RegiSCAR DRESS score (Kardaun 2007)

RegiSCAR

Sum the ten Kardaun 2007 RegiSCAR DRESS scoring-letter items from caller-assigned flags, eosinophilia grade, and organ count, and return the −4 to 9 total and the published none/possible/probable/definite band.

LIVE $0.005 USDC GET /api/calc/regiscar

Markdown: /docs/regiscar.md · Canonical: https://magentlab.com/docs/regiscar

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

When to use

When an agent has already assigned the Kardaun 2007 scoring-letter items and needs the published total and validation band. magent does not count eosinophils, read a biopsy, measure BSA, or diagnose DRESS.

When not to use

Not a medical device and not a DRESS diagnosis.
magent does not count eosinophils or read a biopsy. Each item is caller-assigned. Biopsy unknown is not offered: biopsy_compatible must be true (0) or false (−1).
Not SCORTEN and not J-SCAR.
Scoring is the Kardaun 2007 Br J Dermatol scoring letter, not the 2013 prospective series.

Formula

RegiSCAR = fever_ge_38_5 (true 0, false −1) + lymphadenopathy_ge_2_sites (true 1, false 0) + eosinophilia (none 0, mild 1, severe 2) + atypical_lymphocytes (true 1, false 0) + rash_gt_50_bsa (true 1, false 0) + rash_suggestive (true 1, false −1) + biopsy_compatible (true 0, false −1) + organs (0/1/≥2 → 0/1/2) + resolution_ge_15_days (true 0, false −1) + alternative_causes_excluded (true 1, false 0); Kardaun 2007 scoring letter; sum −4 to 9; none <2, possible 2–3, probable 4–5, definite ≥6

Citation

Title: Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?
Authors: Kardaun SH, Sidoroff A, Valeyrie-Allanore L, Halevy S, Davidovici BB, Mockenhaupt M, Roujeau JC
Source: Br J Dermatol. 2007;156(3):609-611
DOI: 10.1111/j.1365-2133.2006.07704.x

Worked example

Worked example scores −1 none

Given: alternative_causes_excluded=falseatypical_lymphocytes=falsebiopsy_compatible=trueeosinophilia=nonefever_ge_38_5=truelymphadenopathy_ge_2_sites=falseorgans=0rash_gt_50_bsa=falserash_suggestive=falseresolution_ge_15_days=true

fever_ge_38_5 true → 0; lymphadenopathy_ge_2_sites false → 0; eosinophilia none → 0; atypical_lymphocytes false → 0; rash_gt_50_bsa false → 0
rash_suggestive false → −1; biopsy_compatible true → 0; organs 0 → 0; resolution_ge_15_days true → 0; alternative_causes_excluded false → 0
Score = −1 (max 9); regiscar_band none

Also searched as

RegiSCAR DRESS
Kardaun 2007
DRESS validation score
drug reaction with eosinophilia
RegiSCAR score
DRESS syndrome score
Kardaun scoring letter
cutaneous drug reaction score

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/regiscar?fever_ge_38_5=true&lymphadenopathy_ge_2_sites=false&eosinophilia=none&atypical_lymphocytes=false&rash_gt_50_bsa=false&rash_suggestive=false&biopsy_compatible=true&organs=0&resolution_ge_15_days=true&alternative_causes_excluded=false

Full URL: https://api.magentlab.com/api/calc/regiscar?fever_ge_38_5=true&lymphadenopathy_ge_2_sites=false&eosinophilia=none&atypical_lymphocytes=false&rash_gt_50_bsa=false&rash_suggestive=false&biopsy_compatible=true&organs=0&resolution_ge_15_days=true&alternative_causes_excluded=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/regiscar?fever_ge_38_5=true&lymphadenopathy_ge_2_sites=false&eosinophilia=none&atypical_lymphocytes=false&rash_gt_50_bsa=false&rash_suggestive=false&biopsy_compatible=true&organs=0&resolution_ge_15_days=true&alternative_causes_excluded=false"

Parameters

Name	Type	Required	Description
`fever_ge_38_5`	boolean	required	Caller-assigned fever ≥38.5 °C (Kardaun 2007). true scores 0; false scores −1. magent does not measure temperature.
`lymphadenopathy_ge_2_sites`	boolean	required	Caller-assigned lymphadenopathy involving ≥2 sites (Kardaun 2007). true scores 1; false scores 0. magent does not examine lymph nodes.
`eosinophilia`	string	required · none, mild, severe	Caller-assigned eosinophilia (Kardaun 2007): none (0), mild (1; 700–1499/µL or 10–19%), or severe (2; ≥1500/µL or ≥20%). magent does not count eosinophils.
`atypical_lymphocytes`	boolean	required	Caller-assigned atypical lymphocytes (Kardaun 2007). true scores 1; false scores 0. magent does not read a blood film.
`rash_gt_50_bsa`	boolean	required	Caller-assigned rash extent >50% body surface area (Kardaun 2007). true scores 1; false scores 0. magent does not measure BSA.
`rash_suggestive`	boolean	required	Caller-assigned rash morphology suggestive of DRESS (Kardaun 2007). true scores 1; false scores −1. magent does not examine the skin.
`biopsy_compatible`	boolean	required	Caller-assigned skin-biopsy compatibility with DRESS (Kardaun 2007). true scores 0; false scores −1. Unknown is not offered. magent does not read a biopsy.
`organs`	integer	required	Caller-assigned organ involvement count (Kardaun 2007): integer 0, 1, or 2 (≥2 organs scores 2). Values outside 0–2 are rejected. magent does not diagnose organ injury.
`resolution_ge_15_days`	boolean	required	Caller-assigned resolution ≥15 days (Kardaun 2007). true scores 0; false scores −1. magent does not time the illness.
`alternative_causes_excluded`	boolean	required	Caller-assigned exclusion of alternative causes (Kardaun 2007). true scores 1; false scores 0. magent does not exclude infection or other diagnoses.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/regiscar Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "alternative_causes_excluded": "false",
      "atypical_lymphocytes": "false",
      "biopsy_compatible": "true",
      "eosinophilia": "none",
      "fever_ge_38_5": "true",
      "lymphadenopathy_ge_2_sites": "false",
      "organs": "0",
      "rash_gt_50_bsa": "false",
      "rash_suggestive": "false",
      "resolution_ge_15_days": "true"
    },
    {
      "alternative_causes_excluded": "false",
      "atypical_lymphocytes": "false",
      "biopsy_compatible": "true",
      "eosinophilia": "none",
      "fever_ge_38_5": "true",
      "lymphadenopathy_ge_2_sites": "false",
      "organs": "0",
      "rash_gt_50_bsa": "false",
      "rash_suggestive": "false",
      "resolution_ge_15_days": "true"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/regiscar",
  "items": [
    {
      "components": [
        {
          "value": true,
          "factor": "fever_ge_38_5",
          "points": 0,
          "present": true
        },
        {
          "value": false,
          "factor": "lymphadenopathy_ge_2_sites",
          "points": 0,
          "present": true
        },
        {
          "value": "none",
          "factor": "eosinophilia",
          "points": 0,
          "present": true
        },
        {
          "value": false,
          "factor": "atypical_lymphocytes",
          "points": 0,
          "present": true
        },
        {
          "value": false,
          "factor": "rash_gt_50_bsa",
          "points": 0,
          "present": true
        },
        {
          "value": false,
          "factor": "rash_suggestive",
          "points": -1,
          "present": true
        },
        {
          "value": true,
          "factor": "biopsy_compatible",
          "points": 0,
          "present": true
        },
        {
          "value": 0,
          "factor": "organs",
          "points": 0,
          "present": true
        },
        {
          "value": true,
          "factor": "resolution_ge_15_days",
          "points": 0,
          "present": true
        },
        {
          "value": false,
          "factor": "alternative_causes_excluded",
          "points": 0,
          "present": true
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Kardaun SH, Sidoroff A, Valeyrie-Allanore L, Halevy S, Davidovici BB, Mockenhaupt M, Roujeau JC",
        "doi": "10.1111/j.1365-2133.2006.07704.x",
        "id": "kardaun-2007",
        "pmid": "17300272",
        "source": "Br J Dermatol. 2007;156(3):609-611",
        "title": "Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?"
      },
      "formula": "regiscar",
      "formula_expression": "RegiSCAR = fever_ge_38_5 (true 0, false −1) + lymphadenopathy_ge_2_sites (true 1, false 0) + eosinophilia (none 0, mild 1, severe 2) + atypical_lymphocytes (true 1, false 0) + rash_gt_50_bsa (true 1, false 0) + rash_suggestive (true 1, false −1) + biopsy_compatible (true 0, false −1) + organs (0/1/≥2 → 0/1/2) + resolution_ge_15_days (true 0, false −1) + alternative_causes_excluded (true 1, false 0); Kardaun 2007 scoring letter; sum −4 to 9; none <2, possible 2–3, probable 4–5, definite ≥6",
      "max_score": 9,
      "score": -1,
      "regiscar_band": "none"
    },
    {
      "components": [
        {
          "value": true,
          "factor": "fever_ge_38_5",
          "points": 0,
          "present": true
        },
        {
          "value": false,
          "factor": "lymphadenopathy_ge_2_sites",
          "points": 0,
          "present": true
        },
        {
          "value": "none",
          "factor": "eosinophilia",
          "points": 0,
          "present": true
        },
        {
          "value": false,
          "factor": "atypical_lymphocytes",
          "points": 0,
          "present": true
        },
        {
          "value": false,
          "factor": "rash_gt_50_bsa",
          "points": 0,
          "present": true
        },
        {
          "value": false,
          "factor": "rash_suggestive",
          "points": -1,
          "present": true
        },
        {
          "value": true,
          "factor": "biopsy_compatible",
          "points": 0,
          "present": true
        },
        {
          "value": 0,
          "factor": "organs",
          "points": 0,
          "present": true
        },
        {
          "value": true,
          "factor": "resolution_ge_15_days",
          "points": 0,
          "present": true
        },
        {
          "value": false,
          "factor": "alternative_causes_excluded",
          "points": 0,
          "present": true
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Kardaun SH, Sidoroff A, Valeyrie-Allanore L, Halevy S, Davidovici BB, Mockenhaupt M, Roujeau JC",
        "doi": "10.1111/j.1365-2133.2006.07704.x",
        "id": "kardaun-2007",
        "pmid": "17300272",
        "source": "Br J Dermatol. 2007;156(3):609-611",
        "title": "Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?"
      },
      "formula": "regiscar",
      "formula_expression": "RegiSCAR = fever_ge_38_5 (true 0, false −1) + lymphadenopathy_ge_2_sites (true 1, false 0) + eosinophilia (none 0, mild 1, severe 2) + atypical_lymphocytes (true 1, false 0) + rash_gt_50_bsa (true 1, false 0) + rash_suggestive (true 1, false −1) + biopsy_compatible (true 0, false −1) + organs (0/1/≥2 → 0/1/2) + resolution_ge_15_days (true 0, false −1) + alternative_causes_excluded (true 1, false 0); Kardaun 2007 scoring letter; sum −4 to 9; none <2, possible 2–3, probable 4–5, definite ≥6",
      "max_score": 9,
      "score": -1,
      "regiscar_band": "none"
    }
  ]
}

Response

Field	Type	Description
`formula`	string	regiscar
`formula_expression`	string	Exact expression used
`score`	integer	Kardaun 2007 RegiSCAR DRESS points −4 to 9
`max_score`	integer	Always 9
`regiscar_band`	string	Published validation band: none (<2), possible (2–3), probable (4–5), or definite (≥6). Not a DRESS diagnosis.
`components`	array	Per-item caller-assigned points
`citation`	object	Kardaun 2007 Br J Dermatol scoring-letter citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": true,
      "factor": "fever_ge_38_5",
      "points": 0,
      "present": true
    },
    {
      "value": false,
      "factor": "lymphadenopathy_ge_2_sites",
      "points": 0,
      "present": true
    },
    {
      "value": "none",
      "factor": "eosinophilia",
      "points": 0,
      "present": true
    },
    {
      "value": false,
      "factor": "atypical_lymphocytes",
      "points": 0,
      "present": true
    },
    {
      "value": false,
      "factor": "rash_gt_50_bsa",
      "points": 0,
      "present": true
    },
    {
      "value": false,
      "factor": "rash_suggestive",
      "points": -1,
      "present": true
    },
    {
      "value": true,
      "factor": "biopsy_compatible",
      "points": 0,
      "present": true
    },
    {
      "value": 0,
      "factor": "organs",
      "points": 0,
      "present": true
    },
    {
      "value": true,
      "factor": "resolution_ge_15_days",
      "points": 0,
      "present": true
    },
    {
      "value": false,
      "factor": "alternative_causes_excluded",
      "points": 0,
      "present": true
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Kardaun SH, Sidoroff A, Valeyrie-Allanore L, Halevy S, Davidovici BB, Mockenhaupt M, Roujeau JC",
    "doi": "10.1111/j.1365-2133.2006.07704.x",
    "id": "kardaun-2007",
    "pmid": "17300272",
    "source": "Br J Dermatol. 2007;156(3):609-611",
    "title": "Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?"
  },
  "formula": "regiscar",
  "formula_expression": "RegiSCAR = fever_ge_38_5 (true 0, false −1) + lymphadenopathy_ge_2_sites (true 1, false 0) + eosinophilia (none 0, mild 1, severe 2) + atypical_lymphocytes (true 1, false 0) + rash_gt_50_bsa (true 1, false 0) + rash_suggestive (true 1, false −1) + biopsy_compatible (true 0, false −1) + organs (0/1/≥2 → 0/1/2) + resolution_ge_15_days (true 0, false −1) + alternative_causes_excluded (true 1, false 0); Kardaun 2007 scoring letter; sum −4 to 9; none <2, possible 2–3, probable 4–5, definite ≥6",
  "max_score": 9,
  "score": -1,
  "regiscar_band": "none"
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_regiscar`	RegiSCAR items must use the published Kardaun 2007 values (fever/lymphadenopathy/atypical_lymphocytes/rash flags; eosinophilia none, mild, or severe; organs 0-2; resolution_ge_15_days; alternative_causes_excluded). Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

SCORTEN — Sum the seven Bastuji-Garin 2000 SCORTEN risk factors from caller-assigned flags and return the 0–7 score and that paper's predicted in-hospital mortality token.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.