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Maddrey discriminant function (1978)

Maddrey DF

Compute the 1978 Maddrey discriminant function from patient PT, control PT, and bilirubin.

LIVE $0.005 USDC GET /api/calc/maddrey

Markdown: /docs/maddrey.md · Canonical: https://magentlab.com/docs/maddrey

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Compute the 1978 Maddrey discriminant function from patient PT, control PT, and bilirubin.

When to use

When an agent needs the published 1978 PT-seconds arithmetic and must not substitute INR.

When not to use

• Not a diagnosis or treatment order. magent does not recommend corticosteroids or any other therapy.
• Uses prothrombin time in seconds versus laboratory control, as published in 1978. Does not accept or convert INR.
• Later trials used DF ≥ 32 as a severity cut. That threshold is later-trial context, not a 1978 treatment band, and is not returned here.

Formula

DF = 4.6 * (pt_patient_sec - pt_control_sec) + bilirubin_mg_dl

Citation

Title

Corticosteroid therapy of alcoholic hepatitis

Authors

Maddrey WC, Boitnott JK, Bedine MS, Weber FL Jr, Mezey E, White RI Jr

Source

Gastroenterology. 1978;75(2):193-199

DOI

10.1016/0016-5085(78)90401-8

Worked example

Also searched as

• Maddrey DF
• Maddrey's discriminant function
• discriminant function alcoholic hepatitis
• Maddrey score
• PT bilirubin DF

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/maddrey?pt_patient_sec=20&pt_control_sec=12&bilirubin_mg_dl=8

Full URL: https://api.magentlab.com/api/calc/maddrey?pt_patient_sec=20&pt_control_sec=12&bilirubin_mg_dl=8

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/maddrey?pt_patient_sec=20&pt_control_sec=12&bilirubin_mg_dl=8"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/maddrey Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "bilirubin_mg_dl": "8",
      "pt_control_sec": "12",
      "pt_patient_sec": "20"
    },
    {
      "bilirubin_mg_dl": "8",
      "pt_control_sec": "12",
      "pt_patient_sec": "20"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/maddrey",
  "items": [
    {
      "df": 44.8,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Maddrey WC, Boitnott JK, Bedine MS, Weber FL Jr, Mezey E, White RI Jr",
        "doi": "10.1016/0016-5085(78)90401-8",
        "id": "maddrey-1978",
        "source": "Gastroenterology. 1978;75(2):193-199",
        "title": "Corticosteroid therapy of alcoholic hepatitis"
      },
      "formula": "maddrey_1978",
      "formula_expression": "DF = 4.6 * (pt_patient_sec - pt_control_sec) + bilirubin_mg_dl",
      "bilirubin_mg_dl": 8.0,
      "pt_control_sec": 12.0,
      "pt_patient_sec": 20.0
    },
    {
      "df": 44.8,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Maddrey WC, Boitnott JK, Bedine MS, Weber FL Jr, Mezey E, White RI Jr",
        "doi": "10.1016/0016-5085(78)90401-8",
        "id": "maddrey-1978",
        "source": "Gastroenterology. 1978;75(2):193-199",
        "title": "Corticosteroid therapy of alcoholic hepatitis"
      },
      "formula": "maddrey_1978",
      "formula_expression": "DF = 4.6 * (pt_patient_sec - pt_control_sec) + bilirubin_mg_dl",
      "bilirubin_mg_dl": 8.0,
      "pt_control_sec": 12.0,
      "pt_patient_sec": 20.0
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "df": 44.8,
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Maddrey WC, Boitnott JK, Bedine MS, Weber FL Jr, Mezey E, White RI Jr",
    "doi": "10.1016/0016-5085(78)90401-8",
    "id": "maddrey-1978",
    "source": "Gastroenterology. 1978;75(2):193-199",
    "title": "Corticosteroid therapy of alcoholic hepatitis"
  },
  "formula": "maddrey_1978",
  "formula_expression": "DF = 4.6 * (pt_patient_sec - pt_control_sec) + bilirubin_mg_dl",
  "bilirubin_mg_dl": 8.0,
  "pt_control_sec": 12.0,
  "pt_patient_sec": 20.0
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• MELD-Na — Agents must not invent MELD-Na from model memory. This endpoint computes the published OPTN/UNOS 2016 MELD-Na score from creatinine, bilirubin, INR, sodium, and dialysis; pay per request with x402 USDC on Base.
• FIB-4 — Agents must not invent FIB-4 from model memory. This endpoint computes the published Sterling 2006 FIB-4 fibrosis index from age, AST, ALT, and platelets; pay per request with x402 USDC on Base.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.