Dutch Lipid Clinic Network FH

Dutch FH

Apply the Nordestgaard 2013 Table 1 Dutch Lipid Clinic Network score from caller-supplied LDL cholesterol plus family, clinical, physical, and DNA flags, and return the 0–26 score and definite, probable, possible, or unlikely classification. Not a diagnosis.

LIVE $0.005 USDC GET /api/calc/dutch_fh

Markdown: /docs/dutch-fh.md · Canonical: https://magentlab.com/docs/dutch-fh

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

When to use

When an agent already has untreated LDL cholesterol and caller-assigned Dutch Lipid Clinic Network Table 1 family, clinical, physical, and DNA flags and needs the published adult DLCN score and classification. magent does not assay lipids, examine tendons or arcus, or sequence genes.

When not to use

Not a medical device and not a diagnosis of familial hypercholesterolaemia.
magent does not assay lipids, examine tendons or arcus, or sequence genes. The caller supplies exactly one LDL value and assigns every flag.
Adult Dutch Lipid Clinic Network Table 1 (Nordestgaard 2013 EAS consensus) only. Not Simon Broome, not MEDPED, and not homozygous FH.
Per group only the highest applicable score is counted. Family, clinical, and physical items do not add within a group.

Formula

DLCN (Nordestgaard 2013 Table 1) = family + clinical + physical + ldl + dna (per group only the highest); family: first_degree_xanthoma_or_arcus or child_ldl_gt_95th -> 2 else first_degree_premature_chd or first_degree_ldl_gt_95th -> 1; clinical: premature_chd -> 2 else premature_cerebral_or_pvd -> 1; physical: tendon_xanthoma -> 6 else corneal_arcus_age_lt_45 -> 4; ldl mmol/L: >8.5 -> 8, 6.5-8.4 -> 5, 5.0-6.4 -> 3, 4.0-4.9 -> 1; dna causative_mutation_ldlr_apob_pcsk9 -> 8; max 26; definite >8, probable 6-8, possible 3-5, unlikely 0-2

Citation

Title: Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society
Authors: Nordestgaard BG, Chapman MJ, Humphries SE, et al.
Source: Eur Heart J. 2013;34(45):3478-3490
DOI: 10.1093/eurheartj/eht273

Worked example

LDL 9.0 mmol/L with tendon xanthoma is definite FH

Given: causative_mutation_ldlr_apob_pcsk9=falsechild_ldl_gt_95th=falsecorneal_arcus_age_lt_45=falsefirst_degree_ldl_gt_95th=falsefirst_degree_premature_chd=falsefirst_degree_xanthoma_or_arcus=falseldl_mmol_l=9.0premature_cerebral_or_pvd=falsepremature_chd=falsetendon_xanthoma=true

ldl_mmol_l 9.0 > 8.5 → ldl_points 8
tendon_xanthoma true → physical_points 6 (max of the physical group)
family, clinical, and DNA groups 0 → score 14 (max 26); classification definite

Also searched as

Dutch Lipid Clinic Network
DLCN
Dutch FH criteria
familial hypercholesterolaemia score
Nordestgaard FH
DLCN FH
Dutch lipid clinic
familial hypercholesterolemia criteria

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/dutch_fh?ldl_mmol_l=9.0&first_degree_premature_chd=false&first_degree_ldl_gt_95th=false&first_degree_xanthoma_or_arcus=false&child_ldl_gt_95th=false&premature_chd=false&premature_cerebral_or_pvd=false&tendon_xanthoma=true&corneal_arcus_age_lt_45=false&causative_mutation_ldlr_apob_pcsk9=false

Full URL: https://api.magentlab.com/api/calc/dutch_fh?ldl_mmol_l=9.0&first_degree_premature_chd=false&first_degree_ldl_gt_95th=false&first_degree_xanthoma_or_arcus=false&child_ldl_gt_95th=false&premature_chd=false&premature_cerebral_or_pvd=false&tendon_xanthoma=true&corneal_arcus_age_lt_45=false&causative_mutation_ldlr_apob_pcsk9=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/dutch_fh?ldl_mmol_l=9.0&first_degree_premature_chd=false&first_degree_ldl_gt_95th=false&first_degree_xanthoma_or_arcus=false&child_ldl_gt_95th=false&premature_chd=false&premature_cerebral_or_pvd=false&tendon_xanthoma=true&corneal_arcus_age_lt_45=false&causative_mutation_ldlr_apob_pcsk9=false"

Parameters

Name	Type	Required	Description
`ldl_mmol_l`	number	optional	LDL cholesterol in mmol/L (1-20). Nordestgaard 2013 Table 1 bands: >8.5 → 8, 6.5-8.4 → 5, 5.0-6.4 → 3, 4.0-4.9 → 1. Provide exactly one of ldl_mmol_l or ldl_mg_dl. magent does not assay lipids.
`ldl_mg_dl`	number	optional	LDL cholesterol in mg/dL (40-800). Converted to mmol/L as mg/dL / 38.67, then scored on the mmol/L bands. Provide exactly one lipid parameter.
`first_degree_premature_chd`	boolean	required	First-degree relative with premature coronary heart disease (Nordestgaard 2013 Table 1 family history, 1 point). true or false as assigned by the caller. magent does not take a pedigree. Either this or first_degree_ldl_gt_95th scores 1 for the family group; a 2-point family item still yields family 2, not 3.
`first_degree_ldl_gt_95th`	boolean	required	First-degree relative with LDL cholesterol above the 95th percentile (Nordestgaard 2013 Table 1 family history, 1 point). true or false as assigned by the caller. magent does not assay lipids or take a pedigree.
`first_degree_xanthoma_or_arcus`	boolean	required	First-degree relative with tendon xanthoma and/or arcus cornealis (Nordestgaard 2013 Table 1 family history, 2 points). true or false as assigned by the caller. magent does not examine relatives. Either this or child_ldl_gt_95th scores 2 for the family group (max of family items).
`child_ldl_gt_95th`	boolean	required	Child under 18 years with LDL cholesterol above the 95th percentile (Nordestgaard 2013 Table 1 family history, 2 points). true or false as assigned by the caller. magent does not assay lipids or take a pedigree.
`premature_chd`	boolean	required	Premature coronary heart disease in the subject (Nordestgaard 2013 Table 1 clinical history, 2 points; men <55 years / women <60 years as assigned by the caller). true or false. magent does not diagnose CHD or compute age or sex. If premature_cerebral_or_pvd is also true, the clinical group is 2, not 3.
`premature_cerebral_or_pvd`	boolean	required	Premature cerebral or peripheral vascular disease in the subject (Nordestgaard 2013 Table 1 clinical history, 1 point). true or false as assigned by the caller. magent does not diagnose vascular disease.
`tendon_xanthoma`	boolean	required	Tendon xanthoma in the subject (Nordestgaard 2013 Table 1 physical examination, 6 points). true or false as assigned by the caller. magent does not examine tendons. If corneal_arcus_age_lt_45 is also true, the physical group is 6, not 10.
`corneal_arcus_age_lt_45`	boolean	required	Arcus cornealis before age 45 years (Nordestgaard 2013 Table 1 physical examination, 4 points). true or false as assigned by the caller. magent does not examine the cornea or compute age.
`causative_mutation_ldlr_apob_pcsk9`	boolean	required	Causative mutation in LDLR, APOB, or PCSK9 as assigned by the caller (Nordestgaard 2013 Table 1 DNA analysis, 8 points). true or false. magent does not sequence genes. Mutation alone is probable (score 8), not definite.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/dutch_fh Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "causative_mutation_ldlr_apob_pcsk9": "false",
      "child_ldl_gt_95th": "false",
      "corneal_arcus_age_lt_45": "false",
      "first_degree_ldl_gt_95th": "false",
      "first_degree_premature_chd": "false",
      "first_degree_xanthoma_or_arcus": "false",
      "ldl_mmol_l": "9.0",
      "premature_cerebral_or_pvd": "false",
      "premature_chd": "false",
      "tendon_xanthoma": "true"
    },
    {
      "causative_mutation_ldlr_apob_pcsk9": "false",
      "child_ldl_gt_95th": "false",
      "corneal_arcus_age_lt_45": "false",
      "first_degree_ldl_gt_95th": "false",
      "first_degree_premature_chd": "false",
      "first_degree_xanthoma_or_arcus": "false",
      "ldl_mmol_l": "9.0",
      "premature_cerebral_or_pvd": "false",
      "premature_chd": "false",
      "tendon_xanthoma": "true"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/dutch_fh",
  "items": [
    {
      "components": [
        {
          "factor": "family",
          "points": 0,
          "present": false
        },
        {
          "factor": "clinical",
          "points": 0,
          "present": false
        },
        {
          "factor": "physical",
          "points": 6,
          "present": true
        },
        {
          "value": 9.0,
          "factor": "ldl",
          "points": 8,
          "present": true
        },
        {
          "factor": "dna",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Nordestgaard BG, Chapman MJ, Humphries SE, et al.",
        "doi": "10.1093/eurheartj/eht273",
        "id": "nordestgaard-2013",
        "pmid": "23956253",
        "source": "Eur Heart J. 2013;34(45):3478-3490",
        "title": "Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society"
      },
      "formula": "dutch_fh",
      "formula_expression": "DLCN (Nordestgaard 2013 Table 1) = family + clinical + physical + ldl + dna (per group only the highest); family: first_degree_xanthoma_or_arcus or child_ldl_gt_95th -> 2 else first_degree_premature_chd or first_degree_ldl_gt_95th -> 1; clinical: premature_chd -> 2 else premature_cerebral_or_pvd -> 1; physical: tendon_xanthoma -> 6 else corneal_arcus_age_lt_45 -> 4; ldl mmol/L: >8.5 -> 8, 6.5-8.4 -> 5, 5.0-6.4 -> 3, 4.0-4.9 -> 1; dna causative_mutation_ldlr_apob_pcsk9 -> 8; max 26; definite >8, probable 6-8, possible 3-5, unlikely 0-2",
      "max_score": 26,
      "score": 14,
      "clinical_points": 0,
      "classification": "definite",
      "dna_points": 0,
      "family_points": 0,
      "ldl_mmol_l": 9.0,
      "ldl_points": 8,
      "physical_points": 6
    },
    {
      "components": [
        {
          "factor": "family",
          "points": 0,
          "present": false
        },
        {
          "factor": "clinical",
          "points": 0,
          "present": false
        },
        {
          "factor": "physical",
          "points": 6,
          "present": true
        },
        {
          "value": 9.0,
          "factor": "ldl",
          "points": 8,
          "present": true
        },
        {
          "factor": "dna",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Nordestgaard BG, Chapman MJ, Humphries SE, et al.",
        "doi": "10.1093/eurheartj/eht273",
        "id": "nordestgaard-2013",
        "pmid": "23956253",
        "source": "Eur Heart J. 2013;34(45):3478-3490",
        "title": "Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society"
      },
      "formula": "dutch_fh",
      "formula_expression": "DLCN (Nordestgaard 2013 Table 1) = family + clinical + physical + ldl + dna (per group only the highest); family: first_degree_xanthoma_or_arcus or child_ldl_gt_95th -> 2 else first_degree_premature_chd or first_degree_ldl_gt_95th -> 1; clinical: premature_chd -> 2 else premature_cerebral_or_pvd -> 1; physical: tendon_xanthoma -> 6 else corneal_arcus_age_lt_45 -> 4; ldl mmol/L: >8.5 -> 8, 6.5-8.4 -> 5, 5.0-6.4 -> 3, 4.0-4.9 -> 1; dna causative_mutation_ldlr_apob_pcsk9 -> 8; max 26; definite >8, probable 6-8, possible 3-5, unlikely 0-2",
      "max_score": 26,
      "score": 14,
      "clinical_points": 0,
      "classification": "definite",
      "dna_points": 0,
      "family_points": 0,
      "ldl_mmol_l": 9.0,
      "ldl_points": 8,
      "physical_points": 6
    }
  ]
}

Response

Field	Type	Description
`formula`	string	dutch_fh
`formula_expression`	string	Nordestgaard 2013 Table 1 Dutch Lipid Clinic Network expression
`score`	integer	DLCN points 0-26
`max_score`	integer	Always 26
`classification`	string	definite when score >8; probable when 6, 7, or 8; possible when 3, 4, or 5; unlikely when 0, 1, or 2. Score 8 (including mutation alone) is probable, not definite. Not a diagnosis.
`ldl_mmol_l`	number	The supplied LDL converted to mmol/L (mg/dL / 38.67 when ldl_mg_dl is used), rounded
`ldl_points`	integer	LDL group points: 8, 5, 3, 1, or 0
`family_points`	integer	Family-history group points: 2, 1, or 0 (max of family items)
`clinical_points`	integer	Clinical-history group points: 2, 1, or 0 (max of clinical items)
`physical_points`	integer	Physical-examination group points: 6, 4, or 0 (max of physical items)
`dna_points`	integer	DNA-analysis group points: 8 if a causative LDLR/APOB/PCSK9 mutation, else 0
`components`	array	Five group rows (family, clinical, physical, ldl, dna) with factor, present, points, and value on the ldl row
`citation`	object	Nordestgaard 2013 Eur Heart J EAS consensus citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "factor": "family",
      "points": 0,
      "present": false
    },
    {
      "factor": "clinical",
      "points": 0,
      "present": false
    },
    {
      "factor": "physical",
      "points": 6,
      "present": true
    },
    {
      "value": 9.0,
      "factor": "ldl",
      "points": 8,
      "present": true
    },
    {
      "factor": "dna",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Nordestgaard BG, Chapman MJ, Humphries SE, et al.",
    "doi": "10.1093/eurheartj/eht273",
    "id": "nordestgaard-2013",
    "pmid": "23956253",
    "source": "Eur Heart J. 2013;34(45):3478-3490",
    "title": "Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society"
  },
  "formula": "dutch_fh",
  "formula_expression": "DLCN (Nordestgaard 2013 Table 1) = family + clinical + physical + ldl + dna (per group only the highest); family: first_degree_xanthoma_or_arcus or child_ldl_gt_95th -> 2 else first_degree_premature_chd or first_degree_ldl_gt_95th -> 1; clinical: premature_chd -> 2 else premature_cerebral_or_pvd -> 1; physical: tendon_xanthoma -> 6 else corneal_arcus_age_lt_45 -> 4; ldl mmol/L: >8.5 -> 8, 6.5-8.4 -> 5, 5.0-6.4 -> 3, 4.0-4.9 -> 1; dna causative_mutation_ldlr_apob_pcsk9 -> 8; max 26; definite >8, probable 6-8, possible 3-5, unlikely 0-2",
  "max_score": 26,
  "score": 14,
  "clinical_points": 0,
  "classification": "definite",
  "dna_points": 0,
  "family_points": 0,
  "ldl_mmol_l": 9.0,
  "ldl_points": 8,
  "physical_points": 6
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_dutch_ldl`	provide exactly one of ldl_mmol_l (1-20) or ldl_mg_dl (40-800) (Nordestgaard 2013 DLCN). Returned before settlement; you are not charged.
400	`invalid_flag`	boolean clinical flags must be true or false Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

Simon Broome — Apply the 1991 Simon Broome Register adult definite familial hypercholesterolaemia rule and return definite or not_definite from one lipid value plus a caller-assigned tendon-xanthoma flag.
MEDPED — Apply the Williams 1993 US MEDPED total cholesterol tables and return whether caller-supplied total cholesterol exceeds the cutoff for that age and relative degree. Not a diagnosis.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.