WEDGE

Maddrey DF

Compute the 1978 Maddrey discriminant function from patient PT, control PT, and bilirubin.

WEDGE $0.005 USDC GET /api/calc/maddrey

Markdown: /docs/maddrey.md · Canonical: https://magentlab.com/docs/maddrey

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Compute the 1978 Maddrey discriminant function from patient PT, control PT, and bilirubin.

When to use

When an agent needs the published 1978 PT-seconds arithmetic and must not substitute INR.

When not to use

• Not a diagnosis or treatment order. magent does not recommend corticosteroids or any other therapy.
• Uses prothrombin time in seconds versus laboratory control, as published in 1978. Does not accept or convert INR.
• Later trials used DF ≥ 32 as a severity cut. That threshold is later-trial context, not a 1978 treatment band, and is not returned here.

Formula

DF = 4.6 * (pt_patient_sec - pt_control_sec) + bilirubin_mg_dl

Citation

Title

Corticosteroid therapy of alcoholic hepatitis

Authors

Maddrey WC, Boitnott JK, Bedine MS, Weber FL Jr, Mezey E, White RI Jr

Source

Gastroenterology. 1978;75(2):193-199

DOI

10.1016/0016-5085(78)90401-8

Worked example

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/maddrey?pt_patient_sec=20&pt_control_sec=12&bilirubin_mg_dl=8

Full URL: https://api.magentlab.com/api/calc/maddrey?pt_patient_sec=20&pt_control_sec=12&bilirubin_mg_dl=8

x402 V2 curl

Expect HTTP 402 and a PAYMENT-REQUIRED header until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge. HTTP 503 after a signature: retry the same PAYMENT-SIGNATURE — that is not a new 402.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/maddrey?pt_patient_sec=20&pt_control_sec=12&bilirubin_mg_dl=8"

Cursor mcp.json

Intended config for @magent/mcp. This is not npm @x402/fetch (a payment fetch wrapper).

{
  "mcpServers": {
    "magent": {
      "args": [
        "-y",
        "@magent/mcp"
      ],
      "command": "npx",
      "env": {
        "X402_PRIVATE_KEY": "0xYOUR_SPENDING_KEY"
      }
    }
  }
}

Parameters

Bulk (POST)

POST the same path with a JSON items array. Price is n times the GET unit. Invalid items return HTTP 400 before settlement.

POST /api/calc/maddrey Max 25 unit_amount * n PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "bilirubin_mg_dl": "8",
      "pt_control_sec": "12",
      "pt_patient_sec": "20"
    },
    {
      "bilirubin_mg_dl": "8",
      "pt_control_sec": "12",
      "pt_patient_sec": "20"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/maddrey",
  "items": [
    {
      "df": 44.8,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Maddrey WC, Boitnott JK, Bedine MS, Weber FL Jr, Mezey E, White RI Jr",
        "doi": "10.1016/0016-5085(78)90401-8",
        "id": "maddrey-1978",
        "source": "Gastroenterology. 1978;75(2):193-199",
        "title": "Corticosteroid therapy of alcoholic hepatitis"
      },
      "formula": "maddrey_1978",
      "formula_expression": "DF = 4.6 * (pt_patient_sec - pt_control_sec) + bilirubin_mg_dl",
      "bilirubin_mg_dl": 8.0,
      "pt_control_sec": 12.0,
      "pt_patient_sec": 20.0
    },
    {
      "df": 44.8,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Maddrey WC, Boitnott JK, Bedine MS, Weber FL Jr, Mezey E, White RI Jr",
        "doi": "10.1016/0016-5085(78)90401-8",
        "id": "maddrey-1978",
        "source": "Gastroenterology. 1978;75(2):193-199",
        "title": "Corticosteroid therapy of alcoholic hepatitis"
      },
      "formula": "maddrey_1978",
      "formula_expression": "DF = 4.6 * (pt_patient_sec - pt_control_sec) + bilirubin_mg_dl",
      "bilirubin_mg_dl": 8.0,
      "pt_control_sec": 12.0,
      "pt_patient_sec": 20.0
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "df": 44.8,
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Maddrey WC, Boitnott JK, Bedine MS, Weber FL Jr, Mezey E, White RI Jr",
    "doi": "10.1016/0016-5085(78)90401-8",
    "id": "maddrey-1978",
    "source": "Gastroenterology. 1978;75(2):193-199",
    "title": "Corticosteroid therapy of alcoholic hepatitis"
  },
  "formula": "maddrey_1978",
  "formula_expression": "DF = 4.6 * (pt_patient_sec - pt_control_sec) + bilirubin_mg_dl",
  "bilirubin_mg_dl": 8.0,
  "pt_control_sec": 12.0,
  "pt_patient_sec": 20.0
}

Errors

Related tools

• MELD-Na — Compute OPTN/UNOS 2016 MELD and MELD-Na from creatinine, bilirubin, INR, sodium, and dialysis.
• FIB-4 — Compute the FIB-4 fibrosis index from age, AST, ALT, and platelets.

Also searched as

• Maddrey DF
• Maddrey's discriminant function
• discriminant function alcoholic hepatitis
• Maddrey score
• PT bilirubin DF

Payment

Required query parameters must be present and valid. Invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments.

Guarantees

• Invalid query parameters return HTTP 400 before settlement. You are not charged.
• Settlement finishes before the tool executes. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are not persisted. Request logs store path without query.