# VTE-BLEED calculator VTE-BLEED Status: LIVE Price: $0.005 USDC `GET /api/calc/vte_bleed` HTML: https://magentlab.com/docs/vte-bleed Markdown: https://magentlab.com/docs/vte-bleed.md Not a medical device. Not a diagnosis, dose, or listing recommendation. ## What it computes Sum the Klok 2016 VTE-BLEED items for major bleeding on stable anticoagulation after VTE and return low (<2) or high (≥2). ## When to use When an agent needs the published Klok 2016 VTE-BLEED point total and band and must not invent a treatment-duration or HAS-BLED decision. ## When not to use - Not a medical device. magent does not diagnose VTE or bleeding and does not assay hemoglobin or eGFR. - Not HAS-BLED. VTE-BLEED is the Klok 2016 six-item score after VTE on stable anticoagulation, not an atrial-fibrillation bleed score. - Not a treatment-duration order, anticoagulation start/stop protocol, or bleed-treatment recommendation. Bands are low (<2) and high (≥2) only. - Anemia, renal dysfunction, and uncontrolled hypertension (SBP ≥140) are caller-assigned booleans. magent does not take a hemoglobin, eGFR, creatinine, or blood-pressure number. ## Formula ``` VTE-BLEED = active_cancer 2 + (male AND uncontrolled_hypertension) 1 + anemia 1.5 + history_of_bleeding 1.5 + age_ge_60 1.5 + renal_dysfunction 1.5; Klok 2016; max 9; low <2, high >=2 ``` ## Citation [Prediction of bleeding events in patients with venous thromboembolism on stable anticoagulation treatment](https://doi.org/10.1183/13993003.00280-2016) Klok FA, Hösel V, Clemens A, Yollo WD, Tilke C, Schulman S, Lankeit M, Konstantinides SV Eur Respir J. 2016;48(5):1369-1376 DOI: [10.1183/13993003.00280-2016](https://doi.org/10.1183/13993003.00280-2016) ## Worked example ### Age 70 male, no other items Given: `active_cancer=false, age=70, anemia=false, history_of_bleeding=false, renal_dysfunction=false, sex=male, uncontrolled_hypertension=false` 1. Age ≥60 → 1.5; active_cancer, male hypertension, anemia, history_of_bleeding, and renal_dysfunction false → 0 2. Score = 1.5 (max 9); vte_bleed_band = low (<2) ### Active cancer alone Given: `active_cancer=true, age=50, anemia=false, history_of_bleeding=false, renal_dysfunction=false, sex=male, uncontrolled_hypertension=false` 1. active_cancer → 2; age <60 and remaining flags false → 0 2. Score = 2 (max 9); vte_bleed_band = high (≥2) ## Also searched as - VTE-BLEED - VTE BLEED score - Klok VTE-BLEED - Klok 2016 bleed - VTE anticoagulation bleeding - XALIA bleeding score - venous thromboembolism bleed ## Parameters - `age` (integer, required): Age in years (18-120). Age ≥60 scores 1.5 (Klok 2016). magent does not assign age. - `sex` (string, required): female or male. Uncontrolled hypertension scores 1 only when sex is male (Klok 2016 / XALIA SBP ≥140 item). Female never scores that item. - `active_cancer` (boolean, required): Active cancer as assigned by the caller (Klok 2016). true scores 2. magent does not diagnose cancer. - `uncontrolled_hypertension` (boolean, required): Uncontrolled hypertension (SBP ≥140 mmHg) as assigned by the caller (Klok 2016 / XALIA). true scores 1 only in males; females score 0 even when true. magent does not measure blood pressure. - `anemia` (boolean, required): Anemia as assigned by the caller (Klok 2016: hemoglobin <130 g/L in men or <120 g/L in women). true scores 1.5. magent does not take a hemoglobin number. - `history_of_bleeding` (boolean, required): History of bleeding as assigned by the caller (Klok 2016). true scores 1.5. magent does not grade bleeding. - `renal_dysfunction` (boolean, required): Renal dysfunction (eGFR or CrCl <60) as assigned by the caller (Klok 2016). true scores 1.5. magent does not compute eGFR or creatinine clearance. ## Bulk (POST) POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement. Method: `POST /api/calc/vte_bleed` Max items: 25 Price: unit_amount + extra_item_amount * (n - 1) (unit 5000 atomic, extra 2000 atomic) Status: PREVIEW - 1 to 25 items. Each item uses the same keys as the GET query parameters. - POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows. - The first invalid item fails the whole request (index in the 400 JSON). You are not charged. - HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row. - Catalog misses (empty matches, found=false) stay paid 200s inside that slot. - x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items. Example request: ```json { "items": [ { "active_cancer": "false", "age": "70", "anemia": "false", "history_of_bleeding": "false", "renal_dysfunction": "false", "sex": "male", "uncontrolled_hypertension": "false" }, { "active_cancer": "false", "age": "70", "anemia": "false", "history_of_bleeding": "false", "renal_dysfunction": "false", "sex": "male", "uncontrolled_hypertension": "false" } ] } ``` Human paywall (two-item fixture): https://api.magentlab.com/paywall/bulk/vte-bleed Example 200: ```json { "count": 2, "path": "/api/calc/vte_bleed", "items": [ { "components": [ { "factor": "active_cancer", "points": 0, "present": false }, { "factor": "male_uncontrolled_hypertension", "points": 0, "present": false, "sex": "male", "uncontrolled_hypertension": false }, { "factor": "anemia", "points": 0.0, "present": false }, { "factor": "history_of_bleeding", "points": 0.0, "present": false }, { "value": 70, "factor": "age_ge_60", "points": 1.5, "present": true }, { "factor": "renal_dysfunction", "points": 0.0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Klok FA, Hösel V, Clemens A, Yollo WD, Tilke C, Schulman S, Lankeit M, Konstantinides SV", "doi": "10.1183/13993003.00280-2016", "id": "klok-2016", "pmid": "27471209", "source": "Eur Respir J. 2016;48(5):1369-1376", "title": "Prediction of bleeding events in patients with venous thromboembolism on stable anticoagulation treatment" }, "formula": "vte_bleed", "formula_expression": "VTE-BLEED = active_cancer 2 + (male AND uncontrolled_hypertension) 1 + anemia 1.5 + history_of_bleeding 1.5 + age_ge_60 1.5 + renal_dysfunction 1.5; Klok 2016; max 9; low <2, high >=2", "age_years": 70, "max_score": 9, "score": 1.5, "sex": "male", "vte_bleed_band": "low" }, { "components": [ { "factor": "active_cancer", "points": 0, "present": false }, { "factor": "male_uncontrolled_hypertension", "points": 0, "present": false, "sex": "male", "uncontrolled_hypertension": false }, { "factor": "anemia", "points": 0.0, "present": false }, { "factor": "history_of_bleeding", "points": 0.0, "present": false }, { "value": 70, "factor": "age_ge_60", "points": 1.5, "present": true }, { "factor": "renal_dysfunction", "points": 0.0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Klok FA, Hösel V, Clemens A, Yollo WD, Tilke C, Schulman S, Lankeit M, Konstantinides SV", "doi": "10.1183/13993003.00280-2016", "id": "klok-2016", "pmid": "27471209", "source": "Eur Respir J. 2016;48(5):1369-1376", "title": "Prediction of bleeding events in patients with venous thromboembolism on stable anticoagulation treatment" }, "formula": "vte_bleed", "formula_expression": "VTE-BLEED = active_cancer 2 + (male AND uncontrolled_hypertension) 1 + anemia 1.5 + history_of_bleeding 1.5 + age_ge_60 1.5 + renal_dysfunction 1.5; Klok 2016; max 9; low <2, high >=2", "age_years": 70, "max_score": 9, "score": 1.5, "sex": "male", "vte_bleed_band": "low" } ] } ``` ## Response fields - `formula` (string): vte_bleed - `formula_expression` (string): Exact expression used - `score` (number): VTE-BLEED points 0-9 (1.5 steps allowed; not integer-rounded) - `max_score` (integer): Always 9 - `vte_bleed_band` (string): low when score is <2, high when score is ≥2 (Klok 2016). Not a treatment-duration order. - `sex` (string): female or male used for the hypertension item - `age_years` (integer): Age used for the ≥60 criterion - `components` (array): Per-factor points - `citation` (object): Klok 2016 Eur Respir J citation - `disclaimer` (string): Not-a-device notice ## Example JSON Frozen fixture. Not a live lookup. ```json { "components": [ { "factor": "active_cancer", "points": 0, "present": false }, { "factor": "male_uncontrolled_hypertension", "points": 0, "present": false, "sex": "male", "uncontrolled_hypertension": false }, { "factor": "anemia", "points": 0.0, "present": false }, { "factor": "history_of_bleeding", "points": 0.0, "present": false }, { "value": 70, "factor": "age_ge_60", "points": 1.5, "present": true }, { "factor": "renal_dysfunction", "points": 0.0, "present": false } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "citation": { "authors": "Klok FA, Hösel V, Clemens A, Yollo WD, Tilke C, Schulman S, Lankeit M, Konstantinides SV", "doi": "10.1183/13993003.00280-2016", "id": "klok-2016", "pmid": "27471209", "source": "Eur Respir J. 2016;48(5):1369-1376", "title": "Prediction of bleeding events in patients with venous thromboembolism on stable anticoagulation treatment" }, "formula": "vte_bleed", "formula_expression": "VTE-BLEED = active_cancer 2 + (male AND uncontrolled_hypertension) 1 + anemia 1.5 + history_of_bleeding 1.5 + age_ge_60 1.5 + renal_dysfunction 1.5; Klok 2016; max 9; low <2, high >=2", "age_years": 70, "max_score": 9, "score": 1.5, "sex": "male", "vte_bleed_band": "low" } ``` ## Errors - HTTP 400 `invalid_age`: age must be an integer from 18 to 120 Returned before settlement; you are not charged. - HTTP 400 `invalid_sex`: sex must be female or male Returned before settlement; you are not charged. - HTTP 400 `invalid_flag`: boolean clinical flags must be true or false Returned before settlement; you are not charged. - HTTP 400 `invalid_items`: POST body must be a JSON object with only an items array Returned before settlement; you are not charged. - HTTP 400 `invalid_item_count`: items must be an array of 1 to 25 objects Returned before settlement; you are not charged. - HTTP 400 `invalid_item`: each items entry must be a JSON object Returned before settlement; you are not charged. Shared HTTP 402 and 503: https://magentlab.com/docs/payments ## Related tools - [HAS-BLED](https://magentlab.com/docs/has-bled) — Compute the HAS-BLED bleeding-risk score from discrete clinical flags. - [RIETE](https://magentlab.com/docs/riete) — Sum the Ruiz-Giménez 2008 RIETE adverse factors for 3-month major bleeding after documented acute VTE and return low (0), intermediate (1–4), or high (>4). ## Payment Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. - GET the tool with Accept: application/json (do not send Accept: text/html unless you want the human paywall). - HTTP 402 means you have not paid. Decode the base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote. - Sign accepts[0] (exact, EIP-3009) with validBefore = now + maxTimeoutSeconds (600 seconds), or accepts[1] (batch-settlement deposit/voucher) on product GET. Ping and POST {items} stay exact. Magent retries transient facilitator 429/5xx before answering. - Retry the same URL with PAYMENT-SIGNATURE (base64 JSON of accepted and payload). Magent attaches canonical extensions.bazaar on CDP verify/settle; echoing 402 bazaar is optional. - Success is HTTP 200 JSON plus PAYMENT-RESPONSE. exact settles before the tool. batch-settlement verifies (and deposit-settles) before the tool and commits the charge after HTTP 2xx. HTTP 503: retry the same PAYMENT-SIGNATURE. Mint a new exact nonce only after a new HTTP 402. - offered `exact` on eip155:8453: Fixed-price USDC on Base. The buyer authorizes the advertised amount (EIP-3009). magent settles before the tool runs (paymentFlow upfront). extra.assetTransferMethod=eip3009 extra.paymentFlow=upfront. - offered `batch-settlement` on eip155:8453: Payment-channel vouchers claimed later in batches. Exact stays accepts[0]. Same-path POST {items} is still exact. extra.assetTransferMethod=eip3009 extra.paymentFlow=authorization. - not offered `upto`: Not offered. Usage-based: buyer authorizes a ceiling, seller settles the actual amount after work. Reserved for a future metered tool. Not for current calculators or code search. Same-path POST {items} is still scheme exact: one EIP-3009 authorization for GET unit plus $0.002 per extra item. That is not x402 batch-settlement (payment channels / vouchers). Shared HTTP 402 and 503 table: https://magentlab.com/docs/payments Stdio MCP (one process per host): https://magentlab.com/docs/mcp ## Guarantees - HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON. - exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE. - HTTP 402 is unpaid only. Do not sign a second authorization because of a 503. - Execution is timeout-bounded and concurrency-capped. - Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.