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IMWG 2014 multiple myeloma criteria

IMWG myeloma criteria

Apply the Rajkumar 2014 International Myeloma Working Group updated criteria for multiple myeloma requiring therapy: clonal bone marrow plasma cells ≥10% or biopsy-proven plasmacytoma plus at least one myeloma-defining event (CRAB or SLiM).

LIVE $0.005 USDC GET /api/calc/imwg_myeloma

Markdown: /docs/imwg-myeloma.md · Canonical: https://magentlab.com/docs/imwg-myeloma

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply the Rajkumar 2014 International Myeloma Working Group updated criteria for multiple myeloma requiring therapy: clonal bone marrow plasma cells ≥10% or biopsy-proven plasmacytoma plus at least one myeloma-defining event (CRAB or SLiM).

When to use

When an agent already has caller-assigned IMWG 2014 entry and myeloma-defining event flags and needs the published combination. magent does not diagnose myeloma, does not assay calcium, creatinine, hemoglobin, or free light chains, and does not read MRI.

When not to use

• Not a medical device.
• Not a diagnosis. Criteria met is not a multiple myeloma diagnosis without the rest of the IMWG 2014 workup.
• Not smouldering multiple myeloma, MGUS, POEMS, or amyloid. This tool is myeloma requiring therapy only.
• Not Greipp ISS (myeloma-iss). Not R-ISS.
• magent does not assay calcium, creatinine, hemoglobin, or free light chains, and does not read MRI. All flags are caller-assigned.
• If marrow clonal plasma cells are <10%, more than one bone lesion is required to distinguish solitary plasmacytoma; that is the caller’s assignment of osteolytic_lesion.
• flc_ratio_ge_100 is the caller-assigned combination of involved:uninvolved serum free light-chain ratio ≥100 and involved free light chain ≥100 mg/L as published for the Freelite assay (Rajkumar 2014). magent does not assay free light chains.

Formula

myeloma iff clonal_bmpc_ge_10_or_plasmacytoma and ≥1 myeloma-defining event (hypercalcemia, renal_insufficiency, anemia, osteolytic_lesion, bmpc_ge_60, flc_ratio_ge_100, or mri_gt_1_focal) (Rajkumar 2014 IMWG definition of multiple myeloma requiring therapy). Not a diagnosis. Not smouldering MM, MGUS, POEMS, or amyloid. Not Greipp ISS. Not R-ISS

Citation

Title

International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma

Authors

Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, Kumar S, Hillengass J, Kastritis E, Richardson P, Landgren O, Paiva B, Dispenzieri A, Weiss B, LeLeu X, Zweegman S, Lonial S, Rosinol L, Zamagni E, Jagannath S, Sezer O, Kristinsson SY, Caers J, Usmani SZ, Lahuerta JJ, Johnsen HE, Beksac M, Cavo M, Goldschmidt H, Terpos E, Kyle RA, Anderson KC, Durie BGM, San Miguel JF

Source

Lancet Oncol. 2014;15(12):e538-e548

DOI

10.1016/S1470-2045(14)70442-5

Worked example

Also searched as

• IMWG 2014 myeloma
• Rajkumar 2014 myeloma
• myeloma defining events
• CRAB SLiM criteria
• multiple myeloma requiring therapy
• clonal BMPC plasmacytoma
• IMWG updated myeloma criteria
• SLiM biomarkers myeloma

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/imwg_myeloma?clonal_bmpc_ge_10_or_plasmacytoma=true&hypercalcemia=true&renal_insufficiency=false&anemia=false&osteolytic_lesion=false&bmpc_ge_60=false&flc_ratio_ge_100=false&mri_gt_1_focal=false

Full URL: https://api.magentlab.com/api/calc/imwg_myeloma?clonal_bmpc_ge_10_or_plasmacytoma=true&hypercalcemia=true&renal_insufficiency=false&anemia=false&osteolytic_lesion=false&bmpc_ge_60=false&flc_ratio_ge_100=false&mri_gt_1_focal=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/imwg_myeloma?clonal_bmpc_ge_10_or_plasmacytoma=true&hypercalcemia=true&renal_insufficiency=false&anemia=false&osteolytic_lesion=false&bmpc_ge_60=false&flc_ratio_ge_100=false&mri_gt_1_focal=false"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/imwg_myeloma Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "anemia": "false",
      "bmpc_ge_60": "false",
      "clonal_bmpc_ge_10_or_plasmacytoma": "true",
      "flc_ratio_ge_100": "false",
      "hypercalcemia": "true",
      "mri_gt_1_focal": "false",
      "osteolytic_lesion": "false",
      "renal_insufficiency": "false"
    },
    {
      "anemia": "false",
      "bmpc_ge_60": "false",
      "clonal_bmpc_ge_10_or_plasmacytoma": "true",
      "flc_ratio_ge_100": "false",
      "hypercalcemia": "true",
      "mri_gt_1_focal": "false",
      "osteolytic_lesion": "false",
      "renal_insufficiency": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/imwg_myeloma",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, Kumar S, Hillengass J, Kastritis E, Richardson P, Landgren O, Paiva B, Dispenzieri A, Weiss B, LeLeu X, Zweegman S, Lonial S, Rosinol L, Zamagni E, Jagannath S, Sezer O, Kristinsson SY, Caers J, Usmani SZ, Lahuerta JJ, Johnsen HE, Beksac M, Cavo M, Goldschmidt H, Terpos E, Kyle RA, Anderson KC, Durie BGM, San Miguel JF",
        "doi": "10.1016/S1470-2045(14)70442-5",
        "id": "rajkumar-2014",
        "pmid": "25439696",
        "source": "Lancet Oncol. 2014;15(12):e538-e548",
        "title": "International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma"
      },
      "formula": "imwg_myeloma",
      "formula_expression": "myeloma iff clonal_bmpc_ge_10_or_plasmacytoma and ≥1 myeloma-defining event (hypercalcemia, renal_insufficiency, anemia, osteolytic_lesion, bmpc_ge_60, flc_ratio_ge_100, or mri_gt_1_focal) (Rajkumar 2014 IMWG definition of multiple myeloma requiring therapy). Not a diagnosis. Not smouldering MM, MGUS, POEMS, or amyloid. Not Greipp ISS. Not R-ISS",
      "criteria": [
        {
          "factor": "clonal_bmpc_ge_10_or_plasmacytoma",
          "met": true
        },
        {
          "factor": "hypercalcemia",
          "met": true
        },
        {
          "factor": "renal_insufficiency",
          "met": false
        },
        {
          "factor": "anemia",
          "met": false
        },
        {
          "factor": "osteolytic_lesion",
          "met": false
        },
        {
          "factor": "bmpc_ge_60",
          "met": false
        },
        {
          "factor": "flc_ratio_ge_100",
          "met": false
        },
        {
          "factor": "mri_gt_1_focal",
          "met": false
        },
        {
          "factor": "any_mde",
          "met": true
        }
      ],
      "anemia": false,
      "any_mde": true,
      "bmpc_ge_60": false,
      "clonal_bmpc_ge_10_or_plasmacytoma": true,
      "flc_ratio_ge_100": false,
      "hypercalcemia": true,
      "mri_gt_1_focal": false,
      "myeloma": true,
      "osteolytic_lesion": false,
      "renal_insufficiency": false
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, Kumar S, Hillengass J, Kastritis E, Richardson P, Landgren O, Paiva B, Dispenzieri A, Weiss B, LeLeu X, Zweegman S, Lonial S, Rosinol L, Zamagni E, Jagannath S, Sezer O, Kristinsson SY, Caers J, Usmani SZ, Lahuerta JJ, Johnsen HE, Beksac M, Cavo M, Goldschmidt H, Terpos E, Kyle RA, Anderson KC, Durie BGM, San Miguel JF",
        "doi": "10.1016/S1470-2045(14)70442-5",
        "id": "rajkumar-2014",
        "pmid": "25439696",
        "source": "Lancet Oncol. 2014;15(12):e538-e548",
        "title": "International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma"
      },
      "formula": "imwg_myeloma",
      "formula_expression": "myeloma iff clonal_bmpc_ge_10_or_plasmacytoma and ≥1 myeloma-defining event (hypercalcemia, renal_insufficiency, anemia, osteolytic_lesion, bmpc_ge_60, flc_ratio_ge_100, or mri_gt_1_focal) (Rajkumar 2014 IMWG definition of multiple myeloma requiring therapy). Not a diagnosis. Not smouldering MM, MGUS, POEMS, or amyloid. Not Greipp ISS. Not R-ISS",
      "criteria": [
        {
          "factor": "clonal_bmpc_ge_10_or_plasmacytoma",
          "met": true
        },
        {
          "factor": "hypercalcemia",
          "met": true
        },
        {
          "factor": "renal_insufficiency",
          "met": false
        },
        {
          "factor": "anemia",
          "met": false
        },
        {
          "factor": "osteolytic_lesion",
          "met": false
        },
        {
          "factor": "bmpc_ge_60",
          "met": false
        },
        {
          "factor": "flc_ratio_ge_100",
          "met": false
        },
        {
          "factor": "mri_gt_1_focal",
          "met": false
        },
        {
          "factor": "any_mde",
          "met": true
        }
      ],
      "anemia": false,
      "any_mde": true,
      "bmpc_ge_60": false,
      "clonal_bmpc_ge_10_or_plasmacytoma": true,
      "flc_ratio_ge_100": false,
      "hypercalcemia": true,
      "mri_gt_1_focal": false,
      "myeloma": true,
      "osteolytic_lesion": false,
      "renal_insufficiency": false
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, Kumar S, Hillengass J, Kastritis E, Richardson P, Landgren O, Paiva B, Dispenzieri A, Weiss B, LeLeu X, Zweegman S, Lonial S, Rosinol L, Zamagni E, Jagannath S, Sezer O, Kristinsson SY, Caers J, Usmani SZ, Lahuerta JJ, Johnsen HE, Beksac M, Cavo M, Goldschmidt H, Terpos E, Kyle RA, Anderson KC, Durie BGM, San Miguel JF",
    "doi": "10.1016/S1470-2045(14)70442-5",
    "id": "rajkumar-2014",
    "pmid": "25439696",
    "source": "Lancet Oncol. 2014;15(12):e538-e548",
    "title": "International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma"
  },
  "formula": "imwg_myeloma",
  "formula_expression": "myeloma iff clonal_bmpc_ge_10_or_plasmacytoma and ≥1 myeloma-defining event (hypercalcemia, renal_insufficiency, anemia, osteolytic_lesion, bmpc_ge_60, flc_ratio_ge_100, or mri_gt_1_focal) (Rajkumar 2014 IMWG definition of multiple myeloma requiring therapy). Not a diagnosis. Not smouldering MM, MGUS, POEMS, or amyloid. Not Greipp ISS. Not R-ISS",
  "criteria": [
    {
      "factor": "clonal_bmpc_ge_10_or_plasmacytoma",
      "met": true
    },
    {
      "factor": "hypercalcemia",
      "met": true
    },
    {
      "factor": "renal_insufficiency",
      "met": false
    },
    {
      "factor": "anemia",
      "met": false
    },
    {
      "factor": "osteolytic_lesion",
      "met": false
    },
    {
      "factor": "bmpc_ge_60",
      "met": false
    },
    {
      "factor": "flc_ratio_ge_100",
      "met": false
    },
    {
      "factor": "mri_gt_1_focal",
      "met": false
    },
    {
      "factor": "any_mde",
      "met": true
    }
  ],
  "anemia": false,
  "any_mde": true,
  "bmpc_ge_60": false,
  "clonal_bmpc_ge_10_or_plasmacytoma": true,
  "flc_ratio_ge_100": false,
  "hypercalcemia": true,
  "mri_gt_1_focal": false,
  "myeloma": true,
  "osteolytic_lesion": false,
  "renal_insufficiency": false
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• Myeloma ISS — Apply the Greipp 2005 International Staging System for multiple myeloma from serum beta-2 microglobulin and albumin.
• R-ISS — Apply the Palumbo 2015 Revised International Staging System for multiple myeloma from ISS (beta-2 microglobulin and albumin), caller-assigned high-risk cytogenetic abnormalities, and LDH above the upper limit of normal.
• WHO 2016 SM criteria — Apply the Valent 2016 / WHO 2016 systemic mastocytosis diagnostic criteria (Table 1) and return whether the published combination of the major criterion plus at least one minor, or at least three minors, is met. Tryptase >20 ng/mL does not count when an unrelated myeloid neoplasm is present.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.