Infection / VTE · LIVE

2023 Duke-ISCVID criteria for infective endocarditis

Duke-ISCVID

Apply the 2023 Duke-ISCVID (Fowler) criteria for infective endocarditis and return definite, possible, or rejected from caller-assigned pathologic, major (microbiologic, imaging, surgical), minor, and rejected flags.

LIVE $0.005 USDC GET /api/calc/duke_iscvid

Markdown: /docs/duke-iscvid.md · Canonical: https://magentlab.com/docs/duke-iscvid

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply the 2023 Duke-ISCVID (Fowler) criteria for infective endocarditis and return definite, possible, or rejected from caller-assigned pathologic, major (microbiologic, imaging, surgical), minor, and rejected flags.

When to use

When an agent already has caller-assigned 2023 Duke-ISCVID pathologic, major, minor, and rejected flags and needs the published definite / possible / rejected classification. magent does not examine the patient, read imaging, or interpret cultures.

When not to use

• Not a medical device and not a diagnosis of infective endocarditis.
• 2023 Duke-ISCVID (Fowler) only. Not Durack 1994 original Duke. Not Li 2000 modified Duke.
• magent does not examine the patient, read an echocardiogram, cardiac CT, or 18F-FDG PET/CT, or interpret cultures. Organism lists and imaging modalities are caller-assigned into the major and minor flags.
• Possible requires 1 major plus 1 minor or 3 minor. Findings that meet neither definite nor possible are rejected. Rejected flags apply only when definite does not hold.

Formula

definite iff pathologic_definite or clinical_definite; clinical_definite iff major_count >= 2 or (major_count >= 1 and minor_count >= 3) or minor_count >= 5; possible iff not definite and ((major_count >= 1 and minor_count >= 1) or minor_count >= 3); rejected iff not definite and not possible, or (not definite and any rejected flag); definite is not overridden by rejected flags (Fowler 2023 Duke-ISCVID). minor_microbiologic is not counted when major_microbiologic is true. Majors are caller-assigned microbiologic, imaging, and surgical domains. Not Durack 1994. Not Li 2000

Citation

Title

The 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis: Updating the Modified Duke Criteria

Authors

Fowler VG Jr, Durack DT, Selton-Suty C, Athan E, Bayer AS, Chamis JG, Dahl A, DiBernardo L, Durante-Mangoni E, Duval X, Fortes CQ, Fosbøl E, Hannan MM, Hasse B, Hoen B, Iversen K, et al.

Source

Clin Infect Dis. 2023;77(4):518-526

DOI

10.1093/cid/ciad271

Worked example

Also searched as

• Duke-ISCVID
• 2023 Duke criteria
• ISCVID endocarditis
• Fowler 2023 Duke
• Duke-ISCVID IE criteria
• 2023 Duke-ISCVID
• infective endocarditis 2023 criteria
• surgical major IE

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/duke_iscvid?pathologic_definite=false&major_microbiologic=true&major_imaging=true&major_surgical=false&minor_predisposition=false&minor_fever=false&minor_vascular=false&minor_immunologic=false&minor_microbiologic=false&rejected_firm_alternate_diagnosis=false&rejected_resolved_le_4_days_antibiotics=false&rejected_no_pathology_le_4_days_antibiotics=false

Full URL: https://api.magentlab.com/api/calc/duke_iscvid?pathologic_definite=false&major_microbiologic=true&major_imaging=true&major_surgical=false&minor_predisposition=false&minor_fever=false&minor_vascular=false&minor_immunologic=false&minor_microbiologic=false&rejected_firm_alternate_diagnosis=false&rejected_resolved_le_4_days_antibiotics=false&rejected_no_pathology_le_4_days_antibiotics=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/duke_iscvid?pathologic_definite=false&major_microbiologic=true&major_imaging=true&major_surgical=false&minor_predisposition=false&minor_fever=false&minor_vascular=false&minor_immunologic=false&minor_microbiologic=false&rejected_firm_alternate_diagnosis=false&rejected_resolved_le_4_days_antibiotics=false&rejected_no_pathology_le_4_days_antibiotics=false"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/duke_iscvid Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "major_imaging": "true",
      "major_microbiologic": "true",
      "major_surgical": "false",
      "minor_fever": "false",
      "minor_immunologic": "false",
      "minor_microbiologic": "false",
      "minor_predisposition": "false",
      "minor_vascular": "false",
      "pathologic_definite": "false",
      "rejected_firm_alternate_diagnosis": "false",
      "rejected_no_pathology_le_4_days_antibiotics": "false",
      "rejected_resolved_le_4_days_antibiotics": "false"
    },
    {
      "major_imaging": "true",
      "major_microbiologic": "true",
      "major_surgical": "false",
      "minor_fever": "false",
      "minor_immunologic": "false",
      "minor_microbiologic": "false",
      "minor_predisposition": "false",
      "minor_vascular": "false",
      "pathologic_definite": "false",
      "rejected_firm_alternate_diagnosis": "false",
      "rejected_no_pathology_le_4_days_antibiotics": "false",
      "rejected_resolved_le_4_days_antibiotics": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/duke_iscvid",
  "items": [
    {
      "rejected": false,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Fowler VG Jr, Durack DT, Selton-Suty C, Athan E, Bayer AS, Chamis JG, Dahl A, DiBernardo L, Durante-Mangoni E, Duval X, Fortes CQ, Fosbøl E, Hannan MM, Hasse B, Hoen B, Iversen K, et al.",
        "doi": "10.1093/cid/ciad271",
        "id": "fowler-2023",
        "pmid": "37138445",
        "source": "Clin Infect Dis. 2023;77(4):518-526",
        "title": "The 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis: Updating the Modified Duke Criteria"
      },
      "formula": "duke_iscvid",
      "formula_expression": "definite iff pathologic_definite or clinical_definite; clinical_definite iff major_count >= 2 or (major_count >= 1 and minor_count >= 3) or minor_count >= 5; possible iff not definite and ((major_count >= 1 and minor_count >= 1) or minor_count >= 3); rejected iff not definite and not possible, or (not definite and any rejected flag); definite is not overridden by rejected flags (Fowler 2023 Duke-ISCVID). minor_microbiologic is not counted when major_microbiologic is true. Majors are caller-assigned microbiologic, imaging, and surgical domains. Not Durack 1994. Not Li 2000",
      "criteria": [
        {
          "factor": "pathologic_definite",
          "met": false
        },
        {
          "factor": "major_microbiologic",
          "met": true
        },
        {
          "factor": "major_imaging",
          "met": true
        },
        {
          "factor": "major_surgical",
          "met": false
        },
        {
          "factor": "minor_predisposition",
          "met": false
        },
        {
          "factor": "minor_fever",
          "met": false
        },
        {
          "factor": "minor_vascular",
          "met": false
        },
        {
          "factor": "minor_immunologic",
          "met": false
        },
        {
          "factor": "minor_microbiologic",
          "met": false
        },
        {
          "factor": "rejected_firm_alternate_diagnosis",
          "met": false
        },
        {
          "factor": "rejected_resolved_le_4_days_antibiotics",
          "met": false
        },
        {
          "factor": "rejected_no_pathology_le_4_days_antibiotics",
          "met": false
        },
        {
          "factor": "clinical_definite",
          "met": true
        },
        {
          "factor": "rejected",
          "met": false
        }
      ],
      "major_count": 2,
      "minor_count": 0,
      "classification": "definite",
      "definite": true,
      "pathologic_definite": false,
      "possible": false
    },
    {
      "rejected": false,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Fowler VG Jr, Durack DT, Selton-Suty C, Athan E, Bayer AS, Chamis JG, Dahl A, DiBernardo L, Durante-Mangoni E, Duval X, Fortes CQ, Fosbøl E, Hannan MM, Hasse B, Hoen B, Iversen K, et al.",
        "doi": "10.1093/cid/ciad271",
        "id": "fowler-2023",
        "pmid": "37138445",
        "source": "Clin Infect Dis. 2023;77(4):518-526",
        "title": "The 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis: Updating the Modified Duke Criteria"
      },
      "formula": "duke_iscvid",
      "formula_expression": "definite iff pathologic_definite or clinical_definite; clinical_definite iff major_count >= 2 or (major_count >= 1 and minor_count >= 3) or minor_count >= 5; possible iff not definite and ((major_count >= 1 and minor_count >= 1) or minor_count >= 3); rejected iff not definite and not possible, or (not definite and any rejected flag); definite is not overridden by rejected flags (Fowler 2023 Duke-ISCVID). minor_microbiologic is not counted when major_microbiologic is true. Majors are caller-assigned microbiologic, imaging, and surgical domains. Not Durack 1994. Not Li 2000",
      "criteria": [
        {
          "factor": "pathologic_definite",
          "met": false
        },
        {
          "factor": "major_microbiologic",
          "met": true
        },
        {
          "factor": "major_imaging",
          "met": true
        },
        {
          "factor": "major_surgical",
          "met": false
        },
        {
          "factor": "minor_predisposition",
          "met": false
        },
        {
          "factor": "minor_fever",
          "met": false
        },
        {
          "factor": "minor_vascular",
          "met": false
        },
        {
          "factor": "minor_immunologic",
          "met": false
        },
        {
          "factor": "minor_microbiologic",
          "met": false
        },
        {
          "factor": "rejected_firm_alternate_diagnosis",
          "met": false
        },
        {
          "factor": "rejected_resolved_le_4_days_antibiotics",
          "met": false
        },
        {
          "factor": "rejected_no_pathology_le_4_days_antibiotics",
          "met": false
        },
        {
          "factor": "clinical_definite",
          "met": true
        },
        {
          "factor": "rejected",
          "met": false
        }
      ],
      "major_count": 2,
      "minor_count": 0,
      "classification": "definite",
      "definite": true,
      "pathologic_definite": false,
      "possible": false
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "rejected": false,
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Fowler VG Jr, Durack DT, Selton-Suty C, Athan E, Bayer AS, Chamis JG, Dahl A, DiBernardo L, Durante-Mangoni E, Duval X, Fortes CQ, Fosbøl E, Hannan MM, Hasse B, Hoen B, Iversen K, et al.",
    "doi": "10.1093/cid/ciad271",
    "id": "fowler-2023",
    "pmid": "37138445",
    "source": "Clin Infect Dis. 2023;77(4):518-526",
    "title": "The 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis: Updating the Modified Duke Criteria"
  },
  "formula": "duke_iscvid",
  "formula_expression": "definite iff pathologic_definite or clinical_definite; clinical_definite iff major_count >= 2 or (major_count >= 1 and minor_count >= 3) or minor_count >= 5; possible iff not definite and ((major_count >= 1 and minor_count >= 1) or minor_count >= 3); rejected iff not definite and not possible, or (not definite and any rejected flag); definite is not overridden by rejected flags (Fowler 2023 Duke-ISCVID). minor_microbiologic is not counted when major_microbiologic is true. Majors are caller-assigned microbiologic, imaging, and surgical domains. Not Durack 1994. Not Li 2000",
  "criteria": [
    {
      "factor": "pathologic_definite",
      "met": false
    },
    {
      "factor": "major_microbiologic",
      "met": true
    },
    {
      "factor": "major_imaging",
      "met": true
    },
    {
      "factor": "major_surgical",
      "met": false
    },
    {
      "factor": "minor_predisposition",
      "met": false
    },
    {
      "factor": "minor_fever",
      "met": false
    },
    {
      "factor": "minor_vascular",
      "met": false
    },
    {
      "factor": "minor_immunologic",
      "met": false
    },
    {
      "factor": "minor_microbiologic",
      "met": false
    },
    {
      "factor": "rejected_firm_alternate_diagnosis",
      "met": false
    },
    {
      "factor": "rejected_resolved_le_4_days_antibiotics",
      "met": false
    },
    {
      "factor": "rejected_no_pathology_le_4_days_antibiotics",
      "met": false
    },
    {
      "factor": "clinical_definite",
      "met": true
    },
    {
      "factor": "rejected",
      "met": false
    }
  ],
  "major_count": 2,
  "minor_count": 0,
  "classification": "definite",
  "definite": true,
  "pathologic_definite": false,
  "possible": false
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• Duke — Apply the Durack 1994 original Duke criteria for infective endocarditis and return definite, possible, or rejected from caller-assigned pathologic, major, minor, and rejected flags.
• IE mortality — Compute the Park 2016 ICE simplified risk score for 6-month mortality in infective endocarditis from age and caller-assigned Table 5 flags, and return the score, quadratic 6-month mortality percent, and whether score >= 8.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.