OSIRIS osteoporosis index of risk

OSIRIS

Compute the Sedrine 2002 Osteoporosis Index of Risk (OSIRIS) as (-0.2 × age) + (0.2 × weight_kg) + 2 if current HRT/estrogen use + (-2) if prior low-impact fracture, rounded to 1 decimal, then the published low, intermediate, or high band.

LIVE $0.005 USDC GET /api/calc/osiris

Markdown: /docs/osiris.md · Canonical: https://magentlab.com/docs/osiris

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

When to use

When an agent has age, weight, current HRT/estrogen use, and prior low-impact fracture history and needs the published Sedrine 2002 OSIRIS index and band, not FRAX, not a DXA order, and not a diagnosis of osteoporosis.

When not to use

Not a medical device. Not a diagnosis of osteoporosis. magent does not examine the patient.
Not FRAX and not a DXA order. magent returns the Sedrine 2002 OSIRIS index and published band only.
Sedrine 2002 derivation was postmenopausal Western European women. That is a limitation, not a race input. magent does not restrict sex or ethnicity at input.

Formula

OSIRIS = (-0.2 * age) + (0.2 * weight_kg) + (2 if current_hrt) + (-2 if prior_low_impact_fracture); low if score > +1; high if score < -3; intermediate otherwise (including exact +1 and exact -3)

Citation

Title: Development and assessment of the Osteoporosis Index of Risk (OSIRIS) to facilitate selection of women for bone densitometry
Authors: Sedrine WB, Chevallier T, Zegels B, Kvasz A, Micheletti MC, Gelas B, Reginster JY
Source: Gynecol Endocrinol. 2002;16(3):245-250
DOI: 10.1080/gye.16.3.245.250

Worked example

55 years, 70 kg, current HRT, no prior low-impact fracture (low)

Given: age=55current_hrt=trueprior_low_impact_fracture=falseweight_kg=70

(-0.2 × 55) + (0.2 × 70) + 2 + 0 = -11.0 + 14.0 + 2.0 = 5.0
round to 1 decimal → 5.0
score 5.0 > +1 → low

65 years, 55 kg, no HRT, no prior low-impact fracture (intermediate)

Given: age=65current_hrt=falseprior_low_impact_fracture=falseweight_kg=55

(-0.2 × 65) + (0.2 × 55) + 0 + 0 = -13.0 + 11.0 = -2.0
score -2.0 is not > +1 and not < -3 → intermediate

75 years, 50 kg, no HRT, prior low-impact fracture (high)

Given: age=75current_hrt=falseprior_low_impact_fracture=trueweight_kg=50

(-0.2 × 75) + (0.2 × 50) + 0 + (-2) = -15.0 + 10.0 - 2.0 = -7.0
score -7.0 < -3 → high

Also searched as

OSIRIS
Osteoporosis Index of Risk
Sedrine OSIRIS
OSIRIS osteoporosis
HRT osteoporosis index
low-impact fracture osteoporosis index
bone densitometry selection
postmenopausal osteoporosis index

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/osiris?age=55&weight_kg=70&current_hrt=true&prior_low_impact_fracture=false

Full URL: https://api.magentlab.com/api/calc/osiris?age=55&weight_kg=70&current_hrt=true&prior_low_impact_fracture=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/osiris?age=55&weight_kg=70&current_hrt=true&prior_low_impact_fracture=false"

Parameters

Name	Type	Required	Description
`age`	integer	required	Age in years (18-120). Sedrine 2002 OSIRIS uses age as a whole number of years.
`weight_kg`	number	optional	Weight in kilograms. Provide weight_kg or weight_lb.
`weight_lb`	number	optional	Weight in pounds. Converted as kg = lb * 0.45359237.
`current_hrt`	boolean	required	Current HRT/estrogen use (Sedrine 2002). true adds +2; false adds 0. true or false.
`prior_low_impact_fracture`	boolean	required	Prior low-impact fracture (Sedrine 2002). true adds -2; false adds 0. true or false.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/osiris Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "age": "55",
      "current_hrt": "true",
      "prior_low_impact_fracture": "false",
      "weight_kg": "70"
    },
    {
      "age": "55",
      "current_hrt": "true",
      "prior_low_impact_fracture": "false",
      "weight_kg": "70"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/osiris",
  "items": [
    {
      "age": 55,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Sedrine WB, Chevallier T, Zegels B, Kvasz A, Micheletti MC, Gelas B, Reginster JY",
        "doi": "10.1080/gye.16.3.245.250",
        "id": "sedrine-2002",
        "pmid": "12192897",
        "source": "Gynecol Endocrinol. 2002;16(3):245-250",
        "title": "Development and assessment of the Osteoporosis Index of Risk (OSIRIS) to facilitate selection of women for bone densitometry"
      },
      "formula": "osiris",
      "formula_expression": "OSIRIS = (-0.2 * age) + (0.2 * weight_kg) + (2 if current_hrt) + (-2 if prior_low_impact_fracture); low if score > +1; high if score < -3; intermediate otherwise (including exact +1 and exact -3)",
      "weight_kg": 70.0,
      "risk": "low",
      "current_hrt": true,
      "osiris_index": 5.0,
      "prior_low_impact_fracture": false
    },
    {
      "age": 55,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Sedrine WB, Chevallier T, Zegels B, Kvasz A, Micheletti MC, Gelas B, Reginster JY",
        "doi": "10.1080/gye.16.3.245.250",
        "id": "sedrine-2002",
        "pmid": "12192897",
        "source": "Gynecol Endocrinol. 2002;16(3):245-250",
        "title": "Development and assessment of the Osteoporosis Index of Risk (OSIRIS) to facilitate selection of women for bone densitometry"
      },
      "formula": "osiris",
      "formula_expression": "OSIRIS = (-0.2 * age) + (0.2 * weight_kg) + (2 if current_hrt) + (-2 if prior_low_impact_fracture); low if score > +1; high if score < -3; intermediate otherwise (including exact +1 and exact -3)",
      "weight_kg": 70.0,
      "risk": "low",
      "current_hrt": true,
      "osiris_index": 5.0,
      "prior_low_impact_fracture": false
    }
  ]
}

Response

Field	Type	Description
`formula`	string	osiris
`formula_expression`	string	Exact Sedrine 2002 expression
`age`	integer	Age in years used in the index
`weight_kg`	number	Normalized weight in kg
`current_hrt`	boolean	Current HRT/estrogen use used in the index
`prior_low_impact_fracture`	boolean	Prior low-impact fracture used in the index
`osiris_index`	number	Sedrine 2002 OSIRIS index, 1 decimal. Not truncated like OSTA. Not FRAX.
`risk`	string	low (score > +1), high (score < -3), or intermediate otherwise including exact +1 and exact -3. Sedrine 2002 published band, not a diagnosis or DXA order.
`citation`	object	Sedrine 2002 Gynecol Endocrinol citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "age": 55,
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Sedrine WB, Chevallier T, Zegels B, Kvasz A, Micheletti MC, Gelas B, Reginster JY",
    "doi": "10.1080/gye.16.3.245.250",
    "id": "sedrine-2002",
    "pmid": "12192897",
    "source": "Gynecol Endocrinol. 2002;16(3):245-250",
    "title": "Development and assessment of the Osteoporosis Index of Risk (OSIRIS) to facilitate selection of women for bone densitometry"
  },
  "formula": "osiris",
  "formula_expression": "OSIRIS = (-0.2 * age) + (0.2 * weight_kg) + (2 if current_hrt) + (-2 if prior_low_impact_fracture); low if score > +1; high if score < -3; intermediate otherwise (including exact +1 and exact -3)",
  "weight_kg": 70.0,
  "risk": "low",
  "current_hrt": true,
  "osiris_index": 5.0,
  "prior_low_impact_fracture": false
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_age`	age must be an integer from 18 to 120 Returned before settlement; you are not charged.
400	`invalid_weight`	weight_kg (1-500) or weight_lb (2-1100) is required Returned before settlement; you are not charged.
400	`invalid_flag`	boolean clinical flags must be true or false Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

OSTA — Compute the Koh 2001 Osteoporosis Self-Assessment Tool for Asians (OSTA) as trunc(0.2 × (weight_kg − age)) toward zero, then the published low, intermediate, or high band.
BMI — Compute Keys/Quetelet body-mass index from height and weight, plus a WHO adult band.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.