Hemodynamics · LIVE

Grogan 2016 ATTRwt staging

Grogan

Apply the Grogan 2016 two-biomarker staging system for wild-type transthyretin (ATTRwt) cardiac amyloidosis from NT-proBNP and cardiac troponin T.

LIVE $0.005 USDC GET /api/calc/grogan

Markdown: /docs/grogan.md · Canonical: https://magentlab.com/docs/grogan

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply the Grogan 2016 two-biomarker staging system for wild-type transthyretin (ATTRwt) cardiac amyloidosis from NT-proBNP and cardiac troponin T.

When to use

When an agent has caller-supplied NT-proBNP (ng/L) and cardiac troponin T (ng/mL) and needs the published Grogan 2016 ATTRwt stage. Not Gillmore 2018 NAC ATTR staging. Not Mayo AL amyloid staging. Not NYHA. magent does not assay the biomarkers and does not invent a troponin I cutoff.

When not to use

• Not a medical device. magent does not examine the patient and does not assay NT-proBNP or troponin T.
• This is Grogan 2016 wild-type ATTR (ATTRwt) staging only. It is not Gillmore 2018 NAC ATTR staging (no eGFR). It is not Mayo AL amyloid staging. It is not NYHA class.
• Troponin T only (cTnT > 0.05 ng/mL, same as 0.05 μg/L). magent does not invent a troponin I cutoff.
• 4-year OS figures (stage I 57%, II 42%, III 18%) and stage III median survival 20 months are published Grogan 2016 cohort labels, not a patient-specific prediction.
• Not a treatment order. This tool does not recommend tafamidis or any other therapy.

Formula

Grogan = (nt_probnp_ng_l > 3000) + (troponin_t_ng_ml > 0.05); each 1; Grogan 2016 ATTRwt; stage I = 0, II = 1, III = 2; equal to a cutoff does not add a point

Citation

Title

Natural History of Wild-Type Transthyretin Cardiac Amyloidosis and Risk Stratification Using a Novel Staging System

Authors

Grogan M, Scott CG, Kyle RA, Zeldenrust SR, Gertz MA, Lin G, Klarich KW, Miller WL, Maleszewski JJ, Dispenzieri A

Source

J Am Coll Cardiol. 2016;68(10):1014-1020

DOI

10.1016/j.jacc.2016.06.033

Worked example

Also searched as

• Grogan staging
• ATTRwt staging
• wild-type transthyretin amyloidosis stage
• Grogan 2016
• NT-proBNP troponin T ATTR
• wild-type ATTR cardiac stage
• ATTRwt-CM staging
• cTnT NT-proBNP ATTR

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/grogan?nt_probnp_ng_l=1500&troponin_t_ng_ml=0.02

Full URL: https://api.magentlab.com/api/calc/grogan?nt_probnp_ng_l=1500&troponin_t_ng_ml=0.02

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/grogan?nt_probnp_ng_l=1500&troponin_t_ng_ml=0.02"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/grogan Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "nt_probnp_ng_l": "1500",
      "troponin_t_ng_ml": "0.02"
    },
    {
      "nt_probnp_ng_l": "1500",
      "troponin_t_ng_ml": "0.02"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/grogan",
  "items": [
    {
      "components": [
        {
          "value": 1.5e3,
          "factor": "nt_probnp_gt_3000",
          "points": 0,
          "present": false
        },
        {
          "value": 0.02,
          "factor": "troponin_t_gt_0_05",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Grogan M, Scott CG, Kyle RA, Zeldenrust SR, Gertz MA, Lin G, Klarich KW, Miller WL, Maleszewski JJ, Dispenzieri A",
        "doi": "10.1016/j.jacc.2016.06.033",
        "id": "grogan-2016",
        "pmid": "27585505",
        "source": "J Am Coll Cardiol. 2016;68(10):1014-1020",
        "title": "Natural History of Wild-Type Transthyretin Cardiac Amyloidosis and Risk Stratification Using a Novel Staging System"
      },
      "formula": "grogan",
      "formula_expression": "Grogan = (nt_probnp_ng_l > 3000) + (troponin_t_ng_ml > 0.05); each 1; Grogan 2016 ATTRwt; stage I = 0, II = 1, III = 2; equal to a cutoff does not add a point",
      "max_score": 2,
      "score": 0,
      "nt_probnp_ng_l": 1.5e3,
      "grogan_stage": "I",
      "published_os_4_year_percent": 57,
      "troponin_t_ng_ml": 0.02
    },
    {
      "components": [
        {
          "value": 1.5e3,
          "factor": "nt_probnp_gt_3000",
          "points": 0,
          "present": false
        },
        {
          "value": 0.02,
          "factor": "troponin_t_gt_0_05",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Grogan M, Scott CG, Kyle RA, Zeldenrust SR, Gertz MA, Lin G, Klarich KW, Miller WL, Maleszewski JJ, Dispenzieri A",
        "doi": "10.1016/j.jacc.2016.06.033",
        "id": "grogan-2016",
        "pmid": "27585505",
        "source": "J Am Coll Cardiol. 2016;68(10):1014-1020",
        "title": "Natural History of Wild-Type Transthyretin Cardiac Amyloidosis and Risk Stratification Using a Novel Staging System"
      },
      "formula": "grogan",
      "formula_expression": "Grogan = (nt_probnp_ng_l > 3000) + (troponin_t_ng_ml > 0.05); each 1; Grogan 2016 ATTRwt; stage I = 0, II = 1, III = 2; equal to a cutoff does not add a point",
      "max_score": 2,
      "score": 0,
      "nt_probnp_ng_l": 1.5e3,
      "grogan_stage": "I",
      "published_os_4_year_percent": 57,
      "troponin_t_ng_ml": 0.02
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": 1.5e3,
      "factor": "nt_probnp_gt_3000",
      "points": 0,
      "present": false
    },
    {
      "value": 0.02,
      "factor": "troponin_t_gt_0_05",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Grogan M, Scott CG, Kyle RA, Zeldenrust SR, Gertz MA, Lin G, Klarich KW, Miller WL, Maleszewski JJ, Dispenzieri A",
    "doi": "10.1016/j.jacc.2016.06.033",
    "id": "grogan-2016",
    "pmid": "27585505",
    "source": "J Am Coll Cardiol. 2016;68(10):1014-1020",
    "title": "Natural History of Wild-Type Transthyretin Cardiac Amyloidosis and Risk Stratification Using a Novel Staging System"
  },
  "formula": "grogan",
  "formula_expression": "Grogan = (nt_probnp_ng_l > 3000) + (troponin_t_ng_ml > 0.05); each 1; Grogan 2016 ATTRwt; stage I = 0, II = 1, III = 2; equal to a cutoff does not add a point",
  "max_score": 2,
  "score": 0,
  "nt_probnp_ng_l": 1.5e3,
  "grogan_stage": "I",
  "published_os_4_year_percent": 57,
  "troponin_t_ng_ml": 0.02
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• Gillmore — Apply the Gillmore 2018 National Amyloidosis Centre (NAC) three-stage system for cardiac transthyretin amyloidosis from NT-proBNP and caller-assigned eGFR.
• MAGGIC — Sum the Pocock 2013 MAGGIC integer chart from thirteen caller-supplied heart-failure predictors and return the published Table 4 1-year and 3-year death probabilities for scores 0-50.
• NYHA — Return the 1994 NYHA functional capacity class 1-4 from a caller-assigned integer, with the published class description.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.