Hematology · LIVE

Sokal index

Compute the Sokal 1984 relative-risk index for newly diagnosed untreated chronic granulocytic leukemia from age, spleen size below the costal margin, platelet count, and percent circulating blasts, with the paper’s three groups.

LIVE $0.005 USDC GET /api/calc/sokal

Markdown: /docs/sokal.md · Canonical: https://magentlab.com/docs/sokal

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Compute the Sokal 1984 relative-risk index for newly diagnosed untreated chronic granulocytic leukemia from age, spleen size below the costal margin, platelet count, and percent circulating blasts, with the paper’s three groups.

When to use

When an agent needs the published Sokal 1984 index and must not invent later CML scores, diagnose CML, or choose TKI therapy.

When not to use

• Not a medical device. magent does not diagnose CML.
• Sokal 1984 applies to newly diagnosed untreated chronic granulocytic leukemia (CML) only.
• Does not choose TKI therapy or any other treatment.

Formula

sokal_index = exp(0.0116 * (age - 43.4) + 0.0345 * (spleen_cm - 7.51) + 0.188 * ((platelets_10e9_l / 700) ^ 2 - 0.563) + 0.0887 * (blasts_percent - 2.10))

Citation

Title

Prognostic discrimination in "good-risk" chronic granulocytic leukemia

Authors

Sokal JE, Cox EB, Baccarani M, Tura S, Gomez GA, Robertson JE, Tso CY, Braun TJ, Clarkson BD, Cervantes F, Rozman C

Source

Blood. 1984;63(4):789-799

DOI

10.1182/blood.V63.4.789.789

Worked example

Also searched as

• Sokal index
• Sokal score
• CML Sokal
• chronic granulocytic leukemia Sokal
• Sokal 1984
• CML prognostic index
• Sokal hazard ratio

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/sokal?age=50&spleen_cm=10&platelets_10e9_l=350&blasts_percent=2

Full URL: https://api.magentlab.com/api/calc/sokal?age=50&spleen_cm=10&platelets_10e9_l=350&blasts_percent=2

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/sokal?age=50&spleen_cm=10&platelets_10e9_l=350&blasts_percent=2"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/sokal Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "age": "50",
      "blasts_percent": "2",
      "platelets_10e9_l": "350",
      "spleen_cm": "10"
    },
    {
      "age": "50",
      "blasts_percent": "2",
      "platelets_10e9_l": "350",
      "spleen_cm": "10"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/sokal",
  "items": [
    {
      "age": 50,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Sokal JE, Cox EB, Baccarani M, Tura S, Gomez GA, Robertson JE, Tso CY, Braun TJ, Clarkson BD, Cervantes F, Rozman C",
        "doi": "10.1182/blood.V63.4.789.789",
        "id": "sokal-1984",
        "pmid": "6584184",
        "source": "Blood. 1984;63(4):789-799",
        "title": "Prognostic discrimination in \"good-risk\" chronic granulocytic leukemia"
      },
      "formula": "sokal",
      "formula_expression": "sokal_index = exp(0.0116 * (age - 43.4) + 0.0345 * (spleen_cm - 7.51) + 0.188 * ((platelets_10e9_l / 700) ^ 2 - 0.563) + 0.0887 * (blasts_percent - 2.10))",
      "platelets_10e9_l": 350.0,
      "spleen_cm": 10.0,
      "blasts_percent": 2.0,
      "sokal_band": "intermediate",
      "sokal_index": 1.1
    },
    {
      "age": 50,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Sokal JE, Cox EB, Baccarani M, Tura S, Gomez GA, Robertson JE, Tso CY, Braun TJ, Clarkson BD, Cervantes F, Rozman C",
        "doi": "10.1182/blood.V63.4.789.789",
        "id": "sokal-1984",
        "pmid": "6584184",
        "source": "Blood. 1984;63(4):789-799",
        "title": "Prognostic discrimination in \"good-risk\" chronic granulocytic leukemia"
      },
      "formula": "sokal",
      "formula_expression": "sokal_index = exp(0.0116 * (age - 43.4) + 0.0345 * (spleen_cm - 7.51) + 0.188 * ((platelets_10e9_l / 700) ^ 2 - 0.563) + 0.0887 * (blasts_percent - 2.10))",
      "platelets_10e9_l": 350.0,
      "spleen_cm": 10.0,
      "blasts_percent": 2.0,
      "sokal_band": "intermediate",
      "sokal_index": 1.1
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "age": 50,
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Sokal JE, Cox EB, Baccarani M, Tura S, Gomez GA, Robertson JE, Tso CY, Braun TJ, Clarkson BD, Cervantes F, Rozman C",
    "doi": "10.1182/blood.V63.4.789.789",
    "id": "sokal-1984",
    "pmid": "6584184",
    "source": "Blood. 1984;63(4):789-799",
    "title": "Prognostic discrimination in \"good-risk\" chronic granulocytic leukemia"
  },
  "formula": "sokal",
  "formula_expression": "sokal_index = exp(0.0116 * (age - 43.4) + 0.0345 * (spleen_cm - 7.51) + 0.188 * ((platelets_10e9_l / 700) ^ 2 - 0.563) + 0.0887 * (blasts_percent - 2.10))",
  "platelets_10e9_l": 350.0,
  "spleen_cm": 10.0,
  "blasts_percent": 2.0,
  "sokal_band": "intermediate",
  "sokal_index": 1.1
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• ANC — Compute absolute neutrophil count from WBC and neutrophil plus band percents, plus a Bodey 1966 granulocyte band.
• NLR — Compute the Zahorec 2001 neutrophil-to-lymphocyte ratio from relative neutrophil and lymphocyte percents.
• Mentzer index — Compute the Mentzer 1973 index as mean corpuscular volume in fL divided by red-cell count in millions per µL, with the letter’s <13 / >13 / =13 bands.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.