# Simplified AIH criteria (Hennes) Simplified AIH Status: LIVE Price: $0.005 USDC `GET /api/calc/simplified_aih` HTML: https://magentlab.com/docs/simplified-aih Markdown: https://magentlab.com/docs/simplified-aih.md Not a medical device. Not a diagnosis, dose, or listing recommendation. ## What it computes Sum the Hennes 2008 simplified autoimmune-hepatitis criteria (Table 2) from caller-assigned autoantibody, IgG, histology, and viral-hepatitis points and return not_aih (<6), probable (6), or definite (≥7). ## When to use When an agent already has Hennes 2008 Table 2 points assigned and needs the published total and band, not an autoimmune-hepatitis diagnosis and not the original IAHG 1999 score. ## When not to use - Not a medical device and not an autoimmune-hepatitis diagnosis or treatment choice. magent does not examine the patient. - This is the Hennes 2008 simplified score (Table 2), not the original IAHG 1999 scoring system. - magent does not titer autoantibodies, assay IgG vs ULN, or read liver histology. autoantibody_points, igg_points, histology, and viral_hepatitis_absent are caller-assigned. - This API does not collect names, MRNs, or dates of birth. ## Formula ``` simplified AIH = autoantibody_points (0-2) + igg_points (0-2) + histology (none 0, compatible 1, typical 2) + viral_hepatitis_absent (true 2); Hennes 2008 Table 2; max 8; <6 not_aih, 6 probable, ≥7 definite ``` ## Citation [Simplified criteria for the diagnosis of autoimmune hepatitis](https://doi.org/10.1002/hep.22322) Hennes EM, Zeniya M, Czaja AJ, Parés A, Dalekos GN, Krawitt EL, Bittencourt PL, Porta G, Boberg KM, Hofer H, Francesconi F, Dufour JF, Vergani D, Lohse AW; International Autoimmune Hepatitis Group Hepatology. 2008;48(1):169-176 DOI: [10.1002/hep.22322](https://doi.org/10.1002/hep.22322) ## Worked example ### Typical histology with maximum autoantibody, IgG, and viral points Given: `autoantibody_points=2, histology=typical, igg_points=2, viral_hepatitis_absent=true` 1. autoantibody_points 2; igg_points 2; histology typical → 2; viral_hepatitis_absent true → 2 2. Score = 8 (max 8); aih_band = definite ### Compatible histology with IgG 1 point Given: `autoantibody_points=2, histology=compatible, igg_points=1, viral_hepatitis_absent=true` 1. autoantibody_points 2; igg_points 1; histology compatible → 1; viral_hepatitis_absent true → 2 2. Score = 6 (max 8); aih_band = probable ## Also searched as - simplified AIH - Hennes 2008 AIH - simplified autoimmune hepatitis - IAHG simplified criteria - simplified AIH score - autoimmune hepatitis simplified score - Hennes AIH criteria - simplified diagnostic criteria AIH ## Parameters - `autoantibody_points` (integer, required): Caller-assigned Hennes 2008 Table 2 autoantibody points (0, 1, or 2; max 2 across ANA/SMA/LKM/SLA). 0: not scoring. 1: ANA or SMA ≥1:40. 2: ANA or SMA ≥1:80 or LKM ≥1:40 or SLA positive. magent does not titer autoantibodies. - `igg_points` (integer, required): Caller-assigned Hennes 2008 Table 2 IgG points (0, 1, or 2). 0: IgG ≤ULN. 1: IgG >ULN. 2: IgG >1.10×ULN. magent does not assay IgG vs ULN. - `histology` (string, required): Caller-assigned Hennes 2008 Table 2 liver histology. none scores 0 (hepatitis is required for histology points). compatible scores 1. typical scores 2. magent does not read liver histology. - `viral_hepatitis_absent` (boolean, required): Caller-assigned Hennes 2008 Table 2 viral hepatitis absence. true scores 2; false scores 0. magent does not interpret viral serology. ## Bulk (POST) POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement. Method: `POST /api/calc/simplified_aih` Max items: 25 Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic) Status: PREVIEW - 1 to 25 items. Each item uses the same keys as the GET query parameters. - POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows. - The first invalid item fails the whole request (index in the 400 JSON). You are not charged. - HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row. - Catalog misses (empty matches, found=false) stay paid 200s inside that slot. - x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items. Example request: ```json { "items": [ { "autoantibody_points": "2", "histology": "typical", "igg_points": "2", "viral_hepatitis_absent": "true" }, { "autoantibody_points": "2", "histology": "typical", "igg_points": "2", "viral_hepatitis_absent": "true" } ] } ``` Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/simplified-aih Example 200: ```json { "count": 2, "path": "/api/calc/simplified_aih", "items": [ { "components": [ { "value": 2, "factor": "autoantibody_points", "points": 2, "present": true }, { "value": 2, "factor": "igg_points", "points": 2, "present": true }, { "value": "typical", "factor": "histology", "points": 2, "present": true }, { "factor": "viral_hepatitis_absent", "points": 2, "present": true } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Hennes EM, Zeniya M, Czaja AJ, Parés A, Dalekos GN, Krawitt EL, Bittencourt PL, Porta G, Boberg KM, Hofer H, Francesconi F, Dufour JF, Vergani D, Lohse AW; International Autoimmune Hepatitis Group", "doi": "10.1002/hep.22322", "id": "hennes-2008", "pmid": "18537184", "source": "Hepatology. 2008;48(1):169-176", "title": "Simplified criteria for the diagnosis of autoimmune hepatitis" }, "formula": "simplified_aih", "formula_expression": "simplified AIH = autoantibody_points (0-2) + igg_points (0-2) + histology (none 0, compatible 1, typical 2) + viral_hepatitis_absent (true 2); Hennes 2008 Table 2; max 8; <6 not_aih, 6 probable, ≥7 definite", "max_score": 8, "score": 8, "aih_band": "definite" }, { "components": [ { "value": 2, "factor": "autoantibody_points", "points": 2, "present": true }, { "value": 2, "factor": "igg_points", "points": 2, "present": true }, { "value": "typical", "factor": "histology", "points": 2, "present": true }, { "factor": "viral_hepatitis_absent", "points": 2, "present": true } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Hennes EM, Zeniya M, Czaja AJ, Parés A, Dalekos GN, Krawitt EL, Bittencourt PL, Porta G, Boberg KM, Hofer H, Francesconi F, Dufour JF, Vergani D, Lohse AW; International Autoimmune Hepatitis Group", "doi": "10.1002/hep.22322", "id": "hennes-2008", "pmid": "18537184", "source": "Hepatology. 2008;48(1):169-176", "title": "Simplified criteria for the diagnosis of autoimmune hepatitis" }, "formula": "simplified_aih", "formula_expression": "simplified AIH = autoantibody_points (0-2) + igg_points (0-2) + histology (none 0, compatible 1, typical 2) + viral_hepatitis_absent (true 2); Hennes 2008 Table 2; max 8; <6 not_aih, 6 probable, ≥7 definite", "max_score": 8, "score": 8, "aih_band": "definite" } ] } ``` ## Response fields - `formula` (string): simplified_aih - `formula_expression` (string): Exact expression used - `score` (integer): Simplified AIH points 0-8 - `max_score` (integer): Always 8 - `aih_band` (string): not_aih when score is <6, probable when 6, definite when ≥7 (Hennes 2008 Table 2). Not an autoimmune-hepatitis diagnosis. Not the original IAHG 1999 score. - `components` (array): Per-factor points - `citation` (object): Hennes 2008 Hepatology citation - `disclaimer` (string): Not-a-device notice ## Example JSON Frozen fixture. Not a live lookup. ```json { "components": [ { "value": 2, "factor": "autoantibody_points", "points": 2, "present": true }, { "value": 2, "factor": "igg_points", "points": 2, "present": true }, { "value": "typical", "factor": "histology", "points": 2, "present": true }, { "factor": "viral_hepatitis_absent", "points": 2, "present": true } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Hennes EM, Zeniya M, Czaja AJ, Parés A, Dalekos GN, Krawitt EL, Bittencourt PL, Porta G, Boberg KM, Hofer H, Francesconi F, Dufour JF, Vergani D, Lohse AW; International Autoimmune Hepatitis Group", "doi": "10.1002/hep.22322", "id": "hennes-2008", "pmid": "18537184", "source": "Hepatology. 2008;48(1):169-176", "title": "Simplified criteria for the diagnosis of autoimmune hepatitis" }, "formula": "simplified_aih", "formula_expression": "simplified AIH = autoantibody_points (0-2) + igg_points (0-2) + histology (none 0, compatible 1, typical 2) + viral_hepatitis_absent (true 2); Hennes 2008 Table 2; max 8; <6 not_aih, 6 probable, ≥7 definite", "max_score": 8, "score": 8, "aih_band": "definite" } ``` ## Errors - HTTP 400 `invalid_aih_autoantibody`: autoantibody_points must be 0, 1, or 2 (Hennes 2008 Table 2; max 2 across ANA/SMA/LKM/SLA). Returned before settlement; you are not charged. - HTTP 400 `invalid_aih_igg`: igg_points must be 0, 1, or 2 (Hennes 2008: 0 ≤ULN, 1 >ULN, 2 >1.10×ULN). Returned before settlement; you are not charged. - HTTP 400 `invalid_aih_histology`: histology must be none, compatible, or typical (Hennes 2008; hepatitis is required for histology points). Returned before settlement; you are not charged. - HTTP 400 `invalid_flag`: boolean clinical flags must be true or false Returned before settlement; you are not charged. - HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged. - HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged. - HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged. Shared HTTP 402 and 503: https://magentlab.com/docs/payments ## Related tools - [Child–Pugh](https://magentlab.com/docs/child-pugh) — Compute the Child–Turcotte–Pugh cirrhosis severity score from bilirubin, albumin, INR, encephalopathy, and ascites. - [ALBI](https://magentlab.com/docs/albi) — Compute the Johnson 2015 albumin-bilirubin (ALBI) linear predictor and grade from total bilirubin and albumin. ## Payment Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. - GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall). - HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote. - Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering. - Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional. - Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402. - offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront. - offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization. - not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search. Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers). Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments Stdio MCP (one process per host): https://magentlab.com/docs/mcp ## Guarantees - HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. - exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE. - HTTP 402 is unpaid only. Do not sign a second authorization because of a 503. - Execution is timeout-bounded and concurrency-capped. - Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.