IPSS-R (myelodysplastic syndromes)

IPSS-R

Sum the Greenberg 2012 IPSS-R (revised international prognostic scoring system) for myelodysplastic syndromes and return very_low (≤1.5), low (>1.5–3), intermediate (>3–4.5), high (>4.5–6), or very_high (>6).

LIVE $0.005 USDC GET /api/calc/ipss_r

Markdown: /docs/ipss-r.md · Canonical: https://magentlab.com/docs/ipss-r

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

When to use

When an agent needs the published IPSS-R point total and risk group and must not invent an MDS diagnosis, transplant listing, or survival estimate, and must not substitute IPSS 1997 or IPSS-M.

When not to use

Not a medical device and not an MDS diagnosis, treatment choice, or transplant listing. magent does not examine the patient.
This is Greenberg 2012 IPSS-R only, not Greenberg 1997 IPSS and not the molecular IPSS-M.
magent does not karyotype. cytogenetics is the caller-assigned Schanz/Greenberg 2012 subgroup (very_good, good, intermediate, poor, very_poor).
Does not report median survival years or AML transformation times.

Formula

IPSS-R = cytogenetics (very_good 0, good 1, intermediate 2, poor 3, very_poor 4) + BM blasts % (≤2 → 0; >2–<5 → 1; 5–10 → 2; >10 → 3) + hemoglobin g/dL (≥10 → 0; 8–<10 → 1; <8 → 1.5) + platelets 10^9/L (≥100 → 0; 50–<100 → 0.5; <50 → 1) + ANC 10^9/L (≥0.8 → 0; <0.8 → 0.5); Greenberg 2012; max 10; ≤1.5 very_low, >1.5–3 low, >3–4.5 intermediate, >4.5–6 high, >6 very_high

Citation

Title: Revised international prognostic scoring system for myelodysplastic syndromes
Authors: Greenberg PL, Tuechler H, Schanz J, et al.
Source: Blood. 2012;120(12):2454-2465
DOI: 10.1182/blood-2012-03-420489

Worked example

Good cytogenetics, favorable counts

Given: anc_10e9_l=2.0blasts_percent=1cytogenetics=goodhemoglobin_g_dl=12platelets_10e9_l=150

cytogenetics good → 1; blasts 1% ≤2 → 0; hemoglobin 12 ≥10 → 0; platelets 150 ≥100 → 0; ANC 2.0 ≥0.8 → 0
Score = 1 (max 10); risk_group = very_low (≤1.5)

Maximum published score

Given: anc_10e9_l=0.5blasts_percent=15cytogenetics=very_poorhemoglobin_g_dl=7platelets_10e9_l=40

cytogenetics very_poor → 4; blasts >10 → 3; hemoglobin <8 → 1.5; platelets <50 → 1; ANC <0.8 → 0.5
Score = 10 (max 10); risk_group = very_high (>6)

Also searched as

IPSS-R
revised international prognostic scoring system
IPSS-R MDS
Greenberg IPSS-R
myelodysplastic syndrome IPSS-R
revised IPSS
IPSSR
Schanz cytogenetic IPSS-R

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/ipss_r?cytogenetics=good&blasts_percent=1&hemoglobin_g_dl=12&platelets_10e9_l=150&anc_10e9_l=2.0

Full URL: https://api.magentlab.com/api/calc/ipss_r?cytogenetics=good&blasts_percent=1&hemoglobin_g_dl=12&platelets_10e9_l=150&anc_10e9_l=2.0

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/ipss_r?cytogenetics=good&blasts_percent=1&hemoglobin_g_dl=12&platelets_10e9_l=150&anc_10e9_l=2.0"

Parameters

Name	Type	Required	Description
`cytogenetics`	string	required · very_good, good, intermediate, poor, very_poor	Schanz/Greenberg 2012 cytogenetic subgroup as assigned by the caller (very_good 0, good 1, intermediate 2, poor 3, very_poor 4). magent does not karyotype.
`blasts_percent`	number	required	Bone-marrow blasts as a percent (0-30). Greenberg 2012: ≤2 → 0; >2 and <5 → 1; 5–10 → 2; >10 → 3. magent does not count blasts.
`hemoglobin_g_dl`	number	required	Hemoglobin in g/dL (3-20). Greenberg 2012: ≥10 → 0; 8 to <10 → 1; <8 → 1.5. magent does not assay hemoglobin.
`platelets_10e9_l`	number	required	Platelets in 10^9/L (0-2000). Greenberg 2012: ≥100 → 0; 50 to <100 → 0.5; <50 → 1. magent does not assay platelets.
`anc_10e9_l`	number	required	Absolute neutrophil count in 10^9/L (0-50). Greenberg 2012: ≥0.8 → 0; <0.8 → 0.5. magent does not compute ANC.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/ipss_r Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "anc_10e9_l": "2.0",
      "blasts_percent": "1",
      "cytogenetics": "good",
      "hemoglobin_g_dl": "12",
      "platelets_10e9_l": "150"
    },
    {
      "anc_10e9_l": "2.0",
      "blasts_percent": "1",
      "cytogenetics": "good",
      "hemoglobin_g_dl": "12",
      "platelets_10e9_l": "150"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/ipss_r",
  "items": [
    {
      "components": [
        {
          "value": "good",
          "factor": "cytogenetics",
          "points": 1,
          "present": true
        },
        {
          "value": 1.0,
          "factor": "blasts_percent",
          "points": 0,
          "present": false
        },
        {
          "value": 12.0,
          "factor": "hemoglobin_g_dl",
          "points": 0,
          "present": false
        },
        {
          "value": 150.0,
          "factor": "platelets_10e9_l",
          "points": 0,
          "present": false
        },
        {
          "value": 2.0,
          "factor": "anc_10e9_l",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Greenberg PL, Tuechler H, Schanz J, et al.",
        "doi": "10.1182/blood-2012-03-420489",
        "id": "greenberg-2012",
        "pmid": "22740453",
        "source": "Blood. 2012;120(12):2454-2465",
        "title": "Revised international prognostic scoring system for myelodysplastic syndromes"
      },
      "formula": "ipss_r",
      "formula_expression": "IPSS-R = cytogenetics (very_good 0, good 1, intermediate 2, poor 3, very_poor 4) + BM blasts % (≤2 → 0; >2–<5 → 1; 5–10 → 2; >10 → 3) + hemoglobin g/dL (≥10 → 0; 8–<10 → 1; <8 → 1.5) + platelets 10^9/L (≥100 → 0; 50–<100 → 0.5; <50 → 1) + ANC 10^9/L (≥0.8 → 0; <0.8 → 0.5); Greenberg 2012; max 10; ≤1.5 very_low, >1.5–3 low, >3–4.5 intermediate, >4.5–6 high, >6 very_high",
      "max_score": 10,
      "score": 1,
      "platelets_10e9_l": 150.0,
      "risk_group": "very_low",
      "hemoglobin_g_dl": 12.0,
      "anc_10e9_l": 2.0,
      "blasts_percent": 1.0,
      "cytogenetics": "good"
    },
    {
      "components": [
        {
          "value": "good",
          "factor": "cytogenetics",
          "points": 1,
          "present": true
        },
        {
          "value": 1.0,
          "factor": "blasts_percent",
          "points": 0,
          "present": false
        },
        {
          "value": 12.0,
          "factor": "hemoglobin_g_dl",
          "points": 0,
          "present": false
        },
        {
          "value": 150.0,
          "factor": "platelets_10e9_l",
          "points": 0,
          "present": false
        },
        {
          "value": 2.0,
          "factor": "anc_10e9_l",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Greenberg PL, Tuechler H, Schanz J, et al.",
        "doi": "10.1182/blood-2012-03-420489",
        "id": "greenberg-2012",
        "pmid": "22740453",
        "source": "Blood. 2012;120(12):2454-2465",
        "title": "Revised international prognostic scoring system for myelodysplastic syndromes"
      },
      "formula": "ipss_r",
      "formula_expression": "IPSS-R = cytogenetics (very_good 0, good 1, intermediate 2, poor 3, very_poor 4) + BM blasts % (≤2 → 0; >2–<5 → 1; 5–10 → 2; >10 → 3) + hemoglobin g/dL (≥10 → 0; 8–<10 → 1; <8 → 1.5) + platelets 10^9/L (≥100 → 0; 50–<100 → 0.5; <50 → 1) + ANC 10^9/L (≥0.8 → 0; <0.8 → 0.5); Greenberg 2012; max 10; ≤1.5 very_low, >1.5–3 low, >3–4.5 intermediate, >4.5–6 high, >6 very_high",
      "max_score": 10,
      "score": 1,
      "platelets_10e9_l": 150.0,
      "risk_group": "very_low",
      "hemoglobin_g_dl": 12.0,
      "anc_10e9_l": 2.0,
      "blasts_percent": 1.0,
      "cytogenetics": "good"
    }
  ]
}

Response

Field	Type	Description
`formula`	string	ipss_r
`formula_expression`	string	Exact expression used
`score`	number	IPSS-R points 0-10 (half-points allowed)
`max_score`	integer	Always 10 (4+3+1.5+1+0.5)
`risk_group`	string	very_low when score is ≤1.5, low when >1.5–3, intermediate when >3–4.5, high when >4.5–6, very_high when >6 (Greenberg 2012). Not an MDS diagnosis. Not IPSS 1997. Not IPSS-M. Not a transplant listing.
`cytogenetics`	string	Caller-assigned Schanz/Greenberg subgroup used
`blasts_percent`	number	Bone-marrow blast percent used
`hemoglobin_g_dl`	number	Hemoglobin in g/dL used
`platelets_10e9_l`	number	Platelets in 10^9/L used
`anc_10e9_l`	number	ANC in 10^9/L used
`components`	array	Per-factor points
`citation`	object	Greenberg et al. Blood 2012 IPSS-R citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": "good",
      "factor": "cytogenetics",
      "points": 1,
      "present": true
    },
    {
      "value": 1.0,
      "factor": "blasts_percent",
      "points": 0,
      "present": false
    },
    {
      "value": 12.0,
      "factor": "hemoglobin_g_dl",
      "points": 0,
      "present": false
    },
    {
      "value": 150.0,
      "factor": "platelets_10e9_l",
      "points": 0,
      "present": false
    },
    {
      "value": 2.0,
      "factor": "anc_10e9_l",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Greenberg PL, Tuechler H, Schanz J, et al.",
    "doi": "10.1182/blood-2012-03-420489",
    "id": "greenberg-2012",
    "pmid": "22740453",
    "source": "Blood. 2012;120(12):2454-2465",
    "title": "Revised international prognostic scoring system for myelodysplastic syndromes"
  },
  "formula": "ipss_r",
  "formula_expression": "IPSS-R = cytogenetics (very_good 0, good 1, intermediate 2, poor 3, very_poor 4) + BM blasts % (≤2 → 0; >2–<5 → 1; 5–10 → 2; >10 → 3) + hemoglobin g/dL (≥10 → 0; 8–<10 → 1; <8 → 1.5) + platelets 10^9/L (≥100 → 0; 50–<100 → 0.5; <50 → 1) + ANC 10^9/L (≥0.8 → 0; <0.8 → 0.5); Greenberg 2012; max 10; ≤1.5 very_low, >1.5–3 low, >3–4.5 intermediate, >4.5–6 high, >6 very_high",
  "max_score": 10,
  "score": 1,
  "platelets_10e9_l": 150.0,
  "risk_group": "very_low",
  "hemoglobin_g_dl": 12.0,
  "anc_10e9_l": 2.0,
  "blasts_percent": 1.0,
  "cytogenetics": "good"
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_ipss_cytogenetics`	cytogenetics must be very_good, good, intermediate, poor, or very_poor (Greenberg 2012). Returned before settlement; you are not charged.
400	`invalid_ipss_r`	blasts_percent 0-30, hemoglobin_g_dl 3-20, platelets_10e9_l 0-2000, and anc_10e9_l 0-50 (IPSS-R 2012 labs; magent clamps, not Greenberg cutoffs). Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

IPI — Sum the Shipp 1993 five-factor International Prognostic Index (all ages) and return low (0–1), low_intermediate (2), high_intermediate (3), or high (4–5).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.