Infection / VTE · LIVE

Khorana score

Compute the Khorana 2008 Blood predictive model for chemotherapy-associated thrombosis from caller-assigned cancer site, pre-chemotherapy labs, ESA use, and BMI ≥35.

LIVE $0.005 USDC GET /api/calc/khorana

Markdown: /docs/khorana.md · Canonical: https://magentlab.com/docs/khorana

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Compute the Khorana 2008 Blood predictive model for chemotherapy-associated thrombosis from caller-assigned cancer site, pre-chemotherapy labs, ESA use, and BMI ≥35.

When to use

When an agent needs the published Khorana 2008 score (not Padua, Caprini, or a VTE diagnosis) for a patient starting chemotherapy as in the paper.

When not to use

• Not a diagnosis of VTE. magent does not diagnose venous thromboembolism.
• Not Padua or Caprini. This tool is the Khorana 2008 Blood predictive model only.
• magent does not assign cancer site from histology text. Caller must send very_high, high, or other.
• BMI ≥35 is a caller-applied flag; magent does not take height or weight.
• Hemoglobin <10 g/dL or ESA scores 1 once, not twice. Platelets 350 ×10^9/L scores. WBC 11.0 ×10^9/L does not score; >11 does. Score 0 is low, 1–2 intermediate, ≥3 high.

Formula

Khorana = cancer_site (very_high 2, high 1, other 0) + (platelets>=350) + (hemoglobin<10 g/dL or ESA) + (wbc>11 x10^9/L) + (BMI>=35); max 6; 0 low, 1-2 intermediate, >=3 high

Citation

Title

Development and validation of a predictive model for chemotherapy-associated thrombosis

Authors

Khorana AA, Kuderer NM, Culakova E, Lyman GH, Francis CW

Source

Blood. 2008;111(10):4902-4907

DOI

10.1182/blood-2007-10-116327

Worked example

Also searched as

• Khorana score
• Khorana risk score
• chemotherapy-associated thrombosis
• Khorana VTE score
• cancer thrombosis score
• Khorana 2008

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/khorana?cancer_site=other&platelets_10e9_l=200&hemoglobin_g_dl=12&erythropoiesis_stimulating_agent=false&wbc_k_ul=8&bmi_ge_35=false

Full URL: https://api.magentlab.com/api/calc/khorana?cancer_site=other&platelets_10e9_l=200&hemoglobin_g_dl=12&erythropoiesis_stimulating_agent=false&wbc_k_ul=8&bmi_ge_35=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/khorana?cancer_site=other&platelets_10e9_l=200&hemoglobin_g_dl=12&erythropoiesis_stimulating_agent=false&wbc_k_ul=8&bmi_ge_35=false"

Parameters

Bulk (POST)

POST the same path with a JSON items array. Price is n times the GET unit. Invalid items return HTTP 400 before settlement.

POST /api/calc/khorana Max 25 unit_amount * n PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "bmi_ge_35": "false",
      "cancer_site": "other",
      "erythropoiesis_stimulating_agent": "false",
      "hemoglobin_g_dl": "12",
      "platelets_10e9_l": "200",
      "wbc_k_ul": "8"
    },
    {
      "bmi_ge_35": "false",
      "cancer_site": "other",
      "erythropoiesis_stimulating_agent": "false",
      "hemoglobin_g_dl": "12",
      "platelets_10e9_l": "200",
      "wbc_k_ul": "8"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/khorana",
  "items": [
    {
      "components": [
        {
          "value": "other",
          "factor": "cancer_site",
          "points": 0,
          "present": false
        },
        {
          "value": 200.0,
          "factor": "platelets",
          "points": 0,
          "present": false
        },
        {
          "value": {
            "erythropoiesis_stimulating_agent": false,
            "hemoglobin_g_dl": 12.0
          },
          "factor": "hemoglobin_or_esa",
          "points": 0,
          "present": false
        },
        {
          "value": 8.0e3,
          "factor": "wbc",
          "points": 0,
          "present": false
        },
        {
          "factor": "bmi_ge_35",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Khorana AA, Kuderer NM, Culakova E, Lyman GH, Francis CW",
        "doi": "10.1182/blood-2007-10-116327",
        "id": "khorana-2008",
        "source": "Blood. 2008;111(10):4902-4907",
        "title": "Development and validation of a predictive model for chemotherapy-associated thrombosis"
      },
      "formula": "khorana",
      "formula_expression": "Khorana = cancer_site (very_high 2, high 1, other 0) + (platelets>=350) + (hemoglobin<10 g/dL or ESA) + (wbc>11 x10^9/L) + (BMI>=35); max 6; 0 low, 1-2 intermediate, >=3 high",
      "max_score": 6,
      "score": 0,
      "platelets_10e9_l": 200.0,
      "wbc_ul": 8.0e3,
      "erythropoiesis_stimulating_agent": false,
      "hemoglobin_g_dl": 12.0,
      "bmi_ge_35": false,
      "cancer_site": "other",
      "khorana_risk": "low"
    },
    {
      "components": [
        {
          "value": "other",
          "factor": "cancer_site",
          "points": 0,
          "present": false
        },
        {
          "value": 200.0,
          "factor": "platelets",
          "points": 0,
          "present": false
        },
        {
          "value": {
            "erythropoiesis_stimulating_agent": false,
            "hemoglobin_g_dl": 12.0
          },
          "factor": "hemoglobin_or_esa",
          "points": 0,
          "present": false
        },
        {
          "value": 8.0e3,
          "factor": "wbc",
          "points": 0,
          "present": false
        },
        {
          "factor": "bmi_ge_35",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Khorana AA, Kuderer NM, Culakova E, Lyman GH, Francis CW",
        "doi": "10.1182/blood-2007-10-116327",
        "id": "khorana-2008",
        "source": "Blood. 2008;111(10):4902-4907",
        "title": "Development and validation of a predictive model for chemotherapy-associated thrombosis"
      },
      "formula": "khorana",
      "formula_expression": "Khorana = cancer_site (very_high 2, high 1, other 0) + (platelets>=350) + (hemoglobin<10 g/dL or ESA) + (wbc>11 x10^9/L) + (BMI>=35); max 6; 0 low, 1-2 intermediate, >=3 high",
      "max_score": 6,
      "score": 0,
      "platelets_10e9_l": 200.0,
      "wbc_ul": 8.0e3,
      "erythropoiesis_stimulating_agent": false,
      "hemoglobin_g_dl": 12.0,
      "bmi_ge_35": false,
      "cancer_site": "other",
      "khorana_risk": "low"
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": "other",
      "factor": "cancer_site",
      "points": 0,
      "present": false
    },
    {
      "value": 200.0,
      "factor": "platelets",
      "points": 0,
      "present": false
    },
    {
      "value": {
        "erythropoiesis_stimulating_agent": false,
        "hemoglobin_g_dl": 12.0
      },
      "factor": "hemoglobin_or_esa",
      "points": 0,
      "present": false
    },
    {
      "value": 8.0e3,
      "factor": "wbc",
      "points": 0,
      "present": false
    },
    {
      "factor": "bmi_ge_35",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Khorana AA, Kuderer NM, Culakova E, Lyman GH, Francis CW",
    "doi": "10.1182/blood-2007-10-116327",
    "id": "khorana-2008",
    "source": "Blood. 2008;111(10):4902-4907",
    "title": "Development and validation of a predictive model for chemotherapy-associated thrombosis"
  },
  "formula": "khorana",
  "formula_expression": "Khorana = cancer_site (very_high 2, high 1, other 0) + (platelets>=350) + (hemoglobin<10 g/dL or ESA) + (wbc>11 x10^9/L) + (BMI>=35); max 6; 0 low, 1-2 intermediate, >=3 high",
  "max_score": 6,
  "score": 0,
  "platelets_10e9_l": 200.0,
  "wbc_ul": 8.0e3,
  "erythropoiesis_stimulating_agent": false,
  "hemoglobin_g_dl": 12.0,
  "bmi_ge_35": false,
  "cancer_site": "other",
  "khorana_risk": "low"
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• Padua score — Compute the Barbar 2010 Padua Prediction Score for VTE risk in hospitalized medical patients from age and ten caller-assigned findings.
• Wells DVT — Compute the Wells deep-vein thrombosis probability score and return three-tier and two-tier bands.

Payment

Required query parameters must be present and valid. Invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• Invalid query parameters return HTTP 400 before settlement. You are not charged.
• Settlement finishes before the tool executes (paymentFlow upfront). Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.