ASCOD ischemic stroke phenotyping (Amarenco 2013)

ASCOD

Echo caller-assigned Amarenco 2013 ASCOD grades for atherosclerosis (A), small-vessel disease (S), cardiac pathology (C), other causes (O), and dissection (D) and return the canonical phenotype string (for example A1-S0-C2-O0-D0). magent does not read imaging and does not convert the five grades into a single ASCOD score.

LIVE $0.005 USDC GET /api/calc/ascod

Markdown: /docs/ascod.md · Canonical: https://magentlab.com/docs/ascod

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

When to use

When an agent already has Amarenco 2013 ASCOD grades as assigned by the caller and needs the canonical phenotype string. magent does not apply TOAST or CCS, does not read imaging, and does not assign treatment.

When not to use

Not a medical device. magent does not read imaging.
The caller assigns each ASCOD grade (1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, 9 insufficient workup). magent does not grade from stenosis percent, infarct pattern, or cardiac tests.
Not TOAST and not CCS. ASCOD describes overlapping phenotypes, not a single causative subtype.
The five grades are independent and are not summed into an ASCOD score. magent does not invent treatment.

Formula

ASCOD phenotype A{atherosclerosis}-S{small_vessel}-C{cardiac}-O{other}-D{dissection}; each caller-assigned Amarenco 2013 grade is 1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, or 9 insufficient workup to rule out the disease; grades are independent and are not summed; not TOAST; not CCS; magent does not read imaging

Citation

Title: The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping)
Authors: Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG
Source: Cerebrovasc Dis. 2013;36(1):1-5
DOI: 10.1159/000352050

Worked example

All phenotypes grade 0 (absent)

Given: atherosclerosis=0cardiac=0dissection=0other=0small_vessel=0

atherosclerosis 0, small_vessel 0, cardiac 0, other 0, dissection 0 as assigned by the caller
canonical phenotype is A0-S0-C0-O0-D0; grades are not summed

Potentially causal atherosclerosis

Given: atherosclerosis=1cardiac=0dissection=0other=0small_vessel=0

atherosclerosis 1 (potentially causal); other phenotypes 0 (absent)
canonical phenotype is A1-S0-C0-O0-D0; grades are not summed

Also searched as

ASCOD phenotyping
ASCO phenotyping
Amarenco ASCOD
ischemic stroke phenotype
A-S-C-O-D
Updated ASCO phenotyping
atherosclerosis small-vessel cardiac dissection
ASCOD ischemic stroke

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/ascod?atherosclerosis=0&small_vessel=0&cardiac=0&other=0&dissection=0

Full URL: https://api.magentlab.com/api/calc/ascod?atherosclerosis=0&small_vessel=0&cardiac=0&other=0&dissection=0

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/ascod?atherosclerosis=0&small_vessel=0&cardiac=0&other=0&dissection=0"

Parameters

Name	Type	Required	Description
`atherosclerosis`	integer	required · 0, 1, 2, 3, 9	Caller-assigned Amarenco 2013 atherosclerosis (A) grade: 1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, or 9 insufficient workup. magent does not read imaging.
`small_vessel`	integer	required · 0, 1, 2, 3, 9	Caller-assigned Amarenco 2013 small-vessel disease (S) grade: 1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, or 9 insufficient workup. magent does not read imaging.
`cardiac`	integer	required · 0, 1, 2, 3, 9	Caller-assigned Amarenco 2013 cardiac pathology (C) grade: 1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, or 9 insufficient workup. magent does not read imaging.
`other`	integer	required · 0, 1, 2, 3, 9	Caller-assigned Amarenco 2013 other causes (O) grade: 1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, or 9 insufficient workup. magent does not read imaging.
`dissection`	integer	required · 0, 1, 2, 3, 9	Caller-assigned Amarenco 2013 dissection (D) grade: 1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, or 9 insufficient workup. magent does not read imaging.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/ascod Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "atherosclerosis": "0",
      "cardiac": "0",
      "dissection": "0",
      "other": "0",
      "small_vessel": "0"
    },
    {
      "atherosclerosis": "0",
      "cardiac": "0",
      "dissection": "0",
      "other": "0",
      "small_vessel": "0"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/ascod",
  "items": [
    {
      "other": 0,
      "components": [
        {
          "value": 0,
          "factor": "atherosclerosis",
          "met": true
        },
        {
          "value": 0,
          "factor": "small_vessel",
          "met": true
        },
        {
          "value": 0,
          "factor": "cardiac",
          "met": true
        },
        {
          "value": 0,
          "factor": "other",
          "met": true
        },
        {
          "value": 0,
          "factor": "dissection",
          "met": true
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG",
        "doi": "10.1159/000352050",
        "id": "amarenco-2013",
        "pmid": "23899749",
        "source": "Cerebrovasc Dis. 2013;36(1):1-5",
        "title": "The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping)"
      },
      "formula": "ascod",
      "formula_expression": "ASCOD phenotype A{atherosclerosis}-S{small_vessel}-C{cardiac}-O{other}-D{dissection}; each caller-assigned Amarenco 2013 grade is 1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, or 9 insufficient workup to rule out the disease; grades are independent and are not summed; not TOAST; not CCS; magent does not read imaging",
      "atherosclerosis": 0,
      "cardiac": 0,
      "dissection": 0,
      "phenotype": "A0-S0-C0-O0-D0",
      "small_vessel": 0
    },
    {
      "other": 0,
      "components": [
        {
          "value": 0,
          "factor": "atherosclerosis",
          "met": true
        },
        {
          "value": 0,
          "factor": "small_vessel",
          "met": true
        },
        {
          "value": 0,
          "factor": "cardiac",
          "met": true
        },
        {
          "value": 0,
          "factor": "other",
          "met": true
        },
        {
          "value": 0,
          "factor": "dissection",
          "met": true
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG",
        "doi": "10.1159/000352050",
        "id": "amarenco-2013",
        "pmid": "23899749",
        "source": "Cerebrovasc Dis. 2013;36(1):1-5",
        "title": "The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping)"
      },
      "formula": "ascod",
      "formula_expression": "ASCOD phenotype A{atherosclerosis}-S{small_vessel}-C{cardiac}-O{other}-D{dissection}; each caller-assigned Amarenco 2013 grade is 1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, or 9 insufficient workup to rule out the disease; grades are independent and are not summed; not TOAST; not CCS; magent does not read imaging",
      "atherosclerosis": 0,
      "cardiac": 0,
      "dissection": 0,
      "phenotype": "A0-S0-C0-O0-D0",
      "small_vessel": 0
    }
  ]
}

Response

Field	Type	Description
`formula`	string	ascod
`formula_expression`	string	Published Amarenco 2013 ASCOD phenotype rule
`phenotype`	string	Canonical A{grade}-S{grade}-C{grade}-O{grade}-D{grade} string
`atherosclerosis`	integer	Caller-assigned atherosclerosis (A) grade 0, 1, 2, 3, or 9
`small_vessel`	integer	Caller-assigned small-vessel disease (S) grade 0, 1, 2, 3, or 9
`cardiac`	integer	Caller-assigned cardiac pathology (C) grade 0, 1, 2, 3, or 9
`other`	integer	Caller-assigned other causes (O) grade 0, 1, 2, 3, or 9
`dissection`	integer	Caller-assigned dissection (D) grade 0, 1, 2, 3, or 9
`components`	array	Per-phenotype Tree rows atherosclerosis, small_vessel, cardiac, other, dissection with factor, met, and value
`citation`	object	Amarenco 2013 Cerebrovasc Dis citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "other": 0,
  "components": [
    {
      "value": 0,
      "factor": "atherosclerosis",
      "met": true
    },
    {
      "value": 0,
      "factor": "small_vessel",
      "met": true
    },
    {
      "value": 0,
      "factor": "cardiac",
      "met": true
    },
    {
      "value": 0,
      "factor": "other",
      "met": true
    },
    {
      "value": 0,
      "factor": "dissection",
      "met": true
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG",
    "doi": "10.1159/000352050",
    "id": "amarenco-2013",
    "pmid": "23899749",
    "source": "Cerebrovasc Dis. 2013;36(1):1-5",
    "title": "The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping)"
  },
  "formula": "ascod",
  "formula_expression": "ASCOD phenotype A{atherosclerosis}-S{small_vessel}-C{cardiac}-O{other}-D{dissection}; each caller-assigned Amarenco 2013 grade is 1 potentially causal, 2 causality uncertain, 3 unlikely causal but the disease is present, 0 absence of disease, or 9 insufficient workup to rule out the disease; grades are independent and are not summed; not TOAST; not CCS; magent does not read imaging",
  "atherosclerosis": 0,
  "cardiac": 0,
  "dissection": 0,
  "phenotype": "A0-S0-C0-O0-D0",
  "small_vessel": 0
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_ascod`	ASCOD needs Amarenco 2013 grades 0-3 (or 9 insufficient) for A, S, C, O, and D. Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

NIHSS — Sum Brott 1989 NIH stroke scale points from 15 caller-assigned examination integers, including pupillary response and plantar reflex. Weaker-limb motor arm and leg. Does not apply later total-score severity bands.
ABCD2 score — Compute the ABCD2 score as age, blood pressure, caller-assigned clinical features, symptom duration, and diabetes.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.