Lipids · LIVE

Sampson estimated LDL-C

Sampson LDL-C

Estimate LDL-C from total cholesterol, HDL, and triglycerides using Sampson 2020.

LIVE $0.005 USDC GET /api/calc/sampson

Markdown: /docs/sampson.md · Canonical: https://magentlab.com/docs/sampson

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Estimate LDL-C from total cholesterol, HDL, and triglycerides using Sampson 2020.

When to use

When an agent needs Sampson LDL arithmetic (including triglycerides up to 800 mg/dL) and must not apply Friedewald TG/5.

When not to use

• Not a diagnosis and not a statin order. Direct LDL assay is out of scope.
• Triglycerides above 800 mg/dL (or 9.03 mmol/L) are rejected. Sampson 2020 is not applied above that cap.
• Sampson 2020 only. Not Friedewald 1972 and not Martin/Hopkins.

Formula

LDL-C = TC/0.948 - HDL/0.971 - (TG/8.56 + TG*(TC-HDL)/2140 - TG^2/16100) - 9.44 (mg/dL)

Citation

Title

A new equation for calculation of low-density lipoprotein cholesterol in patients with normolipidemia and/or hypertriglyceridemia

Authors

Sampson M, Ling C, Sun Q, et al.

Source

JAMA Cardiol. 2020;5(5):540-548

DOI

10.1001/jamacardiol.2020.0013

Worked example

Also searched as

• Sampson equation
• Sampson LDL-C
• NIH LDL equation
• calculated LDL 800
• Sampson 2020
• LDL-C hypertriglyceridemia

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/sampson?total_cholesterol_mg_dl=200&hdl_mg_dl=50&triglycerides_mg_dl=150

Full URL: https://api.magentlab.com/api/calc/sampson?total_cholesterol_mg_dl=200&hdl_mg_dl=50&triglycerides_mg_dl=150

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/sampson?total_cholesterol_mg_dl=200&hdl_mg_dl=50&triglycerides_mg_dl=150"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/sampson Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "hdl_mg_dl": "50",
      "total_cholesterol_mg_dl": "200",
      "triglycerides_mg_dl": "150"
    },
    {
      "hdl_mg_dl": "50",
      "total_cholesterol_mg_dl": "200",
      "triglycerides_mg_dl": "150"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/sampson",
  "items": [
    {
      "unit": "mg_dl",
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Sampson M, Ling C, Sun Q, et al.",
        "doi": "10.1001/jamacardiol.2020.0013",
        "id": "sampson-2020",
        "source": "JAMA Cardiol. 2020;5(5):540-548",
        "title": "A new equation for calculation of low-density lipoprotein cholesterol in patients with normolipidemia and/or hypertriglyceridemia"
      },
      "formula": "sampson",
      "formula_expression": "LDL-C = TC/0.948 - HDL/0.971 - (TG/8.56 + TG*(TC-HDL)/2140 - TG^2/16100) - 9.44 (mg/dL)",
      "hdl_mg_dl": 50.0,
      "ldl_c_mg_dl": 123.4,
      "ldl_c_mmol_l": 3.2,
      "total_cholesterol_mg_dl": 200.0,
      "triglycerides_mg_dl": 150.0
    },
    {
      "unit": "mg_dl",
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Sampson M, Ling C, Sun Q, et al.",
        "doi": "10.1001/jamacardiol.2020.0013",
        "id": "sampson-2020",
        "source": "JAMA Cardiol. 2020;5(5):540-548",
        "title": "A new equation for calculation of low-density lipoprotein cholesterol in patients with normolipidemia and/or hypertriglyceridemia"
      },
      "formula": "sampson",
      "formula_expression": "LDL-C = TC/0.948 - HDL/0.971 - (TG/8.56 + TG*(TC-HDL)/2140 - TG^2/16100) - 9.44 (mg/dL)",
      "hdl_mg_dl": 50.0,
      "ldl_c_mg_dl": 123.4,
      "ldl_c_mmol_l": 3.2,
      "total_cholesterol_mg_dl": 200.0,
      "triglycerides_mg_dl": 150.0
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "unit": "mg_dl",
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Sampson M, Ling C, Sun Q, et al.",
    "doi": "10.1001/jamacardiol.2020.0013",
    "id": "sampson-2020",
    "source": "JAMA Cardiol. 2020;5(5):540-548",
    "title": "A new equation for calculation of low-density lipoprotein cholesterol in patients with normolipidemia and/or hypertriglyceridemia"
  },
  "formula": "sampson",
  "formula_expression": "LDL-C = TC/0.948 - HDL/0.971 - (TG/8.56 + TG*(TC-HDL)/2140 - TG^2/16100) - 9.44 (mg/dL)",
  "hdl_mg_dl": 50.0,
  "ldl_c_mg_dl": 123.4,
  "ldl_c_mmol_l": 3.2,
  "total_cholesterol_mg_dl": 200.0,
  "triglycerides_mg_dl": 150.0
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• Friedewald LDL-C — Estimate LDL-C from total cholesterol, HDL, and triglycerides using Friedewald 1972.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.