute those organ scores.
- Not ISTH overt DIC (Taylor 2001). Not JAAM-DIC.

## Formula

```
SIC = platelets_10e9_l (>=150 → 0; <150 and >=100 → 1; <100 → 2) + inr (<=1.2 → 0; >1.2 and <=1.4 → 1; >1.4 → 2) + sofa_four_items (0 → 0; 1 → 1; >=2 → 2 cap); max 6; sic iff score >= 4 and (platelet_pts + inr_pts) >= 3
```

## Citation

[New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis of a nationwide survey](https://doi.org/10.1136/bmjopen-2017-017046)
Iba T, Di Nisio M, Levy JH, Kitamura N, Thachil J
BMJ Open. 2017;7(9):e017046
DOI: [10.1136/bmjopen-2017-017046](https://doi.org/10.1136/bmjopen-2017-017046)

## Worked example

### All items non-scoring

Given: `inr=1.0, platelets_10e9_l=180, sofa_four_items=0`

1. Platelets 180 >= 150 → 0; INR 1.0 <= 1.2 → 0; sofa_four_items 0 → 0
2. Score = 0 (max 6); platelet_pts + inr_pts = 0; sic false


## Also searched as

- sepsis-induced coagulopathy
- SIC score
- Iba SIC criteria
- sepsis coagulopathy score
- SIC scoring system

## Parameters

- `platelets_10e9_l` (number, required): Platelet count ×10^9/L (1-2000). >=150 scores 0; <150 and >=100 scores 1; <100 scores 2. 150 scores 0; 100 scores 1; 99 scores 2 (Iba 2017 Table 3).
- `inr` (number, required): INR (0.8-10). <=1.2 scores 0; >1.2 and <=1.4 scores 1; >1.4 scores 2. 1.2 scores 0; 1.4 scores 1; 1.41 scores 2 (Iba 2017 Table 3).
- `sofa_four_items` (integer, required): Caller-assigned sum of respiratory + cardiovascular + hepatic + renal SOFA only (integer 0-16). Do not include coagulation or CNS. 0 scores 0; 1 scores 1; >=2 scores 2 (cap 2). 2 and 16 both score 2 (Iba 2017 Table 3). magent does not compute those organ scores.

## Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

Method: `POST /api/calc/sic`
Max items: 25
Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic)
Status: PREVIEW

- 1 to 25 items. Each item uses the same keys as the GET query parameters.
- POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
- The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
- HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
- Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
- x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request:

```json
{
  "items": [
    {
      "inr": "1.0",
      "platelets_10e9_l": "180",
      "sofa_four_items": "0"
    },
    {
      "inr": "1.0",
      "platelets_10e9_l": "180",
      "sofa_four_items": "0"
    }
  ]
}
```

Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/sic

Example 200:

```json
{
  "count": 2,
  "path": "/api/calc/sic",
  "items": [
    {
      "components": [
        {
          "value": 180.0,
          "factor": "platelets",
          "points": 0,
          "present": false
        },
        {
          "value": 1.0,
          "factor": "inr",
          "points": 0,
          "present": false
        },
        {
          "value": 0,
          "factor": "sofa_four_items",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Iba T, Di Nisio M, Levy JH, Kitamura N, Thachil J",
        "doi": "10.1136/bmjopen-2017-017046",
        "id": "iba-2017",
        "pmid": "28963287",
        "source": "BMJ Open. 2017;7(9):e017046",
        "title": "New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis of a nationwide survey"
      },
      "formula": "sic",
      "formula_expression": "SIC = platelets_10e9_l (>=150 → 0; <150 and >=100 → 1; <100 → 2) + inr (<=1.2 → 0; >1.2 and <=1.4 → 1; >1.4 → 2) + sofa_four_items (0 → 0; 1 → 1; >=2 → 2 cap); max 6; sic iff score >= 4 and (platelet_pts + inr_pts) >= 3",
      "max_score": 6,
      "score": 0,
      "inr": 1.0,
      "platelets_10e9_l": 180.0,
      "inr_pts": 0,
      "platelet_pts": 0,
      "sic": false,
      "sofa_four_items": 0,
      "sofa_pts": 0
    },
    {
      "components": [
        {
          "value": 180.0,
          "factor": "platelets",
          "points": 0,
          "present": false
        },
        {
          "value": 1.0,
          "factor": "inr",
          "points": 0,
          "present": false
        },
        {
          "value": 0,
          "factor": "sofa_four_items",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Iba T, Di Nisio M, Levy JH, Kitamura N, Thachil J",
        "doi": "10.1136/bmjopen-2017-017046",
        "id": "iba-2017",
        "pmid": "28963287",
        "source": "BMJ Open. 2017;7(9):e017046",
        "title": "New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis of a nationwide survey"
      },
      "formula": "sic",
      "formula_expression": "SIC = platelets_10e9_l (>=150 → 0; <150 and >=100 → 1; <100 → 2) + inr (<=1.2 → 0; >1.2 and <=1.4 → 1; >1.4 → 2) + sofa_four_items (0 → 0; 1 → 1; >=2 → 2 cap); max 6; sic iff score >= 4 and (platelet_pts + inr_pts) >= 3",
      "max_score": 6,
      "score": 0,
      "inr": 1.0,
      "platelets_10e9_l": 180.0,
      "inr_pts": 0,
      "platelet_pts": 0,
      "sic": false,
      "sofa_four_items": 0,
      "sofa_pts": 0
    }
  ]
}
```

## Response fields

- `formula` (string): sic
- `formula_expression` (string): Exact expression used
- `score` (integer): Total points 0-6
- `max_score` (integer): Always 6
- `sic` (boolean): true iff score >= 4 and platelet_pts + inr_pts >= 3 (Iba 2017). Not a sepsis or DIC diagnosis.
- `platelet_pts` (integer): Platelet item points 0-2
- `inr_pts` (integer): INR item points 0-2
- `sofa_pts` (integer): Four-item SOFA points 0-2 (capped; 3-16 still score 2)
- `platelets_10e9_l` (number): Platelet count used (×10^9/L)
- `inr` (number): INR used
- `sofa_four_items` (integer): Four-item SOFA sum used (respiratory + cardiovascular + hepatic + renal)
- `components` (array): Per-item points
- `citation` (object): Iba 2017 citation
- `disclaimer` (string): Not-a-device notice

## Example JSON

Frozen fixture. Not a live lookup.

```json
{
  "components": [
    {
      "value": 180.0,
      "factor": "platelets",
      "points": 0,
      "present": false
    },
    {
      "value": 1.0,
      "factor": "inr",
      "points": 0,
      "present": false
    },
    {
      "value": 0,
      "factor": "sofa_four_items",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Iba T, Di Nisio M, Levy JH, Kitamura N, Thachil J",
    "doi": "10.1136/bmjopen-2017-017046",
    "id": "iba-2017",
    "pmid": "28963287",
    "source": "BMJ Open. 2017;7(9):e017046",
    "title": "New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis of a nationwide survey"
  },
  "formula": "sic",
  "formula_expression": "SIC = platelets_10e9_l (>=150 → 0; <150 and >=100 → 1; <100 → 2) + inr (<=1.2 → 0; >1.2 and <=1.4 → 1; >1.4 → 2) + sofa_four_items (0 → 0; 1 → 1; >=2 → 2 cap); max 6; sic iff score >= 4 and (platelet_pts + inr_pts) >= 3",
  "max_score": 6,
  "score": 0,
  "inr": 1.0,
  "platelets_10e9_l": 180.0,
  "inr_pts": 0,
  "platelet_pts": 0,
  "sic": false,
  "sofa_four_items": 0,
  "sofa_pts": 0
}
```

## Errors

- HTTP 400 `invalid_platelets`: platelets_10e9_l must be a number from 1 to 2000 Returned before settlement; you are not charged.
- HTTP 400 `invalid_inr`: inr must be a number from 0.8 to 10 Returned before settlement; you are not charged.
- HTTP 400 `invalid_sic_sofa`: sofa_four_items must be an integer from 0 to 16 (Iba 2017 respiratory plus cardiovascular plus hepatic plus renal SOFA sum). Returned before settlement; you are not charged.
- HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
- HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
- HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged.

Shared HTTP 402 and 503: https://magentlab.com/docs/payments

## Related tools

- [ISTH overt DIC](https://magentlab.com/docs/isth-dic) — Sum the four Taylor 2001 ISTH SSC overt DIC laboratory items (platelets, fibrin-related marker, PT prolongation, fibrinogen) and return the published <5 / >=5 band.
- [SOFA](https://magentlab.com/docs/sofa) — Compute the Vincent 1996 SOFA score from PaO2/FiO2, platelets, bilirubin, MAP and adrenergic agents, GCS, and creatinine or urine output.

## Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s.

- GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall).
- HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote.
- Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering.
- Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional.
- Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402.

- offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront.
- offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization.

- not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search.

Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers).

Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments

Stdio MCP (one process per host): https://magentlab.com/docs/mcp

## Guarantees

- HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
- exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
- HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
- Execution is timeout-bounded and concurrency-capped.
- Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.