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Index of Severity for Eosinophilic Esophagitis

I-SEE

Sum Dellon 2022 Table I I-SEE items (symptoms, food impaction, stacking complications, inflammatory endoscopy and peak eos, fibrostenotic endoscopy and histologic fibrosis) and return the point total (max 78) and published band (inactive, mild, moderate, or severe). Not a diagnosis of EoE and not EREFS.

LIVE $0.005 USDC GET /api/calc/i_see

Markdown: /docs/i-see.md · Canonical: https://magentlab.com/docs/i-see

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum Dellon 2022 Table I I-SEE items (symptoms, food impaction, stacking complications, inflammatory endoscopy and peak eos, fibrostenotic endoscopy and histologic fibrosis) and return the point total (max 78) and published band (inactive, mild, moderate, or severe). Not a diagnosis of EoE and not EREFS.

When to use

When an agent has already assigned Dellon 2022 Table I symptoms, complications, inflammatory findings, and fibrostenotic findings and needs the published I-SEE total and band, not a diagnosis of EoE and not EREFS.

When not to use

• Not a medical device and not a diagnosis of eosinophilic esophagitis or a treatment order.
• Each item is a caller-assigned Dellon 2022 Table I token. magent does not perform endoscopy or count eosinophils. magent does not assign age; the caller maps age into food_impaction and fibro_endoscopy tokens.
• Not EREFS. I-SEE is a clinical severity index (symptoms, complications, inflammatory findings, and fibrostenotic findings), not the Hirano 2013 endoscopic reference score.
• For boxes with more than one element, each selected feature gets points (complications stack). Other rows are exclusive. Bands follow Dellon 2022 Table I only: <1 inactive, 1–6 mild, 7–14 moderate, ≥15 severe.

Formula

I-SEE = symptoms (none 0, weekly 1, daily 2, multiple_or_social 4) + food_impaction (none 0, adult_ge_18 2, child_lt_18 4) + hospitalization_eoe 4 + esophageal_perforation 15 + malnutrition 15 + persistent_inflammation 15 + inflam_endoscopy (none 0, localized 1, diffuse 2) + peak_eos (lt_15 0, 15_60 1, gt_60 2) + fibro_endoscopy (none 0, passes_easily 1, dilation_or_snug 2, cannot_pass_or_repeated 15) + histologic_fibrosis 2; Dellon 2022 Table I; complications stack (each selected feature gets points); exclusive within other rows; bands <1 inactive, 1-6 mild, 7-14 moderate, ≥15 severe; max 78; not EREFS

Citation

Title

A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions

Authors

Dellon ES, Khoury P, Muir AB, Liacouras CA, Safroneeva E, Atkins D, Collins MH, Gonsalves N, Falk GW, Spergel JM, Schoepfer AM, Menard-Katcher C, Furuta GT, Aceves S

Source

J Allergy Clin Immunol. 2022;150(1):33-47

DOI

10.1016/j.jaci.2022.03.015

Worked example

Also searched as

• I-SEE
• Index of Severity for Eosinophilic Esophagitis
• EoE severity index
• Dellon I-SEE
• eosinophilic esophagitis severity
• I SEE score
• Dellon 2022 I-SEE
• EoE clinical severity index

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/i_see?symptoms=daily&food_impaction=none&hospitalization_eoe=false&esophageal_perforation=false&malnutrition=false&persistent_inflammation=false&inflam_endoscopy=localized&peak_eos=15_60&fibro_endoscopy=none&histologic_fibrosis=false

Full URL: https://api.magentlab.com/api/calc/i_see?symptoms=daily&food_impaction=none&hospitalization_eoe=false&esophageal_perforation=false&malnutrition=false&persistent_inflammation=false&inflam_endoscopy=localized&peak_eos=15_60&fibro_endoscopy=none&histologic_fibrosis=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/i_see?symptoms=daily&food_impaction=none&hospitalization_eoe=false&esophageal_perforation=false&malnutrition=false&persistent_inflammation=false&inflam_endoscopy=localized&peak_eos=15_60&fibro_endoscopy=none&histologic_fibrosis=false"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/i_see Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "esophageal_perforation": "false",
      "fibro_endoscopy": "none",
      "food_impaction": "none",
      "histologic_fibrosis": "false",
      "hospitalization_eoe": "false",
      "inflam_endoscopy": "localized",
      "malnutrition": "false",
      "peak_eos": "15_60",
      "persistent_inflammation": "false",
      "symptoms": "daily"
    },
    {
      "esophageal_perforation": "false",
      "fibro_endoscopy": "none",
      "food_impaction": "none",
      "histologic_fibrosis": "false",
      "hospitalization_eoe": "false",
      "inflam_endoscopy": "localized",
      "malnutrition": "false",
      "peak_eos": "15_60",
      "persistent_inflammation": "false",
      "symptoms": "daily"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/i_see",
  "items": [
    {
      "components": [
        {
          "value": "daily",
          "factor": "symptoms",
          "points": 2,
          "present": true
        },
        {
          "value": "none",
          "factor": "food_impaction",
          "points": 0,
          "present": true
        },
        {
          "factor": "hospitalization_eoe",
          "points": 0,
          "present": false
        },
        {
          "factor": "esophageal_perforation",
          "points": 0,
          "present": false
        },
        {
          "factor": "malnutrition",
          "points": 0,
          "present": false
        },
        {
          "factor": "persistent_inflammation",
          "points": 0,
          "present": false
        },
        {
          "value": "localized",
          "factor": "inflam_endoscopy",
          "points": 1,
          "present": true
        },
        {
          "value": "15_60",
          "factor": "peak_eos",
          "points": 1,
          "present": true
        },
        {
          "value": "none",
          "factor": "fibro_endoscopy",
          "points": 0,
          "present": true
        },
        {
          "factor": "histologic_fibrosis",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Dellon ES, Khoury P, Muir AB, Liacouras CA, Safroneeva E, Atkins D, Collins MH, Gonsalves N, Falk GW, Spergel JM, Schoepfer AM, Menard-Katcher C, Furuta GT, Aceves S",
        "doi": "10.1016/j.jaci.2022.03.015",
        "id": "dellon-2022",
        "pmid": "35606166",
        "source": "J Allergy Clin Immunol. 2022;150(1):33-47",
        "title": "A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions"
      },
      "formula": "i_see",
      "formula_expression": "I-SEE = symptoms (none 0, weekly 1, daily 2, multiple_or_social 4) + food_impaction (none 0, adult_ge_18 2, child_lt_18 4) + hospitalization_eoe 4 + esophageal_perforation 15 + malnutrition 15 + persistent_inflammation 15 + inflam_endoscopy (none 0, localized 1, diffuse 2) + peak_eos (lt_15 0, 15_60 1, gt_60 2) + fibro_endoscopy (none 0, passes_easily 1, dilation_or_snug 2, cannot_pass_or_repeated 15) + histologic_fibrosis 2; Dellon 2022 Table I; complications stack (each selected feature gets points); exclusive within other rows; bands <1 inactive, 1-6 mild, 7-14 moderate, ≥15 severe; max 78; not EREFS",
      "max_score": 78,
      "score": 4,
      "esophageal_perforation": false,
      "fibro_endoscopy": "none",
      "food_impaction": "none",
      "histologic_fibrosis": false,
      "hospitalization_eoe": false,
      "inflam_endoscopy": "localized",
      "isee_band": "mild",
      "malnutrition": false,
      "peak_eos": "15_60",
      "persistent_inflammation": false,
      "symptoms": "daily"
    },
    {
      "components": [
        {
          "value": "daily",
          "factor": "symptoms",
          "points": 2,
          "present": true
        },
        {
          "value": "none",
          "factor": "food_impaction",
          "points": 0,
          "present": true
        },
        {
          "factor": "hospitalization_eoe",
          "points": 0,
          "present": false
        },
        {
          "factor": "esophageal_perforation",
          "points": 0,
          "present": false
        },
        {
          "factor": "malnutrition",
          "points": 0,
          "present": false
        },
        {
          "factor": "persistent_inflammation",
          "points": 0,
          "present": false
        },
        {
          "value": "localized",
          "factor": "inflam_endoscopy",
          "points": 1,
          "present": true
        },
        {
          "value": "15_60",
          "factor": "peak_eos",
          "points": 1,
          "present": true
        },
        {
          "value": "none",
          "factor": "fibro_endoscopy",
          "points": 0,
          "present": true
        },
        {
          "factor": "histologic_fibrosis",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Dellon ES, Khoury P, Muir AB, Liacouras CA, Safroneeva E, Atkins D, Collins MH, Gonsalves N, Falk GW, Spergel JM, Schoepfer AM, Menard-Katcher C, Furuta GT, Aceves S",
        "doi": "10.1016/j.jaci.2022.03.015",
        "id": "dellon-2022",
        "pmid": "35606166",
        "source": "J Allergy Clin Immunol. 2022;150(1):33-47",
        "title": "A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions"
      },
      "formula": "i_see",
      "formula_expression": "I-SEE = symptoms (none 0, weekly 1, daily 2, multiple_or_social 4) + food_impaction (none 0, adult_ge_18 2, child_lt_18 4) + hospitalization_eoe 4 + esophageal_perforation 15 + malnutrition 15 + persistent_inflammation 15 + inflam_endoscopy (none 0, localized 1, diffuse 2) + peak_eos (lt_15 0, 15_60 1, gt_60 2) + fibro_endoscopy (none 0, passes_easily 1, dilation_or_snug 2, cannot_pass_or_repeated 15) + histologic_fibrosis 2; Dellon 2022 Table I; complications stack (each selected feature gets points); exclusive within other rows; bands <1 inactive, 1-6 mild, 7-14 moderate, ≥15 severe; max 78; not EREFS",
      "max_score": 78,
      "score": 4,
      "esophageal_perforation": false,
      "fibro_endoscopy": "none",
      "food_impaction": "none",
      "histologic_fibrosis": false,
      "hospitalization_eoe": false,
      "inflam_endoscopy": "localized",
      "isee_band": "mild",
      "malnutrition": false,
      "peak_eos": "15_60",
      "persistent_inflammation": false,
      "symptoms": "daily"
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": "daily",
      "factor": "symptoms",
      "points": 2,
      "present": true
    },
    {
      "value": "none",
      "factor": "food_impaction",
      "points": 0,
      "present": true
    },
    {
      "factor": "hospitalization_eoe",
      "points": 0,
      "present": false
    },
    {
      "factor": "esophageal_perforation",
      "points": 0,
      "present": false
    },
    {
      "factor": "malnutrition",
      "points": 0,
      "present": false
    },
    {
      "factor": "persistent_inflammation",
      "points": 0,
      "present": false
    },
    {
      "value": "localized",
      "factor": "inflam_endoscopy",
      "points": 1,
      "present": true
    },
    {
      "value": "15_60",
      "factor": "peak_eos",
      "points": 1,
      "present": true
    },
    {
      "value": "none",
      "factor": "fibro_endoscopy",
      "points": 0,
      "present": true
    },
    {
      "factor": "histologic_fibrosis",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Dellon ES, Khoury P, Muir AB, Liacouras CA, Safroneeva E, Atkins D, Collins MH, Gonsalves N, Falk GW, Spergel JM, Schoepfer AM, Menard-Katcher C, Furuta GT, Aceves S",
    "doi": "10.1016/j.jaci.2022.03.015",
    "id": "dellon-2022",
    "pmid": "35606166",
    "source": "J Allergy Clin Immunol. 2022;150(1):33-47",
    "title": "A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions"
  },
  "formula": "i_see",
  "formula_expression": "I-SEE = symptoms (none 0, weekly 1, daily 2, multiple_or_social 4) + food_impaction (none 0, adult_ge_18 2, child_lt_18 4) + hospitalization_eoe 4 + esophageal_perforation 15 + malnutrition 15 + persistent_inflammation 15 + inflam_endoscopy (none 0, localized 1, diffuse 2) + peak_eos (lt_15 0, 15_60 1, gt_60 2) + fibro_endoscopy (none 0, passes_easily 1, dilation_or_snug 2, cannot_pass_or_repeated 15) + histologic_fibrosis 2; Dellon 2022 Table I; complications stack (each selected feature gets points); exclusive within other rows; bands <1 inactive, 1-6 mild, 7-14 moderate, ≥15 severe; max 78; not EREFS",
  "max_score": 78,
  "score": 4,
  "esophageal_perforation": false,
  "fibro_endoscopy": "none",
  "food_impaction": "none",
  "histologic_fibrosis": false,
  "hospitalization_eoe": false,
  "inflam_endoscopy": "localized",
  "isee_band": "mild",
  "malnutrition": false,
  "peak_eos": "15_60",
  "persistent_inflammation": false,
  "symptoms": "daily"
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• EREFS — Sum five caller-assigned Hirano 2013 modified EREFS descriptors (edema 0-1, rings 0-3, exudates 0-2, furrows 0-1 after collapsing original 0-2, stricture 0-1) and return the total (max 8). Does not return activity bands, inflammatory or fibrostenotic subscores, or later 0-9 furrows 0-2 expansions.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.