Hematology · LIVE

IOTA Simple Rules

Apply Timmerman 2008 simple ultrasound-based rules from ten caller-assigned M-rule and B-rule flags and return m_count, b_count, and whether the mass classifies as malignant, benign, or inconclusive.

LIVE $0.005 USDC GET /api/calc/iota

Markdown: /docs/iota.md · Canonical: https://magentlab.com/docs/iota

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply Timmerman 2008 simple ultrasound-based rules from ten caller-assigned M-rule and B-rule flags and return m_count, b_count, and whether the mass classifies as malignant, benign, or inconclusive.

When to use

When an agent already has the ten caller-assigned Timmerman 2008 M-rule and B-rule ultrasound flags and needs the published Simple Rules classification. magent does not read ultrasound. Not a diagnosis of ovarian cancer, not RMI, not Swede, and not the later SRRisk logistic model.

When not to use

• Not a medical device.
• Not a diagnosis of ovarian cancer. magent does not diagnose ovarian cancer.
• Timmerman 2008 Simple Rules only. Not the later SRRisk logistic model. Not RMI. Not Swede.
• The caller assigns ten ultrasound flags. magent does not read ultrasound or perform Doppler.
• Rules classify as malignant when one or more M-rules apply and no B-rule applies, and as benign when one or more B-rules apply and no M-rule applies. Otherwise inconclusive. magent does not invent a probability.

Formula

classification malignant iff m_count >= 1 and b_count == 0; benign iff b_count >= 1 and m_count == 0; otherwise inconclusive; m_count counts irregular_solid_tumor, ascites, at_least_four_papillary_structures, irregular_multilocular_solid_ge_100mm, very_high_color_doppler; b_count counts unilocular_cyst, solid_component_lt_7mm, acoustic_shadows, smooth_multilocular_lt_100mm, no_detectable_blood_flow (Timmerman 2008 Simple Rules; not SRRisk)

Citation

Title

Simple ultrasound-based rules for the diagnosis of ovarian cancer.

Authors

Timmerman D, Testa AC, Bourne T, Ameye L, Jurkovic D, Van Holsbeke C, Paladini D, Van Calster B, Vergote I, Van Huffel S, Valentin L

Source

Ultrasound Obstet Gynecol. 2008;31(6):681-690

DOI

10.1002/uog.5365

Worked example

Also searched as

• IOTA Simple Rules
• Timmerman 2008 simple rules
• simple ultrasound-based rules
• ovarian M-rules B-rules
• ovarian ultrasound simple rules
• Timmerman ovarian rules

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/iota?irregular_solid_tumor=false&ascites=true&at_least_four_papillary_structures=false&irregular_multilocular_solid_ge_100mm=false&very_high_color_doppler=false&unilocular_cyst=false&solid_component_lt_7mm=false&acoustic_shadows=false&smooth_multilocular_lt_100mm=false&no_detectable_blood_flow=false

Full URL: https://api.magentlab.com/api/calc/iota?irregular_solid_tumor=false&ascites=true&at_least_four_papillary_structures=false&irregular_multilocular_solid_ge_100mm=false&very_high_color_doppler=false&unilocular_cyst=false&solid_component_lt_7mm=false&acoustic_shadows=false&smooth_multilocular_lt_100mm=false&no_detectable_blood_flow=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/iota?irregular_solid_tumor=false&ascites=true&at_least_four_papillary_structures=false&irregular_multilocular_solid_ge_100mm=false&very_high_color_doppler=false&unilocular_cyst=false&solid_component_lt_7mm=false&acoustic_shadows=false&smooth_multilocular_lt_100mm=false&no_detectable_blood_flow=false"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/iota Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "acoustic_shadows": "false",
      "ascites": "true",
      "at_least_four_papillary_structures": "false",
      "irregular_multilocular_solid_ge_100mm": "false",
      "irregular_solid_tumor": "false",
      "no_detectable_blood_flow": "false",
      "smooth_multilocular_lt_100mm": "false",
      "solid_component_lt_7mm": "false",
      "unilocular_cyst": "false",
      "very_high_color_doppler": "false"
    },
    {
      "acoustic_shadows": "false",
      "ascites": "true",
      "at_least_four_papillary_structures": "false",
      "irregular_multilocular_solid_ge_100mm": "false",
      "irregular_solid_tumor": "false",
      "no_detectable_blood_flow": "false",
      "smooth_multilocular_lt_100mm": "false",
      "solid_component_lt_7mm": "false",
      "unilocular_cyst": "false",
      "very_high_color_doppler": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/iota",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Timmerman D, Testa AC, Bourne T, Ameye L, Jurkovic D, Van Holsbeke C, Paladini D, Van Calster B, Vergote I, Van Huffel S, Valentin L",
        "doi": "10.1002/uog.5365",
        "id": "timmerman-2008",
        "pmid": "18504770",
        "source": "Ultrasound Obstet Gynecol. 2008;31(6):681-690",
        "title": "Simple ultrasound-based rules for the diagnosis of ovarian cancer."
      },
      "formula": "iota",
      "formula_expression": "classification malignant iff m_count >= 1 and b_count == 0; benign iff b_count >= 1 and m_count == 0; otherwise inconclusive; m_count counts irregular_solid_tumor, ascites, at_least_four_papillary_structures, irregular_multilocular_solid_ge_100mm, very_high_color_doppler; b_count counts unilocular_cyst, solid_component_lt_7mm, acoustic_shadows, smooth_multilocular_lt_100mm, no_detectable_blood_flow (Timmerman 2008 Simple Rules; not SRRisk)",
      "criteria": [
        {
          "factor": "irregular_solid_tumor",
          "met": false
        },
        {
          "factor": "ascites",
          "met": true
        },
        {
          "factor": "at_least_four_papillary_structures",
          "met": false
        },
        {
          "factor": "irregular_multilocular_solid_ge_100mm",
          "met": false
        },
        {
          "factor": "very_high_color_doppler",
          "met": false
        },
        {
          "factor": "unilocular_cyst",
          "met": false
        },
        {
          "factor": "solid_component_lt_7mm",
          "met": false
        },
        {
          "factor": "acoustic_shadows",
          "met": false
        },
        {
          "factor": "smooth_multilocular_lt_100mm",
          "met": false
        },
        {
          "factor": "no_detectable_blood_flow",
          "met": false
        }
      ],
      "classification": "malignant",
      "b_count": 0,
      "m_count": 1
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Timmerman D, Testa AC, Bourne T, Ameye L, Jurkovic D, Van Holsbeke C, Paladini D, Van Calster B, Vergote I, Van Huffel S, Valentin L",
        "doi": "10.1002/uog.5365",
        "id": "timmerman-2008",
        "pmid": "18504770",
        "source": "Ultrasound Obstet Gynecol. 2008;31(6):681-690",
        "title": "Simple ultrasound-based rules for the diagnosis of ovarian cancer."
      },
      "formula": "iota",
      "formula_expression": "classification malignant iff m_count >= 1 and b_count == 0; benign iff b_count >= 1 and m_count == 0; otherwise inconclusive; m_count counts irregular_solid_tumor, ascites, at_least_four_papillary_structures, irregular_multilocular_solid_ge_100mm, very_high_color_doppler; b_count counts unilocular_cyst, solid_component_lt_7mm, acoustic_shadows, smooth_multilocular_lt_100mm, no_detectable_blood_flow (Timmerman 2008 Simple Rules; not SRRisk)",
      "criteria": [
        {
          "factor": "irregular_solid_tumor",
          "met": false
        },
        {
          "factor": "ascites",
          "met": true
        },
        {
          "factor": "at_least_four_papillary_structures",
          "met": false
        },
        {
          "factor": "irregular_multilocular_solid_ge_100mm",
          "met": false
        },
        {
          "factor": "very_high_color_doppler",
          "met": false
        },
        {
          "factor": "unilocular_cyst",
          "met": false
        },
        {
          "factor": "solid_component_lt_7mm",
          "met": false
        },
        {
          "factor": "acoustic_shadows",
          "met": false
        },
        {
          "factor": "smooth_multilocular_lt_100mm",
          "met": false
        },
        {
          "factor": "no_detectable_blood_flow",
          "met": false
        }
      ],
      "classification": "malignant",
      "b_count": 0,
      "m_count": 1
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Timmerman D, Testa AC, Bourne T, Ameye L, Jurkovic D, Van Holsbeke C, Paladini D, Van Calster B, Vergote I, Van Huffel S, Valentin L",
    "doi": "10.1002/uog.5365",
    "id": "timmerman-2008",
    "pmid": "18504770",
    "source": "Ultrasound Obstet Gynecol. 2008;31(6):681-690",
    "title": "Simple ultrasound-based rules for the diagnosis of ovarian cancer."
  },
  "formula": "iota",
  "formula_expression": "classification malignant iff m_count >= 1 and b_count == 0; benign iff b_count >= 1 and m_count == 0; otherwise inconclusive; m_count counts irregular_solid_tumor, ascites, at_least_four_papillary_structures, irregular_multilocular_solid_ge_100mm, very_high_color_doppler; b_count counts unilocular_cyst, solid_component_lt_7mm, acoustic_shadows, smooth_multilocular_lt_100mm, no_detectable_blood_flow (Timmerman 2008 Simple Rules; not SRRisk)",
  "criteria": [
    {
      "factor": "irregular_solid_tumor",
      "met": false
    },
    {
      "factor": "ascites",
      "met": true
    },
    {
      "factor": "at_least_four_papillary_structures",
      "met": false
    },
    {
      "factor": "irregular_multilocular_solid_ge_100mm",
      "met": false
    },
    {
      "factor": "very_high_color_doppler",
      "met": false
    },
    {
      "factor": "unilocular_cyst",
      "met": false
    },
    {
      "factor": "solid_component_lt_7mm",
      "met": false
    },
    {
      "factor": "acoustic_shadows",
      "met": false
    },
    {
      "factor": "smooth_multilocular_lt_100mm",
      "met": false
    },
    {
      "factor": "no_detectable_blood_flow",
      "met": false
    }
  ],
  "classification": "malignant",
  "b_count": 0,
  "m_count": 1
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• RMI — Compute the Jacobs 1990 risk of malignancy index as ultrasound score × menopausal score × CA125 (U/ml), then whether that product exceeds the published cutoff of 200.
• Swede score — Sum five caller-assigned Strander 2005 Swede integers (acetowhiteness, margins_surface, vessels, lesion_size, iodine; each 0-2; max 10) and return the published total and <5 / 5-7 / >=8 bands.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.