Infection / VTE · LIVE

Age-adjusted D-dimer cutoff (ADJUST-PE)

Age-adjusted D-dimer cutoff

Apply the Righini 2014 ADJUST-PE age-adjusted D-dimer cutoff and return whether PE is excluded at the published FEU threshold.

LIVE $0.005 USDC GET /api/calc/age_adjusted_dimer

Markdown: /docs/age-adjusted-dimer.md · Canonical: https://magentlab.com/docs/age-adjusted-dimer

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply the Righini 2014 ADJUST-PE age-adjusted D-dimer cutoff and return whether PE is excluded at the published FEU threshold.

When to use

When an agent has caller-assigned age and a D-dimer in ng/mL FEU and needs the published PE-excluded or CTPA-indicated result.

When not to use

• Not a diagnosis of pulmonary embolism or VTE. Age-adjusted D-dimer is a rule-out cutoff, not a PE confirmation.
• Not the YEARS algorithm and not the Wells PE score. Do not substitute those tools.
• D-dimer is ng/mL fibrinogen-equivalent units (FEU) only, not DDU. magent does not convert units.
• PE/VTE is excluded only when D-dimer is strictly below the age-adjusted cutoff: 500 ng/mL FEU when age < 50, or age × 10 when age ≥ 50. Equality is not excluded.
• The caller assigns age and D-dimer. magent does not examine the patient.

Formula

PE excluded iff d_dimer_ng_ml < (500 if age < 50 else age * 10); D-dimer is ng/mL FEU; equality is not excluded

Citation

Title

Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study

Authors

Righini M, Van Es J, Den Exter PL, et al.

Source

JAMA. 2014;311(11):1117-1124

DOI

10.1001/jama.2014.2135

Worked example

Also searched as

• age-adjusted D-dimer
• ADJUST-PE
• Righini D-dimer
• age adjusted dimer cutoff
• age-adjusted D-dimer PE
• ADJUST PE study

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/age_adjusted_dimer?age=40&d_dimer_ng_ml=499

Full URL: https://api.magentlab.com/api/calc/age_adjusted_dimer?age=40&d_dimer_ng_ml=499

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/age_adjusted_dimer?age=40&d_dimer_ng_ml=499"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/age_adjusted_dimer Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "age": "40",
      "d_dimer_ng_ml": "499"
    },
    {
      "age": "40",
      "d_dimer_ng_ml": "499"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/age_adjusted_dimer",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "age_years": 40,
      "citation": {
        "authors": "Righini M, Van Es J, Den Exter PL, et al.",
        "doi": "10.1001/jama.2014.2135",
        "id": "righini-2014",
        "source": "JAMA. 2014;311(11):1117-1124",
        "title": "Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study"
      },
      "formula": "age_adjusted_dimer",
      "formula_expression": "PE excluded iff d_dimer_ng_ml < (500 if age < 50 else age * 10); D-dimer is ng/mL FEU; equality is not excluded",
      "criteria": [
        {
          "value": 40,
          "factor": "age_ge_50",
          "met": false
        }
      ],
      "ctpa_indicated": false,
      "d_dimer_ng_ml": 499.0,
      "d_dimer_threshold_ng_ml": 500.0,
      "pe_excluded": true
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "age_years": 40,
      "citation": {
        "authors": "Righini M, Van Es J, Den Exter PL, et al.",
        "doi": "10.1001/jama.2014.2135",
        "id": "righini-2014",
        "source": "JAMA. 2014;311(11):1117-1124",
        "title": "Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study"
      },
      "formula": "age_adjusted_dimer",
      "formula_expression": "PE excluded iff d_dimer_ng_ml < (500 if age < 50 else age * 10); D-dimer is ng/mL FEU; equality is not excluded",
      "criteria": [
        {
          "value": 40,
          "factor": "age_ge_50",
          "met": false
        }
      ],
      "ctpa_indicated": false,
      "d_dimer_ng_ml": 499.0,
      "d_dimer_threshold_ng_ml": 500.0,
      "pe_excluded": true
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "age_years": 40,
  "citation": {
    "authors": "Righini M, Van Es J, Den Exter PL, et al.",
    "doi": "10.1001/jama.2014.2135",
    "id": "righini-2014",
    "source": "JAMA. 2014;311(11):1117-1124",
    "title": "Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study"
  },
  "formula": "age_adjusted_dimer",
  "formula_expression": "PE excluded iff d_dimer_ng_ml < (500 if age < 50 else age * 10); D-dimer is ng/mL FEU; equality is not excluded",
  "criteria": [
    {
      "value": 40,
      "factor": "age_ge_50",
      "met": false
    }
  ],
  "ctpa_indicated": false,
  "d_dimer_ng_ml": 499.0,
  "d_dimer_threshold_ng_ml": 500.0,
  "pe_excluded": true
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• YEARS algorithm — Apply the van der Hulle 2017 YEARS algorithm: count three caller-assigned items and return whether PE is excluded at the published D-dimer threshold.
• PERC rule — Apply the Kline 2004 eight-factor pulmonary embolism rule-out criteria and return whether all eight are met (PERC-negative).

Payment

Required query parameters must be present and valid. Invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• Invalid query parameters return HTTP 400 before settlement. You are not charged.
• Settlement finishes before the tool executes (paymentFlow upfront). Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.