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HEMORR2HAGES calculator

HEMORR2HAGES

Compute the Gage 2006 HEMORR2HAGES bleeding-risk score from age and caller-assigned clinical flags, with published warfarin major-bleed rates per 100 patient-years.

LIVE $0.005 USDC GET /api/calc/hemorr2hages

Markdown: /docs/hemorr2hages.md · Canonical: https://magentlab.com/docs/hemorr2hages

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Compute the Gage 2006 HEMORR2HAGES bleeding-risk score from age and caller-assigned clinical flags, with published warfarin major-bleed rates per 100 patient-years.

When to use

When an agent needs the published HEMORR2HAGES AF bleeding-risk arithmetic (not HAS-BLED, not ORBIT, not ATRIA) and must not invent the point total from prose.

When not to use

  • Not a medical device. Not a diagnosis and not a decision to start or stop anticoagulation.
  • Not a warfarin prescription. magent does not dose warfarin or interpret INR.
  • Not HAS-BLED, not ORBIT, and not ATRIA. This tool is the Gage 2006 HEMORR2HAGES score only.
  • Age >75 scores 1 (76 scores; 75 does not). Prior bleed scores 2. Hepatic or renal disease is one caller flag. magent does not measure platelets, hemoglobin, or CYP2C9.

Formula

HEMORR2HAGES = prior_bleed (2) + hepatic_or_renal (1) + ethanol (1) + malignancy (1) + age_gt_75 (1) + reduced_platelet (1) + uncontrolled_hypertension (1) + anemia (1) + genetic_factors (1) + excessive_fall_risk (1) + stroke (1); max 12; warfarin major bleed per 100 pt-years: 0=1.9, 1=2.5, 2=5.3, 3=8.4, 4=10.4, >=5=12.3

Citation

Title
Clinical classification schemes for predicting hemorrhage: results from the National Registry of Atrial Fibrillation (NRAF)
Authors
Gage BF, Yan Y, Milligan PE, et al.
Source
Am Heart J. 2006;151(3):713-719
DOI
10.1016/j.ahj.2005.04.017

Worked example

Age 60, all flags false

Given: age=60anemia=falseethanol=falseexcessive_fall_risk=falsegenetic_factors=falsehepatic_or_renal=falsemalignancy=falseprior_bleed=falsereduced_platelet=falsestroke=falseuncontrolled_hypertension=false

  1. Age 60 is not >75 → 0; all flags false → 0
  2. Score = 0 (max 12); bleed_rate_per_100_pt_years 1.9

Also searched as

  • hemorr2hages
  • hemorrhage
  • atrial fibrillation
  • HEMORR2HAGES score
  • HEMORR₂HAGES
  • Gage 2006 bleeding score
  • NRAF hemorrhage score

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/hemorr2hages?age=60&prior_bleed=false&hepatic_or_renal=false&ethanol=false&malignancy=false&reduced_platelet=false&uncontrolled_hypertension=false&anemia=false&genetic_factors=false&excessive_fall_risk=false&stroke=false

Full URL: https://api.magentlab.com/api/calc/hemorr2hages?age=60&prior_bleed=false&hepatic_or_renal=false&ethanol=false&malignancy=false&reduced_platelet=false&uncontrolled_hypertension=false&anemia=false&genetic_factors=false&excessive_fall_risk=false&stroke=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge. 

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/hemorr2hages?age=60&prior_bleed=false&hepatic_or_renal=false&ethanol=false&malignancy=false&reduced_platelet=false&uncontrolled_hypertension=false&anemia=false&genetic_factors=false&excessive_fall_risk=false&stroke=false"

Parameters

Name Type Required Description
age integer required Age in years (18-120). Age >75 scores 1 (76 scores; 75 does not).
prior_bleed boolean required Prior bleed / rebleeding as assigned by the caller. true or false. Scores 2 (the 2 in HEMORR2HAGES).
hepatic_or_renal boolean required Hepatic or renal disease as assigned by the caller. true or false. Scores 1 as a single flag.
ethanol boolean required Ethanol abuse as assigned by the caller. true or false. Scores 1.
malignancy boolean required Malignancy as assigned by the caller. true or false. Scores 1.
reduced_platelet boolean required Reduced platelet count or function as assigned by the caller. true or false. Scores 1. magent does not take a platelet count.
uncontrolled_hypertension boolean required Uncontrolled hypertension as assigned by the caller. true or false. Scores 1.
anemia boolean required Anemia as assigned by the caller. true or false. Scores 1. magent does not take hemoglobin.
genetic_factors boolean required Genetic factors as assigned by the caller (paper: CYP2C9). true or false. Scores 1. magent does not genotype.
excessive_fall_risk boolean required Excessive fall risk as assigned by the caller. true or false. Scores 1.
stroke boolean required Prior stroke as assigned by the caller. true or false. Scores 1.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/hemorr2hages Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

  • 1 to 25 items. Each item uses the same keys as the GET query parameters.
  • POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
  • The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
  • HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
  • Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
  • x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "age": "60",
      "anemia": "false",
      "ethanol": "false",
      "excessive_fall_risk": "false",
      "genetic_factors": "false",
      "hepatic_or_renal": "false",
      "malignancy": "false",
      "prior_bleed": "false",
      "reduced_platelet": "false",
      "stroke": "false",
      "uncontrolled_hypertension": "false"
    },
    {
      "age": "60",
      "anemia": "false",
      "ethanol": "false",
      "excessive_fall_risk": "false",
      "genetic_factors": "false",
      "hepatic_or_renal": "false",
      "malignancy": "false",
      "prior_bleed": "false",
      "reduced_platelet": "false",
      "stroke": "false",
      "uncontrolled_hypertension": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/hemorr2hages",
  "items": [
    {
      "components": [
        {
          "factor": "prior_bleed",
          "points": 0,
          "present": false
        },
        {
          "factor": "hepatic_or_renal",
          "points": 0,
          "present": false
        },
        {
          "factor": "ethanol",
          "points": 0,
          "present": false
        },
        {
          "factor": "malignancy",
          "points": 0,
          "present": false
        },
        {
          "value": 60,
          "factor": "age_gt_75",
          "points": 0,
          "present": false
        },
        {
          "factor": "reduced_platelet",
          "points": 0,
          "present": false
        },
        {
          "factor": "uncontrolled_hypertension",
          "points": 0,
          "present": false
        },
        {
          "factor": "anemia",
          "points": 0,
          "present": false
        },
        {
          "factor": "genetic_factors",
          "points": 0,
          "present": false
        },
        {
          "factor": "excessive_fall_risk",
          "points": 0,
          "present": false
        },
        {
          "factor": "stroke",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Gage BF, Yan Y, Milligan PE, et al.",
        "doi": "10.1016/j.ahj.2005.04.017",
        "id": "gage-2006",
        "pmid": "16504638",
        "source": "Am Heart J. 2006;151(3):713-719",
        "title": "Clinical classification schemes for predicting hemorrhage: results from the National Registry of Atrial Fibrillation (NRAF)"
      },
      "formula": "hemorr2hages",
      "formula_expression": "HEMORR2HAGES = prior_bleed (2) + hepatic_or_renal (1) + ethanol (1) + malignancy (1) + age_gt_75 (1) + reduced_platelet (1) + uncontrolled_hypertension (1) + anemia (1) + genetic_factors (1) + excessive_fall_risk (1) + stroke (1); max 12; warfarin major bleed per 100 pt-years: 0=1.9, 1=2.5, 2=5.3, 3=8.4, 4=10.4, >=5=12.3",
      "max_score": 12,
      "score": 0,
      "age_years": 60,
      "bleed_rate_per_100_pt_years": 1.9
    },
    {
      "components": [
        {
          "factor": "prior_bleed",
          "points": 0,
          "present": false
        },
        {
          "factor": "hepatic_or_renal",
          "points": 0,
          "present": false
        },
        {
          "factor": "ethanol",
          "points": 0,
          "present": false
        },
        {
          "factor": "malignancy",
          "points": 0,
          "present": false
        },
        {
          "value": 60,
          "factor": "age_gt_75",
          "points": 0,
          "present": false
        },
        {
          "factor": "reduced_platelet",
          "points": 0,
          "present": false
        },
        {
          "factor": "uncontrolled_hypertension",
          "points": 0,
          "present": false
        },
        {
          "factor": "anemia",
          "points": 0,
          "present": false
        },
        {
          "factor": "genetic_factors",
          "points": 0,
          "present": false
        },
        {
          "factor": "excessive_fall_risk",
          "points": 0,
          "present": false
        },
        {
          "factor": "stroke",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Gage BF, Yan Y, Milligan PE, et al.",
        "doi": "10.1016/j.ahj.2005.04.017",
        "id": "gage-2006",
        "pmid": "16504638",
        "source": "Am Heart J. 2006;151(3):713-719",
        "title": "Clinical classification schemes for predicting hemorrhage: results from the National Registry of Atrial Fibrillation (NRAF)"
      },
      "formula": "hemorr2hages",
      "formula_expression": "HEMORR2HAGES = prior_bleed (2) + hepatic_or_renal (1) + ethanol (1) + malignancy (1) + age_gt_75 (1) + reduced_platelet (1) + uncontrolled_hypertension (1) + anemia (1) + genetic_factors (1) + excessive_fall_risk (1) + stroke (1); max 12; warfarin major bleed per 100 pt-years: 0=1.9, 1=2.5, 2=5.3, 3=8.4, 4=10.4, >=5=12.3",
      "max_score": 12,
      "score": 0,
      "age_years": 60,
      "bleed_rate_per_100_pt_years": 1.9
    }
  ]
}

Response

Field Type Description
formula string hemorr2hages
formula_expression string Exact expression used
score integer Total points 0-12
max_score integer Always 12
bleed_rate_per_100_pt_years number Gage 2006 warfarin major bleed rate per 100 patient-years: 1.9 (0), 2.5 (1), 5.3 (2), 8.4 (3), 10.4 (4), 12.3 (≥5). Not a diagnosis.
age_years integer Age used for the >75 criterion
components array Per-factor points
citation object Gage 2006 Am Heart J citation
disclaimer string Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup. 

{
  "components": [
    {
      "factor": "prior_bleed",
      "points": 0,
      "present": false
    },
    {
      "factor": "hepatic_or_renal",
      "points": 0,
      "present": false
    },
    {
      "factor": "ethanol",
      "points": 0,
      "present": false
    },
    {
      "factor": "malignancy",
      "points": 0,
      "present": false
    },
    {
      "value": 60,
      "factor": "age_gt_75",
      "points": 0,
      "present": false
    },
    {
      "factor": "reduced_platelet",
      "points": 0,
      "present": false
    },
    {
      "factor": "uncontrolled_hypertension",
      "points": 0,
      "present": false
    },
    {
      "factor": "anemia",
      "points": 0,
      "present": false
    },
    {
      "factor": "genetic_factors",
      "points": 0,
      "present": false
    },
    {
      "factor": "excessive_fall_risk",
      "points": 0,
      "present": false
    },
    {
      "factor": "stroke",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Gage BF, Yan Y, Milligan PE, et al.",
    "doi": "10.1016/j.ahj.2005.04.017",
    "id": "gage-2006",
    "pmid": "16504638",
    "source": "Am Heart J. 2006;151(3):713-719",
    "title": "Clinical classification schemes for predicting hemorrhage: results from the National Registry of Atrial Fibrillation (NRAF)"
  },
  "formula": "hemorr2hages",
  "formula_expression": "HEMORR2HAGES = prior_bleed (2) + hepatic_or_renal (1) + ethanol (1) + malignancy (1) + age_gt_75 (1) + reduced_platelet (1) + uncontrolled_hypertension (1) + anemia (1) + genetic_factors (1) + excessive_fall_risk (1) + stroke (1); max 12; warfarin major bleed per 100 pt-years: 0=1.9, 1=2.5, 2=5.3, 3=8.4, 4=10.4, >=5=12.3",
  "max_score": 12,
  "score": 0,
  "age_years": 60,
  "bleed_rate_per_100_pt_years": 1.9
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP Code When
400 invalid_age age must be an integer from 18 to 120 Returned before settlement; you are not charged.
400 invalid_flag boolean clinical flags must be true or false Returned before settlement; you are not charged.
400 invalid_items POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400 invalid_item_count items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400 invalid_item each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

  • HAS-BLED — Compute the HAS-BLED bleeding-risk score from discrete clinical flags.
  • ORBIT bleeding score — Compute the O'Brien 2015 ORBIT bleeding score from age and caller-assigned anemia, bleeding history, insufficient kidney, and antiplatelet flags.
  • ATRIA hemorrhage score — Compute the Fang 2011 ATRIA hemorrhage score from caller-assigned anemia, severe renal disease, age, prior hemorrhage, and hypertension flags.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

  • HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged.
  • exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
  • HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
  • Execution is timeout-bounded and concurrency-capped.
  • Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.