International Prognostic Index (Shipp)

IPI

Sum the Shipp 1993 five-factor International Prognostic Index (all ages) and return low (0–1), low_intermediate (2), high_intermediate (3), or high (4–5).

LIVE $0.005 USDC GET /api/calc/ipi

Markdown: /docs/ipi.md · Canonical: https://magentlab.com/docs/ipi

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum the Shipp 1993 five-factor International Prognostic Index (all ages) and return low (0–1), low_intermediate (2), high_intermediate (3), or high (4–5).

When to use

When an agent needs the published IPI 1993 point total and risk group and must not invent a lymphoma diagnosis or treatment choice, and must not substitute age-adjusted IPI, R-IPI, or NCCN-IPI.

When not to use

Not a medical device and not a lymphoma diagnosis or treatment choice. magent does not examine the patient.
This is the five-factor International Prognostic Index for all ages (Shipp / NEJM 1993), not the age-adjusted three-factor IPI for patients ≤60, not R-IPI (Sehn 2007), and not NCCN-IPI.
magent does not stage lymphoma, count extranodal sites, assign ECOG, or assay LDH. stage_iii_or_iv, extranodal_gt_1, and ldh_gt_uln are caller-assigned flags; ECOG is a caller-assigned integer 0–4.

Formula

IPI = age_gt_60 1 + stage_iii_or_iv 1 + extranodal_gt_1 1 + ecog_ge_2 1 + ldh_gt_uln 1; Shipp 1993; max 5; low 0-1, low_intermediate 2, high_intermediate 3, high 4-5

Citation

Title: A predictive model for aggressive non-Hodgkin's lymphoma
Authors: The International Non-Hodgkin's Lymphoma Prognostic Factors Project
Source: N Engl J Med. 1993;329(14):987-994
DOI: 10.1056/NEJM199309303291402

Worked example

Age 50, no adverse factors

Given: age=50ecog=0extranodal_gt_1=falseldh_gt_uln=falsestage_iii_or_iv=false

Age 50 is not >60 → 0; all flags false; ECOG 0 is not ≥2 → 0
Score = 0 (max 5); ipi_risk = low

Ann Arbor III–IV, extranodal >1, ECOG 2, LDH > ULN

Given: age=50ecog=2extranodal_gt_1=trueldh_gt_uln=truestage_iii_or_iv=true

age_gt_60 → 0; stage_iii_or_iv → 1; extranodal_gt_1 → 1; ecog_ge_2 → 1; ldh_gt_uln → 1
Score = 4 (max 5); ipi_risk = high (4–5)

Also searched as

IPI
International Prognostic Index
Shipp IPI
NHL IPI
aggressive lymphoma IPI
Ann Arbor IPI
IPI score
non-Hodgkin lymphoma prognostic index

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/ipi?age=50&stage_iii_or_iv=false&extranodal_gt_1=false&ecog=0&ldh_gt_uln=false

Full URL: https://api.magentlab.com/api/calc/ipi?age=50&stage_iii_or_iv=false&extranodal_gt_1=false&ecog=0&ldh_gt_uln=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/ipi?age=50&stage_iii_or_iv=false&extranodal_gt_1=false&ecog=0&ldh_gt_uln=false"

Parameters

Name	Type	Required	Description
`age`	integer	required	Age in years (18-120). Age >60 scores 1 (Shipp 1993). Age 60 is the ≤60 arm and scores 0.
`stage_iii_or_iv`	boolean	required	Ann Arbor stage III or IV as assigned by the caller (Shipp 1993). true scores 1. magent does not stage lymphoma.
`extranodal_gt_1`	boolean	required	More than one extranodal site as assigned by the caller (Shipp 1993). true scores 1. magent does not count extranodal sites.
`ecog`	integer	required	ECOG performance status 0-4 as assigned by the caller (Shipp 1993). ≥2 scores 1. magent does not assign ECOG.
`ldh_gt_uln`	boolean	required	Serum LDH above the upper limit of normal as assigned by the caller (Shipp 1993). true scores 1. magent does not assay LDH.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/ipi Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "age": "50",
      "ecog": "0",
      "extranodal_gt_1": "false",
      "ldh_gt_uln": "false",
      "stage_iii_or_iv": "false"
    },
    {
      "age": "50",
      "ecog": "0",
      "extranodal_gt_1": "false",
      "ldh_gt_uln": "false",
      "stage_iii_or_iv": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/ipi",
  "items": [
    {
      "components": [
        {
          "value": 50,
          "factor": "age_gt_60",
          "points": 0,
          "present": false
        },
        {
          "factor": "stage_iii_or_iv",
          "points": 0,
          "present": false
        },
        {
          "factor": "extranodal_gt_1",
          "points": 0,
          "present": false
        },
        {
          "value": 0,
          "factor": "ecog_ge_2",
          "points": 0,
          "present": false
        },
        {
          "factor": "ldh_gt_uln",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "The International Non-Hodgkin's Lymphoma Prognostic Factors Project",
        "doi": "10.1056/NEJM199309303291402",
        "id": "shipp-1993",
        "pmid": "8141877",
        "source": "N Engl J Med. 1993;329(14):987-994",
        "title": "A predictive model for aggressive non-Hodgkin's lymphoma"
      },
      "formula": "ipi",
      "formula_expression": "IPI = age_gt_60 1 + stage_iii_or_iv 1 + extranodal_gt_1 1 + ecog_ge_2 1 + ldh_gt_uln 1; Shipp 1993; max 5; low 0-1, low_intermediate 2, high_intermediate 3, high 4-5",
      "age_years": 50,
      "max_score": 5,
      "score": 0,
      "ecog": 0,
      "ipi_risk": "low"
    },
    {
      "components": [
        {
          "value": 50,
          "factor": "age_gt_60",
          "points": 0,
          "present": false
        },
        {
          "factor": "stage_iii_or_iv",
          "points": 0,
          "present": false
        },
        {
          "factor": "extranodal_gt_1",
          "points": 0,
          "present": false
        },
        {
          "value": 0,
          "factor": "ecog_ge_2",
          "points": 0,
          "present": false
        },
        {
          "factor": "ldh_gt_uln",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "The International Non-Hodgkin's Lymphoma Prognostic Factors Project",
        "doi": "10.1056/NEJM199309303291402",
        "id": "shipp-1993",
        "pmid": "8141877",
        "source": "N Engl J Med. 1993;329(14):987-994",
        "title": "A predictive model for aggressive non-Hodgkin's lymphoma"
      },
      "formula": "ipi",
      "formula_expression": "IPI = age_gt_60 1 + stage_iii_or_iv 1 + extranodal_gt_1 1 + ecog_ge_2 1 + ldh_gt_uln 1; Shipp 1993; max 5; low 0-1, low_intermediate 2, high_intermediate 3, high 4-5",
      "age_years": 50,
      "max_score": 5,
      "score": 0,
      "ecog": 0,
      "ipi_risk": "low"
    }
  ]
}

Response

Field	Type	Description
`formula`	string	ipi
`formula_expression`	string	Exact expression used
`score`	integer	IPI points 0-5
`max_score`	integer	Always 5
`ipi_risk`	string	low when score is 0-1, low_intermediate when 2, high_intermediate when 3, high when 4-5 (Shipp 1993). Not a lymphoma diagnosis or treatment choice. Five-factor IPI (all ages), not age-adjusted IPI, not R-IPI, not NCCN-IPI.
`age_years`	integer	Age used for the >60 criterion
`ecog`	integer	Caller-assigned ECOG 0-4 used for ≥2
`components`	array	Per-factor points
`citation`	object	Shipp 1993 N Engl J Med citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": 50,
      "factor": "age_gt_60",
      "points": 0,
      "present": false
    },
    {
      "factor": "stage_iii_or_iv",
      "points": 0,
      "present": false
    },
    {
      "factor": "extranodal_gt_1",
      "points": 0,
      "present": false
    },
    {
      "value": 0,
      "factor": "ecog_ge_2",
      "points": 0,
      "present": false
    },
    {
      "factor": "ldh_gt_uln",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "The International Non-Hodgkin's Lymphoma Prognostic Factors Project",
    "doi": "10.1056/NEJM199309303291402",
    "id": "shipp-1993",
    "pmid": "8141877",
    "source": "N Engl J Med. 1993;329(14):987-994",
    "title": "A predictive model for aggressive non-Hodgkin's lymphoma"
  },
  "formula": "ipi",
  "formula_expression": "IPI = age_gt_60 1 + stage_iii_or_iv 1 + extranodal_gt_1 1 + ecog_ge_2 1 + ldh_gt_uln 1; Shipp 1993; max 5; low 0-1, low_intermediate 2, high_intermediate 3, high 4-5",
  "age_years": 50,
  "max_score": 5,
  "score": 0,
  "ecog": 0,
  "ipi_risk": "low"
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_age`	age must be an integer from 18 to 120 Returned before settlement; you are not charged.
400	`invalid_ecog`	ecog must be an integer from 0 to 4 (Shipp 1993 IPI). Returned before settlement; you are not charged.
400	`invalid_flag`	boolean clinical flags must be true or false Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

FLIPI — Sum the Solal-Céligny 2004 FLIPI adverse factors for follicular lymphoma and return low (0–1), intermediate (2), or high (≥3).
Myeloma ISS — Apply the Greipp 2005 International Staging System for multiple myeloma from serum beta-2 microglobulin and albumin.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.