SEDAN score

SEDAN

Compute the Strbian 2012 SEDAN score (Sugar, Early infarct signs, (hyper)Dense artery, Age, NIHSS) for symptomatic intracranial hemorrhage after stroke thrombolysis.

LIVE $0.005 USDC GET /api/calc/sedan

Markdown: /docs/sedan.md · Canonical: https://magentlab.com/docs/sedan

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Compute the Strbian 2012 SEDAN score (Sugar, Early infarct signs, (hyper)Dense artery, Age, NIHSS) for symptomatic intracranial hemorrhage after stroke thrombolysis.

When to use

When an agent has caller-assigned admission glucose, CT early infarct signs, hyperdense artery sign, age, and NIHSS and needs the published SEDAN total and derivation sICH percents for scores 0-5, without inventing a percent for score 6 or a tPA decision.

When not to use

Not a medical device and not a tPA withhold, thrombolysis, or treatment decision.
Derived in intravenous thrombolysis cohorts (Strbian 2012). It is not a recommendation for or against alteplase.
The caller assigns NIHSS (0-42), early infarct signs, and hyperdense cerebral artery sign. magent does not examine the patient, assign NIHSS, or read CT.
Glucose uses mmol/L cutoffs after converting mg/dL / 18. 8.1-12.0 inclusive scores 1; >12.0 scores 2; 8.0 and 12.0 follow those bounds.
Derivation absolute sICH percents are returned for scores 0-5 only (1.4, 2.9, 8.5, 12.2, 21.7, 33.3). Score 6 has no published percent in Strbian 2012; magent does not invent one.

Formula

SEDAN = glucose (8.1-12.0 mmol/L 1; >12.0 mmol/L 2) + early_infarct_signs 1 + hyperdense_artery 1 + (age >75) 1 + (NIHSS >=10) 1; max 6; derivation sICH 1.4/2.9/8.5/12.2/21.7/33.3% for scores 0-5 (Strbian 2012); no published percent for 6

Citation

Title: Symptomatic intracranial hemorrhage after stroke thrombolysis: the SEDAN score
Authors: Strbian D, Engelter S, Michel P, Meretoja A, Sekoranja L, Ahlhelm FJ, Mustanoja S, Lynch J, Soinne L, Sairanen T, Lyrer P, Tatlisumak T
Source: Ann Neurol. 2012;71(5):634-641
DOI: 10.1002/ana.23546

Worked example

Age 60, NIHSS 5, glucose 6.0 mmol/L, no CT signs

Given: age=60early_infarct_signs=falseglucose_mmol_l=6.0hyperdense_artery=falsenihss=5

Glucose 6.0 < 8.1 → 0; early infarct signs 0; hyperdense artery 0; age 60 is not >75 → 0; NIHSS 5 < 10 → 0
Score = 0 (max 6); derivation sICH 1.4%

All items (score 6; no published sICH percent)

Given: age=120early_infarct_signs=trueglucose_mmol_l=20.0hyperdense_artery=truenihss=42

Glucose 20.0 > 12.0 → 2; early infarct signs +1; hyperdense artery +1; age 120 >75 → 1; NIHSS 42 ≥10 → 1
Score = 6 (max 6); sich_percent omitted

Also searched as

SEDAN score
Strbian SEDAN
symptomatic intracranial hemorrhage SEDAN
sICH thrombolysis score
sugar early infarct dense artery NIHSS
hyperdense artery sign SEDAN
Strbian 2012 SEDAN
SEDAN stroke thrombolysis

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/sedan?age=60&nihss=5&glucose_mmol_l=6.0&early_infarct_signs=false&hyperdense_artery=false

Full URL: https://api.magentlab.com/api/calc/sedan?age=60&nihss=5&glucose_mmol_l=6.0&early_infarct_signs=false&hyperdense_artery=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/sedan?age=60&nihss=5&glucose_mmol_l=6.0&early_infarct_signs=false&hyperdense_artery=false"

Parameters

Name	Type	Required	Description
`age`	integer	required	Age in years (18-120). >75 scores 1; 75 does not (Strbian 2012). magent does not date the patient.
`nihss`	integer	required	Caller-assigned NIH Stroke Scale total (integer 0-42). ≥10 scores 1; 9 does not. magent does not compute NIHSS or examine the patient.
`glucose_mmol_l`	number	optional	Baseline glucose in mmol/L (2.8-55.5). Provide this or glucose_mg_dl, not both. 8.1-12.0 inclusive scores 1; >12.0 scores 2; else 0 (Strbian 2012).
`glucose_mg_dl`	number	optional	Baseline glucose in mg/dL (50-1000). Converted as mmol/L = mg/dL / 18. Provide this or glucose_mmol_l, not both.
`early_infarct_signs`	boolean	required	Early infarct signs on admission CT as assigned by the caller (Strbian 2012). true scores 1; false scores 0. magent does not read the CT.
`hyperdense_artery`	boolean	required	(Hyper)dense cerebral artery sign on admission CT as assigned by the caller (Strbian 2012). true scores 1; false scores 0. magent does not read the CT.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/sedan Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "age": "60",
      "early_infarct_signs": "false",
      "glucose_mmol_l": "6.0",
      "hyperdense_artery": "false",
      "nihss": "5"
    },
    {
      "age": "60",
      "early_infarct_signs": "false",
      "glucose_mmol_l": "6.0",
      "hyperdense_artery": "false",
      "nihss": "5"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/sedan",
  "items": [
    {
      "components": [
        {
          "value": 6.0,
          "factor": "glucose",
          "points": 0,
          "present": false
        },
        {
          "factor": "early_infarct_signs",
          "points": 0,
          "present": false
        },
        {
          "factor": "hyperdense_artery",
          "points": 0,
          "present": false
        },
        {
          "value": 60,
          "factor": "age",
          "points": 0,
          "present": false
        },
        {
          "value": 5,
          "factor": "nihss",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "age_years": 60,
      "citation": {
        "authors": "Strbian D, Engelter S, Michel P, Meretoja A, Sekoranja L, Ahlhelm FJ, Mustanoja S, Lynch J, Soinne L, Sairanen T, Lyrer P, Tatlisumak T",
        "doi": "10.1002/ana.23546",
        "id": "strbian-2012-sedan",
        "source": "Ann Neurol. 2012;71(5):634-641",
        "title": "Symptomatic intracranial hemorrhage after stroke thrombolysis: the SEDAN score"
      },
      "formula": "sedan",
      "formula_expression": "SEDAN = glucose (8.1-12.0 mmol/L 1; >12.0 mmol/L 2) + early_infarct_signs 1 + hyperdense_artery 1 + (age >75) 1 + (NIHSS >=10) 1; max 6; derivation sICH 1.4/2.9/8.5/12.2/21.7/33.3% for scores 0-5 (Strbian 2012); no published percent for 6",
      "max_score": 6,
      "score": 0,
      "glucose_mmol_l": 6.0,
      "nihss": 5,
      "early_infarct_signs": false,
      "hyperdense_artery": false,
      "sich_percent": 1.4
    },
    {
      "components": [
        {
          "value": 6.0,
          "factor": "glucose",
          "points": 0,
          "present": false
        },
        {
          "factor": "early_infarct_signs",
          "points": 0,
          "present": false
        },
        {
          "factor": "hyperdense_artery",
          "points": 0,
          "present": false
        },
        {
          "value": 60,
          "factor": "age",
          "points": 0,
          "present": false
        },
        {
          "value": 5,
          "factor": "nihss",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "age_years": 60,
      "citation": {
        "authors": "Strbian D, Engelter S, Michel P, Meretoja A, Sekoranja L, Ahlhelm FJ, Mustanoja S, Lynch J, Soinne L, Sairanen T, Lyrer P, Tatlisumak T",
        "doi": "10.1002/ana.23546",
        "id": "strbian-2012-sedan",
        "source": "Ann Neurol. 2012;71(5):634-641",
        "title": "Symptomatic intracranial hemorrhage after stroke thrombolysis: the SEDAN score"
      },
      "formula": "sedan",
      "formula_expression": "SEDAN = glucose (8.1-12.0 mmol/L 1; >12.0 mmol/L 2) + early_infarct_signs 1 + hyperdense_artery 1 + (age >75) 1 + (NIHSS >=10) 1; max 6; derivation sICH 1.4/2.9/8.5/12.2/21.7/33.3% for scores 0-5 (Strbian 2012); no published percent for 6",
      "max_score": 6,
      "score": 0,
      "glucose_mmol_l": 6.0,
      "nihss": 5,
      "early_infarct_signs": false,
      "hyperdense_artery": false,
      "sich_percent": 1.4
    }
  ]
}

Response

Field	Type	Description
`formula`	string	sedan
`formula_expression`	string	Exact expression used
`score`	integer	SEDAN points 0-6
`max_score`	integer	Always 6
`sich_percent`	number	Strbian 2012 derivation absolute sICH percent for scores 0-5 (1.4, 2.9, 8.5, 12.2, 21.7, 33.3). Omitted for score 6; no published percent.
`age_years`	integer	Age used for the >75 point
`nihss`	integer	Caller-assigned NIHSS used for the ≥10 point
`glucose_mmol_l`	number	Baseline glucose in mmol/L (mg/dL inputs converted /18)
`early_infarct_signs`	boolean	Whether early infarct signs were scored
`hyperdense_artery`	boolean	Whether hyperdense cerebral artery sign was scored
`components`	array	Per-item Strbian 2012 points
`citation`	object	Strbian 2012 Ann Neurol citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": 6.0,
      "factor": "glucose",
      "points": 0,
      "present": false
    },
    {
      "factor": "early_infarct_signs",
      "points": 0,
      "present": false
    },
    {
      "factor": "hyperdense_artery",
      "points": 0,
      "present": false
    },
    {
      "value": 60,
      "factor": "age",
      "points": 0,
      "present": false
    },
    {
      "value": 5,
      "factor": "nihss",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "age_years": 60,
  "citation": {
    "authors": "Strbian D, Engelter S, Michel P, Meretoja A, Sekoranja L, Ahlhelm FJ, Mustanoja S, Lynch J, Soinne L, Sairanen T, Lyrer P, Tatlisumak T",
    "doi": "10.1002/ana.23546",
    "id": "strbian-2012-sedan",
    "source": "Ann Neurol. 2012;71(5):634-641",
    "title": "Symptomatic intracranial hemorrhage after stroke thrombolysis: the SEDAN score"
  },
  "formula": "sedan",
  "formula_expression": "SEDAN = glucose (8.1-12.0 mmol/L 1; >12.0 mmol/L 2) + early_infarct_signs 1 + hyperdense_artery 1 + (age >75) 1 + (NIHSS >=10) 1; max 6; derivation sICH 1.4/2.9/8.5/12.2/21.7/33.3% for scores 0-5 (Strbian 2012); no published percent for 6",
  "max_score": 6,
  "score": 0,
  "glucose_mmol_l": 6.0,
  "nihss": 5,
  "early_infarct_signs": false,
  "hyperdense_artery": false,
  "sich_percent": 1.4
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_age`	age must be an integer from 18 to 120 Returned before settlement; you are not charged.
400	`invalid_nihss`	nihss must be an integer from 0 to 42. Returned before settlement; you are not charged.
400	`invalid_glucose`	glucose_mg_dl (50-1000) or glucose_mmol_l (2.8-55.5) is required Returned before settlement; you are not charged.
400	`invalid_flag`	boolean clinical flags must be true or false Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

THRIVE — Compute the Flint 2010 THRIVE (Totaled Health Risks in Vascular Events) score from trichotomized age, trichotomized NIHSS, and the chronic disease scale (hypertension, diabetes mellitus, atrial fibrillation).
ASTRAL — Compute the Ntaios 2012 ASTRAL integer score (Age, Severity NIHSS, Time delay, Range of visual fields, Acute glucose, Level of consciousness) for 3-month mRS >2 after acute ischemic stroke.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.