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SLICC SLE classification criteria

SLICC SLE

Apply the 2012 SLICC classification criteria for systemic lupus erythematosus (Petri Table 3): return clinical_count, immunologic_count, the biopsy-nephritis shortcut, and whether the published rule classifies SLE. Not a diagnosis.

LIVE $0.005 USDC GET /api/calc/slicc_sle

Markdown: /docs/slicc-sle.md · Canonical: https://magentlab.com/docs/slicc-sle

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply the 2012 SLICC classification criteria for systemic lupus erythematosus (Petri Table 3): return clinical_count, immunologic_count, the biopsy-nephritis shortcut, and whether the published rule classifies SLE. Not a diagnosis.

When to use

When an agent already has caller-assigned Petri 2012 clinical, immunologic, and biopsy flags and needs the published SLE classification result for research, not a diagnosis, not 1997 ACR, and not 2019 EULAR/ACR.

When not to use

• Not a medical device and not a diagnosis of systemic lupus erythematosus. Classification criteria for research (Petri 2012).
• Not the 1997 ACR SLE criteria and not the 2019 EULAR/ACR SLE classification criteria.
• magent does not examine skin, assay serologies, or read a biopsy. Caller assigns each flag. Criteria need not be concurrent.
• Direct Coombs’ test counts toward immunologic_count only in the absence of hemolytic anemia (Petri 2012 Table 3).
• biopsy_lupus_nephritis with ANA or anti-dsDNA classifies without four criteria. The renal clinical item is proteinuria ≥500 mg/24 h or red blood cell casts, not the biopsy shortcut.

Formula

SLICC 2012 SLE classification (Petri Table 3 + classification rule): 11 clinical flags (acute_cutaneous_lupus, chronic_cutaneous_lupus, oral_or_nasal_ulcers, nonscarring_alopecia, synovitis, serositis, renal, neurologic, hemolytic_anemia, leukopenia_or_lymphopenia, thrombocytopenia) and 6 immunologic flags (ana, anti_dsdna, anti_sm, antiphospholipid, low_complement, direct_coombs). clinical_count = count of clinical flags that are true. immunologic_count = count of immunologic flags that are true, except direct_coombs counts only when hemolytic_anemia is false. nephritis_shortcut iff biopsy_lupus_nephritis and (ana or anti_dsdna). classified iff nephritis_shortcut or (clinical_count ≥1 and immunologic_count ≥1 and clinical_count + immunologic_count ≥4). Criteria need not be concurrent. Not a diagnosis. Not 1997 ACR. Not 2019 EULAR/ACR

Citation

Title

Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus

Authors

Petri M, Orbai AM, Alarcón GS, Gordon C, Merrill JT, Fortin PR, Bruce IN, Isenberg D, Wallace DJ, Nived O, Sturfelt G, Ramsey-Goldman R, Bae SC, Hanly JG, Sánchez-Guerrero J, Clarke A, Aranow C, Manzi S, Urowitz M, Gladman D, Kalunian K, Costner M, Werth VP, Zoma A, Bernatsky S, Ruiz-Irastorza G, Khamashta MA, Jacobsen S, Buyon JP, Maddison P, Dooley MA, van Vollenhoven RF, Ginzler E, Stoll T, Peschken C, Jorizzo JL, Callen JP, Lim SS, Fessler BJ, Inanc M, Kamen DL, Rahman A, Steinsson K, Franks AG, Sigler L, Hameed S, Fang H, Pham N, Brey R, Weisman MH, McGwin G, Magder LS

Source

Arthritis Rheum. 2012;64(8):2677-2686

DOI

10.1002/art.34473

Worked example

Also searched as

• SLICC SLE classification criteria
• Petri 2012 lupus classification
• Systemic Lupus International Collaborating Clinics
• SLE classification not 1997 ACR
• not 2019 EULAR/ACR SLE
• lupus nephritis ANA anti-dsDNA
• immunologic clinical SLE criteria

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/slicc_sle?acute_cutaneous_lupus=true&chronic_cutaneous_lupus=false&oral_or_nasal_ulcers=true&nonscarring_alopecia=false&synovitis=true&serositis=false&renal=false&neurologic=false&hemolytic_anemia=false&leukopenia_or_lymphopenia=false&thrombocytopenia=false&ana=true&anti_dsdna=true&anti_sm=false&antiphospholipid=false&low_complement=false&direct_coombs=false&biopsy_lupus_nephritis=false

Full URL: https://api.magentlab.com/api/calc/slicc_sle?acute_cutaneous_lupus=true&chronic_cutaneous_lupus=false&oral_or_nasal_ulcers=true&nonscarring_alopecia=false&synovitis=true&serositis=false&renal=false&neurologic=false&hemolytic_anemia=false&leukopenia_or_lymphopenia=false&thrombocytopenia=false&ana=true&anti_dsdna=true&anti_sm=false&antiphospholipid=false&low_complement=false&direct_coombs=false&biopsy_lupus_nephritis=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/slicc_sle?acute_cutaneous_lupus=true&chronic_cutaneous_lupus=false&oral_or_nasal_ulcers=true&nonscarring_alopecia=false&synovitis=true&serositis=false&renal=false&neurologic=false&hemolytic_anemia=false&leukopenia_or_lymphopenia=false&thrombocytopenia=false&ana=true&anti_dsdna=true&anti_sm=false&antiphospholipid=false&low_complement=false&direct_coombs=false&biopsy_lupus_nephritis=false"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/slicc_sle Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "acute_cutaneous_lupus": "true",
      "ana": "true",
      "anti_dsdna": "true",
      "anti_sm": "false",
      "antiphospholipid": "false",
      "biopsy_lupus_nephritis": "false",
      "chronic_cutaneous_lupus": "false",
      "direct_coombs": "false",
      "hemolytic_anemia": "false",
      "leukopenia_or_lymphopenia": "false",
      "low_complement": "false",
      "neurologic": "false",
      "nonscarring_alopecia": "false",
      "oral_or_nasal_ulcers": "true",
      "renal": "false",
      "serositis": "false",
      "synovitis": "true",
      "thrombocytopenia": "false"
    },
    {
      "acute_cutaneous_lupus": "true",
      "ana": "true",
      "anti_dsdna": "true",
      "anti_sm": "false",
      "antiphospholipid": "false",
      "biopsy_lupus_nephritis": "false",
      "chronic_cutaneous_lupus": "false",
      "direct_coombs": "false",
      "hemolytic_anemia": "false",
      "leukopenia_or_lymphopenia": "false",
      "low_complement": "false",
      "neurologic": "false",
      "nonscarring_alopecia": "false",
      "oral_or_nasal_ulcers": "true",
      "renal": "false",
      "serositis": "false",
      "synovitis": "true",
      "thrombocytopenia": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/slicc_sle",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Petri M, Orbai AM, Alarcón GS, Gordon C, Merrill JT, Fortin PR, Bruce IN, Isenberg D, Wallace DJ, Nived O, Sturfelt G, Ramsey-Goldman R, Bae SC, Hanly JG, Sánchez-Guerrero J, Clarke A, Aranow C, Manzi S, Urowitz M, Gladman D, Kalunian K, Costner M, Werth VP, Zoma A, Bernatsky S, Ruiz-Irastorza G, Khamashta MA, Jacobsen S, Buyon JP, Maddison P, Dooley MA, van Vollenhoven RF, Ginzler E, Stoll T, Peschken C, Jorizzo JL, Callen JP, Lim SS, Fessler BJ, Inanc M, Kamen DL, Rahman A, Steinsson K, Franks AG, Sigler L, Hameed S, Fang H, Pham N, Brey R, Weisman MH, McGwin G, Magder LS",
        "doi": "10.1002/art.34473",
        "id": "petri-2012",
        "pmid": "22553077",
        "source": "Arthritis Rheum. 2012;64(8):2677-2686",
        "title": "Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus"
      },
      "formula": "slicc_sle",
      "formula_expression": "SLICC 2012 SLE classification (Petri Table 3 + classification rule): 11 clinical flags (acute_cutaneous_lupus, chronic_cutaneous_lupus, oral_or_nasal_ulcers, nonscarring_alopecia, synovitis, serositis, renal, neurologic, hemolytic_anemia, leukopenia_or_lymphopenia, thrombocytopenia) and 6 immunologic flags (ana, anti_dsdna, anti_sm, antiphospholipid, low_complement, direct_coombs). clinical_count = count of clinical flags that are true. immunologic_count = count of immunologic flags that are true, except direct_coombs counts only when hemolytic_anemia is false. nephritis_shortcut iff biopsy_lupus_nephritis and (ana or anti_dsdna). classified iff nephritis_shortcut or (clinical_count ≥1 and immunologic_count ≥1 and clinical_count + immunologic_count ≥4). Criteria need not be concurrent. Not a diagnosis. Not 1997 ACR. Not 2019 EULAR/ACR",
      "classified": true,
      "clinical_count": 3,
      "immunologic_count": 2,
      "nephritis_shortcut": false
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Petri M, Orbai AM, Alarcón GS, Gordon C, Merrill JT, Fortin PR, Bruce IN, Isenberg D, Wallace DJ, Nived O, Sturfelt G, Ramsey-Goldman R, Bae SC, Hanly JG, Sánchez-Guerrero J, Clarke A, Aranow C, Manzi S, Urowitz M, Gladman D, Kalunian K, Costner M, Werth VP, Zoma A, Bernatsky S, Ruiz-Irastorza G, Khamashta MA, Jacobsen S, Buyon JP, Maddison P, Dooley MA, van Vollenhoven RF, Ginzler E, Stoll T, Peschken C, Jorizzo JL, Callen JP, Lim SS, Fessler BJ, Inanc M, Kamen DL, Rahman A, Steinsson K, Franks AG, Sigler L, Hameed S, Fang H, Pham N, Brey R, Weisman MH, McGwin G, Magder LS",
        "doi": "10.1002/art.34473",
        "id": "petri-2012",
        "pmid": "22553077",
        "source": "Arthritis Rheum. 2012;64(8):2677-2686",
        "title": "Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus"
      },
      "formula": "slicc_sle",
      "formula_expression": "SLICC 2012 SLE classification (Petri Table 3 + classification rule): 11 clinical flags (acute_cutaneous_lupus, chronic_cutaneous_lupus, oral_or_nasal_ulcers, nonscarring_alopecia, synovitis, serositis, renal, neurologic, hemolytic_anemia, leukopenia_or_lymphopenia, thrombocytopenia) and 6 immunologic flags (ana, anti_dsdna, anti_sm, antiphospholipid, low_complement, direct_coombs). clinical_count = count of clinical flags that are true. immunologic_count = count of immunologic flags that are true, except direct_coombs counts only when hemolytic_anemia is false. nephritis_shortcut iff biopsy_lupus_nephritis and (ana or anti_dsdna). classified iff nephritis_shortcut or (clinical_count ≥1 and immunologic_count ≥1 and clinical_count + immunologic_count ≥4). Criteria need not be concurrent. Not a diagnosis. Not 1997 ACR. Not 2019 EULAR/ACR",
      "classified": true,
      "clinical_count": 3,
      "immunologic_count": 2,
      "nephritis_shortcut": false
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Petri M, Orbai AM, Alarcón GS, Gordon C, Merrill JT, Fortin PR, Bruce IN, Isenberg D, Wallace DJ, Nived O, Sturfelt G, Ramsey-Goldman R, Bae SC, Hanly JG, Sánchez-Guerrero J, Clarke A, Aranow C, Manzi S, Urowitz M, Gladman D, Kalunian K, Costner M, Werth VP, Zoma A, Bernatsky S, Ruiz-Irastorza G, Khamashta MA, Jacobsen S, Buyon JP, Maddison P, Dooley MA, van Vollenhoven RF, Ginzler E, Stoll T, Peschken C, Jorizzo JL, Callen JP, Lim SS, Fessler BJ, Inanc M, Kamen DL, Rahman A, Steinsson K, Franks AG, Sigler L, Hameed S, Fang H, Pham N, Brey R, Weisman MH, McGwin G, Magder LS",
    "doi": "10.1002/art.34473",
    "id": "petri-2012",
    "pmid": "22553077",
    "source": "Arthritis Rheum. 2012;64(8):2677-2686",
    "title": "Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus"
  },
  "formula": "slicc_sle",
  "formula_expression": "SLICC 2012 SLE classification (Petri Table 3 + classification rule): 11 clinical flags (acute_cutaneous_lupus, chronic_cutaneous_lupus, oral_or_nasal_ulcers, nonscarring_alopecia, synovitis, serositis, renal, neurologic, hemolytic_anemia, leukopenia_or_lymphopenia, thrombocytopenia) and 6 immunologic flags (ana, anti_dsdna, anti_sm, antiphospholipid, low_complement, direct_coombs). clinical_count = count of clinical flags that are true. immunologic_count = count of immunologic flags that are true, except direct_coombs counts only when hemolytic_anemia is false. nephritis_shortcut iff biopsy_lupus_nephritis and (ana or anti_dsdna). classified iff nephritis_shortcut or (clinical_count ≥1 and immunologic_count ≥1 and clinical_count + immunologic_count ≥4). Criteria need not be concurrent. Not a diagnosis. Not 1997 ACR. Not 2019 EULAR/ACR",
  "classified": true,
  "clinical_count": 3,
  "immunologic_count": 2,
  "nephritis_shortcut": false
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

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Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.