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GALAD score

GALAD

Compute the Johnson 2014 GALAD linear predictor from age, sex, AFP, AFP-L3 percent, and DCP.

LIVE $0.005 USDC GET /api/calc/galad

Markdown: /docs/galad.md · Canonical: https://magentlab.com/docs/galad

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Compute the Johnson 2014 GALAD linear predictor from age, sex, AFP, AFP-L3 percent, and DCP.

When to use

When an agent needs the published Johnson 2014 GALAD linear predictor from age, sex, and serological biomarkers and must not invent an HCC diagnosis, listing protocol, probability, or ALBI grade.

When not to use

• Not a medical device. Not an HCC diagnosis or transplant listing protocol.
• Age 18–120 is an implementation clamp; Johnson 2014 is adult chronic liver disease.
• AFP and DCP enter as ng/mL with log10. AFP-L3 enters as a raw percent, not logged. magent does not convert DCP from mAU/mL.
• Johnson 2014 GALAD linear predictor only. Does not return a −0.63 cutoff, probability, or HCC-likely band. This is not Johnson 2015 ALBI.

Formula

galad_score = -10.08 + 0.09*age + 1.67*sex + 2.34*log10(afp_ng_ml) + 0.04*afp_l3_percent + 1.33*log10(dcp_ng_ml)

Citation

Title

The detection of hepatocellular carcinoma using a prospectively developed and validated model based on serological biomarkers

Authors

Johnson PJ, Pirrie SJ, Cox TF, Berhane S, Teng M, Palmer D, Morse J, Hull D, Patman G, Kagebayashi C, et al.

Source

Cancer Epidemiol Biomarkers Prev. 2014;23(1):144-153

DOI

10.1158/1055-9965.EPI-13-0870

Worked example

Also searched as

• GALAD score
• GALAD model
• Johnson GALAD
• AFP AFP-L3 DCP
• hepatocellular carcinoma biomarkers
• des-gamma-carboxy prothrombin GALAD

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/galad?age=60&sex=male&afp_ng_ml=10&afp_l3_percent=10&dcp_ng_ml=10

Full URL: https://api.magentlab.com/api/calc/galad?age=60&sex=male&afp_ng_ml=10&afp_l3_percent=10&dcp_ng_ml=10

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/galad?age=60&sex=male&afp_ng_ml=10&afp_l3_percent=10&dcp_ng_ml=10"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/galad Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "afp_l3_percent": "10",
      "afp_ng_ml": "10",
      "age": "60",
      "dcp_ng_ml": "10",
      "sex": "male"
    },
    {
      "afp_l3_percent": "10",
      "afp_ng_ml": "10",
      "age": "60",
      "dcp_ng_ml": "10",
      "sex": "male"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/galad",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Johnson PJ, Pirrie SJ, Cox TF, Berhane S, Teng M, Palmer D, Morse J, Hull D, Patman G, Kagebayashi C, et al.",
        "doi": "10.1158/1055-9965.EPI-13-0870",
        "id": "johnson-2014",
        "pmid": "24220911",
        "source": "Cancer Epidemiol Biomarkers Prev. 2014;23(1):144-153",
        "title": "The detection of hepatocellular carcinoma using a prospectively developed and validated model based on serological biomarkers"
      },
      "formula": "galad",
      "formula_expression": "galad_score = -10.08 + 0.09*age + 1.67*sex + 2.34*log10(afp_ng_ml) + 0.04*afp_l3_percent + 1.33*log10(dcp_ng_ml)",
      "age_years": 60,
      "sex": "male",
      "afp_l3_percent": 10.0,
      "afp_ng_ml": 10.0,
      "dcp_ng_ml": 10.0,
      "galad_score": 1.06
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Johnson PJ, Pirrie SJ, Cox TF, Berhane S, Teng M, Palmer D, Morse J, Hull D, Patman G, Kagebayashi C, et al.",
        "doi": "10.1158/1055-9965.EPI-13-0870",
        "id": "johnson-2014",
        "pmid": "24220911",
        "source": "Cancer Epidemiol Biomarkers Prev. 2014;23(1):144-153",
        "title": "The detection of hepatocellular carcinoma using a prospectively developed and validated model based on serological biomarkers"
      },
      "formula": "galad",
      "formula_expression": "galad_score = -10.08 + 0.09*age + 1.67*sex + 2.34*log10(afp_ng_ml) + 0.04*afp_l3_percent + 1.33*log10(dcp_ng_ml)",
      "age_years": 60,
      "sex": "male",
      "afp_l3_percent": 10.0,
      "afp_ng_ml": 10.0,
      "dcp_ng_ml": 10.0,
      "galad_score": 1.06
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Johnson PJ, Pirrie SJ, Cox TF, Berhane S, Teng M, Palmer D, Morse J, Hull D, Patman G, Kagebayashi C, et al.",
    "doi": "10.1158/1055-9965.EPI-13-0870",
    "id": "johnson-2014",
    "pmid": "24220911",
    "source": "Cancer Epidemiol Biomarkers Prev. 2014;23(1):144-153",
    "title": "The detection of hepatocellular carcinoma using a prospectively developed and validated model based on serological biomarkers"
  },
  "formula": "galad",
  "formula_expression": "galad_score = -10.08 + 0.09*age + 1.67*sex + 2.34*log10(afp_ng_ml) + 0.04*afp_l3_percent + 1.33*log10(dcp_ng_ml)",
  "age_years": 60,
  "sex": "male",
  "afp_l3_percent": 10.0,
  "afp_ng_ml": 10.0,
  "dcp_ng_ml": 10.0,
  "galad_score": 1.06
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• ALBI — Compute the Johnson 2015 albumin-bilirubin (ALBI) linear predictor and grade from total bilirubin and albumin.
• FIB-4 — Compute the FIB-4 fibrosis index from age, AST, ALT, and platelets.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.