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Stool osmotic gap
Compute the Eherer–Fordtran fecal osmotic gap from stool sodium and potassium, using measured stool osmolality when supplied or 290 mOsm/kg when omitted.
Markdown: /docs/stool-osmotic-gap.md · Canonical: https://magentlab.com/docs/stool-osmotic-gap
Not a medical device. Not a diagnosis, dose, or listing recommendation.
What it computes
Compute the Eherer–Fordtran fecal osmotic gap from stool sodium and potassium, using measured stool osmolality when supplied or 290 mOsm/kg when omitted.
When to use
When an agent needs the published fecal osmotic-gap arithmetic and must not invent an osmotic-versus-secretory diagnosis.
When not to use
- Not a diagnosis of osmotic versus secretory diarrhea. gap_gt_50 flags whether the gap exceeds the paper’s ~50 mOsm/kg separator; it is not a clinical classification.
- When measured stool osmolality is omitted, 290 mOsm/kg is assumed. A negative gap is returned when 2×(Na+K) exceeds the osmolality used (for example from laboratory error) and is not rejected.
Formula
osmotic_gap = stool_osm_mosm_kg - 2 * (stool_sodium_mmol_l + stool_potassium_mmol_l)
Citation
- Title
- Fecal osmotic gap and pH in experimental diarrhea of various causes
- Authors
- Eherer AJ, Fordtran JS
- Source
- Gastroenterology. 1992;103(2):545-551
Worked example
Stool Na 30, K 75, assumed osm 290
Given:
stool_potassium_mmol_l=75stool_sodium_mmol_l=30
- 2 × (30 + 75) = 210
- assumed stool osm = 290 mOsm/kg
- osmotic_gap = 290 − 210 = 80.0
Try
Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.
/api/calc/stool_osmotic_gap?stool_sodium_mmol_l=30&stool_potassium_mmol_l=75
Full URL: https://api.magentlab.com/api/calc/stool_osmotic_gap?stool_sodium_mmol_l=30&stool_potassium_mmol_l=75
x402 V2 curl
Expect HTTP 402 and a PAYMENT-REQUIRED
header until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP
400 before any quote or charge. HTTP 503 after a signature: retry the same
PAYMENT-SIGNATURE
— that is not a new 402.
curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/stool_osmotic_gap?stool_sodium_mmol_l=30&stool_potassium_mmol_l=75"
Cursor mcp.json
Intended config for @magent/mcp. This is not npm @x402/fetch
(a payment fetch wrapper).
{
"mcpServers": {
"magent": {
"args": [
"-y",
"@magent/mcp"
],
"command": "npx",
"env": {
"X402_PRIVATE_KEY": "0xYOUR_SPENDING_KEY"
}
}
}
}
Parameters
| Name | Type | Required | Description |
|---|---|---|---|
stool_sodium_mmol_l |
number | required | Stool sodium in mmol/L (1-150). |
stool_potassium_mmol_l |
number | required | Stool potassium in mmol/L (1-150). |
stool_osm_mosm_kg |
number | optional | Measured stool osmolality in mOsm/kg (200-600). When omitted, 290 mOsm/kg is assumed. |
Bulk (POST)
POST the same path with a JSON items array. Price is n times the GET unit. Invalid items return HTTP 400 before settlement.
- 1 to 25 items. Each item uses the same keys as the GET query parameters.
- The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
- HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
- Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
- x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.
Example request (fixture)
{
"items": [
{
"stool_potassium_mmol_l": "75",
"stool_sodium_mmol_l": "30"
},
{
"stool_potassium_mmol_l": "75",
"stool_sodium_mmol_l": "30"
}
]
}
Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.
Example 200 (fixture)
{
"count": 2,
"path": "/api/calc/stool_osmotic_gap",
"items": [
{
"disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
"citation": {
"authors": "Eherer AJ, Fordtran JS",
"doi": "10.1016/0016-5085(92)90845-P",
"id": "eherer-fordtran-1992",
"source": "Gastroenterology. 1992;103(2):545-551",
"title": "Fecal osmotic gap and pH in experimental diarrhea of various causes"
},
"formula": "eherer_fordtran",
"formula_expression": "osmotic_gap = stool_osm_mosm_kg - 2 * (stool_sodium_mmol_l + stool_potassium_mmol_l)",
"assumed_osmolality": true,
"gap_gt_50": true,
"osmotic_gap": 80.0,
"stool_osm_mosm_kg": 290.0,
"stool_potassium_mmol_l": 75.0,
"stool_sodium_mmol_l": 30.0
},
{
"disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
"citation": {
"authors": "Eherer AJ, Fordtran JS",
"doi": "10.1016/0016-5085(92)90845-P",
"id": "eherer-fordtran-1992",
"source": "Gastroenterology. 1992;103(2):545-551",
"title": "Fecal osmotic gap and pH in experimental diarrhea of various causes"
},
"formula": "eherer_fordtran",
"formula_expression": "osmotic_gap = stool_osm_mosm_kg - 2 * (stool_sodium_mmol_l + stool_potassium_mmol_l)",
"assumed_osmolality": true,
"gap_gt_50": true,
"osmotic_gap": 80.0,
"stool_osm_mosm_kg": 290.0,
"stool_potassium_mmol_l": 75.0,
"stool_sodium_mmol_l": 30.0
}
]
}
Response
| Field | Type | Description |
|---|---|---|
formula |
string | eherer_fordtran |
formula_expression |
string | Exact expression used |
stool_sodium_mmol_l |
number | Input stool sodium in mmol/L |
stool_potassium_mmol_l |
number | Input stool potassium in mmol/L |
stool_osm_mosm_kg |
number | Stool osmolality used in mOsm/kg (measured or assumed 290) |
assumed_osmolality |
boolean | true when stool_osm_mosm_kg was omitted and 290 mOsm/kg was used |
osmotic_gap |
number | Fecal osmotic gap in mOsm/kg, 1 decimal. May be negative. |
gap_gt_50 |
boolean | true when osmotic_gap is greater than 50, the Eherer–Fordtran separator. Not a diagnosis. |
citation |
object | Eherer and Fordtran 1992 citation |
disclaimer |
string | Not-a-device notice |
Example JSON
Machine form of the same example. Frozen fixture. Not a live lookup.
{
"disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
"citation": {
"authors": "Eherer AJ, Fordtran JS",
"doi": "10.1016/0016-5085(92)90845-P",
"id": "eherer-fordtran-1992",
"source": "Gastroenterology. 1992;103(2):545-551",
"title": "Fecal osmotic gap and pH in experimental diarrhea of various causes"
},
"formula": "eherer_fordtran",
"formula_expression": "osmotic_gap = stool_osm_mosm_kg - 2 * (stool_sodium_mmol_l + stool_potassium_mmol_l)",
"assumed_osmolality": true,
"gap_gt_50": true,
"osmotic_gap": 80.0,
"stool_osm_mosm_kg": 290.0,
"stool_potassium_mmol_l": 75.0,
"stool_sodium_mmol_l": 30.0
}
Errors
| HTTP | Code | When |
|---|---|---|
| 400 | invalid_stool_sodium |
stool_sodium_mmol_l must be a number from 1 to 150. Returned before settlement; you are not charged. |
| 400 | invalid_stool_potassium |
stool_potassium_mmol_l must be a number from 1 to 150. Returned before settlement; you are not charged. |
| 400 | invalid_stool_osmolality |
stool_osm_mosm_kg must be a number from 200 to 600 when provided. Returned before settlement; you are not charged. |
| 400 | invalid_items |
POST body must be a JSON object with only an items array Returned before settlement; you are not charged. |
| 400 | invalid_item_count |
items must be an array of 1 to 25 objects Returned before settlement; you are not charged. |
| 400 | invalid_item |
each items entry must be a JSON object Returned before settlement; you are not charged. |
| 402 | payment_required |
Missing or invalid PAYMENT-SIGNATURE; decode the PAYMENT-REQUIRED header |
| 409 | payment_in_progress |
The same authorization nonce is already being settled; retry shortly |
| 429 | rate_limited |
Too many requests from this client |
| 503 | settlement_uncertain |
Settlement is unconfirmed; retry with the same PAYMENT-SIGNATURE |
| 503 | settle_failed |
Settlement failed; retry with the same PAYMENT-SIGNATURE shortly |
| 503 | facilitator_unavailable |
Payment facilitator unavailable |
| 503 | facilitator_misconfigured |
Payment facilitator is not configured |
| 503 | facilitator_unauthorized |
Payment facilitator rejected credentials |
| 503 | ledger_unavailable |
Payment ledger unavailable |
| 503 | payment_unavailable |
Payment processing unavailable |
Related tools
- Serum osmolality — Compute Worthley calculated serum osmolality from sodium, glucose, and BUN, plus an optional osmolar gap when a measured osm is supplied.
Also searched as
- fecal osmotic gap
- stool osmotic gap
- stool osmolar gap
- fecal osm gap
- Eherer Fordtran gap
- stool sodium potassium gap
Payment
Required query parameters must be present and valid. Invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64
PAYMENT-REQUIRED
header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake
and shared payment errors: Payments.
Guarantees
- Invalid query parameters return HTTP 400 before settlement. You are not charged.
- Settlement finishes before the tool executes (paymentFlow upfront). Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
- HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
- Execution is timeout-bounded and concurrency-capped.
- Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.