CNS International Prognostic Index (Schmitz)

CNS-IPI

Sum the Schmitz 2016 CNS International Prognostic Index (Shipp IPI factors plus kidney/adrenal involvement) and return low (0–1), intermediate (2–3), or high (4–6).

LIVE $0.005 USDC GET /api/calc/cns_ipi

Markdown: /docs/cns-ipi.md · Canonical: https://magentlab.com/docs/cns-ipi

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum the Schmitz 2016 CNS International Prognostic Index (Shipp IPI factors plus kidney/adrenal involvement) and return low (0–1), intermediate (2–3), or high (4–6).

When to use

When an agent needs the published CNS-IPI point total and CNS-relapse risk group for DLBCL treated with R-CHOP and must not invent a CNS prophylaxis or LP order, a DLBCL diagnosis, or substitute NCCN-IPI or R-IPI.

When not to use

Not a medical device and not a DLBCL diagnosis or treatment choice. magent does not examine the patient.
This is Schmitz 2016 CNS-IPI (Shipp IPI factors plus kidney/adrenal involvement). It is not a CNS prophylaxis or LP order, not NCCN-IPI, and not R-IPI.
magent does not stage lymphoma or image kidneys. stage_iii_or_iv, extranodal_gt_1, ldh_gt_uln, and kidney_or_adrenal are caller-assigned flags; ECOG is a caller-assigned integer 0–4.

Formula

CNS-IPI = age_gt_60 1 + ecog_ge_2 1 + ldh_gt_uln 1 + stage_iii_or_iv 1 + extranodal_gt_1 1 + kidney_or_adrenal 1; Schmitz 2016; max 6; low 0-1, intermediate 2-3, high 4-6

Citation

Title: CNS International Prognostic Index: A Risk Model for CNS Relapse in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP
Authors: Schmitz N, Zeynalova S, Nickelsen M, Kansara R, Villa D, Sehn LH, Glass B, Scott DW, Gascoyne RD, Connors JM, Ziepert M, Pfreundschuh M, Loeffler M, Savage KJ
Source: J Clin Oncol. 2016;34(26):3150-3156
DOI: 10.1200/JCO.2015.65.6520

Worked example

Age 50, no adverse factors

Given: age=50ecog=0extranodal_gt_1=falsekidney_or_adrenal=falseldh_gt_uln=falsestage_iii_or_iv=false

Age 50 is not >60 → 0; ECOG 0 is not ≥2 → 0; all flags false
Score = 0 (max 6); cns_ipi_risk = low

All six CNS-IPI factors present

Given: age=61ecog=2extranodal_gt_1=truekidney_or_adrenal=trueldh_gt_uln=truestage_iii_or_iv=true

age_gt_60 → 1; ecog_ge_2 → 1; ldh_gt_uln → 1; stage_iii_or_iv → 1; extranodal_gt_1 → 1; kidney_or_adrenal → 1
Score = 6 (max 6); cns_ipi_risk = high (4–6)

Also searched as

CNS-IPI
CNS International Prognostic Index
CNS IPI
Schmitz CNS-IPI
CNS relapse IPI
DLBCL CNS IPI
kidney adrenal IPI
CNS-IPI score

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/cns_ipi?age=50&ecog=0&ldh_gt_uln=false&stage_iii_or_iv=false&extranodal_gt_1=false&kidney_or_adrenal=false

Full URL: https://api.magentlab.com/api/calc/cns_ipi?age=50&ecog=0&ldh_gt_uln=false&stage_iii_or_iv=false&extranodal_gt_1=false&kidney_or_adrenal=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/cns_ipi?age=50&ecog=0&ldh_gt_uln=false&stage_iii_or_iv=false&extranodal_gt_1=false&kidney_or_adrenal=false"

Parameters

Name	Type	Required	Description
`age`	integer	required	Age in years (18-120). Age >60 scores 1 (Schmitz 2016). Age 60 is the ≤60 arm and scores 0.
`ecog`	integer	required	ECOG performance status 0-4 as assigned by the caller (Schmitz 2016). ≥2 scores 1. magent does not assign ECOG.
`ldh_gt_uln`	boolean	required	Serum LDH above the upper limit of normal as assigned by the caller (Schmitz 2016). true scores 1. magent does not assay LDH.
`stage_iii_or_iv`	boolean	required	Ann Arbor stage III or IV as assigned by the caller (Schmitz 2016). true scores 1. magent does not stage lymphoma.
`extranodal_gt_1`	boolean	required	More than one extranodal site as assigned by the caller (Schmitz 2016). true scores 1. magent does not count extranodal sites.
`kidney_or_adrenal`	boolean	required	Kidney and/or adrenal involvement as assigned by the caller (Schmitz 2016). true scores 1. magent does not image kidneys.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/cns_ipi Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "age": "50",
      "ecog": "0",
      "extranodal_gt_1": "false",
      "kidney_or_adrenal": "false",
      "ldh_gt_uln": "false",
      "stage_iii_or_iv": "false"
    },
    {
      "age": "50",
      "ecog": "0",
      "extranodal_gt_1": "false",
      "kidney_or_adrenal": "false",
      "ldh_gt_uln": "false",
      "stage_iii_or_iv": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/cns_ipi",
  "items": [
    {
      "components": [
        {
          "value": 50,
          "factor": "age_gt_60",
          "points": 0,
          "present": false
        },
        {
          "value": 0,
          "factor": "ecog_ge_2",
          "points": 0,
          "present": false
        },
        {
          "factor": "ldh_gt_uln",
          "points": 0,
          "present": false
        },
        {
          "factor": "stage_iii_or_iv",
          "points": 0,
          "present": false
        },
        {
          "factor": "extranodal_gt_1",
          "points": 0,
          "present": false
        },
        {
          "factor": "kidney_or_adrenal",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Schmitz N, Zeynalova S, Nickelsen M, Kansara R, Villa D, Sehn LH, Glass B, Scott DW, Gascoyne RD, Connors JM, Ziepert M, Pfreundschuh M, Loeffler M, Savage KJ",
        "doi": "10.1200/JCO.2015.65.6520",
        "id": "schmitz-2016",
        "pmid": "27382100",
        "source": "J Clin Oncol. 2016;34(26):3150-3156",
        "title": "CNS International Prognostic Index: A Risk Model for CNS Relapse in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP"
      },
      "formula": "cns_ipi",
      "formula_expression": "CNS-IPI = age_gt_60 1 + ecog_ge_2 1 + ldh_gt_uln 1 + stage_iii_or_iv 1 + extranodal_gt_1 1 + kidney_or_adrenal 1; Schmitz 2016; max 6; low 0-1, intermediate 2-3, high 4-6",
      "age_years": 50,
      "max_score": 6,
      "score": 0,
      "cns_ipi_risk": "low",
      "ecog": 0,
      "kidney_or_adrenal": false
    },
    {
      "components": [
        {
          "value": 50,
          "factor": "age_gt_60",
          "points": 0,
          "present": false
        },
        {
          "value": 0,
          "factor": "ecog_ge_2",
          "points": 0,
          "present": false
        },
        {
          "factor": "ldh_gt_uln",
          "points": 0,
          "present": false
        },
        {
          "factor": "stage_iii_or_iv",
          "points": 0,
          "present": false
        },
        {
          "factor": "extranodal_gt_1",
          "points": 0,
          "present": false
        },
        {
          "factor": "kidney_or_adrenal",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Schmitz N, Zeynalova S, Nickelsen M, Kansara R, Villa D, Sehn LH, Glass B, Scott DW, Gascoyne RD, Connors JM, Ziepert M, Pfreundschuh M, Loeffler M, Savage KJ",
        "doi": "10.1200/JCO.2015.65.6520",
        "id": "schmitz-2016",
        "pmid": "27382100",
        "source": "J Clin Oncol. 2016;34(26):3150-3156",
        "title": "CNS International Prognostic Index: A Risk Model for CNS Relapse in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP"
      },
      "formula": "cns_ipi",
      "formula_expression": "CNS-IPI = age_gt_60 1 + ecog_ge_2 1 + ldh_gt_uln 1 + stage_iii_or_iv 1 + extranodal_gt_1 1 + kidney_or_adrenal 1; Schmitz 2016; max 6; low 0-1, intermediate 2-3, high 4-6",
      "age_years": 50,
      "max_score": 6,
      "score": 0,
      "cns_ipi_risk": "low",
      "ecog": 0,
      "kidney_or_adrenal": false
    }
  ]
}

Response

Field	Type	Description
`formula`	string	cns_ipi
`formula_expression`	string	Exact expression used
`score`	integer	CNS-IPI points 0-6
`max_score`	integer	Always 6
`cns_ipi_risk`	string	low when score is 0-1, intermediate when 2-3, high when 4-6 (Schmitz 2016). Not a CNS prophylaxis or LP order. Not a DLBCL diagnosis. CNS-IPI (Shipp IPI factors plus kidney/adrenal involvement), not NCCN-IPI, not R-IPI.
`age_years`	integer	Age used for the >60 criterion
`ecog`	integer	Caller-assigned ECOG 0-4 used for ≥2
`kidney_or_adrenal`	boolean	Caller-assigned kidney and/or adrenal involvement flag used for +1
`components`	array	Per-factor points
`citation`	object	Schmitz 2016 J Clin Oncol citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": 50,
      "factor": "age_gt_60",
      "points": 0,
      "present": false
    },
    {
      "value": 0,
      "factor": "ecog_ge_2",
      "points": 0,
      "present": false
    },
    {
      "factor": "ldh_gt_uln",
      "points": 0,
      "present": false
    },
    {
      "factor": "stage_iii_or_iv",
      "points": 0,
      "present": false
    },
    {
      "factor": "extranodal_gt_1",
      "points": 0,
      "present": false
    },
    {
      "factor": "kidney_or_adrenal",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Schmitz N, Zeynalova S, Nickelsen M, Kansara R, Villa D, Sehn LH, Glass B, Scott DW, Gascoyne RD, Connors JM, Ziepert M, Pfreundschuh M, Loeffler M, Savage KJ",
    "doi": "10.1200/JCO.2015.65.6520",
    "id": "schmitz-2016",
    "pmid": "27382100",
    "source": "J Clin Oncol. 2016;34(26):3150-3156",
    "title": "CNS International Prognostic Index: A Risk Model for CNS Relapse in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP"
  },
  "formula": "cns_ipi",
  "formula_expression": "CNS-IPI = age_gt_60 1 + ecog_ge_2 1 + ldh_gt_uln 1 + stage_iii_or_iv 1 + extranodal_gt_1 1 + kidney_or_adrenal 1; Schmitz 2016; max 6; low 0-1, intermediate 2-3, high 4-6",
  "age_years": 50,
  "max_score": 6,
  "score": 0,
  "cns_ipi_risk": "low",
  "ecog": 0,
  "kidney_or_adrenal": false
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_age`	age must be an integer from 18 to 120 Returned before settlement; you are not charged.
400	`invalid_ecog`	ecog must be an integer from 0 to 4 (Shipp 1993 IPI). Returned before settlement; you are not charged.
400	`invalid_flag`	boolean clinical flags must be true or false Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

IPI — Sum the Shipp 1993 five-factor International Prognostic Index (all ages) and return low (0–1), low_intermediate (2), high_intermediate (3), or high (4–5).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.