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ICC 2022 systemic mastocytosis criteria

ICC 2022 SM criteria

Apply the Arber 2022 International Consensus Classification systemic mastocytosis criteria and return whether the published combination of the major criterion alone, or at least three minors, is met. Tryptase >20 ng/mL does not count when an associated myeloid neoplasm (SM-AMN) is present.

LIVE $0.005 USDC GET /api/calc/icc_sm

Markdown: /docs/icc-sm.md · Canonical: https://magentlab.com/docs/icc-sm

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply the Arber 2022 International Consensus Classification systemic mastocytosis criteria and return whether the published combination of the major criterion alone, or at least three minors, is met. Tryptase >20 ng/mL does not count when an associated myeloid neoplasm (SM-AMN) is present.

When to use

When an agent already has caller-assigned ICC 2022 SM major and minor flags and needs the published criteria result. magent does not diagnose systemic mastocytosis, does not read a biopsy, and does not assay tryptase.

When not to use

• Not a medical device.
• Not a diagnosis. Criteria met is not a systemic mastocytosis diagnosis without the rest of the ICC 2022 workup.
• Not Valent 2016 WHO SM. ICC major infiltrates alone is enough; WHO 2016 required major plus at least one minor, or at least three minors.
• Not WHO 5th edition / Khoury 2022 classification.
• Not cutaneous mastocytosis only. This tool is ICC 2022 systemic mastocytosis only.
• magent does not read a biopsy or assay tryptase. All flags are caller-assigned.
• ICC names the associated disease SM-AMN (systemic mastocytosis with an associated myeloid neoplasm). When associated_myeloid_neoplasm is true, tryptase_gt_20 does not count as a minor.

Formula

diagnosed iff major_infiltrates or minor_count ≥ 3; minor_count counts atypical_or_spindle, kit_activating, cd2_cd25_or_cd30, and tryptase_gt_20 only when associated_myeloid_neoplasm is false (Arber 2022 ICC SM). Not a diagnosis. Not Valent 2016 WHO SM. Not cutaneous mastocytosis only

Citation

Title

International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data

Authors

Arber DA, Orazi A, Hasserjian RP, Borowitz MJ, Calvo KR, Kvasnicka HM, Wang SA, Bagg A, Barbui T, Bennett JM, de la Fuente J, et al.

Source

Blood. 2022;140(11):1200-1228

DOI

10.1182/blood.2022015850

Worked example

Also searched as

• ICC 2022 systemic mastocytosis
• SM diagnostic criteria ICC
• KIT activating mutation mastocytosis
• Arber 2022 myeloid neoplasms
• CD30 mast cells ICC
• serum tryptase SM-AMN
• ICC SM major minor criteria
• spindle atypical mast cells

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/icc_sm?major_infiltrates=true&atypical_or_spindle=false&kit_activating=false&cd2_cd25_or_cd30=false&tryptase_gt_20=false&associated_myeloid_neoplasm=false

Full URL: https://api.magentlab.com/api/calc/icc_sm?major_infiltrates=true&atypical_or_spindle=false&kit_activating=false&cd2_cd25_or_cd30=false&tryptase_gt_20=false&associated_myeloid_neoplasm=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/icc_sm?major_infiltrates=true&atypical_or_spindle=false&kit_activating=false&cd2_cd25_or_cd30=false&tryptase_gt_20=false&associated_myeloid_neoplasm=false"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/icc_sm Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "associated_myeloid_neoplasm": "false",
      "atypical_or_spindle": "false",
      "cd2_cd25_or_cd30": "false",
      "kit_activating": "false",
      "major_infiltrates": "true",
      "tryptase_gt_20": "false"
    },
    {
      "associated_myeloid_neoplasm": "false",
      "atypical_or_spindle": "false",
      "cd2_cd25_or_cd30": "false",
      "kit_activating": "false",
      "major_infiltrates": "true",
      "tryptase_gt_20": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/icc_sm",
  "items": [
    {
      "major": true,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Arber DA, Orazi A, Hasserjian RP, Borowitz MJ, Calvo KR, Kvasnicka HM, Wang SA, Bagg A, Barbui T, Bennett JM, de la Fuente J, et al.",
        "doi": "10.1182/blood.2022015850",
        "id": "arber-2022",
        "pmid": "35767897",
        "source": "Blood. 2022;140(11):1200-1228",
        "title": "International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data"
      },
      "formula": "icc_sm",
      "formula_expression": "diagnosed iff major_infiltrates or minor_count ≥ 3; minor_count counts atypical_or_spindle, kit_activating, cd2_cd25_or_cd30, and tryptase_gt_20 only when associated_myeloid_neoplasm is false (Arber 2022 ICC SM). Not a diagnosis. Not Valent 2016 WHO SM. Not cutaneous mastocytosis only",
      "criteria": [
        {
          "factor": "major",
          "met": true
        },
        {
          "factor": "atypical_or_spindle",
          "met": false
        },
        {
          "factor": "kit_activating",
          "met": false
        },
        {
          "factor": "cd2_cd25_or_cd30",
          "met": false
        },
        {
          "factor": "tryptase_counts",
          "met": false
        },
        {
          "factor": "associated_myeloid_neoplasm",
          "met": false
        },
        {
          "factor": "minor_count_ge_3",
          "met": false
        }
      ],
      "minor_count": 0,
      "associated_myeloid_neoplasm": false,
      "atypical_or_spindle": false,
      "cd2_cd25_or_cd30": false,
      "diagnosed": true,
      "kit_activating": false,
      "major_infiltrates": true,
      "tryptase_counts": false,
      "tryptase_gt_20": false
    },
    {
      "major": true,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Arber DA, Orazi A, Hasserjian RP, Borowitz MJ, Calvo KR, Kvasnicka HM, Wang SA, Bagg A, Barbui T, Bennett JM, de la Fuente J, et al.",
        "doi": "10.1182/blood.2022015850",
        "id": "arber-2022",
        "pmid": "35767897",
        "source": "Blood. 2022;140(11):1200-1228",
        "title": "International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data"
      },
      "formula": "icc_sm",
      "formula_expression": "diagnosed iff major_infiltrates or minor_count ≥ 3; minor_count counts atypical_or_spindle, kit_activating, cd2_cd25_or_cd30, and tryptase_gt_20 only when associated_myeloid_neoplasm is false (Arber 2022 ICC SM). Not a diagnosis. Not Valent 2016 WHO SM. Not cutaneous mastocytosis only",
      "criteria": [
        {
          "factor": "major",
          "met": true
        },
        {
          "factor": "atypical_or_spindle",
          "met": false
        },
        {
          "factor": "kit_activating",
          "met": false
        },
        {
          "factor": "cd2_cd25_or_cd30",
          "met": false
        },
        {
          "factor": "tryptase_counts",
          "met": false
        },
        {
          "factor": "associated_myeloid_neoplasm",
          "met": false
        },
        {
          "factor": "minor_count_ge_3",
          "met": false
        }
      ],
      "minor_count": 0,
      "associated_myeloid_neoplasm": false,
      "atypical_or_spindle": false,
      "cd2_cd25_or_cd30": false,
      "diagnosed": true,
      "kit_activating": false,
      "major_infiltrates": true,
      "tryptase_counts": false,
      "tryptase_gt_20": false
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "major": true,
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Arber DA, Orazi A, Hasserjian RP, Borowitz MJ, Calvo KR, Kvasnicka HM, Wang SA, Bagg A, Barbui T, Bennett JM, de la Fuente J, et al.",
    "doi": "10.1182/blood.2022015850",
    "id": "arber-2022",
    "pmid": "35767897",
    "source": "Blood. 2022;140(11):1200-1228",
    "title": "International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data"
  },
  "formula": "icc_sm",
  "formula_expression": "diagnosed iff major_infiltrates or minor_count ≥ 3; minor_count counts atypical_or_spindle, kit_activating, cd2_cd25_or_cd30, and tryptase_gt_20 only when associated_myeloid_neoplasm is false (Arber 2022 ICC SM). Not a diagnosis. Not Valent 2016 WHO SM. Not cutaneous mastocytosis only",
  "criteria": [
    {
      "factor": "major",
      "met": true
    },
    {
      "factor": "atypical_or_spindle",
      "met": false
    },
    {
      "factor": "kit_activating",
      "met": false
    },
    {
      "factor": "cd2_cd25_or_cd30",
      "met": false
    },
    {
      "factor": "tryptase_counts",
      "met": false
    },
    {
      "factor": "associated_myeloid_neoplasm",
      "met": false
    },
    {
      "factor": "minor_count_ge_3",
      "met": false
    }
  ],
  "minor_count": 0,
  "associated_myeloid_neoplasm": false,
  "atypical_or_spindle": false,
  "cd2_cd25_or_cd30": false,
  "diagnosed": true,
  "kit_activating": false,
  "major_infiltrates": true,
  "tryptase_counts": false,
  "tryptase_gt_20": false
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• WHO 2016 SM criteria — Apply the Valent 2016 / WHO 2016 systemic mastocytosis diagnostic criteria (Table 1) and return whether the published combination of the major criterion plus at least one minor, or at least three minors, is met. Tryptase >20 ng/mL does not count when an unrelated myeloid neoplasm is present.
• MARS — Sum the Jawhar 2019 mutation-adjusted risk score (MARS) for advanced systemic mastocytosis and return low (0–1), intermediate (2), or high (3–5).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.