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Myeloma ISS (Greipp 2005)

Myeloma ISS

Apply the Greipp 2005 International Staging System for multiple myeloma from serum beta-2 microglobulin and albumin.

LIVE $0.005 USDC GET /api/calc/myeloma_iss

Markdown: /docs/myeloma-iss.md · Canonical: https://magentlab.com/docs/myeloma-iss

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply the Greipp 2005 International Staging System for multiple myeloma from serum beta-2 microglobulin and albumin.

When to use

When an agent has caller-supplied serum beta-2 microglobulin (mg/L) and albumin and needs the published Greipp 2005 ISS stage, not R-ISS, not Durie-Salmon, and not a treatment recommendation.

When not to use

  • Not a medical device. magent does not examine the patient and does not assay beta-2 microglobulin or albumin.
  • Not a myeloma diagnosis or treatment choice. This is Greipp 2005 ISS only, not R-ISS (no LDH, no cytogenetics) and not Durie-Salmon.
  • This is not trauma ISS (Baker 1974 Injury Severity Score).

Formula

ISS stage I: beta2_microglobulin_mg_l < 3.5 AND albumin_g_dl >= 3.5; stage III: beta2_microglobulin_mg_l >= 5.5; stage II: neither I nor III (Greipp 2005)

Citation

Title
International staging system for multiple myeloma
Authors
Greipp PR, San Miguel J, Durie BGM, Crowley JJ, Barlogie B, Bladé J, Boccadoro M, Child JA, Avet-Loiseau H, Kyle RA, Lahuerta JJ, Ludwig H, Morgan G, Powles R, Shimizu K, Shustik C, Sonneveld P, Tosi P, Turesson I, Westin J
Source
J Clin Oncol. 2005;23(15):3412-3420
DOI
10.1200/JCO.2005.04.242

Worked example

Beta-2 microglobulin 2.0 mg/L, albumin 4.0 g/dL

Given: albumin_g_dl=4.0beta2_microglobulin_mg_l=2.0

  1. Sβ2M 2.0 mg/L is < 3.5 and albumin 4.0 g/dL is >= 3.5
  2. Stage I

Beta-2 microglobulin 6.0 mg/L with albumin 4.0 g/dL

Given: albumin_g_dl=4.0beta2_microglobulin_mg_l=6.0

  1. Sβ2M 6.0 mg/L is >= 5.5
  2. Stage III; albumin is ignored

Also searched as

  • ISS myeloma
  • Greipp ISS
  • international staging system
  • multiple myeloma staging
  • ISS 2005
  • serum beta-2 microglobulin ISS
  • myeloma ISS stage
  • Greipp 2005 ISS

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/myeloma_iss?beta2_microglobulin_mg_l=2.0&albumin_g_dl=4.0

Full URL: https://api.magentlab.com/api/calc/myeloma_iss?beta2_microglobulin_mg_l=2.0&albumin_g_dl=4.0

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge. 

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/myeloma_iss?beta2_microglobulin_mg_l=2.0&albumin_g_dl=4.0"

Parameters

Name Type Required Description
beta2_microglobulin_mg_l number required Serum beta-2 microglobulin in mg/L (0.2-40). Greipp 2005 Sβ2M. Stage I requires < 3.5; stage III when >= 5.5. magent does not assay beta-2 microglobulin.
albumin_g_dl number optional Serum albumin in g/dL (1-6). Provide this or albumin_g_l, not both. Greipp 2005 stages use g/dL. Stage I requires albumin >= 3.5 when Sβ2M < 3.5. Ignored when Sβ2M >= 5.5.
albumin_g_l number optional Serum albumin in g/L (10-60). Converted as g/dL = g/L / 10. Provide this or albumin_g_dl, not both.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/myeloma_iss Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

  • 1 to 25 items. Each item uses the same keys as the GET query parameters.
  • POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
  • The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
  • HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
  • Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
  • x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "albumin_g_dl": "4.0",
      "beta2_microglobulin_mg_l": "2.0"
    },
    {
      "albumin_g_dl": "4.0",
      "beta2_microglobulin_mg_l": "2.0"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/myeloma_iss",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Greipp PR, San Miguel J, Durie BGM, Crowley JJ, Barlogie B, Bladé J, Boccadoro M, Child JA, Avet-Loiseau H, Kyle RA, Lahuerta JJ, Ludwig H, Morgan G, Powles R, Shimizu K, Shustik C, Sonneveld P, Tosi P, Turesson I, Westin J",
        "doi": "10.1200/JCO.2005.04.242",
        "id": "greipp-2005",
        "pmid": "15809451",
        "source": "J Clin Oncol. 2005;23(15):3412-3420",
        "title": "International staging system for multiple myeloma"
      },
      "formula": "myeloma_iss",
      "formula_expression": "ISS stage I: beta2_microglobulin_mg_l < 3.5 AND albumin_g_dl >= 3.5; stage III: beta2_microglobulin_mg_l >= 5.5; stage II: neither I nor III (Greipp 2005)",
      "albumin_g_dl": 4.0,
      "beta2_microglobulin_mg_l": 2.0,
      "iss_stage": 1,
      "iss_stage_label": "I"
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Greipp PR, San Miguel J, Durie BGM, Crowley JJ, Barlogie B, Bladé J, Boccadoro M, Child JA, Avet-Loiseau H, Kyle RA, Lahuerta JJ, Ludwig H, Morgan G, Powles R, Shimizu K, Shustik C, Sonneveld P, Tosi P, Turesson I, Westin J",
        "doi": "10.1200/JCO.2005.04.242",
        "id": "greipp-2005",
        "pmid": "15809451",
        "source": "J Clin Oncol. 2005;23(15):3412-3420",
        "title": "International staging system for multiple myeloma"
      },
      "formula": "myeloma_iss",
      "formula_expression": "ISS stage I: beta2_microglobulin_mg_l < 3.5 AND albumin_g_dl >= 3.5; stage III: beta2_microglobulin_mg_l >= 5.5; stage II: neither I nor III (Greipp 2005)",
      "albumin_g_dl": 4.0,
      "beta2_microglobulin_mg_l": 2.0,
      "iss_stage": 1,
      "iss_stage_label": "I"
    }
  ]
}

Response

Field Type Description
formula string myeloma_iss
formula_expression string Greipp 2005 ISS stage I / II / III rules in paper units (mg/L and g/dL)
beta2_microglobulin_mg_l number Serum beta-2 microglobulin used in mg/L
albumin_g_dl number Serum albumin used in g/dL (after g/L conversion when supplied)
iss_stage integer 1, 2, or 3 (Greipp 2005 ISS). Not Roman in this field.
iss_stage_label string I, II, or III matching iss_stage
citation object Greipp 2005 J Clin Oncol citation
disclaimer string Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup. 

{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Greipp PR, San Miguel J, Durie BGM, Crowley JJ, Barlogie B, Bladé J, Boccadoro M, Child JA, Avet-Loiseau H, Kyle RA, Lahuerta JJ, Ludwig H, Morgan G, Powles R, Shimizu K, Shustik C, Sonneveld P, Tosi P, Turesson I, Westin J",
    "doi": "10.1200/JCO.2005.04.242",
    "id": "greipp-2005",
    "pmid": "15809451",
    "source": "J Clin Oncol. 2005;23(15):3412-3420",
    "title": "International staging system for multiple myeloma"
  },
  "formula": "myeloma_iss",
  "formula_expression": "ISS stage I: beta2_microglobulin_mg_l < 3.5 AND albumin_g_dl >= 3.5; stage III: beta2_microglobulin_mg_l >= 5.5; stage II: neither I nor III (Greipp 2005)",
  "albumin_g_dl": 4.0,
  "beta2_microglobulin_mg_l": 2.0,
  "iss_stage": 1,
  "iss_stage_label": "I"
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP Code When
400 invalid_beta2_microglobulin beta2_microglobulin_mg_l must be a number from 0.2 to 40 (Greipp 2005 ISS). Returned before settlement; you are not charged.
400 invalid_albumin albumin_g_dl (1-6) or albumin_g_l (10-60) is required Returned before settlement; you are not charged.
400 invalid_items POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400 invalid_item_count items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400 invalid_item each items entry must be a JSON object Returned before settlement; you are not charged.

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Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

  • HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged.
  • exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
  • HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
  • Execution is timeout-bounded and concurrency-capped.
  • Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.