Hematology · LIVE

PLASMIC score

Sum the seven Bendapudi 2017 PLASMIC items and return the published 0-4 / 5 / 6-7 pretest band for severe ADAMTS13 deficiency.

LIVE $0.005 USDC GET /api/calc/plasmic

Markdown: /docs/plasmic.md · Canonical: https://magentlab.com/docs/plasmic

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum the seven Bendapudi 2017 PLASMIC items and return the published 0-4 / 5 / 6-7 pretest band for severe ADAMTS13 deficiency.

When to use

When an agent needs the published PLASMIC point total and pretest band and must not invent a plasma-exchange order or an ADAMTS13 activity result.

When not to use

Not a medical device.
Not a plasma-exchange order and not a diagnosis of TTP.
magent does not assay hemolysis. hemolysis is a caller-assigned flag (reticulocyte count >2.5% or undetectable haptoglobin or indirect bilirubin >2.0 mg/dL per Bendapudi 2017).
Does not return percents or ADAMTS13 activity. Bands 0-4 / 5 / 6-7 are pretest groups for severe ADAMTS13 deficiency.
Platelets 30×10^9/L, MCV 90 fL, INR 1.5, and creatinine 2.0 mg/dL do not score (strict <).
A point is given for no active cancer and for no solid-organ or stem-cell transplant (those flags true score 0).

Formula

PLASMIC = (platelets_10e9_l<30) + hemolysis + (not active_cancer) + (not solid_organ_or_stem_cell_transplant) + (mcv_fl<90) + (inr<1.5) + (creatinine_mg_dl<2.0); each 1; max 7; bands 0-4 / 5 / 6-7

Citation

Title: Derivation and external validation of the PLASMIC score for rapid assessment of adults with thrombotic microangiopathies: a cohort study
Authors: Bendapudi PK, Hurwitz S, Fry A, et al.
Source: Lancet Haematol. 2017;4(4):e157-e164
DOI: 10.1016/S2352-3026(17)30026-1

Worked example

All seven items present

Given: active_cancer=falsecreatinine_mg_dl=1.0hemolysis=trueinr=1.1mcv_fl=85platelets_10e9_l=15solid_organ_or_stem_cell_transplant=false

Platelets 15 < 30 → 1; hemolysis true → 1; no active cancer → 1; no transplant → 1; MCV 85 < 90 → 1; INR 1.1 < 1.5 → 1; creatinine 1.0 < 2.0 → 1
Score = 7 (max 7); band 6-7

Also searched as

PLASMIC score
Bendapudi PLASMIC
TMA PLASMIC
ADAMTS13 pretest
thrombotic microangiopathy score
PLASMIC TTP
severe ADAMTS13 deficiency score
hemolytic TMA score

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/plasmic?platelets_10e9_l=15&hemolysis=true&active_cancer=false&solid_organ_or_stem_cell_transplant=false&mcv_fl=85&inr=1.1&creatinine_mg_dl=1.0

Full URL: https://api.magentlab.com/api/calc/plasmic?platelets_10e9_l=15&hemolysis=true&active_cancer=false&solid_organ_or_stem_cell_transplant=false&mcv_fl=85&inr=1.1&creatinine_mg_dl=1.0

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/plasmic?platelets_10e9_l=15&hemolysis=true&active_cancer=false&solid_organ_or_stem_cell_transplant=false&mcv_fl=85&inr=1.1&creatinine_mg_dl=1.0"

Parameters

Name	Type	Required	Description
`platelets_10e9_l`	number	required	Platelet count ×10^9/L (1-2000). Scores 1 when <30; 30 does not score (Bendapudi 2017).
`hemolysis`	boolean	required	Caller-assigned hemolysis (Bendapudi 2017: reticulocyte count >2.5% or undetectable haptoglobin or indirect bilirubin >2.0 mg/dL). true or false. magent does not assay. 1 point if true.
`active_cancer`	boolean	required	Active cancer as assigned by the caller. true or false. 1 point when false (no active cancer).
`solid_organ_or_stem_cell_transplant`	boolean	required	History of solid-organ or stem-cell transplant as assigned by the caller. true or false. 1 point when false (no transplant history).
`mcv_fl`	number	required	Mean corpuscular volume in fL (50-120). Scores 1 when <90; 90.0 does not score.
`inr`	number	required	INR (0.8-10). Scores 1 when <1.5; 1.5 does not score.
`creatinine_mg_dl`	number	optional	Serum creatinine in mg/dL (0.1-20). Provide this or creatinine_umol_l. Scores 1 when <2.0; 2.0 does not score.
`creatinine_umol_l`	number	optional	Serum creatinine in µmol/L (9-1768). Converted as mg/dL = µmol/L / 88.42. Provide this or creatinine_mg_dl.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/plasmic Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "active_cancer": "false",
      "creatinine_mg_dl": "1.0",
      "hemolysis": "true",
      "inr": "1.1",
      "mcv_fl": "85",
      "platelets_10e9_l": "15",
      "solid_organ_or_stem_cell_transplant": "false"
    },
    {
      "active_cancer": "false",
      "creatinine_mg_dl": "1.0",
      "hemolysis": "true",
      "inr": "1.1",
      "mcv_fl": "85",
      "platelets_10e9_l": "15",
      "solid_organ_or_stem_cell_transplant": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/plasmic",
  "items": [
    {
      "components": [
        {
          "value": 15.0,
          "factor": "platelets_lt_30",
          "points": 1,
          "present": true
        },
        {
          "factor": "hemolysis",
          "points": 1,
          "present": true
        },
        {
          "factor": "no_active_cancer",
          "points": 1,
          "present": true
        },
        {
          "factor": "no_solid_organ_or_stem_cell_transplant",
          "points": 1,
          "present": true
        },
        {
          "value": 85.0,
          "factor": "mcv_lt_90",
          "points": 1,
          "present": true
        },
        {
          "value": 1.1,
          "factor": "inr_lt_1_5",
          "points": 1,
          "present": true
        },
        {
          "value": 1.0,
          "factor": "creatinine_lt_2",
          "points": 1,
          "present": true
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Bendapudi PK, Hurwitz S, Fry A, et al.",
        "doi": "10.1016/S2352-3026(17)30026-1",
        "id": "bendapudi-2017",
        "pmid": "28259520",
        "source": "Lancet Haematol. 2017;4(4):e157-e164",
        "title": "Derivation and external validation of the PLASMIC score for rapid assessment of adults with thrombotic microangiopathies: a cohort study"
      },
      "formula": "plasmic",
      "formula_expression": "PLASMIC = (platelets_10e9_l<30) + hemolysis + (not active_cancer) + (not solid_organ_or_stem_cell_transplant) + (mcv_fl<90) + (inr<1.5) + (creatinine_mg_dl<2.0); each 1; max 7; bands 0-4 / 5 / 6-7",
      "max_score": 7,
      "score": 7,
      "inr": 1.1,
      "platelets_10e9_l": 15.0,
      "creatinine_mg_dl": 1.0,
      "mcv_fl": 85.0,
      "active_cancer": false,
      "hemolysis": true,
      "plasmic_band": "6-7",
      "solid_organ_or_stem_cell_transplant": false
    },
    {
      "components": [
        {
          "value": 15.0,
          "factor": "platelets_lt_30",
          "points": 1,
          "present": true
        },
        {
          "factor": "hemolysis",
          "points": 1,
          "present": true
        },
        {
          "factor": "no_active_cancer",
          "points": 1,
          "present": true
        },
        {
          "factor": "no_solid_organ_or_stem_cell_transplant",
          "points": 1,
          "present": true
        },
        {
          "value": 85.0,
          "factor": "mcv_lt_90",
          "points": 1,
          "present": true
        },
        {
          "value": 1.1,
          "factor": "inr_lt_1_5",
          "points": 1,
          "present": true
        },
        {
          "value": 1.0,
          "factor": "creatinine_lt_2",
          "points": 1,
          "present": true
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Bendapudi PK, Hurwitz S, Fry A, et al.",
        "doi": "10.1016/S2352-3026(17)30026-1",
        "id": "bendapudi-2017",
        "pmid": "28259520",
        "source": "Lancet Haematol. 2017;4(4):e157-e164",
        "title": "Derivation and external validation of the PLASMIC score for rapid assessment of adults with thrombotic microangiopathies: a cohort study"
      },
      "formula": "plasmic",
      "formula_expression": "PLASMIC = (platelets_10e9_l<30) + hemolysis + (not active_cancer) + (not solid_organ_or_stem_cell_transplant) + (mcv_fl<90) + (inr<1.5) + (creatinine_mg_dl<2.0); each 1; max 7; bands 0-4 / 5 / 6-7",
      "max_score": 7,
      "score": 7,
      "inr": 1.1,
      "platelets_10e9_l": 15.0,
      "creatinine_mg_dl": 1.0,
      "mcv_fl": 85.0,
      "active_cancer": false,
      "hemolysis": true,
      "plasmic_band": "6-7",
      "solid_organ_or_stem_cell_transplant": false
    }
  ]
}

Response

Field	Type	Description
`formula`	string	plasmic
`formula_expression`	string	Exact expression used
`score`	integer	Total points 0-7
`max_score`	integer	Always 7
`plasmic_band`	string	0-4, 5, or 6-7 (Bendapudi 2017 pretest groups for severe ADAMTS13 deficiency). Not a percent and not a plasma-exchange order.
`platelets_10e9_l`	number	Platelet count used (×10^9/L)
`hemolysis`	boolean	Caller-assigned hemolysis flag used
`active_cancer`	boolean	Caller-assigned active-cancer flag used
`solid_organ_or_stem_cell_transplant`	boolean	Caller-assigned transplant-history flag used
`mcv_fl`	number	MCV used, fL
`inr`	number	INR used
`creatinine_mg_dl`	number	Creatinine used in mg/dL (after µmol/L conversion when that unit is supplied)
`components`	array	Per-item points
`citation`	object	Bendapudi 2017 citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": 15.0,
      "factor": "platelets_lt_30",
      "points": 1,
      "present": true
    },
    {
      "factor": "hemolysis",
      "points": 1,
      "present": true
    },
    {
      "factor": "no_active_cancer",
      "points": 1,
      "present": true
    },
    {
      "factor": "no_solid_organ_or_stem_cell_transplant",
      "points": 1,
      "present": true
    },
    {
      "value": 85.0,
      "factor": "mcv_lt_90",
      "points": 1,
      "present": true
    },
    {
      "value": 1.1,
      "factor": "inr_lt_1_5",
      "points": 1,
      "present": true
    },
    {
      "value": 1.0,
      "factor": "creatinine_lt_2",
      "points": 1,
      "present": true
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Bendapudi PK, Hurwitz S, Fry A, et al.",
    "doi": "10.1016/S2352-3026(17)30026-1",
    "id": "bendapudi-2017",
    "pmid": "28259520",
    "source": "Lancet Haematol. 2017;4(4):e157-e164",
    "title": "Derivation and external validation of the PLASMIC score for rapid assessment of adults with thrombotic microangiopathies: a cohort study"
  },
  "formula": "plasmic",
  "formula_expression": "PLASMIC = (platelets_10e9_l<30) + hemolysis + (not active_cancer) + (not solid_organ_or_stem_cell_transplant) + (mcv_fl<90) + (inr<1.5) + (creatinine_mg_dl<2.0); each 1; max 7; bands 0-4 / 5 / 6-7",
  "max_score": 7,
  "score": 7,
  "inr": 1.1,
  "platelets_10e9_l": 15.0,
  "creatinine_mg_dl": 1.0,
  "mcv_fl": 85.0,
  "active_cancer": false,
  "hemolysis": true,
  "plasmic_band": "6-7",
  "solid_organ_or_stem_cell_transplant": false
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_platelets`	platelets_10e9_l must be a number from 1 to 2000 Returned before settlement; you are not charged.
400	`invalid_flag`	boolean clinical flags must be true or false Returned before settlement; you are not charged.
400	`invalid_mcv`	mcv_fl must be a number from 50 to 120. Returned before settlement; you are not charged.
400	`invalid_inr`	inr must be a number from 0.8 to 10 Returned before settlement; you are not charged.
400	`invalid_creatinine`	creatinine_mg_dl (0.1-20) or creatinine_umol_l (9-1768) is required Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

4Ts score — Compute the Lo 2006 4Ts score as the sum of four caller-assigned integers 0-2 (thrombocytopenia, timing, thrombosis, other causes).
NLR — Compute the Zahorec 2001 neutrophil-to-lymphocyte ratio from relative neutrophil and lymphocyte percents.
ANC — Compute absolute neutrophil count from WBC and neutrophil plus band percents, plus a Bodey 1966 granulocyte band.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.