MAGENT

Hematology · LIVE

HCT-CI (hematopoietic cell transplantation comorbidity index)

HCT-CI

Sum the Sorror 2005 HCT-specific comorbidity index weights and return low (0), intermediate (1–2), or high (≥3).

LIVE $0.005 USDC GET /api/calc/hct_ci

Markdown: /docs/hct-ci.md · Canonical: https://magentlab.com/docs/hct-ci

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum the Sorror 2005 HCT-specific comorbidity index weights and return low (0), intermediate (1–2), or high (≥3).

When to use

When an agent needs the published HCT-CI point total and risk group from caller-assigned comorbidities and must not substitute Charlson weights or invent a transplant listing.

When not to use

  • Not a medical device and not a diagnosis. Not a transplant listing. magent does not examine the patient.
  • This is the Sorror 2005 HCT-CI, not the Charlson comorbidity index. Weights are the HCT-CI published integers, not Charlson weights.
  • magent does not interpret PFTs, echo, BMI, or laboratory values. The caller assigns each comorbidity as present or absent, including the published pulmonary and hepatic grades.
  • Moderate and severe pulmonary grades are mutually exclusive. Mild and moderate/severe hepatic grades are mutually exclusive. Both-true returns HTTP 400. Mild pulmonary and mild renal are not scored in Sorror 2005.
  • Risk groups follow Sorror 2005 (0 low, 1–2 intermediate, ≥3 high). JSON does not include unofficial survival percentages.

Formula

HCT-CI = arrhythmia 1 + cardiac 1 + inflammatory_bowel_disease 1 + diabetes 1 + cerebrovascular_disease 1 + psychiatric_disturbance 1 + mild_hepatic 1 + obesity 1 + infection 1 + rheumatologic 2 + peptic_ulcer 2 + moderate_severe_renal 2 + moderate_pulmonary 2 + prior_solid_tumor 3 + heart_valve_disease 3 + severe_pulmonary 3 + moderate_severe_hepatic 3; Sorror 2005 HCT-CI weights; max 26; pulmonary moderate vs severe exclusive; hepatic mild vs moderate/severe exclusive; risk groups 0 low / 1-2 intermediate / >=3 high

Citation

Title
Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT
Authors
Sorror ML, Maris MB, Storb R, et al.
Source
Blood. 2005;106(9):2912-2919
DOI
10.1182/blood-2005-05-2004

Worked example

No comorbidities

Given: arrhythmia=falsecardiac=falsecerebrovascular_disease=falsediabetes=falseheart_valve_disease=falseinfection=falseinflammatory_bowel_disease=falsemild_hepatic=falsemoderate_pulmonary=falsemoderate_severe_hepatic=falsemoderate_severe_renal=falseobesity=falsepeptic_ulcer=falseprior_solid_tumor=falsepsychiatric_disturbance=falserheumatologic=falsesevere_pulmonary=false

  1. All 17 flags false
  2. score = 0
  3. risk_group = low

Mutually compatible maxima

Given: arrhythmia=truecardiac=truecerebrovascular_disease=truediabetes=trueheart_valve_disease=trueinfection=trueinflammatory_bowel_disease=truemild_hepatic=falsemoderate_pulmonary=falsemoderate_severe_hepatic=truemoderate_severe_renal=trueobesity=truepeptic_ulcer=trueprior_solid_tumor=truepsychiatric_disturbance=truerheumatologic=truesevere_pulmonary=true

  1. Severe pulmonary 3 and moderate/severe hepatic 3; remaining independent weights
  2. score = 26 (max 26); risk_group = high

Also searched as

  • HCT-CI
  • hematopoietic cell transplantation comorbidity index
  • HCT specific comorbidity index
  • Sorror comorbidity index
  • Sorror 2005 HCT-CI
  • HCT comorbidity index
  • hematopoietic cell transplant CI

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/hct_ci?arrhythmia=false&cardiac=false&inflammatory_bowel_disease=false&diabetes=false&cerebrovascular_disease=false&psychiatric_disturbance=false&mild_hepatic=false&obesity=false&infection=false&rheumatologic=false&peptic_ulcer=false&moderate_severe_renal=false&moderate_pulmonary=false&prior_solid_tumor=false&heart_valve_disease=false&severe_pulmonary=false&moderate_severe_hepatic=false

Full URL: https://api.magentlab.com/api/calc/hct_ci?arrhythmia=false&cardiac=false&inflammatory_bowel_disease=false&diabetes=false&cerebrovascular_disease=false&psychiatric_disturbance=false&mild_hepatic=false&obesity=false&infection=false&rheumatologic=false&peptic_ulcer=false&moderate_severe_renal=false&moderate_pulmonary=false&prior_solid_tumor=false&heart_valve_disease=false&severe_pulmonary=false&moderate_severe_hepatic=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge. 

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/hct_ci?arrhythmia=false&cardiac=false&inflammatory_bowel_disease=false&diabetes=false&cerebrovascular_disease=false&psychiatric_disturbance=false&mild_hepatic=false&obesity=false&infection=false&rheumatologic=false&peptic_ulcer=false&moderate_severe_renal=false&moderate_pulmonary=false&prior_solid_tumor=false&heart_valve_disease=false&severe_pulmonary=false&moderate_severe_hepatic=false"

Parameters

Name Type Required Description
arrhythmia boolean required Arrhythmia as assigned by the caller (Sorror 2005: atrial fibrillation or flutter, sick sinus syndrome, or ventricular arrhythmias). true scores 1. magent does not diagnose arrhythmia.
cardiac boolean required Cardiac comorbidity as assigned by the caller (Sorror 2005: coronary artery disease, congestive heart failure, myocardial infarction, or ejection fraction ≤50%). true scores 1. magent does not interpret echo or diagnose cardiac disease.
inflammatory_bowel_disease boolean required Inflammatory bowel disease as assigned by the caller (Sorror 2005: Crohn disease or ulcerative colitis). true scores 1. magent does not diagnose IBD.
diabetes boolean required Diabetes requiring insulin or oral hypoglycemics, not diet alone, as assigned by the caller (Sorror 2005). true scores 1. magent does not diagnose diabetes.
cerebrovascular_disease boolean required Cerebrovascular disease as assigned by the caller (Sorror 2005: TIA or cerebrovascular accident). true scores 1. magent does not diagnose stroke or TIA.
psychiatric_disturbance boolean required Psychiatric disturbance as assigned by the caller (Sorror 2005: depression or anxiety requiring psychiatric consult or treatment). true scores 1. magent does not diagnose psychiatric disease.
mild_hepatic boolean required Mild hepatic comorbidity as assigned by the caller (Sorror 2005: chronic hepatitis, bilirubin >ULN to 1.5×ULN, or AST/ALT >ULN to 2.5×ULN). true scores 1. Mutually exclusive with moderate_severe_hepatic. magent does not grade liver tests.
obesity boolean required Obesity as assigned by the caller (Sorror 2005: body mass index >35 kg/m²). true scores 1. magent does not compute BMI.
infection boolean required Infection requiring continuation of antimicrobial treatment after day 0 as assigned by the caller (Sorror 2005). true scores 1. magent does not diagnose infection.
rheumatologic boolean required Rheumatologic comorbidity as assigned by the caller (Sorror 2005: SLE, RA, polymyositis, mixed CTD, or polymyalgia rheumatica). true scores 2. magent does not diagnose rheumatologic disease.
peptic_ulcer boolean required Peptic ulcer requiring treatment as assigned by the caller (Sorror 2005). true scores 2. magent does not diagnose ulcer disease.
moderate_severe_renal boolean required Moderate/severe renal comorbidity as assigned by the caller (Sorror 2005: serum creatinine >2 mg/dL, dialysis, or prior renal transplantation). true scores 2. magent does not grade kidney disease from creatinine.
moderate_pulmonary boolean required Moderate pulmonary comorbidity as assigned by the caller (Sorror 2005: DLco and/or FEV1 66%–80% or dyspnea on slight activity). true scores 2. Mutually exclusive with severe_pulmonary. magent does not interpret PFTs.
prior_solid_tumor boolean required Prior solid tumor treated at any time, excluding nonmelanoma skin cancer, as assigned by the caller (Sorror 2005). true scores 3. magent does not diagnose cancer.
heart_valve_disease boolean required Heart valve disease except mitral valve prolapse as assigned by the caller (Sorror 2005). true scores 3. magent does not interpret echo.
severe_pulmonary boolean required Severe pulmonary comorbidity as assigned by the caller (Sorror 2005: DLco and/or FEV1 ≤65% or dyspnea at rest or requiring oxygen). true scores 3. Mutually exclusive with moderate_pulmonary. magent does not interpret PFTs.
moderate_severe_hepatic boolean required Moderate/severe hepatic comorbidity as assigned by the caller (Sorror 2005: cirrhosis, bilirubin >1.5×ULN, or AST/ALT >2.5×ULN). true scores 3. Mutually exclusive with mild_hepatic. magent does not grade liver tests.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/hct_ci Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

  • 1 to 25 items. Each item uses the same keys as the GET query parameters.
  • POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
  • The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
  • HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
  • Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
  • x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "arrhythmia": "false",
      "cardiac": "false",
      "cerebrovascular_disease": "false",
      "diabetes": "false",
      "heart_valve_disease": "false",
      "infection": "false",
      "inflammatory_bowel_disease": "false",
      "mild_hepatic": "false",
      "moderate_pulmonary": "false",
      "moderate_severe_hepatic": "false",
      "moderate_severe_renal": "false",
      "obesity": "false",
      "peptic_ulcer": "false",
      "prior_solid_tumor": "false",
      "psychiatric_disturbance": "false",
      "rheumatologic": "false",
      "severe_pulmonary": "false"
    },
    {
      "arrhythmia": "false",
      "cardiac": "false",
      "cerebrovascular_disease": "false",
      "diabetes": "false",
      "heart_valve_disease": "false",
      "infection": "false",
      "inflammatory_bowel_disease": "false",
      "mild_hepatic": "false",
      "moderate_pulmonary": "false",
      "moderate_severe_hepatic": "false",
      "moderate_severe_renal": "false",
      "obesity": "false",
      "peptic_ulcer": "false",
      "prior_solid_tumor": "false",
      "psychiatric_disturbance": "false",
      "rheumatologic": "false",
      "severe_pulmonary": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/hct_ci",
  "items": [
    {
      "components": [
        {
          "factor": "arrhythmia",
          "points": 0,
          "present": false
        },
        {
          "factor": "cardiac",
          "points": 0,
          "present": false
        },
        {
          "factor": "inflammatory_bowel_disease",
          "points": 0,
          "present": false
        },
        {
          "factor": "diabetes",
          "points": 0,
          "present": false
        },
        {
          "factor": "cerebrovascular_disease",
          "points": 0,
          "present": false
        },
        {
          "factor": "psychiatric_disturbance",
          "points": 0,
          "present": false
        },
        {
          "factor": "mild_hepatic",
          "points": 0,
          "present": false
        },
        {
          "factor": "obesity",
          "points": 0,
          "present": false
        },
        {
          "factor": "infection",
          "points": 0,
          "present": false
        },
        {
          "factor": "rheumatologic",
          "points": 0,
          "present": false
        },
        {
          "factor": "peptic_ulcer",
          "points": 0,
          "present": false
        },
        {
          "factor": "moderate_severe_renal",
          "points": 0,
          "present": false
        },
        {
          "factor": "moderate_pulmonary",
          "points": 0,
          "present": false
        },
        {
          "factor": "prior_solid_tumor",
          "points": 0,
          "present": false
        },
        {
          "factor": "heart_valve_disease",
          "points": 0,
          "present": false
        },
        {
          "factor": "severe_pulmonary",
          "points": 0,
          "present": false
        },
        {
          "factor": "moderate_severe_hepatic",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Sorror ML, Maris MB, Storb R, et al.",
        "doi": "10.1182/blood-2005-05-2004",
        "id": "sorror-2005",
        "pmid": "15994282",
        "source": "Blood. 2005;106(9):2912-2919",
        "title": "Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT"
      },
      "formula": "hct_ci",
      "formula_expression": "HCT-CI = arrhythmia 1 + cardiac 1 + inflammatory_bowel_disease 1 + diabetes 1 + cerebrovascular_disease 1 + psychiatric_disturbance 1 + mild_hepatic 1 + obesity 1 + infection 1 + rheumatologic 2 + peptic_ulcer 2 + moderate_severe_renal 2 + moderate_pulmonary 2 + prior_solid_tumor 3 + heart_valve_disease 3 + severe_pulmonary 3 + moderate_severe_hepatic 3; Sorror 2005 HCT-CI weights; max 26; pulmonary moderate vs severe exclusive; hepatic mild vs moderate/severe exclusive; risk groups 0 low / 1-2 intermediate / >=3 high",
      "max_score": 26,
      "score": 0,
      "risk_group": "low"
    },
    {
      "components": [
        {
          "factor": "arrhythmia",
          "points": 0,
          "present": false
        },
        {
          "factor": "cardiac",
          "points": 0,
          "present": false
        },
        {
          "factor": "inflammatory_bowel_disease",
          "points": 0,
          "present": false
        },
        {
          "factor": "diabetes",
          "points": 0,
          "present": false
        },
        {
          "factor": "cerebrovascular_disease",
          "points": 0,
          "present": false
        },
        {
          "factor": "psychiatric_disturbance",
          "points": 0,
          "present": false
        },
        {
          "factor": "mild_hepatic",
          "points": 0,
          "present": false
        },
        {
          "factor": "obesity",
          "points": 0,
          "present": false
        },
        {
          "factor": "infection",
          "points": 0,
          "present": false
        },
        {
          "factor": "rheumatologic",
          "points": 0,
          "present": false
        },
        {
          "factor": "peptic_ulcer",
          "points": 0,
          "present": false
        },
        {
          "factor": "moderate_severe_renal",
          "points": 0,
          "present": false
        },
        {
          "factor": "moderate_pulmonary",
          "points": 0,
          "present": false
        },
        {
          "factor": "prior_solid_tumor",
          "points": 0,
          "present": false
        },
        {
          "factor": "heart_valve_disease",
          "points": 0,
          "present": false
        },
        {
          "factor": "severe_pulmonary",
          "points": 0,
          "present": false
        },
        {
          "factor": "moderate_severe_hepatic",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Sorror ML, Maris MB, Storb R, et al.",
        "doi": "10.1182/blood-2005-05-2004",
        "id": "sorror-2005",
        "pmid": "15994282",
        "source": "Blood. 2005;106(9):2912-2919",
        "title": "Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT"
      },
      "formula": "hct_ci",
      "formula_expression": "HCT-CI = arrhythmia 1 + cardiac 1 + inflammatory_bowel_disease 1 + diabetes 1 + cerebrovascular_disease 1 + psychiatric_disturbance 1 + mild_hepatic 1 + obesity 1 + infection 1 + rheumatologic 2 + peptic_ulcer 2 + moderate_severe_renal 2 + moderate_pulmonary 2 + prior_solid_tumor 3 + heart_valve_disease 3 + severe_pulmonary 3 + moderate_severe_hepatic 3; Sorror 2005 HCT-CI weights; max 26; pulmonary moderate vs severe exclusive; hepatic mild vs moderate/severe exclusive; risk groups 0 low / 1-2 intermediate / >=3 high",
      "max_score": 26,
      "score": 0,
      "risk_group": "low"
    }
  ]
}

Response

Field Type Description
formula string hct_ci
formula_expression string Exact expression used
score integer HCT-CI points 0-26
max_score integer 26
risk_group string low when score is 0, intermediate when 1-2, high when ≥3 (Sorror 2005). A group, not a diagnosis and not a transplant listing.
components array Per-comorbidity points
citation object Sorror et al. Blood 2005 citation
disclaimer string Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup. 

{
  "components": [
    {
      "factor": "arrhythmia",
      "points": 0,
      "present": false
    },
    {
      "factor": "cardiac",
      "points": 0,
      "present": false
    },
    {
      "factor": "inflammatory_bowel_disease",
      "points": 0,
      "present": false
    },
    {
      "factor": "diabetes",
      "points": 0,
      "present": false
    },
    {
      "factor": "cerebrovascular_disease",
      "points": 0,
      "present": false
    },
    {
      "factor": "psychiatric_disturbance",
      "points": 0,
      "present": false
    },
    {
      "factor": "mild_hepatic",
      "points": 0,
      "present": false
    },
    {
      "factor": "obesity",
      "points": 0,
      "present": false
    },
    {
      "factor": "infection",
      "points": 0,
      "present": false
    },
    {
      "factor": "rheumatologic",
      "points": 0,
      "present": false
    },
    {
      "factor": "peptic_ulcer",
      "points": 0,
      "present": false
    },
    {
      "factor": "moderate_severe_renal",
      "points": 0,
      "present": false
    },
    {
      "factor": "moderate_pulmonary",
      "points": 0,
      "present": false
    },
    {
      "factor": "prior_solid_tumor",
      "points": 0,
      "present": false
    },
    {
      "factor": "heart_valve_disease",
      "points": 0,
      "present": false
    },
    {
      "factor": "severe_pulmonary",
      "points": 0,
      "present": false
    },
    {
      "factor": "moderate_severe_hepatic",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Sorror ML, Maris MB, Storb R, et al.",
    "doi": "10.1182/blood-2005-05-2004",
    "id": "sorror-2005",
    "pmid": "15994282",
    "source": "Blood. 2005;106(9):2912-2919",
    "title": "Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT"
  },
  "formula": "hct_ci",
  "formula_expression": "HCT-CI = arrhythmia 1 + cardiac 1 + inflammatory_bowel_disease 1 + diabetes 1 + cerebrovascular_disease 1 + psychiatric_disturbance 1 + mild_hepatic 1 + obesity 1 + infection 1 + rheumatologic 2 + peptic_ulcer 2 + moderate_severe_renal 2 + moderate_pulmonary 2 + prior_solid_tumor 3 + heart_valve_disease 3 + severe_pulmonary 3 + moderate_severe_hepatic 3; Sorror 2005 HCT-CI weights; max 26; pulmonary moderate vs severe exclusive; hepatic mild vs moderate/severe exclusive; risk groups 0 low / 1-2 intermediate / >=3 high",
  "max_score": 26,
  "score": 0,
  "risk_group": "low"
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP Code When
400 invalid_flag boolean clinical flags must be true or false Returned before settlement; you are not charged.
400 invalid_hct_ci each HCT-CI 2005 comorbidity must be scored as in Sorror 2005. Returned before settlement; you are not charged.
400 invalid_items POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400 invalid_item_count items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400 invalid_item each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

  • Charlson CCI — Sum the nineteen Charlson 1987 original comorbidity weights and return the published 1-year mortality group.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

  • HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
  • exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
  • HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
  • Execution is timeout-bounded and concurrency-capped.
  • Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.