Neurology · LIVE

ESUS

Apply the Hart 2014 ESUS construct (Panel 2 criteria plus Panel 3 minimum diagnostic assessment) and return whether caller-assigned flags meet embolic stroke of undetermined source.

LIVE $0.005 USDC GET /api/calc/esus

Markdown: /docs/esus.md · Canonical: https://magentlab.com/docs/esus

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply the Hart 2014 ESUS construct (Panel 2 criteria plus Panel 3 minimum diagnostic assessment) and return whether caller-assigned flags meet embolic stroke of undetermined source.

When to use

When an agent has caller-assigned imaging and workup flags after ischaemic stroke and needs the Hart 2014 ESUS construct, not TOAST cryptogenic stroke and not an anticoagulation recommendation.

When not to use

• Not a medical device. Not a stroke diagnosis. magent does not read imaging or examine the patient.
• This tool is the Hart 2014 ESUS construct only (Panel 2 plus Panel 3 minimum diagnostic assessment). It is not TOAST cryptogenic stroke, which includes incomplete workup and multiple causes.
• Incomplete workup (minimum_workup false) means the construct is not met (esus false). It is not an HTTP 400.
• Not a recommendation for anticoagulation. Later NAVIGATE ESUS and RESPECT ESUS trials did not show a uniform DOAC benefit; those trials are not the formula.
• The caller assigns all five booleans. magent does not enumerate each major-risk cardioembolic source as a separate required param and does not classify infarct size from raw imaging.

Formula

esus iff non_lacunar_infarct and no_stenosis_ge_50 and no_major_risk_cardioembolic and no_other_specific_cause and minimum_workup (Hart 2014 Panel 2 + Panel 3)

Citation

Title

Embolic strokes of undetermined source: the case for a new clinical construct

Authors

Hart RG, Diener HC, Coutts SB, Easton JD, Granger CB, O'Donnell MJ, Sacco RL, Connolly SJ, Cryptogenic Stroke/ESUS International Working Group

Source

Lancet Neurol. 2014;13(4):429-438

DOI

10.1016/S1474-4422(13)70310-7

Worked example

Also searched as

• embolic stroke of undetermined source
• ESUS Hart 2014
• cryptogenic embolic stroke
• Hart ESUS construct
• non-lacunar cryptogenic stroke
• ESUS diagnostic criteria
• Panel 2 ESUS

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/esus?non_lacunar_infarct=true&no_stenosis_ge_50=true&no_major_risk_cardioembolic=true&no_other_specific_cause=true&minimum_workup=true

Full URL: https://api.magentlab.com/api/calc/esus?non_lacunar_infarct=true&no_stenosis_ge_50=true&no_major_risk_cardioembolic=true&no_other_specific_cause=true&minimum_workup=true

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/esus?non_lacunar_infarct=true&no_stenosis_ge_50=true&no_major_risk_cardioembolic=true&no_other_specific_cause=true&minimum_workup=true"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/esus Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "minimum_workup": "true",
      "no_major_risk_cardioembolic": "true",
      "no_other_specific_cause": "true",
      "no_stenosis_ge_50": "true",
      "non_lacunar_infarct": "true"
    },
    {
      "minimum_workup": "true",
      "no_major_risk_cardioembolic": "true",
      "no_other_specific_cause": "true",
      "no_stenosis_ge_50": "true",
      "non_lacunar_infarct": "true"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/esus",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Hart RG, Diener HC, Coutts SB, Easton JD, Granger CB, O'Donnell MJ, Sacco RL, Connolly SJ, Cryptogenic Stroke/ESUS International Working Group",
        "doi": "10.1016/S1474-4422(13)70310-7",
        "id": "hart-2014",
        "pmid": "24646875",
        "source": "Lancet Neurol. 2014;13(4):429-438",
        "title": "Embolic strokes of undetermined source: the case for a new clinical construct"
      },
      "formula": "esus",
      "formula_expression": "esus iff non_lacunar_infarct and no_stenosis_ge_50 and no_major_risk_cardioembolic and no_other_specific_cause and minimum_workup (Hart 2014 Panel 2 + Panel 3)",
      "criteria": [
        {
          "factor": "non_lacunar_infarct",
          "met": true
        },
        {
          "factor": "no_stenosis_ge_50",
          "met": true
        },
        {
          "factor": "no_major_risk_cardioembolic",
          "met": true
        },
        {
          "factor": "no_other_specific_cause",
          "met": true
        },
        {
          "factor": "minimum_workup",
          "met": true
        }
      ],
      "esus": true
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Hart RG, Diener HC, Coutts SB, Easton JD, Granger CB, O'Donnell MJ, Sacco RL, Connolly SJ, Cryptogenic Stroke/ESUS International Working Group",
        "doi": "10.1016/S1474-4422(13)70310-7",
        "id": "hart-2014",
        "pmid": "24646875",
        "source": "Lancet Neurol. 2014;13(4):429-438",
        "title": "Embolic strokes of undetermined source: the case for a new clinical construct"
      },
      "formula": "esus",
      "formula_expression": "esus iff non_lacunar_infarct and no_stenosis_ge_50 and no_major_risk_cardioembolic and no_other_specific_cause and minimum_workup (Hart 2014 Panel 2 + Panel 3)",
      "criteria": [
        {
          "factor": "non_lacunar_infarct",
          "met": true
        },
        {
          "factor": "no_stenosis_ge_50",
          "met": true
        },
        {
          "factor": "no_major_risk_cardioembolic",
          "met": true
        },
        {
          "factor": "no_other_specific_cause",
          "met": true
        },
        {
          "factor": "minimum_workup",
          "met": true
        }
      ],
      "esus": true
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Hart RG, Diener HC, Coutts SB, Easton JD, Granger CB, O'Donnell MJ, Sacco RL, Connolly SJ, Cryptogenic Stroke/ESUS International Working Group",
    "doi": "10.1016/S1474-4422(13)70310-7",
    "id": "hart-2014",
    "pmid": "24646875",
    "source": "Lancet Neurol. 2014;13(4):429-438",
    "title": "Embolic strokes of undetermined source: the case for a new clinical construct"
  },
  "formula": "esus",
  "formula_expression": "esus iff non_lacunar_infarct and no_stenosis_ge_50 and no_major_risk_cardioembolic and no_other_specific_cause and minimum_workup (Hart 2014 Panel 2 + Panel 3)",
  "criteria": [
    {
      "factor": "non_lacunar_infarct",
      "met": true
    },
    {
      "factor": "no_stenosis_ge_50",
      "met": true
    },
    {
      "factor": "no_major_risk_cardioembolic",
      "met": true
    },
    {
      "factor": "no_other_specific_cause",
      "met": true
    },
    {
      "factor": "minimum_workup",
      "met": true
    }
  ],
  "esus": true
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• CHA2DS2-VASc — Compute the CHA2DS2-VASc stroke-risk score from discrete clinical flags.
• HAS-BLED — Compute the HAS-BLED bleeding-risk score from discrete clinical flags.
• Canadian TIA Score — Compute the Perry 2021 Canadian TIA Score from caller-assigned clinical findings and investigations for subsequent 7-day stroke or carotid revascularization risk after TIA.
• ABCD2 score — Compute the ABCD2 score as age, blood pressure, caller-assigned clinical features, symptom duration, and diabetes.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.