Lipids · LIVE

Simon Broome definite FH

Simon Broome

Apply the 1991 Simon Broome Register adult definite familial hypercholesterolaemia rule and return definite or not_definite from one lipid value plus a caller-assigned tendon-xanthoma flag.

LIVE $0.005 USDC GET /api/calc/simon_broome

Markdown: /docs/simon-broome.md · Canonical: https://magentlab.com/docs/simon-broome

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply the 1991 Simon Broome Register adult definite familial hypercholesterolaemia rule and return definite or not_definite from one lipid value plus a caller-assigned tendon-xanthoma flag.

When to use

When an agent already has adult total cholesterol or LDL cholesterol and a caller-assigned tendon-xanthoma flag (patient or listed relative) and needs the 1991 definite-register classification. magent does not assay lipids or examine tendons. Not possible FH and not a DNA-based classifier.

When not to use

• Not a medical device and not a diagnosis of familial hypercholesterolaemia.
• magent does not assay lipids or examine tendons. The caller supplies exactly one lipid and the xanthoma flag.
• Adult definite FH as used for the 1991 register only. Does not classify possible FH, apply child cholesterol cutoffs (6.7 / 4.0 mmol/L), or use DNA mutation evidence.
• Tendon xanthomas in the patient or a relative (parent, child, grandparent, sibling, uncle, or aunt) are caller-assigned. magent does not take a pedigree.

Formula

definite FH iff (total cholesterol >7.5 mmol/L or LDL cholesterol >4.9 mmol/L) and tendon xanthomas in the patient or a relative (parent, child, grandparent, sibling, uncle, or aunt); adult 1991 register definition

Citation

Title

Risk of fatal coronary heart disease in familial hypercholesterolaemia

Authors

Scientific Steering Committee on behalf of the Simon Broome Register Group

Source

BMJ. 1991;303(6807):893-896

DOI

10.1136/bmj.303.6807.893

Worked example

Also searched as

• Simon Broome
• Simon Broome Register
• definite familial hypercholesterolaemia
• tendon xanthoma FH
• Simon Broome criteria
• familial hypercholesterolemia criteria
• adult definite FH cholesterol

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/simon_broome?total_cholesterol_mmol_l=8.0&tendon_xanthoma_patient_or_relative=true

Full URL: https://api.magentlab.com/api/calc/simon_broome?total_cholesterol_mmol_l=8.0&tendon_xanthoma_patient_or_relative=true

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/simon_broome?total_cholesterol_mmol_l=8.0&tendon_xanthoma_patient_or_relative=true"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/simon_broome Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "tendon_xanthoma_patient_or_relative": "true",
      "total_cholesterol_mmol_l": "8.0"
    },
    {
      "tendon_xanthoma_patient_or_relative": "true",
      "total_cholesterol_mmol_l": "8.0"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/simon_broome",
  "items": [
    {
      "components": [
        {
          "value": 8.0,
          "factor": "cholesterol_threshold",
          "met": true
        },
        {
          "factor": "tendon_xanthoma",
          "met": true
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Scientific Steering Committee on behalf of the Simon Broome Register Group",
        "doi": "10.1136/bmj.303.6807.893",
        "id": "simon-broome-1991",
        "source": "BMJ. 1991;303(6807):893-896",
        "title": "Risk of fatal coronary heart disease in familial hypercholesterolaemia"
      },
      "formula": "simon_broome",
      "formula_expression": "definite FH iff (total cholesterol >7.5 mmol/L or LDL cholesterol >4.9 mmol/L) and tendon xanthomas in the patient or a relative (parent, child, grandparent, sibling, uncle, or aunt); adult 1991 register definition",
      "classification": "definite",
      "cholesterol_threshold_met": true,
      "lipid_kind": "total_cholesterol",
      "lipid_mmol_l": 8.0,
      "tendon_xanthoma_patient_or_relative": true
    },
    {
      "components": [
        {
          "value": 8.0,
          "factor": "cholesterol_threshold",
          "met": true
        },
        {
          "factor": "tendon_xanthoma",
          "met": true
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Scientific Steering Committee on behalf of the Simon Broome Register Group",
        "doi": "10.1136/bmj.303.6807.893",
        "id": "simon-broome-1991",
        "source": "BMJ. 1991;303(6807):893-896",
        "title": "Risk of fatal coronary heart disease in familial hypercholesterolaemia"
      },
      "formula": "simon_broome",
      "formula_expression": "definite FH iff (total cholesterol >7.5 mmol/L or LDL cholesterol >4.9 mmol/L) and tendon xanthomas in the patient or a relative (parent, child, grandparent, sibling, uncle, or aunt); adult 1991 register definition",
      "classification": "definite",
      "cholesterol_threshold_met": true,
      "lipid_kind": "total_cholesterol",
      "lipid_mmol_l": 8.0,
      "tendon_xanthoma_patient_or_relative": true
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": 8.0,
      "factor": "cholesterol_threshold",
      "met": true
    },
    {
      "factor": "tendon_xanthoma",
      "met": true
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Scientific Steering Committee on behalf of the Simon Broome Register Group",
    "doi": "10.1136/bmj.303.6807.893",
    "id": "simon-broome-1991",
    "source": "BMJ. 1991;303(6807):893-896",
    "title": "Risk of fatal coronary heart disease in familial hypercholesterolaemia"
  },
  "formula": "simon_broome",
  "formula_expression": "definite FH iff (total cholesterol >7.5 mmol/L or LDL cholesterol >4.9 mmol/L) and tendon xanthomas in the patient or a relative (parent, child, grandparent, sibling, uncle, or aunt); adult 1991 register definition",
  "classification": "definite",
  "cholesterol_threshold_met": true,
  "lipid_kind": "total_cholesterol",
  "lipid_mmol_l": 8.0,
  "tendon_xanthoma_patient_or_relative": true
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• Friedewald LDL-C — Estimate LDL-C from total cholesterol, HDL, and triglycerides using Friedewald 1972.
• Sampson LDL-C — Estimate LDL-C from total cholesterol, HDL, and triglycerides using Sampson 2020.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.